Current Hypertension Reports最新文献_第2页

Posterior Reversible Encephalopathy Syndrome in Children and Adolescents. 儿童和青少年后可逆性脑病综合征。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-08-01 Epub Date: 2024-05-10 DOI: 10.1007/s11906-024-01303-6

Susan M Halbach, Deborah Stein

引用次数: 0

Management of Pulmonary Hypertension in the Context of Heart Failure with Preserved Ejection Fraction. 保留射血分数心力衰竭时的肺动脉高压管理。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-07-01 Epub Date: 2024-04-01 DOI: 10.1007/s11906-024-01296-2

Elie Kozaily, Ecem Raziye Akdogan, Natalie Stringer Dorsey, Ryan J Tedford

{"title":"Management of Pulmonary Hypertension in the Context of Heart Failure with Preserved Ejection Fraction.","authors":"Elie Kozaily, Ecem Raziye Akdogan, Natalie Stringer Dorsey, Ryan J Tedford","doi":"10.1007/s11906-024-01296-2","DOIUrl":"10.1007/s11906-024-01296-2","url":null,"abstract":"Purpose of review: To review the current evidence and modalities for treating pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF).Recent findings: In recent years, several therapies have been developed that improve morbidity in HFpEF, though these studies have not specifically studied patients with PF-HFpEF. Multiple trials of therapies specifically targeting the pulmonary vasculature such as phosphodiesterase (PDE) inhibitors, prostacyclin analogs, endothelin receptor antagonists (ERA), and soluble guanylate cyclase stimulators have also been conducted. However, these therapies demonstrated lack of consistency in improving hemodynamics or functional outcomes in PH-HFpEF. There is limited evidence to support the use of pulmonary vasculature-targeting therapies in PH-HFpEF. The mainstay of therapy remains the treatment of the underlying HFpEF condition. There is emerging evidence that newer HF therapies such as sodium-glucose transporter 2 inhibitors and angiotensin-receptor-neprilysin inhibitors are associated with improved hemodynamics and quality of life of patients with PH-HFpEF. There is also a growing realization that more robust phenotyping PH and right ventricular (RV) function may hold promise for therapeutic strategies for patients with PH-HFpEF.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140335107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis. 子痫前期与后代血压之间的关系：系统回顾与元分析》。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-07-01 Epub Date: 2024-05-23 DOI: 10.1007/s11906-024-01306-3

Min Xu, Hai-Xia Wang, Ping Zu, Nan Jiang, Jing-Feng Bian, Ji-Rong Xu, Wei Luo, Peng Zhu

{"title":"Association Between Preeclampsia and Blood Pressure in Offspring: A Systematic Review and Meta-Analysis.","authors":"Min Xu, Hai-Xia Wang, Ping Zu, Nan Jiang, Jing-Feng Bian, Ji-Rong Xu, Wei Luo, Peng Zhu","doi":"10.1007/s11906-024-01306-3","DOIUrl":"10.1007/s11906-024-01306-3","url":null,"abstract":"Purpose of review: Pregnancy-induced preeclampsia is a severe pregnancy complication and preeclampsia has been associated with an increased risk of chronic hypertension for offspring. However, the magnitude of the overall effect of exposure to preeclampsia in pregnancy on blood pressure (BP) in offspring is unknown. This systematic review and meta-analysis was sought to systematically assess the effects of preeclampsia on the BP of the offspring.Recent findings: Of 2550 publications identified, 23 studies were included. The meta-analysis indicated that preeclampsia increases the potential risk of hypertension in offspring. Systolic blood pressure (SBP) was 2.0 mm Hg (95% CI: 1.2, 2.8) and diastolic blood pressure (DBP) was 1.4 mm Hg (95% CI: 0.9, 1.9) higher in offspring exposed to pre-eclampsia in utero, compared to those born to normotensive mothers. The correlations were similar in stratified analyses of children and adolescents by sex, geographic area, ages, and gestational age. During childhood and young adulthood, the offspring of pregnant women with preeclampsia are at an increased risk of high BP. It is crucial to monitor their BP.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine Learning Algorithms Versus Classical Regression Models in Pre-Eclampsia Prediction: A Systematic Review. 子痫前期预测中的机器学习算法与经典回归模型：系统综述。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s11906-024-01297-1

