Current medicinal chemistry最新文献

{"title":"Comparative Glycoproteomic Analysis of Mouse 4T1 Breast Cancer Model.","authors":"Aik-Aun Tan, Yin-Ling Wong, Subash C B Gopinath, Lik Voon Kiew, Sreenivasan Sasidharan, Yeng Chen","doi":"10.2174/0109298673360978250329065548","DOIUrl":"https://doi.org/10.2174/0109298673360978250329065548","url":null,"abstract":"<p><strong>Background: </strong>Glycosylation is a post-translational modification process that plays a fundamental role in malignant transformation. Moreover, aberrant glycosylation is known to be associated with cancer progression. Thus, the characterization of cancer-specific protein glycosylation profiles might reveal important diagnostic and/or prognostic biomarkers for cancer.</p><p><strong>Objective: </strong>In the present study, we have analysed serum protein and glycoprotein profiles during breast cancer progression using a mouse model. Specifically, 4T1 tumour cells were injected into the mammary fat pad of BALB/c mice to induce tumours.</p><p><strong>Methods: </strong>Sera samples were subsequently collected weekly for four weeks and examined using two-dimensional electrophoresis (2D-E) coupled with lectin-based analysis, followed by mass spectrometry.</p><p><strong>Results: </strong>This glycoproteomic profiling identified eight differentially expressed proteins, of which alpha-1 protease inhibitor 2, contraption (CON), haptoglobin (HP), and kininogen-1 were significantly up-regulated during the first 4 weeks of tumour progression. Notably, aberrantly N-glycosylated prothrombin was also detected in sera samples from all mice over the 4 weeks post-tumour injection. Additionally, O-glycosylated alpha-2-macroglobulin, CON, and HP were detected in weeks 1 and 2, whereas O-glycosylated alpha-2-HS-glycoprotein and CON were detected on weeks 3 and 4 post-implantation.</p><p><strong>Conclusion: </strong>Our findings indicate that the combination of 2D-E with lectin-based chromatography represents an effective approach for identifying prognostic biomarkers for breast cancer.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Experimental Validation of Tumor Antigens and Hypoxia Subtypes of Osteosarcoma for Potential mRNA Vaccine Development.","authors":"Chunnian Ren, Dawei He, Quan Wang","doi":"10.2174/0109298673348041250407062346","DOIUrl":"https://doi.org/10.2174/0109298673348041250407062346","url":null,"abstract":"<p><strong>Background: </strong>Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. The aim of this study was to explore the possibility of OS hypoxia subtype for anti-OS mRNA vaccine development and select suitable patients for precision therapy.</p><p><strong>Methods: </strong>We comprehensively explored hypoxia-related genes (HRGs) as potential sources of tumor neoantigens in OS patients. Gene set enrichment analysis algorithm and consensus clustering analysis were used to determine immune subtypes and evaluate tumor microenvironment. Estimation of stromal and immune cells in malignant tumour tissues using expression data algorithm was used to assess tumour immune activity. The OS hypoxia landscape was visualized using dimensionality reduction analysis based on the DDRTree algorithm. Assessment of clinical samples and molecular experiments were performed to verify the determined tumor antigens.</p><p><strong>Results: </strong>Four overexpressed and mutated tumor antigens associated with prognosis and infiltration of antigen-presenting cells were identified and verified by clinical samples and molecular experiments. Furthermore, OS patients were stratified into two OS hypoxia subtypes. Interestingly, patients with the OS hypoxia subtype 1 tumor had a superior survival than those with the OS hypoxia subtype 2 tumor. Distinct expressions of immune checkpoint proteins (ICPs) and immunogenic cell death (ICD) modulators were observed in different immune subtype tumors. Finally, the immune landscape of OS showed a high degree of heterogeneity between individual patients.</p><p><strong>Conclusion: </strong>This study identified potential antigens for the anti-OS mRNA vaccine as well as different OS hypoxia subtypes, guiding more effective immunotherapeutic strategies and selecting appropriate patients for tumor vaccine therapy.