Current medicinal chemistry最新文献

{"title":"WITHDRAWN: In Vitro and In Vivo Anti-lung Cancer Activity of Emodin: An RNAseq Transcriptome Analysis","authors":"Aikebaier Maimaiti, Liu Xingliang, Linsen Shi","doi":"10.2174/0929867329666220921120314","DOIUrl":"10.2174/0929867329666220921120314","url":null,"abstract":"<p><p>Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.</p><p><p>Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.</p><p><p>The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php</p><p><strong>Bentham science disclaimer: </strong>It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33480594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Body Mass Index and Abdominal Obesity with Incidence of Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction","authors":"Xinyi Huang, Xiao Liu, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Zhiteng Chen, Runlu Sun, Peng Yu, Jianyong Ma, Wengen Zhu, Yangxin Chen, Guifu Wu, Yuling Zhang, Jingfeng Wang","doi":"10.2174/0929867330666230606100903","DOIUrl":"10.2174/0929867330666230606100903","url":null,"abstract":"<p><strong>Introduction: </strong>The association between obesity and atrial fibrillation (AF) incidence in\u0000heart failure with preserved ejection fraction (HFpEF) patients is currently unclear. Our analyses\u0000and results are based on the whole Treatment of Preserved Cardiac Function Heart Failure with an\u0000Aldosterone Antagonist (TOPCAT) trial (placebo and spironolactone).</p><p><strong>Methods: </strong>A total of 2138 subjects without baseline AF were included in the trial. Kaplan-Meier\u0000(K-M) curves and Cox regression with hazard ratios (HRs) and confidence intervals (CIs) were\u0000used to assess the incidence of AF with obesity.</p><p><strong>Results: </strong>Of 2138 HFpEF patients without baseline AF, 1165 were obese (body mass index [BMI]≥\u000030 kg/m2). The K-M curve showed obese patients developed AF more than overweight (25≤\u0000BMI ≤29.9 kg/m2) patients (p=0.013), confirmed by multivariable analysis, while there’s no statistical\u0000difference between overweight and normal weight (18.5≤ BMI ≤24.9 kg/m2) patients. The occurrence\u0000of AF increased by 3% for every kg/m2 increase in BMI (adjusted HR, aHR: 1.03; 95%\u0000CI: 1.00-1.06), with a positive linear association (p for nonlinear: 0.145). Obesity was associated\u0000with AF incidence (aHR: 1.62; 95% CI: 1.05-2.50) compared with non-obesity (including overweight\u0000and normal-weight patients). Abdominal obesity was associated with increased AF incidence\u0000(aHR: 1.70; 95% CI: 1.04-2.77), and AF incidence rose by 18% per centimeter in circumference\u0000(aHR: 1.18; 95% CI:1.04-1.34).</p><p><strong>Conclusion: </strong>Obesity and abdominal obesity increase the incidence of AF in HFpEF patients. Further\u0000studies need to determine whether there is a difference in AF in response to spironolactone\u0000across obese HFpEF pheno groups.</p><p><strong>Clinical trial registration: </strong>URL: https://clinicaltrials.gov. Unique identifier: NCT00094302. Registered\u0000on October 15, 2004</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9586696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Possible Roles of <i>β</i>-alanine and L-carnosine in Anti-aging.","authors":"Amin Gasmi, Pavan Kumar Mujawdiya, Roman Lysiuk, Mariia Shanaida, Massimiliano Peana, Salva Piscopo, Nataliya Beley, Svitlana Dzyha, Kateryna Smetanina, Volodymyr Shanaida, Stephane Resimont, Geir Bjorklund","doi":"10.2174/0109298673263561231117054447","DOIUrl":"10.2174/0109298673263561231117054447","url":null,"abstract":"<p><p>β-alanine (BA), being a non-proteinogenic amino acid, is an important constituent of L-carnosine (LC), which is necessary for maintaining the muscle buffering capacity and preventing a loss of muscle mass associated with aging effects. BA is also very important for normal human metabolism due to the formation of a part of pantothenate, which is incorporated into coenzyme A. BA is synthesized in the liver, and its combination with histidine results in the formation of LC, which accumulates in the muscles and brain tissues and has a well-defined physiological role as a good buffer for the pH range of muscles that caused its rapidly increased popularity as ergogenic support to sports performance. The main antioxidant mechanisms of LC include reactive oxygen species (ROS) scavenging and chelation of metal ions. With age, the buffering capacity of muscles also declines due to reduced concentration of LC and sarcopenia. Moreover, LC acts as an