Current Hypertension Reports最新文献_第3页

The Role of Obesity in the Development of Preeclampsia. 肥胖在先兆子痫发病中的作用。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI: 10.1007/s11906-024-01299-z

Miguel Javier Schiavone, Mariana Paula Pérez, Analía Aquieri, Daniela Nosetto, María Victoria Pronotti, María Mazzei, Cyntia Kudrle, Horacio Avaca

{"title":"The Role of Obesity in the Development of Preeclampsia.","authors":"Miguel Javier Schiavone, Mariana Paula Pérez, Analía Aquieri, Daniela Nosetto, María Victoria Pronotti, María Mazzei, Cyntia Kudrle, Horacio Avaca","doi":"10.1007/s11906-024-01299-z","DOIUrl":"10.1007/s11906-024-01299-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>This comprehensive review provides an in-depth exploration of the complex relationship between obesity and preeclampsia (PE) and emphasizes the clinical implications of this association. It highlights the crucial role of screening tools in assessing individual risk and determining the need for additional antenatal care among women with obesity. The review investigates various markers for identifying the risk of developing PE, while emphasizing the significance of interventions such as exercise, weight management, and a balanced diet in reducing the incidence of preeclampsia and improving outcomes for both mother and fetus.</p><p><strong>Recent findings: </strong>Actually, there is a global pandemic of obesity, particularly among women of childbearing age and pregnant women. PE, which is characterized by maternal hypertension, proteinuria, and complications, affects 2-4% of pregnancies worldwide, posing significant risks to maternal and perinatal health. Women with obesity face an elevated risk of developing PE due to the systemic inflammation resulting from excess adiposity, which can adversely affect placental development. Adipose tissue, rich in proinflammatory cytokines and complement proteins, contributes to the pathogenesis of PE by promoting the expression of antiangiogenic factors in the mother. This review emphasizes the need for appropriate screening, interventions, and a holistic approach to reduce the incidence of preeclampsia and enhance maternal-fetal well-being, thus providing valuable insights into the multifaceted association between obesity and PE.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"247-258"},"PeriodicalIF":5.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistant Hypertension: Disease Burden and Emerging Treatment Options. 耐药性高血压：疾病负担与新兴治疗方案。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-05-01 Epub Date: 2024-02-16 DOI: 10.1007/s11906-023-01282-0

John M Flack, Michael G Buhnerkempe, Kenneth Todd Moore

{"title":"Resistant Hypertension: Disease Burden and Emerging Treatment Options.","authors":"John M Flack, Michael G Buhnerkempe, Kenneth Todd Moore","doi":"10.1007/s11906-023-01282-0","DOIUrl":"10.1007/s11906-023-01282-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>To define resistant hypertension (RHT), review its pathophysiology and disease burden, identify barriers to effective hypertension management, and to highlight emerging treatment options.</p><p><strong>Recent findings: </strong>RHT is defined as uncontrolled blood pressure (BP) ≥ 130/80 mm Hg despite concurrent prescription of ≥ 3 or ≥ 4 antihypertensive drugs in different classes or controlled BP despite prescription of ≥ to 4 drugs, at maximally tolerated doses, including a diuretic. BP is regulated by a complex interplay between the renin-angiotensin-aldosterone system, the sympathetic nervous system, the endothelin system, natriuretic peptides, the arterial vasculature, and the immune system; disruption of any of these can increase BP. RHT is disproportionately manifest in African Americans, older patients, and those with diabetes and/or chronic kidney disease (CKD). Amongst drug-treated hypertensives, only one-quarter have been treated intensively enough (prescribed > 2 drugs) to be considered for this diagnosis. New treatment strategies aimed at novel therapeutic targets include inhibition of sodium-glucose cotransporter 2, aminopeptidase A, aldosterone synthesis, phosphodiesterase 5, xanthine oxidase, and dopamine beta-hydroxylase, as well as soluble guanylate cyclase stimulation, nonsteroidal mineralocorticoid receptor antagonism, and dual endothelin receptor antagonism. The burden of RHT remains high. Better use of currently approved therapies and integrating emerging therapies are welcome additions to the therapeutic armamentarium for addressing needs in high-risk aTRH patients.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"183-199"},"PeriodicalIF":3.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection. RAAS 相关 SNPs 的遗传评估：感染 HIV 的先兆子痫妇女的 REN (rs16853055)、AGT (rs3789678) 和 ACE (rs4305)。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-05-01 Epub Date: 2024-02-27 DOI: 10.1007/s11906-023-01292-y

