纳米生物传感器诊断动脉粥样硬化生物标志物的研究进展。

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Thangavel Lakshmipriya, Subash C B Gopinath, Yeng Chen, Sreeramanan Subramaniam
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引用次数: 0

摘要

动脉粥样硬化是一种由血管壁炎症引起的慢性疾病,炎症导致血管内皮形成斑块。先前存在的动脉粥样硬化会导致各种心血管问题,包括心肌梗死、充血性心力衰竭、心律失常和急性冠状动脉综合征,所有这些都与较高的术后死亡率和发病率相关。动脉粥样硬化破裂会引发心脏病发作,这是一个重大的健康问题。因此,早期识别动脉粥样硬化对于预防健康并发症及其后续后果至关重要。动脉粥样硬化通常通过血管造影、计算机断层扫描和压力测试来诊断。此外,在动脉粥样硬化的发病过程中,周围组织和动脉壁的炎症细胞释放各种生物标志物。量化这些生物标志物有助于诊断和确定与心血管疾病相关的动脉粥样硬化的严重程度。本文综述了近年来在动脉粥样硬化的形成和生物标志物在纳米生物传感器中的应用方面的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current Attainments on Nanobiosensors for Diagnosing Atherosclerosis Biomarkers.

Atherosclerosis is a chronic disease caused by inflammation in the blood vessel wall, which leads to plaque formation in the endothelial lining. Preexisting atherosclerosis contributes to various cardiovascular problems, including myocardial infarction, congestive cardiac failure, arrhythmias, and acute coronary syndrome, all of which are associated with higher postoperative mortality and morbidity. Rupturing of atherosclerosis poses a significant health concern as triggering a heart attack. Therefore, it is essential to identify atherosclerosis early to prevent health complications and their subsequent consequences. Atherosclerosis is typically diagnosed by angiograms, computerized tomography scans and stress tests. Additionally, various biomarkers are released by inflammatory cells in the surrounding tissue and artery walls during the pathogenesis of atherosclerosis. Quantifying these biomarkers can aid in diagnosing and determining the severity of atherosclerosis in relation to cardiovascular diseases. This review focuses on the recent advancements in understanding the formation of atherosclerosis and the implementation of biomarkers in nano biosensors.

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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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