antiglycation agent, ultimately reducing the development of degenerative diseases. LC has an anti-inflammatory effect in autoimmune diseases such as osteoarthritis. As histidine is always present in the human body in higher concentrations than BA, humans have to get BA from dietary sources to support the required amount of this critical constituent to supply the necessary amount of LC synthesis. Also, BA has other beneficial effects, such as preventing skin aging and intestinal damage, improving the stress-- fighting capability of the muscle cells, and managing an age-related decline in memory and learning. In this review, the results of a detailed analysis of the role and various beneficial properties of BA and LC from the anti-aging perspective are presented.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":"6-22"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomics Analysis of Five Potential Plasma-derived Exosomal Biomarkers for Acute Myocardial Infarction.","authors":"Shasha Xu, Yi Zhai, Chen Wang, Yang Zhang, Xiaowei Liu, Jianjun Jiang, Yafei Mi","doi":"10.2174/0109298673346007241113072114","DOIUrl":"https://doi.org/10.2174/0109298673346007241113072114","url":null,"abstract":"<p><strong>Aims: </strong>This study was to explore the relationship between plasma exosomes and Acute myocardial infarction (AMI).</p><p><strong>Background: </strong>Acute myocardial infarction (AMI) is one of the most common cardiovascular complications. Recent studies have shown that exosomes play a crucial role in the development and progression of cardiovascular diseases. However, there is a lack of relevant research on the relationship between plasma exosomes and AMI.</p><p><strong>Objective: </strong>This study was designed to explore the relationship between plasma exosomes and AMI.</p><p><strong>Methods: </strong>This retrospective study collected the basic clinical data of patients with AMI (n = 10), stable angina pectoris (SAP, n = 10), and noncoronary heart disease (CON, n = 10) at the Department of Cardiovascular Medicine at Taizhou Hospital (Zhejiang, China, 2021.01 to 2021.12). Proteomics was used to systematically screen the differential proteins of plasma exosomes in patients with clinical AMI, SAP, and CON. Then, the results were further verified using parallel reaction monitoring (PRM).</p><p><strong>Results: </strong>Five of all the differentially expressed proteins (DEPs) were quantified by PRM. Compared with the CON group, heparin cofactor 2 (SERPIND1), mannan-binding lectin serine protease 1 (MASP1), ficolin-2 (FCN2), and α1-Microglobulin/bikunin precursor (AMBP) were upregulated in patients with AMI and SAP, with a higher expression in AMI than in SAP. Additionally, human leukocyte antigen (HLA-C) was downregulated in both exosomes and plasma.</p><p><strong>Conclusion: </strong>The expression of four plasma exosome biomarkers in AMI and SAP patients was higher than that in noncoronary heart disease (NCHD) patients. HLA-C was downregulated in both exosomes and plasma, showing a potential to serve as a new candidate target for the detection and therapy of AMI.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive Oxygen Species and its Manipulation Strategies in Cancer Treatment.","authors":"Kabil Malhotra, Arzoo Malik, Waleed H Almalki, Amirhossein Sahebkar, Prashant Kesharwani","doi":"10.2174/0929867330666230609110455","DOIUrl":"10.2174/0929867330666230609110455","url":null,"abstract":"<p><p>Cancer is one of the serious diseases of modern times, occurring in all parts of the world and shows a wide range of effects on the human body. Reactive Oxygen Species (ROS) such as oxide and superoxide ions have both advantages and disadvantages during the progression of cancer, dependent on their concentration. It is a necessary part of the normal cellular mechanisms. Changes in its normal level can cause oncogenesis and other relatable problems. Metastasis can also be controlled by ROS levels in the tumor cells, which can be prevented by the use of antioxidants. However, ROS is also used for the initiation of apoptosis in cells by different mediators. There exists a cycle between the production of oxygen reactive species, their effect on the genes, role of mitochondria and the progression of tumors. ROS levels cause DNA damage by the oxidation process, gene damage, altered expression of the genes and signalling mechanisms. They finally lead to mitochondrial disability and mutations, resulting in cancer. This review summarizes the important role and activity of ROS in developing different types of cancers like cervical, gastric, bladder, liver, colorectal and ovarian cancers.