Annelene Govindsamy, Shoohana Singh, Thajasvarie Naicker

{"title":"Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection.","authors":"Annelene Govindsamy, Shoohana Singh, Thajasvarie Naicker","doi":"10.1007/s11906-023-01292-y","DOIUrl":"10.1007/s11906-023-01292-y","url":null,"abstract":"<p><strong>Purpose of review: </strong>The primary goal of this review article was to determine whether the three RAAS-associated SNPs, Renin-rs16853055, AGT-rs3789678 and ACE-rs4305 are genetically linked to the development of hypertension in preeclampsia. The secondary goal was to establish if there was a link between these SNPs and HIV infection.</p><p><strong>Recent findings: </strong>There is a paucity of findings related to the aforementioned SNPs and preeclampsia. There are no recent findings on the rs16853055 renin polymorphism. The rs3789678 angiotensinogen polymorphism correlated significantly with gestational hypertension. The rs4305 ACE polymorphism showed no significant association with the development of pregnancy-induced hypertension. There are conflicting findings when determining the relationship between ethnicity and the predisposition of preeclampsia and hypertension in relation to the discussed RAAS-associated SNPs. To date, the association between RAAS-associated SNPs and preeclamptic women co-morbid with HIV in South Africa has revealed that certain alleles of the AGT gene are more prominent in HIV-infected PE compared to normotensive pregnant HIV-infected women.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"213-224"},"PeriodicalIF":5.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Continuous Positive Airway Pressure on Blood Pressure in Patients with Resistant Hypertension and Obstructive Sleep Apnea: An Updated Meta-analysis. 持续正压通气对耐药性高血压和阻塞性睡眠呼吸暂停患者血压的影响：最新 Meta 分析。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-05-01 Epub Date: 2024-03-09 DOI: 10.1007/s11906-024-01294-4

Ling Sun, Ya-Fei Chang, Yun-Fei Wang, Quan-Xin Xie, Xian-Zhong Ran, Chun-Yang Hu, Bin Luo, Bin Ning

{"title":"Effect of Continuous Positive Airway Pressure on Blood Pressure in Patients with Resistant Hypertension and Obstructive Sleep Apnea: An Updated Meta-analysis.","authors":"Ling Sun, Ya-Fei Chang, Yun-Fei Wang, Quan-Xin Xie, Xian-Zhong Ran, Chun-Yang Hu, Bin Luo, Bin Ning","doi":"10.1007/s11906-024-01294-4","DOIUrl":"10.1007/s11906-024-01294-4","url":null,"abstract":"<p><strong>Purpose of review: </strong>The effect of continuous positive airway pressure (CPAP) on resistant hypertension in patients at high risk with obstructive sleep apnea (OSA) needs further investigation. We aimed to determine the effect of CPAP on blood pressure in patients with resistant hypertension and OSA. Databases including PubMed, EMBASE, MEDLINE, the Cochrane Library, and CMB were searched. Data were pooled using a random-effects or fixed-effects model to derive weighted mean differences (WMDs) and 95% confidence intervals (CIs).</p><p><strong>Recent findings: </strong>A total of 12 trials and 718 participants were included. Compared with control, CPAP significantly reduced 24-h systolic blood pressure (SBP) (WMD: - 5.92 mmHg [ - 8.72, - 3.11]; P＜0.001), 24-h diastolic blood pressure (DBP) (WMD: - 4.44 mmHg [- 6.26 , - 2.62]; P ＜0.001), daytime SBP (WMD: - 5.76 mmHg [ - 9.16, - 2.36]; P ＜0.001), daytime DBP (WMD: - 3.92 mmHg [- 5.55, - 2.30]; nighttime SBP (WMD: - 4.87 mmHg [ - 7.96 , - 1.78]; P = 0.002), and nighttime DBP (WMD: - 2.05 mmHg [- 2.99, - 1.11]; P＜0.001) in patients with resistant hypertension and OSA. CPAP improved the blood pressure both in the short (＜3 months) and long term (≥ 3 months). No significant impact on mean heart rate was noted (WMD: -2.76 beats per min [- 7.50, 1.97]; P = 0.25). CPAP treatment was associated with BP reduction in patients with resistant hypertension and OSA.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"201-211"},"PeriodicalIF":3.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considering Adverse Effects of Common Antihypertensive Medications in the ED 考虑急诊室常用抗高血压药物的不良反应

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-30 DOI: 10.1007/s11906-024-01304-5

Charles R. Wira, Thomas Kearns, Alex Fleming-Nouri, John D. Tyrrell, Christina M. Wira, Ani Aydin

引用次数: 0

Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure 心外膜脂肪组织厚度与保留射血分数心衰

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-20 DOI: 10.1007/s11906-024-01302-7

