Current Chemistry Letters最新文献

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Synthesis of novel pyrazolic analogues of chalcones as potential antibacterial and antifungal agents 新型吡唑类查尔酮潜在抗菌抗真菌药物的合成
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.2.001
C. Kumar, S. Manjunatha, B. Nandeshwarappa
{"title":"Synthesis of novel pyrazolic analogues of chalcones as potential antibacterial and antifungal agents","authors":"C. Kumar, S. Manjunatha, B. Nandeshwarappa","doi":"10.5267/j.ccl.2023.2.001","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.2.001","url":null,"abstract":"The present includes the synthesis of pyrazoline derivatives using chalcones and phenyl hydrazine in the presence of ethanol. It also reveals that 2-pyrazoline complexes are physiologically active and may be used in a variety of therapeutic functions. FT-IR, 1H-NMR, 13C-NMR, LC-MS, and elemental analyses were used to characterise newly synthesised phenyl-pyrazoline derivatives. The antimicrobial activity of the synthesised compounds was assessed using the agar well diffusion assay and the Minimum Inhibition Concentration (MIC). Compounds 4b, 4f, and 4h have exhibited remarkable antibiotic action against bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Salmonella. Typhi, and Shigella sp. On the other hand, compound 4h had significant antifungal activity against Candida albicans and Aspergillus fusarium and was a highly promising agent when compared to standard nystatin.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80199009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insecticidal activity and structure activity relationship study of some synthesized hydrazone, dihydropyridine and 3-cyano-1, 4-dihydro-pyradazin-4-one derivatives against Aphis nerii 合成的腙类、二氢吡啶类和3-氰基- 1,4 -二氢吡达嗪-4- 1类衍生物对灰蚜的杀虫活性及构效关系研究
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.2.003
M. El-Gaby, Modather F. Hussein, Faraghally A. Faraghally, A. Drar, Mohamed A Gad
{"title":"Insecticidal activity and structure activity relationship study of some synthesized hydrazone, dihydropyridine and 3-cyano-1, 4-dihydro-pyradazin-4-one derivatives against Aphis nerii","authors":"M. El-Gaby, Modather F. Hussein, Faraghally A. Faraghally, A. Drar, Mohamed A Gad","doi":"10.5267/j.ccl.2023.2.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.2.003","url":null,"abstract":"In our work we study the toxic effects of the prepared pyridine and pyradazine derivatives. Five compounds have been synthesized in pure state as reported procedures, and their toxicity as potential insecticidal agents against adult and nymphs of Aphis nerii were screened. The toxicity data in adults, exhibited that compound 6a is more toxic than other synthesized compounds, which LC50 was1.04 ppm while, in nymph compound 4a is more toxic than other synthesized compounds, which LC50 was 0.02 ppm. The other screened compounds showed weak to strong toxicological activity. The structure-activity relationships (SAR) for these compounds were also discussed.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82271828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Synthesis and catalytic activity of Cu (II) complex with 4-phenyl 2, 6-di (thiazol-2-yl) pyridine in the oxidation of para-aminophenol Cu (II)与4-苯基2,6 -二(噻唑-2-基)吡啶配合物氧化对氨基苯酚的合成及催化活性研究
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.8.005
A. Goel, M. Rani
{"title":"Synthesis and catalytic activity of Cu (II) complex with 4-phenyl 2, 6-di (thiazol-2-yl) pyridine in the oxidation of para-aminophenol","authors":"A. Goel, M. Rani","doi":"10.5267/j.ccl.2022.8.005","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.8.005","url":null,"abstract":"In the present work the synthesis of 4-phenyl-2, 6-di (thiazol-2-yl) pyridine copper chloride (abbreviated as Cu-DTPy) complex using copper (II) chloride and 2, 6-di (thiazol-2-yl) pyridine has been carried out. The complex has been specified by UV-Vis, FT-IR, CHNS and ESI-MS methods of analysis. The synthesized copper complex has been used as catalyst in the oxidation of p-aminophenol using hexacyanoferrate (III) ions as an oxidant in aqueous alkaline medium by kinetic-spectrophotometric method. This experimental work was carried out at optimum pH 11.0 and temperature 25ºC. The variation of effect of concentration of p-aminophenol (abbreviated as PAP), hexacyanoferrate (III) ions, and Cu-DTPy catalyst on reaction rate has been studied. Thermodynamic parameters such as free energy of activation, activation energy, enthalpy and frequency factor have been evaluated with the change in rate of the reaction at four disparate temperatures i.e. 25-40ᵒC. The oxidation products have been identified by FT-IR and ESI-MS spectroscopic analytical techniques. The major product of this reaction is NN’-bis-(p-hydroxyphenyl)-2-hydroxy-5-amino-1,4-benzoquinone di-imine. Thus, this method is highly efficient and environmentally safe to remove PAP from polluted water resources.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83875617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives 二氧化硅-氯化锌(SiO2-ZnCl2)催化活性亚甲基化合物与β-硝基苯乙烯的Michael加成反应:功能化吡唑衍生物的合成
