新基因TM6SF1的克隆揭示了人类染色体15q24- >q26和19p13.3- >p12之间同源基因簇的保守性。

L Carim-Todd, M Escarceller, X Estivill, L Sumoy
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引用次数: 33

摘要

作为EUROIMAGE联盟测序项目的结果,我们在15号染色体上分离并鉴定了一个新基因TM6SF1。它编码一种370个氨基酸的产物,在脾脏、睾丸和外周血白细胞中表达增强。我们在19p12染色体上发现了另一个与TM6SF1相似的基因TM6SF2,在蛋白质水平上的总体相似性为68%,同源性为52%。这种保守性使我们发现了位于19p13.3- >p12的一系列11个基因与位于15q24- > q26的基因具有密切的同源性。在蛋白质水平上,每一对同源基因之间的序列相似性百分比在43 - 89%之间。与小鼠染色体7,8和9的部分同源性也被观察到。人TM6SF1和TM6SF2在小鼠中对应的同源基因表现出高度的氨基酸序列保守性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cloning of the novel gene TM6SF1 reveals conservation of clusters of paralogous genes between human chromosomes 15q24-->q26 and 19p13.3-->p12.

As the result of the EUROIMAGE Consortium sequencing project, we have isolated and characterized a novel gene on chromosome 15, TM6SF1. It encodes a 370 amino acid product with enhanced expression in spleen, testis and peripheral blood leukocytes. We have identified another gene, paralogous to TM6SF1 on chromosome 19p12, TM6SF2, with an overall similarity of 68% and 52% identity at the protein level. This conservation has led us to uncover a series of eleven genes in 19p13.3-->p12 with close homology to genes in 15q24--> q26. The percentage of sequence similarity between each paralogous pair of genes at the protein level ranges between 43 and 89%. A partial conservation of synteny with mouse chromosomes 7, 8 and 9 is also observed. The corresponding orthologous genes in mouse of human TM6SF1 and TM6SF2 show a high degree of amino acid sequence conservation.

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