Aneesh Dhore-Patil, Daniela Urina-Jassir, Rohan Samson, Thierry H. Le Jemtel, Suzanne Oparil

{"title":"Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure","authors":"Aneesh Dhore-Patil, Daniela Urina-Jassir, Rohan Samson, Thierry H. Le Jemtel, Suzanne Oparil","doi":"10.1007/s11906-024-01302-7","DOIUrl":"https://doi.org/10.1007/s11906-024-01302-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of the Review</h3><p>Preserved ejection fraction heart failure and obesity frequently coexist. Whether obesity plays a consistent role in the pathogenesis of preserved ejection fraction heart failure is unclear. Accumulation of visceral adiposity underlies the pathogenic aftermaths of obesity. However, visceral adiposity imaging is assessed by computed tomography or magnetic resonance and thus not routinely available. In contrast, epicardial adiposity thickness is assessed by echocardiography and thus routinely available. We review the rationale for assessing epicardial adiposity thickness in patients with preserved ejection fraction heart failure and elevated body mass index.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>Body mass index correlates poorly with visceral, and epicardial adiposity. Visceral and epicardial adiposity enlarges as preserved ejection fraction heart failure progresses. Epicardial adiposity may hasten the progression of coronary artery disease and impairs left ventricular sub-endocardial perfusion and diastolic function.</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>Epicardial adiposity thickness may help monitor the therapeutic response in patients with preserved ejection failure heart failure and elevated body mass index.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"51 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimmunology of Cardiovascular Disease 心血管疾病的神经免疫学

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-13 DOI: 10.1007/s11906-024-01301-8

Sara M. Zarate, Annet Kirabo, Antentor O. Hinton Jr., Monica M. Santisteban

{"title":"Neuroimmunology of Cardiovascular Disease","authors":"Sara M. Zarate, Annet Kirabo, Antentor O. Hinton Jr., Monica M. Santisteban","doi":"10.1007/s11906-024-01301-8","DOIUrl":"https://doi.org/10.1007/s11906-024-01301-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>Cardiovascular disease (CVD) is a leading cause of death and chronic disability worldwide. Yet, despite extensive intervention strategies the number of persons affected by CVD continues to rise. Thus, there is great interest in unveiling novel mechanisms that may lead to new treatments. Considering this dilemma, recent focus has turned to the neuroimmune mechanisms involved in CVD pathology leading to a deeper understanding of the brain’s involvement in disease pathology. This review provides an overview of new and salient findings regarding the neuroimmune mechanisms that contribute to CVD.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>The brain contains neuroimmune niches comprised of glia in the parenchyma and immune cells at the brain’s borders, and there is strong evidence that these neuroimmune niches are important in both health and disease. Mechanistic studies suggest that the activation of glia and immune cells in these niches modulates CVD progression in hypertension and heart failure and contributes to the inevitable end-organ damage to the brain.</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>This review provides evidence supporting the role of neuroimmune niches in CVD progression. However, additional research is needed to understand the effects of prolonged neuroimmune activation on brain function.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"21 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoplasmic Reticulum Stress in Hypertension and Salt Sensitivity of Blood Pressure 高血压中的内质网应激和血压对盐的敏感性

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-11 DOI: 10.1007/s11906-024-01300-9

Maria Balhara, Kit Neikirk, Andrea Marshall, Antentor Hinton, Annet Kirabo

{"title":"Endoplasmic Reticulum Stress in Hypertension and Salt Sensitivity of Blood Pressure","authors":"Maria Balhara, Kit Neikirk, Andrea Marshall, Antentor Hinton, Annet Kirabo","doi":"10.1007/s11906-024-01300-9","DOIUrl":"https://doi.org/10.1007/s11906-024-01300-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>Hypertension is a principal risk factor for cardiovascular morbidity and mortality, with its severity exacerbated by high sodium intake, particularly in individuals with salt-sensitive blood pressure. However, the mechanisms underlying hypertension and salt sensitivity are only partly understood. Herein, we review potential interactions in hypertension pathophysiology involving the immune system, endoplasmic reticulum (ER) stress, the unfolded protein response (UPR), and proteostasis pathways; identify knowledge gaps; and discuss future directions.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>Recent advancements by our research group and others reveal interactions within and between adaptive and innate immune responses in hypertension pathophysiology. The salt-immune-hypertension axis is further supported by the discovery of the role of dendritic cells in hypertension, marked by isolevuglandin (IsoLG) formation. Alongside these broadened understandings of immune-mediated salt sensitivity, the contributions of T cells to hypertension have been recently challenged by groups whose findings did not support increased resistance of Rag-1-deficient mice to Ang II infusion. Hypertension has also been linked to ER stress and the UPR. Notably, a holistic approach is needed because the UPR engages in crosstalk with autophagy, the ubiquitin proteasome, and other proteostasis pathways, that may all involve hypertension.</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>There is a critical need for studies to establish cause and effect relationships between ER stress and the UPR in hypertension pathophysiology in humans and to determine whether the immune system and ER stress function mainly to exacerbate or initiate hypertension and target organ injury. This review of recent studies proposes new avenues for future research for targeted therapeutic interventions.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":"26 1","pages":""},"PeriodicalIF":5.6,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-Free Nucleic Acids for Early Prediction of Preeclampsia. 用于子痫前期早期预测的无细胞核酸。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-01 Epub Date: 2023-12-26 DOI: 10.1007/s11906-023-01291-z

