儿童癌症幸存者的高血压:原因、筛查和管理。

IF 3.9 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE
Natalie L Wu, Coral D Hanevold
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引用次数: 0

摘要

回顾的目的:儿童癌症和造血细胞移植的幸存者有发展为慢性健康状况的风险,包括高血压。研究已经确定高血压是儿童癌症幸存者晚期肾功能障碍和心血管疾病的重要危险因素。高血压的总体风险取决于具体的癌症治疗,从化疗到手术再到放疗。在本报告中,我们旨在回顾儿童癌症幸存者高血压的主要原因,重点是新的治疗方法,以及目前对这一患者群体高血压筛查和管理的建议。最新发现:新的靶向疗法和免疫疗法越来越多地用于儿童癌症治疗,对长期健康的影响尚不清楚。各种儿童癌症合作小组根据现有的最佳证据和专家意见,发布了幸存者高血压筛查指南。较新的研究集中在个体风险预测上,这可能有助于改善高血压的诊断和管理,特别是在高危人群中。尽管高血压是影响心血管和肾脏健康的少数可改变的危险因素之一,但研究尚未确定儿童癌症幸存者的最佳血压目标、筛查参数或管理策略。此外,需要进一步的研究来证明高血压干预后的结果改善,特别是在这一患者群体中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypertension in Childhood Cancer Survivors: Causes, Screening, and Management.

Purpose of review: Survivors of childhood cancer and hematopoietic cell transplant are at risk for developing chronic health conditions, including hypertension. Studies have identified hypertension as an influential risk factor for late kidney dysfunction and cardiovascular disease in childhood cancer survivors. The overall risk of hypertension depends on the specific cancer treatment, from chemotherapy to surgery to radiation. In this report, we aim to review the main causes of hypertension in childhood cancer survivors, with a focus on newer therapies, as well as the current recommendations for screening and management of hypertension in this patient population.

Recent findings: Novel targeted therapies and immunotherapies are being increasingly used in pediatric cancer treatment, with unclear impact on long-term health. Screening guidelines for hypertension in the survivor population have been issued by various childhood cancer cooperative groups based on best available evidence and expert opinion. Newer studies have focused on individual risk prediction, which may help improve the diagnosis and management of hypertension, particularly in higher-risk individuals. Despite the importance of hypertension as one of the few modifiable risk factors for cardiovascular and renal health, studies have yet to define optimal blood pressure targets, screening parameters, or management strategies in childhood cancer survivors. Additionally, further studies are needed to demonstrate improvement in outcomes following interventions for hypertension specifically in this patient population.

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来源期刊
Current Hypertension Reports
Current Hypertension Reports 医学-外周血管病
CiteScore
10.50
自引率
0.00%
发文量
65
审稿时长
6-12 weeks
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of hypertension. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as antihypertensive therapies, associated metabolic disorders, and therapeutic trials. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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