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":"55-73"},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9617693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Synthetic Strategies of Glycans and their Pharmaceutical Applications.","authors":"He Wang, Marco Terreni, Matthieu Sollogoub, Yongmin Zhang","doi":"10.2174/0109298673340376241031041048","DOIUrl":"https://doi.org/10.2174/0109298673340376241031041048","url":null,"abstract":"<p><p>The understanding of glycans, the third life chain, is widely desired. Naturally, the glycoconjugates are found in heterogeneous forms due to the enzyme competition in the same process. As a result, the synthesis of homogeneous glycans has become one of the trending research topics. In this review, orthogonal protection strategies were summarized to overcome the difficulties, such as the numerous hydroxyl groups of oligosaccharides and stereoselectivities during glycosylations. A variety of synthetic glycomics, including glycoproteins, glycolipids, and newly discovered glycoRNAs, were also presented. Their applications were categorized by different diseases, which elucidated the great potential of glycans as drug candidates in the next generation.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dancing Glycoproteins: Memory Pattern Formation by Protein Folding through Hydrogen Bonding.","authors":"Atta-Ur-Rahman","doi":"10.2174/0929867332999241228174430","DOIUrl":"https://doi.org/10.2174/0929867332999241228174430","url":null,"abstract":"<p><p>A considerable amount of work has been carried out on the biology of learning and memory acquisition, and retention [1-6]; however, little is known regarding how the information is written in the brain [7-9]. It is notable that in the Neuron Theory postulated by Santiago Ramón y Cajal [10], neurons were conceived to form a contiguous instead of a continuous structure. They were physically separated but could function through their connections by synapses [11]. The electric impulses are initiated by the presynaptic neurons and transmitted through a synapse to the postsynaptic neuron, and they then travel toward the axon. A considerable amount of work on the molecular and cellular mechanisms has been undertaken in this fast-evolving field [11-16].</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-COVID-19 Syndrome-associated Risk Factors for Acne Exacerbation.","authors":"Mingxia Sun, Jing Guo, Yuanyuan Li, Lamei Chen, Yunfang Meng, Jing Wu, Ningning Dang","doi":"10.2174/0109298673345685241114104703","DOIUrl":"https://doi.org/10.2174/0109298673345685241114104703","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to investigate the impact of coronavirus disease 2019 (COVID-19) syndrome on various aspects of acne exacerbation. Additionally, we aimed to explore the risk factors for acne exacerbation after COVID-19 syndrome.</p><p><strong>Method: </strong>A total of 211 subjects with acne were enrolled, and their key demographic characteristics and lifestyle factors were recorded. They were asked whether acne exacerbation occurred after COVID-19 syndrome, as well as the latency of exacerbation, the exacerbation location, and the form of skin lesions. The risk factors were analyzed using the Cox proportional hazard regression model. Overall, 41.2% of cases reported exacerbation of acne after COVID-19 syndrome. Age was found to be a protective factor. Additionally, sufficient fruit intake may slightly prevent exacerbation. For participants engaging in daily physical exercise, the likelihood of exacerbation was significantly increased after COVID-19 syndrome.</p><p><strong>Result: </strong>The probability of exacerbation was significantly higher if an acne itch was present. Patients who experienced exacerbation in the chin area were more likely to develop acne-induced anxiety. Males had a higher risk of aggravation of the cyst form. Interestingly, those with lower education levels were more likely to have aggravation in the right cheek after COVID-19 syndrome. Moreover, physical exercise might prevent aggravation in the front or back areas.</p><p><strong>Conclusion: </strong>Finally, fish intake of ≥240 g per week was related to the aggravation of the hard nodule form. In conclusion, age and adequate fruit intake may play a protective role, while acne itch and daily exercise may be risk factors for acne exacerbation.