Mira N Moufarrej, Virginia D Winn, Stephen R Quake

{"title":"Cell-Free Nucleic Acids for Early Prediction of Preeclampsia.","authors":"Mira N Moufarrej, Virginia D Winn, Stephen R Quake","doi":"10.1007/s11906-023-01291-z","DOIUrl":"10.1007/s11906-023-01291-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review summarizes the potential of cell-free nucleic acids for predicting preeclampsia, contrasts them with other methods, and discusses these findings' relevance to preeclampsia's pathogenesis and care.</p><p><strong>Recent findings: </strong>Recent studies have demonstrated the utility of cell-free nucleic acids in early preeclampsia risk prediction. Encouragingly, nucleic acid measurement exhibits similar or better sensitivity as compared to standard screening assays and furthermore sheds light on preeclampsia's underlying placental biology. Over the past decade, liquid biopsies measuring cell-free nucleic acids have found diverse applications, including in prenatal care. Recent advances have extended their utility to predict preeclampsia, a major cause of maternal mortality. These assays assess methylation patterns in cell-free DNA (cfDNA) or gene levels in cell-free RNA (cfRNA). Currently, preeclampsia care focuses on blood pressure control, seizure prevention, and delivery. If validated, early prediction of preeclampsia through liquid biopsies can improve maternal health and deepen our understanding of its causes.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"175-182"},"PeriodicalIF":5.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HEARTS in the Americas: Targeting Health System Change to Improve Population Hypertension Control. 美洲的心脏:以卫生系统变革为目标，改善人群高血压控制。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-01 Epub Date: 2023-12-02 DOI: 10.1007/s11906-023-01286-w

Pedro Ordunez, Norm R C Campbell, Donald J DiPette, Marc G Jaffe, Andres Rosende, Ramon Martinez, Angelo Gamarra, Cintia Lombardi, Natalia Parra, Libardo Rodriguez, Yenny Rodriguez, Jeffrey Brettler

{"title":"HEARTS in the Americas: Targeting Health System Change to Improve Population Hypertension Control.","authors":"Pedro Ordunez, Norm R C Campbell, Donald J DiPette, Marc G Jaffe, Andres Rosende, Ramon Martinez, Angelo Gamarra, Cintia Lombardi, Natalia Parra, Libardo Rodriguez, Yenny Rodriguez, Jeffrey Brettler","doi":"10.1007/s11906-023-01286-w","DOIUrl":"10.1007/s11906-023-01286-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>HEARTS in the Americas is the regional adaptation of Global Hearts, the World Health Organization initiative for cardiovascular disease (CVD) prevention and control. Its overarching goal is to drive health services to change managerial and clinical practice in primary care settings to improve hypertension control and CVD risk management. This review describes the HEARTS in the Americas initiative. First, the regional epidemiological situation of CVD mortality and population hypertension control trends are summarized; then the rationale for its main intervention components: the primary care-oriented management system and the HEARTS Clinical Pathway are described. Finally, the key factors for accelerating the expansion of HEARTS are examined: medicines, team-based care, and a system for monitoring and evaluation.</p><p><strong>Recent findings: </strong>Thus far, 33 countries in Latin America and the Caribbean have committed to integrating this program across their primary healthcare network by 2025. The increase in hypertension coverage and control in primary health care settings compared with the traditional model is promising and confirms that the interventions under the HEARTS umbrella are feasible and acceptable to communities, patients, providers, decision-makers, and funders. This review highlights some cases of successful implementation. Scaling up effective treatment for hypertension and optimization of CVD risk management is a pragmatic way to accelerate the reduction of CVD mortality while strengthening primary healthcare systems to respond effectively, with quality, and equitably, to the challenge of non-communicable diseases, not only in low-middle income countries but in all communities globally.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":" ","pages":"141-156"},"PeriodicalIF":5.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0