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Transcriptomic Data and Mendelian Randomization Analyses Reveals Potentially Novel Sepsis-related Targets.","authors":"Wenting Tao, Liang Chen","doi":"10.2174/0109298673370740250403141421","DOIUrl":"https://doi.org/10.2174/0109298673370740250403141421","url":null,"abstract":"<p><strong>Background: </strong>Sepsis remains a leading cause of global morbidity and mortality.</p><p><strong>Objective: </strong>To identify candidate biomarkers that may be mechanistically related to the pathogenesis of sepsis.</p><p><strong>Methods: </strong>The Gene Expression Omnibus database was leveraged to identify differentially expressed genes (DEGs) between the healthy control and septicemia groups. Genes causally related to sepsis were probed through the integration of GWAS and expression quantitative trait loci (eQTL) data in a two-sample Mendelian randomization (MR) analysis. A set of key sepsis-related genes was then selected based on the overlap between these putative causal genes and the DEGs. These genes were then subjected to enrichment analyses, testing set validation, and analyses of their expression dynamics in clinical samples.</p><p><strong>Results: </strong>An examination of the overlap between 228 sepsis-related DEGs identified in the training dataset and 275 candidate causal genes linked to sepsis derived from the MR analysis led to the selection of four overlapping (SLC22A15, IL5RA, HDC, and SLC46A2) that may play a key role in sepsis. Enrichment analyses indicated that these genes were involved in the regulation of histidine metabolism and immune/inflammatory responses. In immune cell infiltration analyses, these genes were positively correlated with inflammatory response activation and the suppression of adaptive immunity. Consistent findings were obtained through qPCR verification in clinical samples.</p><p><strong>Conclusion: </strong>These results offer potential insight into the mechanisms that govern septicemia and thus suggest a promising series of candidates that may be amenable to targeting to prevent or treat sepsis more effectively.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Functional and Prognostic Significance of miR-217 in Uterine Corpus Endometrial Carcinoma.","authors":"Guizhen Lyu, Dongbing Li","doi":"10.2174/0109298673365101250404105130","DOIUrl":"10.2174/0109298673365101250404105130","url":null,"abstract":"<p><strong>Background: </strong>The presence of microRNA-217 (miR-217) has been observed across various malignancies. However, its specific contribution to uterine corpus endometrial carcinoma (UCEC) is yet to be fully understood.</p><p><strong>Objective: </strong>We aimed to explore the role of miR-217 in UCEC.</p><p><strong>Methods: </strong>Clinical and genomic data, alongside prognostic insights, for UCEC patients were sourced from the TCGA repository. A suite of statistical tools, including the Kruskal-Wallis test, Wilcoxon sign-rank test, and logistic regression, was deployed to scrutinize the correlation between miR-217 levels and clinical profiles. The Kaplan-Meier method was applied to chart survival curves, thereby assessing the prognostic implications of miR-217 levels and its target genes in UCEC. TargetScan, PicTar, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were conducted to uncover the functional envelope of miR-217 target genes. An immune infiltration analysis provided further context to the role of miR-217 in immune modulation. We validated the expression of miR-217 in cell lines.</p><p><strong>Results: </strong>miR-217 demonstrates atypical expression across a spectrum of cancers, including UCEC. The expression of miR-217 in the Mixed&Serous subtypes of UCEC is significantly higher than that in the Endometrioid subtype (p = 0.008). The presence of miR-217 is associated with adverse impacts on overall survival (OS) and disease-specific survival (DSS) in UCEC patients, with hazard ratios (HR) of 1.55 (95% CI: 1.00-2.38, p = 0.048) and 2.05 (95% CI: 1.19-3.53, p = 0.010), indicating statistical significance. The prognostic significance of miR-217 in UCEC is highlighted by its status as a standalone indicator of patient outcomes. Diminished expression of genes targeted by miR-217, such as BCL2, DYRK1A, IGF1R, NDN, and NHS, is correlated with diminished OS in UCEC. miR-217 is intricately involved in the pathogenesis of UCEC, potentially through involvement in pathways like the AMPK signaling and FoxO signaling pathways. The expression of miR-217 in UCEC is significantly correlated with the infiltration level of some immune cells. Notably, in cell lines derived from UCEC, miR-217 expression is markedly increased.