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LncRNA-Associated ceRNA Network Revealing the Potential Regulatory Roles of Ferroptosis and Immune Infiltration in Osteosarcoma as well as Construction of the Prognostic Model.","authors":"Zhixian Lin, Zhen Wang, Danyan Shao, Jiangfeng Chen, Yunxia Liu, Yongwei Yao","doi":"10.2174/0109298673322797241001054036","DOIUrl":"https://doi.org/10.2174/0109298673322797241001054036","url":null,"abstract":"<p><strong>Background: </strong>Osteosarcoma (OS) is the most common primary bone malignancy in the world. Increasing studies indicate that long non-coding RNAs (lncRNAs) are involved in ferroptosis and OS progression. Therefore, this study aims to identify ferroptosis- related lncRNAs (frlncRNAs), explore potential competing endogenous RNA (ceRNA) networks, and establish a new model for predicting OS prognosis.</p><p><strong>Methods: </strong>Firstly, we downloaded data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), University of California, Santa Cruz (UCSC), and FerrDB, and screened for differentially expressed FRlncRNAs (DEFRlncRNAs) between OS patients and healthy controls. Then, we constructed the ceRNA network using the Lncbase 3.0, starBase, miRDB, miRTarBase, and TargetScan databases. Subsequently, prognosis- related DEFRlncRNAs were selected through Cox analysis, and a prognostic model was constructed. Next, the proportions of different immune cells in high and low-risk groups were quantified and evaluated using the \"CIBERSORT\" algorithm. Finally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed on prognosis-related DEFRlncRNAs to identify topranked biological processes and pathways.</p><p><strong>Results: </strong>We identified 247 DEFRlncRNAs and constructed the ceRNA network comprising 37 lncRNAs, 84 microRNAs (miRNAs), and 865 messenger RNAs (mRNAs). Subsequently, we obtained 8 prognosis-related DEFRlncRNAs (AL645728.1, AL161785.1, LINC00539, AL590764.1, OLMALINC, AC110995.1, AC091180.2, and AL160006.1) and constructed a prognostic model, where metastasis and risk score were identified as important clinical factors for predicting OS prognosis. Additionally, only OLMALINC and AL160006.1 had corresponding target miRNAs in the prognosis-related ceRNA network. Lastly, we revealed the infiltration proportions of different immune cells in OS, with higher proportions of macrophages (M0 and M2 subgroups) and T cells (T cells CD4 memory resting and T cells CD8) observed.</p><p><strong>Conclusion: </strong>This study explored the ferroptosis-related lncRNA-miRNA-mRNA regulatory network in OS, constructed a ferroptosis-related prognostic model, and characterized its association with immune infiltration, providing new insights into the pathological mechanisms and targeted therapy development for OS.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Biomedical Hydrogels on Exercise-induced Muscle Damage: A Narrative Review.","authors":"Jie Cai, Mingbo Fan, Ailin Yu, Chenghu Wu","doi":"10.2174/0109298673360294241217061953","DOIUrl":"https://doi.org/10.2174/0109298673360294241217061953","url":null,"abstract":"<p><p>Exercise-induced muscle damage (EIMD) is a common occurrence among athletes and individuals engaged in physical fitness activities. Muscle strains result from excessive or repetitive muscle tension, leading to tissue damage, inflammation, and pain. These strains can range from mild discomfort to severe damage, resulting in pain, inflammation, and reduced functionality. Effective management of muscle damage is crucial for promoting recovery and returning individuals to their desired level of activity. Conventional treatment modalities such as rest, ice, compression, and elevation (RICE), physical therapy, and nonsteroidal anti-inflammatory drugs (NSAIDs) have limitations in terms of efficacy and long-term outcomes. Consequently, there is a need for innovative approaches that not only address the symptoms but also promote healing and prevention of future injuries. Hydrogels are three-dimensional crosslinked networks of hydrophilic polymers that have gained significant attention in the field of biomedicine. Their unique properties, drug-delivery capabilities, and capacity to provide mechanical support make them promising tools in muscle damage management. Biomedical hydrogels hold significant potential as a preventive or alleviative approach for EIMD. This review provides a comprehensive overview of biomedical hydrogels as a promising approach for preventing and alleviating EIMD, addressing current challenges, and outlining future directions for research and development in the field.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}