Cytogenetics and cell genetics最新文献

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Spectral karyotyping of the human colon cancer cell lines SW480 and SW620. 人结肠癌细胞系SW480和SW620的光谱核型分析。
Cytogenetics and cell genetics Pub Date : 2000-04-01 DOI: 10.1016/S0016-5085(00)82310-0
R. Melcher, H. Luehrs, C. Steinlein, W. Feichtinger, C. Mueller, Michael Schmid, Wolfgang Scheppach, T. Menzel
{"title":"Spectral karyotyping of the human colon cancer cell lines SW480 and SW620.","authors":"R. Melcher, H. Luehrs, C. Steinlein, W. Feichtinger, C. Mueller, Michael Schmid, Wolfgang Scheppach, T. Menzel","doi":"10.1016/S0016-5085(00)82310-0","DOIUrl":"https://doi.org/10.1016/S0016-5085(00)82310-0","url":null,"abstract":"","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"21 1","pages":"145-52"},"PeriodicalIF":0.0,"publicationDate":"2000-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77118946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD). 原发性纤毛运动障碍(PCD)患者FOXJ1(别名hhh -4)基因无有害突变。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015645
A K Maiti, L Bartoloni, H M Mitchison, M Meeks, E Chung, S Spiden, C Gehrig, C Rossier, C D DeLozier-Blanchet, J Blouin, R M Gardiner, S E Antonarakis
{"title":"No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD).","authors":"A K Maiti,&nbsp;L Bartoloni,&nbsp;H M Mitchison,&nbsp;M Meeks,&nbsp;E Chung,&nbsp;S Spiden,&nbsp;C Gehrig,&nbsp;C Rossier,&nbsp;C D DeLozier-Blanchet,&nbsp;J Blouin,&nbsp;R M Gardiner,&nbsp;S E Antonarakis","doi":"10.1159/000015645","DOIUrl":"https://doi.org/10.1159/000015645","url":null,"abstract":"<p><p>The transcription factor FOXJ1 (alias HFH-4 or FKHL13) of the winged-helix/forkhead family is expressed in cells with cilia or flagella, and seems to be involved in the regulation of axonemal structural proteins. The knockout mouse Foxj1(-/-) shows abnormalities of organ situs, consistent with random determination of left-right asymmetry, and a complete absence of cilia. The human FOXJ1 gene which maps to chromosome 17q, is thus an excellent candidate gene for Kartagener Syndrome (KS), a subphenotype of Primary Ciliary Dyskinesia (PCD), characterized by bronchiectasis, chronic sinusitis and situs inversus. We have collected samples from 61 PCD families, in 31 of which there are at least two affected individuals. Two families with complete aciliogenesis, and six families, in which the affected members have microsatellite alleles concordant for a locus on distal chromosome 17q, were screened for mutations in the two exons and intron-exon junctions of the FOXJ1 gene. No sequence abnormalities were observed in the DNAs of the affected individuals of the selected families. These results demonstrate that the FOXJ1 gene is not responsible for the PCD/KS phenotype in the families examined.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 1-2","pages":"119-22"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015645","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21886951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains. 转录因子NFAT5在人染色体16q22.1、鼠染色体8D和猪染色体6p1.4上的定位及多聚谷氨酰胺结构域的比较
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015665
A Hebinck, A Dalski, H Engel, M Mattei, R Hawken, E Schwinger, C Zühlke
{"title":"Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains.","authors":"A Hebinck,&nbsp;A Dalski,&nbsp;H Engel,&nbsp;M Mattei,&nbsp;R Hawken,&nbsp;E Schwinger,&nbsp;C Zühlke","doi":"10.1159/000015665","DOIUrl":"https://doi.org/10.1159/000015665","url":null,"abstract":"<p><p>To date, transcription factors of the NFAT family (nuclear factors of activated T cells) have been described for mouse and man. Recently, we mapped the human NFAT5 gene to chromosome 16 by PCR using DNA from hybrid cell lines. Here we report the exact position of the human gene between D16S496 and WI5254 within the 16q22.1 subband, the localization of the murine gene at chromosome 8D, and the identification and mapping of the porcine counterpart to chromosome 6p1.4.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 1-2","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21887670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Detection of chromosomal imbalances in leiomyosarcoma by comparative genomic hybridization and interphase cytogenetics. 通过比较基因组杂交和间期细胞遗传学检测平滑肌肉瘤的染色体失衡。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015640
