小鼠RelA p65基因(RelA)的基因组结构和染色体定位。

Cytogenetics and cell genetics Pub Date : 2000-01-01 DOI:10.1159/000015591

E R Lemmer, J L Welch, T Tsai, C L Keck-Waggoner, C Huh, D B Zimonjic, N C Popescu, S S Thorgeirsson

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引用次数: 2

摘要

转录因子NF-kappaB的RelA (p65)亚基在发育过程中起关键作用，RelA(-/-)敲除小鼠在子宫内死于大量肝脏凋亡。只有小鼠Rela基因的部分序列是可用的。我们已经确定了小鼠Rela和启动子的基因组结构，并将其定位在染色体19B1-3上。

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Genomic structure and chromosome location of the mouse RelA p65 gene (Rela).

The RelA (p65) subunit of transcription factor NF-kappaB plays a critical role in development, and rela(-/-) knockout mice die in utero from massive liver apoptosis. Only partial sequences of the mouse Rela gene are available. We have determined the genomic structure of mouse Rela and promoter, and have mapped the gene to chromosome 19B1-3.

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Cytogenetics and cell genetics

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