Hypertension and Cardiovascular Outcomes in Inflammatory and Autoimmune Diseases: A Systematic Review and Meta-analysis.

IF 3.9 2区医学 Q1 PERIPHERAL VASCULAR DISEASE

Current Hypertension Reports Pub Date : 2024-11-01 Epub Date: 2024-05-31 DOI:10.1007/s11906-024-01311-6

Marie Barozet, Olivier Le Tilly, Theodora Bejan-Angoulvant, Pierre Fesler, Camille Roubille

{"title":"Hypertension and Cardiovascular Outcomes in Inflammatory and Autoimmune Diseases: A Systematic Review and Meta-analysis.","authors":"Marie Barozet, Olivier Le Tilly, Theodora Bejan-Angoulvant, Pierre Fesler, Camille Roubille","doi":"10.1007/s11906-024-01311-6","DOIUrl":null,"url":null,"abstract":"Purpose: This review aimed to investigate the prevalence of hypertension and cardiovascular (CV) complications in various inflammatory and autoimmune diseases (IAD).Recent findings: Despite recent improvements in the management of IAD, patients with IAD still have an increased CV mortality and CV complications, mostly related to CV risk factors such as hypertension and inflammation. We systematically searched MEDLINE and EMBASE libraries for controlled studies involving hypertension and CV complications in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriasis including psoriatic arthritis (PsA), Sjogren's syndrome (SS), or antineutrophil cytoplasmic antibody-associated vasculitis (AAV) between January 2000 and March 2022. We extracted data on the prevalence of hypertension and CV complications. Then, random-effects meta-analyses and exploratory multivariate meta-regression were performed to explore factors related to the prevalence of hypertension. Of 2726 studies screened, 122 were selected for the meta-analysis. The prevalence of hypertension was higher among patients with IAD than controls, with an overall unadjusted odds ratio (OR) [95% confidence interval] of 1.67 [1.58-1.76] and an adjusted OR of 1.36 [1.24-1.50]. All diseases were found to be associated with increased risk of hypertension: SLE, adjusted OR 3.40 [1.93-6.00]; psoriasis, OR 1.32 [1.16-1.51]; PsA, OR 1.49 [1.15-1.94]; RA, OR 1.28 [1.04-1.58]; SS, OR 2.02 [1.19-3.44]. Age and female sex were significantly associated with hypertension in patients with IAD. The risk of CV complications was increased: ischemic heart disease, adjusted OR 1.38 [1.21-1.57]; cerebrovascular disease, OR 1.37 [1.03-1.81]; heart failure, OR 1.28 [1.05-1.55]; atherosclerotic plaques presence, OR 2.46 [1.84-3.29]. The prevalence of hypertension and CV complications is higher among patients with IAD. Screening and management of hypertension appears to be of paramount importance in these patients.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":3.9000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Hypertension Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11906-024-01311-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This review aimed to investigate the prevalence of hypertension and cardiovascular (CV) complications in various inflammatory and autoimmune diseases (IAD).

Recent findings: Despite recent improvements in the management of IAD, patients with IAD still have an increased CV mortality and CV complications, mostly related to CV risk factors such as hypertension and inflammation. We systematically searched MEDLINE and EMBASE libraries for controlled studies involving hypertension and CV complications in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriasis including psoriatic arthritis (PsA), Sjogren's syndrome (SS), or antineutrophil cytoplasmic antibody-associated vasculitis (AAV) between January 2000 and March 2022. We extracted data on the prevalence of hypertension and CV complications. Then, random-effects meta-analyses and exploratory multivariate meta-regression were performed to explore factors related to the prevalence of hypertension. Of 2726 studies screened, 122 were selected for the meta-analysis. The prevalence of hypertension was higher among patients with IAD than controls, with an overall unadjusted odds ratio (OR) [95% confidence interval] of 1.67 [1.58-1.76] and an adjusted OR of 1.36 [1.24-1.50]. All diseases were found to be associated with increased risk of hypertension: SLE, adjusted OR 3.40 [1.93-6.00]; psoriasis, OR 1.32 [1.16-1.51]; PsA, OR 1.49 [1.15-1.94]; RA, OR 1.28 [1.04-1.58]; SS, OR 2.02 [1.19-3.44]. Age and female sex were significantly associated with hypertension in patients with IAD. The risk of CV complications was increased: ischemic heart disease, adjusted OR 1.38 [1.21-1.57]; cerebrovascular disease, OR 1.37 [1.03-1.81]; heart failure, OR 1.28 [1.05-1.55]; atherosclerotic plaques presence, OR 2.46 [1.84-3.29]. The prevalence of hypertension and CV complications is higher among patients with IAD. Screening and management of hypertension appears to be of paramount importance in these patients.

Abstract Image

查看原文本刊更多论文

炎症性和自身免疫性疾病中的高血压与心血管结局：系统综述与元分析》。

目的：本综述旨在研究各种炎症性和自身免疫性疾病（IAD）中高血压和心血管并发症的发病率：尽管最近IAD的治疗有所改善，但IAD患者的心血管死亡率和心血管并发症仍在增加，这主要与高血压和炎症等心血管风险因素有关。我们系统检索了 MEDLINE 和 EMBASE 文库中 2000 年 1 月至 2022 年 3 月期间涉及系统性红斑狼疮 (SLE)、类风湿性关节炎 (RA)、银屑病（包括银屑病关节炎 (PsA)）、Sjogren 综合征 (SS) 或抗中性粒细胞胞浆抗体相关性血管炎 (AAV) 的高血压和心血管并发症的对照研究。我们提取了高血压和冠心病并发症发病率的数据。然后，我们进行了随机效应荟萃分析和探索性多变量荟萃回归，以探索与高血压患病率相关的因素。在筛选出的 2726 项研究中，有 122 项被选中进行荟萃分析。与对照组相比，IAD 患者的高血压患病率较高，总体未调整比值比 (OR) [95% 置信区间] 为 1.67 [1.58-1.76]，调整比值比为 1.36 [1.24-1.50]。所有疾病都与高血压风险增加有关：系统性红斑狼疮的调整 OR 值为 3.40 [1.93-6.00]；银屑病的 OR 值为 1.32 [1.16-1.51]；PsA 的 OR 值为 1.49 [1.15-1.94]；RA 的 OR 值为 1.28 [1.04-1.58]；SS 的 OR 值为 2.02 [1.19-3.44]。年龄和女性性别与 IAD 患者的高血压明显相关。心血管并发症的风险增加：缺血性心脏病，调整后 OR 值为 1.38 [1.21-1.57]；脑血管疾病，OR 值为 1.37 [1.03-1.81]；心力衰竭，OR 值为 1.28 [1.05-1.55]；动脉粥样硬化斑块，OR 值为 2.46 [1.84-3.29]。在 IAD 患者中，高血压和心血管并发症的发病率较高。对这些患者进行高血压筛查和管理似乎至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Hypertension Reports 医学-外周血管病

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.