M Otaño-Joos, G Mechtersheimer, S Ohl, K K Wilgenbus, W Scheurlen, T Lehnert, F Willeke, H F Otto, P Lichter, S Joos
{"title":"Detection of chromosomal imbalances in leiomyosarcoma by comparative genomic hybridization and interphase cytogenetics.","authors":"M Otaño-Joos,&nbsp;G Mechtersheimer,&nbsp;S Ohl,&nbsp;K K Wilgenbus,&nbsp;W Scheurlen,&nbsp;T Lehnert,&nbsp;F Willeke,&nbsp;H F Otto,&nbsp;P Lichter,&nbsp;S Joos","doi":"10.1159/000015640","DOIUrl":"https://doi.org/10.1159/000015640","url":null,"abstract":"<p><p>Leiomyosarcomas comprise a group of malignant soft-tissue tumors with smooth-muscle differentiation. In this study, 14 cases of leiomyosarcoma were screened for changes in relative chromosome copy number by comparative genomic hybridization. A high number of imbalances (mean, 16.3; range, 6-26) was detected, with chromosomal gains occurring about twice as much as losses. The most frequent gains were found in 5p15, 8q24, 15q25-->q26, 17p, and Xp (43% to 50%), whereas the most frequent losses were found in 10q and 13q (50% and 78%, respectively). Twenty high-level amplifications affecting 15 different chromosomal subregions were detected in nine different tumors. In three leiomyosarcomas, sequences on chromosome arm 17p were found to be highly amplified, with a minimal overlapping region on subbands 17p12-->p11. We further discovered that the Smith-Magenis syndrome critical region on 17p11.2 is included in the 17p amplicons of two leiomyosarcoma cases. Using probes flanking this genetically unstable region, a mean of 14 and 22 signals per nucleus, respectively, was detected in both leiomyosarcomas by fluorescence in situ hybridization. In conclusion, this analysis identifies a number of characteristic chromosomal imbalances in leiomyosarcomas and provides evidence for the localization of potential oncogenes and tumor suppressor genes active in leiomyosarcoma genomes.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 1-2","pages":"86-92"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21887675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolation and characterization of a new FHL1 variant (FHL1C) from porcine skeletal muscle. 猪骨骼肌FHL1新变体(FHL1C)的分离和鉴定
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015643
A Krempler, S Kollers, R Fries, B Brenig
{"title":"Isolation and characterization of a new FHL1 variant (FHL1C) from porcine skeletal muscle.","authors":"A Krempler,&nbsp;S Kollers,&nbsp;R Fries,&nbsp;B Brenig","doi":"10.1159/000015643","DOIUrl":"https://doi.org/10.1159/000015643","url":null,"abstract":"<p><p>Four and a half LIM domain protein 1 (FHL1) was initially described as an abundant skeletal muscle protein with four LIM domains and a GATA like zinc finger. FHL1 was shown to be expressed in skeletal muscle as well as in a variety of other tissues. Recently, alternatively spliced FHL1 mRNAs were identified coding for C-terminal truncated proteins. The tissue distribution of these variants is more restricted and their functional properties seem to be different. We have isolated and characterized a new variant of FHL1 from porcine skeletal muscle (FHL1C). FHL1C is characterized by a newly identified start codon resulting in a 16 amino acids longer N- terminal region. We have isolated and characterized the porcine FHL1C gene spanning approximately 14 kb and harboring six exons. Using primer extension analysis, the transcription start site of FHL1C was mapped, indicating that FHL1C is regulated by an alternative promoter. The tissue distribution of FHL1C expression was studied by RT-PCR. The porcine FHL1C gene was assigned to the distal part of the long arm of the X chromosome by fluorescence in situ hybridization and screening of a somatic porcine/rodent cell hybrid panel.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 1-2","pages":"106-14"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21887678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Assignment of maltase glucoamylase (MGAM) to pig chromosome 2 (2q21) by fluorescence in situ hybridization and confirmation by genetic mapping. 猪2号染色体(2q21)上麦芽糖淀粉酶(MGAM)的荧光原位杂交和遗传作图鉴定。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000056777
