没食子儿茶素-没食子酸酯（EGCG）的抗癌特性及其信号通路。

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2025-04-17 DOI:10.2174/0109298673348926250331150429

Amin Gasmi, Alain Menzel, Asma Gasmi Benahmed, Kateryna Uminska, Olha Mykhailenko, Victoriya Georgiyants, Salva Piscopo, Massimiliano Peana, Geir Bjørklund

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引用次数: 0

摘要

绿茶是亚洲国家的一种传统饮料，由四种衍生物组成。其中一种衍生物是表没食子儿茶素-3-没食子酸酯（EGCG）。EGCG对癌症、心脏病、糖尿病和肥胖症有治疗作用。然而，它的吸收率差和不稳定性限制了它的有效性，可以通过纳米颗粒封装来改善它的有效性。本文对绿茶多酚、促氧化剂和EGCG在癌症预防中的作用及其纳米技术的研究进行了综述。本文还讨论了鞣花单宁的其他植物来源及其理化性质，EGCG在乳腺癌中的治疗和预防作用，以及纳米金（NpAu）载体可以治疗的其他癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Anti-cancer Properties of Epigallocatechin-3-gallate (EGCG) and its Signaling Pathways.

Green tea is a traditional drink found in Asian countries, made up of four derivatives. One of the derivatives is epigallocatechin-3-gallate (EGCG). EGCG provides therapeutic benefits for cancer, heart disease, diabetes, and obesity. However, its poor absorption and instability limit its effectiveness, which can be improved using nanoparticle encapsulation. This work is a comprehensive review of the studies on green tea polyphenols, the impact of pro-oxidants and EGCG in cancer prevention, and their delivery using nanotechnology. Other plant sources of ellagitannin and its physicochemical properties, the therapeutic and preventive role of EGCG in breast cancer, and other cancers that can be treated using nano gold (NpAu) carriers are also discussed.

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.