Current Hypertension Reports最新文献_第3页

Considering Adverse Effects of Common Antihypertensive Medications in the ED 考虑急诊室常用抗高血压药物的不良反应

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-30 DOI: 10.1007/s11906-024-01304-5

Charles R. Wira, Thomas Kearns, Alex Fleming-Nouri, John D. Tyrrell, Christina M. Wira, Ani Aydin

引用次数: 0

Breaking the Barrier: The Role of Gut Epithelial Permeability in the Pathogenesis of Hypertension. 打破屏障：肠道上皮渗透性在高血压发病机制中的作用。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-25 DOI: 10.1007/s11906-024-01307-2

M. Snelson, T. Vanuytsel, Francine Z Marques

引用次数: 0

Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure 心外膜脂肪组织厚度与保留射血分数心衰

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-20 DOI: 10.1007/s11906-024-01302-7

Aneesh Dhore-Patil, Daniela Urina-Jassir, Rohan Samson, Thierry H. Le Jemtel, Suzanne Oparil

{"title":"Epicardial Adipose Tissue Thickness and Preserved Ejection Fraction Heart Failure","authors":"Aneesh Dhore-Patil, Daniela Urina-Jassir, Rohan Samson, Thierry H. Le Jemtel, Suzanne Oparil","doi":"10.1007/s11906-024-01302-7","DOIUrl":"https://doi.org/10.1007/s11906-024-01302-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of the Review</h3><p>Preserved ejection fraction heart failure and obesity frequently coexist. Whether obesity plays a consistent role in the pathogenesis of preserved ejection fraction heart failure is unclear. Accumulation of visceral adiposity underlies the pathogenic aftermaths of obesity. However, visceral adiposity imaging is assessed by computed tomography or magnetic resonance and thus not routinely available. In contrast, epicardial adiposity thickness is assessed by echocardiography and thus routinely available. We review the rationale for assessing epicardial adiposity thickness in patients with preserved ejection fraction heart failure and elevated body mass index.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>Body mass index correlates poorly with visceral, and epicardial adiposity. Visceral and epicardial adiposity enlarges as preserved ejection fraction heart failure progresses. Epicardial adiposity may hasten the progression of coronary artery disease and impairs left ventricular sub-endocardial perfusion and diastolic function.</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>Epicardial adiposity thickness may help monitor the therapeutic response in patients with preserved ejection failure heart failure and elevated body mass index.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140628025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimmunology of Cardiovascular Disease 心血管疾病的神经免疫学

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-13 DOI: 10.1007/s11906-024-01301-8

Sara M. Zarate, Annet Kirabo, Antentor O. Hinton Jr., Monica M. Santisteban

{"title":"Neuroimmunology of Cardiovascular Disease","authors":"Sara M. Zarate, Annet Kirabo, Antentor O. Hinton Jr., Monica M. Santisteban","doi":"10.1007/s11906-024-01301-8","DOIUrl":"https://doi.org/10.1007/s11906-024-01301-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>Cardiovascular disease (CVD) is a leading cause of death and chronic disability worldwide. Yet, despite extensive intervention strategies the number of persons affected by CVD continues to rise. Thus, there is great interest in unveiling novel mechanisms that may lead to new treatments. Considering this dilemma, recent focus has turned to the neuroimmune mechanisms involved in CVD pathology leading to a deeper understanding of the brain’s involvement in disease pathology. This review provides an overview of new and salient findings regarding the neuroimmune mechanisms that contribute to CVD.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>The brain contains neuroimmune niches comprised of glia in the parenchyma and immune cells at the brain’s borders, and there is strong evidence that these neuroimmune niches are important in both health and disease. Mechanistic studies suggest that the activation of glia and immune cells in these niches modulates CVD progression in hypertension and heart failure and contributes to the inevitable end-organ damage to the brain.</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>This review provides evidence supporting the role of neuroimmune niches in CVD progression. However, additional research is needed to understand the effects of prolonged neuroimmune activation on brain function.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoplasmic Reticulum Stress in Hypertension and Salt Sensitivity of Blood Pressure 高血压中的内质网应激和血压对盐的敏感性

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-11 DOI: 10.1007/s11906-024-01300-9

