Assignment of transcription factor NFAT5 to human chromosome 16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and comparison of the polyglutamine domains.

A Hebinck, A Dalski, H Engel, M Mattei, R Hawken, E Schwinger, C Zühlke
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引用次数: 9

Abstract

To date, transcription factors of the NFAT family (nuclear factors of activated T cells) have been described for mouse and man. Recently, we mapped the human NFAT5 gene to chromosome 16 by PCR using DNA from hybrid cell lines. Here we report the exact position of the human gene between D16S496 and WI5254 within the 16q22.1 subband, the localization of the murine gene at chromosome 8D, and the identification and mapping of the porcine counterpart to chromosome 6p1.4.

转录因子NFAT5在人染色体16q22.1、鼠染色体8D和猪染色体6p1.4上的定位及多聚谷氨酰胺结构域的比较
迄今为止,NFAT家族的转录因子(活化T细胞的核因子)已被描述为小鼠和人。最近,我们利用杂交细胞系的DNA,通过PCR将人类NFAT5基因定位到16号染色体上。本文报道了人类基因D16S496和WI5254在16q22.1亚带中的确切位置,小鼠基因在8D染色体上的定位,以及猪基因在6p1.4染色体上的对应体的鉴定和定位。
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