</p><p><strong>Conclusion: </strong>The up-regulation of miR-217 is strongly linked to an adverse prognosis in UCEC patients, suggesting its potential as a prognostic biomarker and a predictor of immunotherapy response in UCEC patients.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfur and Selenium Modifications at Phosphorus Atom in Nucleoside Monophosphates, Activity and Potential Applications.","authors":"Agnieszka Krakowiak","doi":"10.2174/0109298673361335250404171911","DOIUrl":"https://doi.org/10.2174/0109298673361335250404171911","url":null,"abstract":"<p><p>Nucleotides and nucleosides play an essential role in many cellular processes but have low physiological stability, which limits their usefulness. Nucleosides modified with chalcogen at the phosphorus atom are more stable in body fluids and tissues. They can act as activators or inhibitors in many processes, including signal transduction through receptors and intracellular signaling. Some of them are also used as drugs or prodrugs that can serve as potential therapeutics in cancer and other diseases. This review focuses primarily on the activity and potential application of the nucleoside monophosphates modified with sulfur and selenium at the phosphorus atom, such as nucleoside 5'- O-phosphorothioate and 5'-O-phosphoroselenoates as well as adenosine cyclic 5', 3'- monothiophosphate and guanosine cyclic 5', 3'-monothiophosphate.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Attainments on Nanobiosensors for Diagnosing Atherosclerosis Biomarkers.","authors":"Thangavel Lakshmipriya, Subash C B Gopinath, Yeng Chen, Sreeramanan Subramaniam","doi":"10.2174/0109298673360990250408111013","DOIUrl":"https://doi.org/10.2174/0109298673360990250408111013","url":null,"abstract":"<p><p>Atherosclerosis is a chronic disease caused by inflammation in the blood vessel wall, which leads to plaque formation in the endothelial lining. Preexisting atherosclerosis contributes to various cardiovascular problems, including myocardial infarction, congestive cardiac failure, arrhythmias, and acute coronary syndrome, all of which are associated with higher postoperative mortality and morbidity. Rupturing of atherosclerosis poses a significant health concern as triggering a heart attack. Therefore, it is essential to identify atherosclerosis early to prevent health complications and their subsequent consequences. Atherosclerosis is typically diagnosed by angiograms, computerized tomography scans and stress tests. Additionally, various biomarkers are released by inflammatory cells in the surrounding tissue and artery walls during the pathogenesis of atherosclerosis. Quantifying these biomarkers can aid in diagnosing and determining the severity of atherosclerosis in relation to cardiovascular diseases. This review focuses on the recent advancements in understanding the formation of atherosclerosis and the implementation of biomarkers in nano biosensors.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gut Microbiota-anxiety Connection: Evidence, Mechanisms, and Therapeutic Strategies.","authors":"Geir Bjørklund, Monica Butnariu, Maryam Dadar, Yuliya Semenova","doi":"10.2174/0109298673356125250409182218","DOIUrl":"https://doi.org/10.2174/0109298673356125250409182218","url":null,"abstract":"<p><p>The gut-brain axis (GBA), a bidirectional communication system between the gut and the brain, has emerged as a critical player in mental health. The interest in the connection between anxiety disorders (AD) and the gut microbiota is growing. This paper provides an overview of gut microbiota's role in dysregulation in anxiety, including alterations in gut microbiota (dysbiosis), leaky gut, metabolic endotoxemia, and the effect of antipsychotic medications. The mechanisms underlying the gut microbiota-anxiety (GMA) connection, such as neurotransmitter production, immune dysregulation, and GBA communication, are discussed. Furthermore, the paper explores gut microbiota- based therapeutic strategies, including probiotics, prebiotics, symbiotics, fecal microbiota transplantation, and dietary interventions, as potential approaches for anxiety management. This research field's clinical implications and future directions are also examined, underscoring that more studies are needed on gut microbiota's role in anxiety disorders. The conclusion highlights the importance of this ongoing research and the potential for personalized therapeutic interventions, instilling hope and optimism for the future of anxiety management and providing reassurance about the potential for personalized therapeutic interventions in this field.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Glycation End Products and Skin Autoimmune Disorders: Pathogenic Insights into Vitiligo, Bullous Pemphigoid, and Type 1 Diabetes Mellitus.","authors":"Geir Bjørklund, Leonard Gurgas, Tony Hangan","doi":"10.2174/0109298673374335250410074811","DOIUrl":"https://doi.org/10.2174/0109298673374335250410074811","url":null,"abstract":"<p><p>AGEs are molecules formed by nonenzymatic glycation of proteins, lipids, and nucleic acids, a process accelerated under hyperglycemic conditions such as DM1. These molecules interact with specific receptors, particularly the Receptor for AGEs (RAGE), triggering intracellular signaling cascades that promote oxidative stress through the generation of Reactive Oxygen Species (ROS) and activation of inflammatory pathways. A critical pathological mechanism involves the formation of neoantigens, modified self-proteins that elicit immune responses. Structural alterations caused by AGEs expose new epitopes or modify existing ones, making them targets for autoreactive T cells and autoantibodies. This mechanism is implicated in autoimmune skin diseases such as vitiligo and bullous pemphigoid. Oxidative stress plays a central role in these diseases, exacerbated by AGEs through the generation of ROS and depletion of antioxidants, leading to melanocyte destruction in vitiligo and tissue damage in bullous pemphigoid. In addition, hypoxia enhances ROS production, mitochondria, and other cellular systems contributing to oxidative stress. Emerging evidence suggests that hypoxia can be mitigated by oxygen nanobubbles. Targeting AGE formation and oxidative stress presents a promising approach for the management of autoimmune skin disorders in DM1. Therapeutic strategies targeting AGE formation, oxidative stress, and immune dysregulation show promise for managing autoimmune skin disorders in Type 1 Diabetes Mellitus (T1DM). AGE inhibitors, such as aminoguanidine and pyridoxamine, reduce non-enzymatic protein glycation, limiting AGE accumulation and inflammatory signaling. Antioxidants, including polyphenols, vitamins C and E, N-acetylcysteine, selenium, and hydrogen-rich water, help neutralize Reactive Oxygen Species (ROS), restoring oxidative balance. Combining AGE inhibitors and antioxidants may provide synergistic benefits by reducing oxidative stress and protein immunogenicity. Additionally, immune modulation therapies, such as Treg therapy and cytokine inhibitors, aim to restore immune tolerance and prevent autoimmune activation. Anti-TNF-α and IL-6 inhibitors offer targeted inflammation suppression, while RAGE antagonists mitigate AGE-induced immune dysregulation. This study aims to explore the role of Advanced Glycation End products (AGEs) in the pathogenesis of autoimmune skin disorders associated with type 1 Diabetes Mellitus (DM1) and to evaluate potential therapeutic strategies targeting AGE formation and oxidative stress.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage Oligomeric Matrix Protein: A Potential Prognostic Biomarker and Therapeutic Target in Gastric Cancer.","authors":"Dongbing Li, Guizhen Lyu","doi":"10.2174/0109298673360512250329171036","DOIUrl":"https://doi.org/10.2174/0109298673360512250329171036","url":null,"abstract":"<p><strong>Background: </strong>Cartilage oligomeric matrix protein (COMP) is a protein that has been implicated in the development of some tumors, but its exact role in gastric cancer (GC) remains unclear.