Sofonyas Abebaw Tiruneh, Tra Thuan Thanh Vu, Daniel Lorber Rolnik, Helena J Teede, Joanne Enticott

{"title":"Machine Learning Algorithms Versus Classical Regression Models in Pre-Eclampsia Prediction: A Systematic Review.","authors":"Sofonyas Abebaw Tiruneh, Tra Thuan Thanh Vu, Daniel Lorber Rolnik, Helena J Teede, Joanne Enticott","doi":"10.1007/s11906-024-01297-1","DOIUrl":"10.1007/s11906-024-01297-1","url":null,"abstract":"Purpose of review: Machine learning (ML) approaches are an emerging alternative for healthcare risk prediction. We aimed to synthesise the literature on ML and classical regression studies exploring potential prognostic factors and to compare prediction performance for pre-eclampsia.Recent findings: From 9382 studies retrieved, 82 were included. Sixty-six publications exclusively reported eighty-four classical regression models to predict variable timing of onset of pre-eclampsia. Another six publications reported purely ML algorithms, whilst another 10 publications reported ML algorithms and classical regression models in the same sample with 8 of 10 findings that ML algorithms outperformed classical regression models. The most frequent prognostic factors were age, pre-pregnancy body mass index, chronic medical conditions, parity, prior history of pre-eclampsia, mean arterial pressure, uterine artery pulsatility index, placental growth factor, and pregnancy-associated plasma protein A. Top performing ML algorithms were random forest (area under the curve (AUC) = 0.94, 95% confidence interval (CI) 0.91-0.96) and extreme gradient boosting (AUC = 0.92, 95% CI 0.90-0.94). The competing risk model had similar performance (AUC = 0.92, 95% CI 0.91-0.92) compared with a neural network. Calibration performance was not reported in the majority of publications. ML algorithms had better performance compared to classical regression models in pre-eclampsia prediction. Random forest and boosting-type algorithms had the best prediction performance. Further research should focus on comparing ML algorithms to classical regression models using the same samples and evaluation metrics to gain insight into their performance. External validation of ML algorithms is warranted to gain insights into their generalisability.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperuricemia: An Intriguing Connection to Metabolic Syndrome, Diabetes, Kidney Disease, and Hypertension. 高尿酸血症：高尿酸血症：与代谢综合征、糖尿病、肾病和高血压之间的有趣联系。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-06-01 Epub Date: 2024-01-25 DOI: 10.1007/s11906-024-01295-3

Ramzi Vareldzis, Annalisa Perez, Efrain Reisin

引用次数: 0

Screening and Management of Pediatric High Blood Pressure-Challenges to Implementing the Clinical Practice Guideline. 小儿高血压的筛查和管理--实施《临床实践指南》的挑战。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-06-01 Epub Date: 2024-03-09 DOI: 10.1007/s11906-024-01298-0

Coral D Hanevold, Tammy M Brady

引用次数: 0

The Role of Obesity in the Development of Preeclampsia. 肥胖在先兆子痫发病中的作用。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-06-01 Epub Date: 2024-03-21 DOI: 10.1007/s11906-024-01299-z

Miguel Javier Schiavone, Mariana Paula Pérez, Analía Aquieri, Daniela Nosetto, María Victoria Pronotti, María Mazzei, Cyntia Kudrle, Horacio Avaca