J H Calvo, N L Lopez-Corrales, R Osta, T M Skinner, S I Anderson, C Rodellar, P Zaragoza, A L Archibald
{"title":"Assignment of maltase glucoamylase (MGAM) to pig chromosome 2 (2q21) by fluorescence in situ hybridization and confirmation by genetic mapping.","authors":"J H Calvo,&nbsp;N L Lopez-Corrales,&nbsp;R Osta,&nbsp;T M Skinner,&nbsp;S I Anderson,&nbsp;C Rodellar,&nbsp;P Zaragoza,&nbsp;A L Archibald","doi":"10.1159/000056777","DOIUrl":"https://doi.org/10.1159/000056777","url":null,"abstract":"Maltase glucoamylase, one of the major constituents of the intestinal microvillar membrane (Norén et al., 1986), together with sucrase-isomaltase, has a role in the final digestion of starch. It has been hypothesized that human maltase glucoamylase activity serves as an alternative pathway for starch digestion when lumenal alpha-amylase activity is reduced as a result of immaturity or malnutrition and that maltase glucoamylase plays a unique role in the digestion of malted dietary oligosaccharides (Nichols et al., 1998). The human MGAM gene has been cloned, sequenced and located to chromosome 7 (HSA7) (Nichols et al., 1998), but as yet, the porcine MGAM gene has not been mapped. We report the localization of the porcine MGAM gene to porcine (SSC) chromosome 2 by fluorescent in situ hybridization and linkage analysis. This assignment represents the first evidence of homology between SCC2 and HSA7.","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 3-4","pages":"236-7"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000056777","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21946199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-->q26 and 19p13.3-->p12. 新基因TM6SF1的克隆揭示了人类染色体15q24- >q26和19p13.3- >p12之间同源基因簇的保守性。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000056784
L Carim-Todd, M Escarceller, X Estivill, L Sumoy
{"title":"Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-->q26 and 19p13.3-->p12.","authors":"L Carim-Todd,&nbsp;M Escarceller,&nbsp;X Estivill,&nbsp;L Sumoy","doi":"10.1159/000056784","DOIUrl":"https://doi.org/10.1159/000056784","url":null,"abstract":"<p><p>As the result of the EUROIMAGE Consortium sequencing project, we have isolated and characterized a novel gene on chromosome 15, TM6SF1. It encodes a 370 amino acid product with enhanced expression in spleen, testis and peripheral blood leukocytes. We have identified another gene, paralogous to TM6SF1 on chromosome 19p12, TM6SF2, with an overall similarity of 68% and 52% identity at the protein level. This conservation has led us to uncover a series of eleven genes in 19p13.3-->p12 with close homology to genes in 15q24--> q26. The percentage of sequence similarity between each paralogous pair of genes at the protein level ranges between 43 and 89%. A partial conservation of synteny with mouse chromosomes 7, 8 and 9 is also observed. The corresponding orthologous genes in mouse of human TM6SF1 and TM6SF2 show a high degree of amino acid sequence conservation.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 3-4","pages":"255-60"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000056784","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21947236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Spectral karyotyping of mouse cell line WMP2. 小鼠WMP2细胞系的光谱核型分析。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000056787
G Liu, W Lu, S Bremer, H Hameister, B Schreiner, M Hughes, H H Heng