Maria Balhara, Kit Neikirk, Andrea Marshall, Antentor Hinton, Annet Kirabo

{"title":"Endoplasmic Reticulum Stress in Hypertension and Salt Sensitivity of Blood Pressure","authors":"Maria Balhara, Kit Neikirk, Andrea Marshall, Antentor Hinton, Annet Kirabo","doi":"10.1007/s11906-024-01300-9","DOIUrl":"https://doi.org/10.1007/s11906-024-01300-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose of Review</h3><p>Hypertension is a principal risk factor for cardiovascular morbidity and mortality, with its severity exacerbated by high sodium intake, particularly in individuals with salt-sensitive blood pressure. However, the mechanisms underlying hypertension and salt sensitivity are only partly understood. Herein, we review potential interactions in hypertension pathophysiology involving the immune system, endoplasmic reticulum (ER) stress, the unfolded protein response (UPR), and proteostasis pathways; identify knowledge gaps; and discuss future directions.</p><h3 data-test=\"abstract-sub-heading\">Recent Findings</h3><p>Recent advancements by our research group and others reveal interactions within and between adaptive and innate immune responses in hypertension pathophysiology. The salt-immune-hypertension axis is further supported by the discovery of the role of dendritic cells in hypertension, marked by isolevuglandin (IsoLG) formation. Alongside these broadened understandings of immune-mediated salt sensitivity, the contributions of T cells to hypertension have been recently challenged by groups whose findings did not support increased resistance of Rag-1-deficient mice to Ang II infusion. Hypertension has also been linked to ER stress and the UPR. Notably, a holistic approach is needed because the UPR engages in crosstalk with autophagy, the ubiquitin proteasome, and other proteostasis pathways, that may all involve hypertension.</p><h3 data-test=\"abstract-sub-heading\">Summary</h3><p>There is a critical need for studies to establish cause and effect relationships between ER stress and the UPR in hypertension pathophysiology in humans and to determine whether the immune system and ER stress function mainly to exacerbate or initiate hypertension and target organ injury. This review of recent studies proposes new avenues for future research for targeted therapeutic interventions.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140562637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HEARTS in the Americas: Targeting Health System Change to Improve Population Hypertension Control. 美洲的心脏:以卫生系统变革为目标，改善人群高血压控制。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-01 Epub Date: 2023-12-02 DOI: 10.1007/s11906-023-01286-w

Pedro Ordunez, Norm R C Campbell, Donald J DiPette, Marc G Jaffe, Andres Rosende, Ramon Martinez, Angelo Gamarra, Cintia Lombardi, Natalia Parra, Libardo Rodriguez, Yenny Rodriguez, Jeffrey Brettler

{"title":"HEARTS in the Americas: Targeting Health System Change to Improve Population Hypertension Control.","authors":"Pedro Ordunez, Norm R C Campbell, Donald J DiPette, Marc G Jaffe, Andres Rosende, Ramon Martinez, Angelo Gamarra, Cintia Lombardi, Natalia Parra, Libardo Rodriguez, Yenny Rodriguez, Jeffrey Brettler","doi":"10.1007/s11906-023-01286-w","DOIUrl":"10.1007/s11906-023-01286-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>HEARTS in the Americas is the regional adaptation of Global Hearts, the World Health Organization initiative for cardiovascular disease (CVD) prevention and control. Its overarching goal is to drive health services to change managerial and clinical practice in primary care settings to improve hypertension control and CVD risk management. This review describes the HEARTS in the Americas initiative. First, the regional epidemiological situation of CVD mortality and population hypertension control trends are summarized; then the rationale for its main intervention components: the primary care-oriented management system and the HEARTS Clinical Pathway are described. Finally, the key factors for accelerating the expansion of HEARTS are examined: medicines, team-based care, and a system for monitoring and evaluation.</p><p><strong>Recent findings: </strong>Thus far, 33 countries in Latin America and the Caribbean have committed to integrating this program across their primary healthcare network by 2025. The increase in hypertension coverage and control in primary health care settings compared with the traditional model is promising and confirms that the interventions under the HEARTS umbrella are feasible and acceptable to communities, patients, providers, decision-makers, and funders. This review highlights some cases of successful implementation. Scaling up effective treatment for hypertension and optimization of CVD risk management is a pragmatic way to accelerate the reduction of CVD mortality while strengthening primary healthcare systems to respond effectively, with quality, and equitably, to the challenge of non-communicable diseases, not only in low-middle income countries but in all communities globally.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell-Free Nucleic Acids for Early Prediction of Preeclampsia. 用于子痫前期早期预测的无细胞核酸。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-01 Epub Date: 2023-12-26 DOI: 10.1007/s11906-023-01291-z