{"title":"The Role of Obesity in the Development of Preeclampsia.","authors":"Miguel Javier Schiavone, Mariana Paula Pérez, Analía Aquieri, Daniela Nosetto, María Victoria Pronotti, María Mazzei, Cyntia Kudrle, Horacio Avaca","doi":"10.1007/s11906-024-01299-z","DOIUrl":"10.1007/s11906-024-01299-z","url":null,"abstract":"Purpose of review: This comprehensive review provides an in-depth exploration of the complex relationship between obesity and preeclampsia (PE) and emphasizes the clinical implications of this association. It highlights the crucial role of screening tools in assessing individual risk and determining the need for additional antenatal care among women with obesity. The review investigates various markers for identifying the risk of developing PE, while emphasizing the significance of interventions such as exercise, weight management, and a balanced diet in reducing the incidence of preeclampsia and improving outcomes for both mother and fetus.Recent findings: Actually, there is a global pandemic of obesity, particularly among women of childbearing age and pregnant women. PE, which is characterized by maternal hypertension, proteinuria, and complications, affects 2-4% of pregnancies worldwide, posing significant risks to maternal and perinatal health. Women with obesity face an elevated risk of developing PE due to the systemic inflammation resulting from excess adiposity, which can adversely affect placental development. Adipose tissue, rich in proinflammatory cytokines and complement proteins, contributes to the pathogenesis of PE by promoting the expression of antiangiogenic factors in the mother. This review emphasizes the need for appropriate screening, interventions, and a holistic approach to reduce the incidence of preeclampsia and enhance maternal-fetal well-being, thus providing valuable insights into the multifaceted association between obesity and PE.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140183988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistant Hypertension: Disease Burden and Emerging Treatment Options. 耐药性高血压：疾病负担与新兴治疗方案。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-05-01 Epub Date: 2024-02-16 DOI: 10.1007/s11906-023-01282-0

John M Flack, Michael G Buhnerkempe, Kenneth Todd Moore

{"title":"Resistant Hypertension: Disease Burden and Emerging Treatment Options.","authors":"John M Flack, Michael G Buhnerkempe, Kenneth Todd Moore","doi":"10.1007/s11906-023-01282-0","DOIUrl":"10.1007/s11906-023-01282-0","url":null,"abstract":"Purpose of review: To define resistant hypertension (RHT), review its pathophysiology and disease burden, identify barriers to effective hypertension management, and to highlight emerging treatment options.Recent findings: RHT is defined as uncontrolled blood pressure (BP) ≥ 130/80 mm Hg despite concurrent prescription of ≥ 3 or ≥ 4 antihypertensive drugs in different classes or controlled BP despite prescription of ≥ to 4 drugs, at maximally tolerated doses, including a diuretic. BP is regulated by a complex interplay between the renin-angiotensin-aldosterone system, the sympathetic nervous system, the endothelin system, natriuretic peptides, the arterial vasculature, and the immune system; disruption of any of these can increase BP. RHT is disproportionately manifest in African Americans, older patients, and those with diabetes and/or chronic kidney disease (CKD). Amongst drug-treated hypertensives, only one-quarter have been treated intensively enough (prescribed > 2 drugs) to be considered for this diagnosis. New treatment strategies aimed at novel therapeutic targets include inhibition of sodium-glucose cotransporter 2, aminopeptidase A, aldosterone synthesis, phosphodiesterase 5, xanthine oxidase, and dopamine beta-hydroxylase, as well as soluble guanylate cyclase stimulation, nonsteroidal mineralocorticoid receptor antagonism, and dual endothelin receptor antagonism. The burden of RHT remains high. Better use of currently approved therapies and integrating emerging therapies are welcome additions to the therapeutic armamentarium for addressing needs in high-risk aTRH patients.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection. RAAS 相关 SNPs 的遗传评估：感染 HIV 的先兆子痫妇女的 REN (rs16853055)、AGT (rs3789678) 和 ACE (rs4305)。

IF 5.6 2区医学

Current Hypertension Reports Pub Date : 2024-05-01 Epub Date: 2024-02-27 DOI: 10.1007/s11906-023-01292-y