</p><p><strong>Objective: </strong>The study aims to comprehensively examine COMP in GC and to confirm its effects through experimental methods.</p><p><strong>Methods: </strong>The research harnessed data from the Cancer Genome Atlas (TCGA) to explore the significance of COMP in GC and its potential as a diagnostic tool. The study also examined the regulatory networks involving COMP, including its interactions with immune cells, immune checkpoint genes, tumor mutational burden (TMB), microsatellite instability (MSI), and the stemness index based on mRNA expression (mRNAsi). Additionally, the study explored the relationship between COMP expression and drug sensitivity in GC. Genomic variations of COMP in GC were assessed. The expression of COMP was validated by the GEPIA2 tool and confirmed with quantitative reverse transcription PCR (qRT-PCR) in cell lines (normal human gastric epithelial cells GES-1 and GC cell lines AGS and HGC-27).</p><p><strong>Results: </strong>Abnormal expression patterns of COMP were observed in various cancers, including GC. Higher levels of COMP in GC were significantly associated with the pathologic T stage and a history of reflux (p < 0.05 for both). Elevated COMP expression was correlated with poorer progression-free survival (PFS) (p = 0.027). COMP expression levels were identified as an independent prognostic factor for GC (p = 0.017). COMP was linked to TCF-dependent signaling in response to ECM receptor interaction, focal adhesion, and other pathways. There was an association between COMP expression and immune infiltration, immune checkpoint genes, TMB/MSI, and mRNAsi in GC. COMP expression was inversely correlated with the sensitivity to several drugs, indicating that higher levels of COMP may reduce the effectiveness of these drugs. COMP was found to be significantly up-regulated in GC cell lines.</p><p><strong>Conclusions: </strong>COMP could serve as a prognostic biomarker and a potential therapeutic target for the treatment of GC.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer Efficacy of Gingerol in Breast Cancer: Chemoprevention, Drug Synergism, and Nano-Formulations.","authors":"Pratibha Pandey, Sorabh Lakhanpal, Ashok Kumar Bishoyi, Subbulakshmi Ganesan, Mandeep Kaur, M Ravi Kumar, Mithilesh Singh, Renu Arya, Ajay Singh, Seema Ramniwas, Meenakshi Verma, Fahad Khan","doi":"10.2174/0109298673358402250407052100","DOIUrl":"https://doi.org/10.2174/0109298673358402250407052100","url":null,"abstract":"<p><p>Breast cancer is the most prevalent type of carcinoma among women worldwide and is the primary cause of cancer-related mortality. It is one of the most challenging cancers to manage and constitutes a significant proportion of cancer-related fatalities. The rising incidence of breast cancer necessitates the pursuit of more effective treatments. Due to the association of most chemotherapeutic medications with drug resistance, cancer recurrence, and adverse effects, researchers are exploring more effective alternatives, such as natural chemicals for the treatment and prevention of breast cancer. Chemoprevention using chemicals derived from plants has become a viable and accessible method for managing and controlling cancer. Among the numerous phytochemicals exhibiting an extensive range of biochemical and pharmacologic properties, gingerols have been documented to be efficacious in inhibiting the transformation, hyperproliferation, and inflammatory mechanisms that commence and foster carcinogenesis, along with the subsequent stages of carcinogenesis, angiogenesis, and metastasis. The chemotherapeutic potential of gingerol has been shown in several in vitro and in vivo studies. Clinical research has also documented the effectiveness of gingerol in cancer management. This review seeks to explore the pharmacological effects and mechanisms of gingerol with a primary emphasis on breast cancer therapy. This study aimed to highlight gingerol potential in addressing breast cancer and to inform future research pathways for the development of natural product-derived therapies.</p>","PeriodicalId":10984,"journal":{"name":"Current medicinal chemistry","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}