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.10.001
V. Krishnan, Santha Kumari Merugu, V. K. Reddy, H. Bollikolla
{"title":"Silica-zinc chloride (SiO2-ZnCl2) catalyzed Michael addition reaction of active methylene compounds to β-nitrostyrenes: Synthesis of functionalized pyrazole derivatives","authors":"V. Krishnan, Santha Kumari Merugu, V. K. Reddy, H. Bollikolla","doi":"10.5267/j.ccl.2022.10.001","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.10.001","url":null,"abstract":"Under solvent-free conditions, a simple and efficient procedure has been developed for the Michael addition reaction of active methylene compounds to β-nitrostyrenes. The resulting Michael adducts are efficiently converted into functionalized pyrazole derivatives with hydrazine hydrate in excellent yields. All the compounds were well characterized by spectroscopic techniques.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83898128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles 一些三唑[3,4-b][1,3,4]噻二唑的抗癌性质
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.4.001
I. Myrko, T. Chaban, Y. Horak, olodymyr Ogurtsov, I. Drapak, I. Chaban, V. Matiychuk
{"title":"Anticancer properties of some triazolo[3,4-b][1,3,4]thiadiazoles","authors":"I. Myrko, T. Chaban, Y. Horak, olodymyr Ogurtsov, I. Drapak, I. Chaban, V. Matiychuk","doi":"10.5267/j.ccl.2023.4.001","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.4.001","url":null,"abstract":"In the present work, we presented an efficient synthesis and anticancer activity evaluation of some new 3-R-6-(5-arylfuran-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. We have shown that the proposed synthetic protocols provided the possibility to design triazolothiadiazoles diversity with a considerable chemical novelty. The structures of target substances were confirmed by using 1H NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds were selected by the National Cancer Institute Developmental Therapeutic Program for the in vitro cell line screening. Among all the substances tested, three compounds exhibited significant cytotoxic activity.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"276 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80054912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insecticidal efficacy and structure activity relationship study of some synthesized cyano-benzylidene and bisbenzylidene derivatives against Aphis nerii 合成的几种氰亚苄基和双亚苄基衍生物对灰蚜的杀虫效果及构效关系研究
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.3.003
M. El-Gaby, M. Bakry, Modather F. Hussein, Faraghally A. Faraghally, A. Khalil, Mohamed A Gad, A. Drar
{"title":"Insecticidal efficacy and structure activity relationship study of some synthesized cyano-benzylidene and bisbenzylidene derivatives against Aphis nerii","authors":"M. El-Gaby, M. Bakry, Modather F. Hussein, Faraghally A. Faraghally, A. Khalil, Mohamed A Gad, A. Drar","doi":"10.5267/j.ccl.2023.3.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.3.003","url":null,"abstract":"In this study, seven cyano-benzylidene and bisbenzylidene derivatives were designed and synthesized. All synthesized compounds were evaluated to determine their insecticidal activities as potential insecticides against nymphs and adults of Aphis nerii. These efforts led to the discovery of compounds 3a-d, 5, 7 and 10 with potent insecticidal activity (LC50 range from 0.0141 to 3.4351ppm). Compound 5 exhibited the highest insecticidal potency with 0.0141ppm. In addition, it indicated that compound 3b is less toxic than benzylidene and other precursors. Therefore, our results suggest that compound 5 has strong potential as a candidate component for developing a novel eco-friendly insecticide for control Aphids.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79417091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Isotherms, kinetics, and thermodynamics of methionine adsorption onto poorly crystalline hydroxyapatite with different Ca/P ratios 不同钙磷比下蛋氨酸在低结晶羟基磷灰石上吸附的等温线、动力学和热力学