{"title":"Spectral karyotyping of mouse cell line WMP2.","authors":"G Liu,&nbsp;W Lu,&nbsp;S Bremer,&nbsp;H Hameister,&nbsp;B Schreiner,&nbsp;M Hughes,&nbsp;H H Heng","doi":"10.1159/000056787","DOIUrl":"https://doi.org/10.1159/000056787","url":null,"abstract":"<p><p>We have evaluated the mouse cell line WMP2 using both GTG-banding analysis and spectral karyotyping to verify the reliability of using this established cell line derived from WMP/WMP mice. The WMP cell lines contain easily identifiable metacentric fusion chromosomes and are used extensively for gene mapping. Because of karyotypical changes in the WMP1 cell line, WMP2 was examined. Our results demonstrate that WMP2 is stable during culture, and the karyotype is simple and easy to use. Based on the findings discussed in this paper, we recommend the use of the WMP2 cell line for future prospective gene mapping in the mouse.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"90 3-4","pages":"271-4"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000056787","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21947239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization. 用荧光原位杂交技术鉴定人3-磷酸甘油酸脱氢酶(PHGDH)在人染色体1p12带上的位置。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015577
J Y Baek, D Y Jun, D Taub, Y H Kim
{"title":"Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization.","authors":"J Y Baek,&nbsp;D Y Jun,&nbsp;D Taub,&nbsp;Y H Kim","doi":"10.1159/000015577","DOIUrl":"https://doi.org/10.1159/000015577","url":null,"abstract":"3-Phosphoglycerate dehydrogenase (PHGDH) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the initiating and rate-limiting step in the phosphorylated pathway of serine biosynthesis. It has been suggested that an enhanced capacity of serine synthesis resulting from upregulation of the activity of PHGDH may confer a growthadvantage to tumor cells through its coupling to nucleotide biosynthesis (Snell et al., 1988). It has also been reported that the deficiency of human PHGDH activity can be a main cause for the inborn errors of serine biosynthesis, which result in a severe neurological syndrome and growth retardation (Jaeken et al., 1996). To elucidate the molecular basis for the changes of PHGDH activity directly associated with these human diseases, we have recently cloned and sequenced the human PHGDH gene (Cho et al., 1999). Here we report assignment of human PHGDH to human chromosome 1p12 by fluorescence in situ hybridization. Materials and methods","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"89 1-2","pages":"6-7"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015577","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21735837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Genomic structure and chromosome location of the mouse RelA p65 gene (Rela). 小鼠RelA p65基因(RelA)的基因组结构和染色体定位。
Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI: 10.1159/000015591
E R Lemmer, J L Welch, T Tsai, C L Keck-Waggoner, C Huh, D B Zimonjic, N C Popescu, S S Thorgeirsson
{"title":"Genomic structure and chromosome location of the mouse RelA p65 gene (Rela).","authors":"E R Lemmer,&nbsp;J L Welch,&nbsp;T Tsai,&nbsp;C L Keck-Waggoner,&nbsp;C Huh,&nbsp;D B Zimonjic,&nbsp;N C Popescu,&nbsp;S S Thorgeirsson","doi":"10.1159/000015591","DOIUrl":"https://doi.org/10.1159/000015591","url":null,"abstract":"<p><p>The RelA (p65) subunit of transcription factor NF-kappaB plays a critical role in development, and rela(-/-) knockout mice die in utero from massive liver apoptosis. Only partial sequences of the mouse Rela gene are available. We have determined the genomic structure of mouse Rela and promoter, and have mapped the gene to chromosome 19B1-3.</p>","PeriodicalId":10982,"journal":{"name":"Cytogenetics and cell genetics","volume":"89 1-2","pages":"129-32"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000015591","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21736275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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