Annelene Govindsamy, Shoohana Singh, Thajasvarie Naicker

{"title":"Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection.","authors":"Annelene Govindsamy, Shoohana Singh, Thajasvarie Naicker","doi":"10.1007/s11906-023-01292-y","DOIUrl":"10.1007/s11906-023-01292-y","url":null,"abstract":"Purpose of review: The primary goal of this review article was to determine whether the three RAAS-associated SNPs, Renin-rs16853055, AGT-rs3789678 and ACE-rs4305 are genetically linked to the development of hypertension in preeclampsia. The secondary goal was to establish if there was a link between these SNPs and HIV infection.Recent findings: There is a paucity of findings related to the aforementioned SNPs and preeclampsia. There are no recent findings on the rs16853055 renin polymorphism. The rs3789678 angiotensinogen polymorphism correlated significantly with gestational hypertension. The rs4305 ACE polymorphism showed no significant association with the development of pregnancy-induced hypertension. There are conflicting findings when determining the relationship between ethnicity and the predisposition of preeclampsia and hypertension in relation to the discussed RAAS-associated SNPs. To date, the association between RAAS-associated SNPs and preeclamptic women co-morbid with HIV in South Africa has revealed that certain alleles of the AGT gene are more prominent in HIV-infected PE compared to normotensive pregnant HIV-infected women.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":5.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11153260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Continuous Positive Airway Pressure on Blood Pressure in Patients with Resistant Hypertension and Obstructive Sleep Apnea: An Updated Meta-analysis. 持续正压通气对耐药性高血压和阻塞性睡眠呼吸暂停患者血压的影响：最新 Meta 分析。

IF 3.9 2区医学

Current Hypertension Reports Pub Date : 2024-05-01 Epub Date: 2024-03-09 DOI: 10.1007/s11906-024-01294-4

Ling Sun, Ya-Fei Chang, Yun-Fei Wang, Quan-Xin Xie, Xian-Zhong Ran, Chun-Yang Hu, Bin Luo, Bin Ning

{"title":"Effect of Continuous Positive Airway Pressure on Blood Pressure in Patients with Resistant Hypertension and Obstructive Sleep Apnea: An Updated Meta-analysis.","authors":"Ling Sun, Ya-Fei Chang, Yun-Fei Wang, Quan-Xin Xie, Xian-Zhong Ran, Chun-Yang Hu, Bin Luo, Bin Ning","doi":"10.1007/s11906-024-01294-4","DOIUrl":"10.1007/s11906-024-01294-4","url":null,"abstract":"Purpose of review: The effect of continuous positive airway pressure (CPAP) on resistant hypertension in patients at high risk with obstructive sleep apnea (OSA) needs further investigation. We aimed to determine the effect of CPAP on blood pressure in patients with resistant hypertension and OSA. Databases including PubMed, EMBASE, MEDLINE, the Cochrane Library, and CMB were searched. Data were pooled using a random-effects or fixed-effects model to derive weighted mean differences (WMDs) and 95% confidence intervals (CIs).Recent findings: A total of 12 trials and 718 participants were included. Compared with control, CPAP significantly reduced 24-h systolic blood pressure (SBP) (WMD: - 5.92 mmHg [ - 8.72, - 3.11]; P＜0.001), 24-h diastolic blood pressure (DBP) (WMD: - 4.44 mmHg [- 6.26 , - 2.62]; P ＜0.001), daytime SBP (WMD: - 5.76 mmHg [ - 9.16, - 2.36]; P ＜0.001), daytime DBP (WMD: - 3.92 mmHg [- 5.55, - 2.30]; nighttime SBP (WMD: - 4.87 mmHg [ - 7.96 , - 1.78]; P = 0.002), and nighttime DBP (WMD: - 2.05 mmHg [- 2.99, - 1.11]; P＜0.001) in patients with resistant hypertension and OSA. CPAP improved the blood pressure both in the short (＜3 months) and long term (≥ 3 months). No significant impact on mean heart rate was noted (WMD: -2.76 beats per min [- 7.50, 1.97]; P = 0.25). CPAP treatment was associated with BP reduction in patients with resistant hypertension and OSA.","PeriodicalId":10963,"journal":{"name":"Current Hypertension Reports","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0