Mira N Moufarrej, Virginia D Winn, Stephen R Quake

{"title":"Cell-Free Nucleic Acids for Early Prediction of Preeclampsia.","authors":"Mira N Moufarrej, Virginia D Winn, Stephen R Quake","doi":"10.1007/s11906-023-01291-z","DOIUrl":"10.1007/s11906-023-01291-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review summarizes the potential of cell-free nucleic acids for predicting preeclampsia, contrasts them with other methods, and discusses these findings' relevance to preeclampsia's pathogenesis and care.</p><p><strong>Recent findings: </strong>Recent studies have demonstrated the utility of cell-free nucleic acids in early preeclampsia risk prediction. Encouragingly, nucleic acid measurement exhibits similar or better sensitivity as compared to standard screening assays and furthermore sheds light on preeclampsia's underlying placental biology. Over the past decade, liquid biopsies measuring cell-free nucleic acids have found diverse applications, including in prenatal care. Recent advances have extended their utility to predict preeclampsia, a major cause of maternal mortality. These assays assess methylation patterns in cell-free DNA (cfDNA) or gene levels in cell-free RNA (cfRNA). Currently, preeclampsia care focuses on blood pressure control, seizure prevention, and delivery. If validated, early prediction of preeclampsia through liquid biopsies can improve maternal health and deepen our understanding of its causes.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139037515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Hypertension in Older Adults. 管理老年人的高血压。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-01 Epub Date: 2023-12-27 DOI: 10.1007/s11906-023-01289-7

Brent M Egan, Holly J Mattix-Kramer, Jan N Basile, Susan E Sutherland

{"title":"Managing Hypertension in Older Adults.","authors":"Brent M Egan, Holly J Mattix-Kramer, Jan N Basile, Susan E Sutherland","doi":"10.1007/s11906-023-01289-7","DOIUrl":"10.1007/s11906-023-01289-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>The population of older adults 60-79 years globally is projected to double from 800 million to 1.6 billion between 2015 and 2050, while adults ≥ 80 years were forecast to more than triple from 125 to 430 million. The risk for cardiovascular events doubles with each decade of aging and each 20 mmHg increase of systolic blood pressure. Thus, successful management of hypertension in older adults is critical in mitigating the projected global health and economic burden of cardiovascular disease.</p><p><strong>Recent findings: </strong>Women live longer than men, yet with aging systolic blood pressure and prevalent hypertension increase more, and hypertension control decreases more than in men, i.e., hypertension in older adults is disproportionately a women's health issue. Among older adults who are healthy to mildly frail, the absolute benefit of hypertension control, including more intensive control, on cardiovascular events is greater in adults ≥ 80 than 60-79 years old. The absolute rate of serious adverse events during antihypertensive therapy is greater in adults ≥ 80 years older than 60-79 years, yet the excess adverse event rate with intensive versus standard care is only moderately increased. Among adults ≥ 80 years, benefits of more intensive therapy appear non-existent to reversed with moderate to marked frailty and when cognitive function is less than roughly the twenty-fifth percentile. Accordingly, assessment of functional and cognitive status is important in setting blood pressure targets in older adults. Given substantial absolute cardiovascular benefits of more intensive antihypertensive therapy in independent-living older adults, this group merits shared-decision making for hypertension targets.</p>","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10904451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139039641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preeclampsia and the Retina. 子痫前期与视网膜。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-04-01 Epub Date: 2023-12-22 DOI: 10.1007/s11906-023-01290-0

Safiya Soullane, Marc-André Rhéaume, Nathalie Auger

引用次数: 0

Slow on the Draw-ED Management of Elevated BP in Older Adults. 老年人血压升高的抽ed治疗进展缓慢。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-03-01 Epub Date: 2023-11-21 DOI: 10.1007/s11906-023-01284-y

Kianna Eurick-Bering, Brett Todd, Lauren Cameron-Comasco

引用次数: 0