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.4.003
A. E. Rhilassi, Oumaima Oukkass, M. Bennani-Ziatni
{"title":"Isotherms, kinetics, and thermodynamics of methionine adsorption onto poorly crystalline hydroxyapatite with different Ca/P ratios","authors":"A. E. Rhilassi, Oumaima Oukkass, M. Bennani-Ziatni","doi":"10.5267/j.ccl.2023.4.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.4.003","url":null,"abstract":"The adsorption properties of hydroxyapatite of low crystallinity towards methionine have been examined. The chemical composition of hydroxyapatite was taken as an experimental variable in order to have a point of view on the parameters of the adsorption process and the mechanisms established between adsorbent-adsorbate. The adsorption kinetics are relatively fast, and the high amounts adsorbed at saturation are obtained for non-stoichiometric hydroxyapatite, containing more HPO42- ions and having a high specific surface area. The good agreement of the experimental data with kinetic models confirms that the mechanism can be perfectly described by pseudo-second-order kinetics. Adsorption isotherm models show that Langmuir's model gives a better fit of experimental data compared to that of Freundlich, Temkin and Dubinin-Kaganer-Radushkevich. Fourier transform infrared spectroscopy confirmed the interaction between the -COO- ions of methionine and the Ca2+ ions of hydroxyapatite. The thermodynamic parameters, the isoelectric point of methionine and the point of zero charge of hydroxyapatite with different Ca/P ratios show that the adsorption process is considered spontaneous, exothermic and often controlled by physisorption with interactions electrostatic.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84900273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and characterization of λ-shaped azo liquid crystals: The effect of terminal alkoxy group λ型偶氮液晶的合成与表征:末端烷氧基的影响
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.1.007
Akshay Thakor, V. Sharma, Suryajitsinji L. Rathod, P. Shrivastav, R. Shah
{"title":"Synthesis and characterization of λ-shaped azo liquid crystals: The effect of terminal alkoxy group","authors":"Akshay Thakor, V. Sharma, Suryajitsinji L. Rathod, P. Shrivastav, R. Shah","doi":"10.5267/j.ccl.2023.1.007","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.1.007","url":null,"abstract":"The construction of a λ-shaped three side substituted alkoxy based molecular system (E1-E8) with azo-ester group was carried out and studied for liquid crystalline applications. The mesogenic behaviour and thermal stability of synthesized derivatives were checked and analyzed by POM, DSC and TGA analysis. These azo-ester based compounds show smectic C and nematic type mesomorphic properties. The observed texture patterns of the synthesized compounds are fan, broken fan, schlieren and threaded types. All derivatives shows broad temperature range of mesophase and further stabilized upto the room temperature. The structure-property relationship has been further studied to understand the effect of variable side-chain on liquid crystalline properties.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75797737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pyrrole Based Schiff Base as a Highly Sensitive Fluorescent Sensor for Fe3+ and Sn2+ Ions 吡咯基席夫碱作为Fe3+和Sn2+离子的高灵敏度荧光传感器
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2022.12.003
D. Udhayakumari
{"title":"Pyrrole Based Schiff Base as a Highly Sensitive Fluorescent Sensor for Fe3+ and Sn2+ Ions","authors":"D. Udhayakumari","doi":"10.5267/j.ccl.2022.12.003","DOIUrl":"https://doi.org/10.5267/j.ccl.2022.12.003","url":null,"abstract":"Condensation product of o-aminophenol and pyrrole-2-carboxylaldehyde behaves as a fluorescent sensor for Fe3+ and Sn2+ ions in aqueous medium over the other metal ions like Na+, K+, Mg2+, Zn2+, Cd2+, Hg2+, Mn2+ and Cr3+. In aqueous solution, Fe3+ and Sn2+ ions coordinate to the receptor through a NON binding site which induces a strong fluorescence enhancement. Receptor can be applied as fluorescence enhanced probes for transition metal ions due to the inhibition of photo induced electron transfer (PET) mechanism.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91033421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
N,N-Dimethylaniline and Zno nanoparticles mediated photochemical transformation of metronidazole N,N-二甲基苯胺和Zno纳米粒子介导甲硝唑光化学转化
Current Chemistry Letters Pub Date : 2023-01-01 DOI: 10.5267/j.ccl.2023.5.002
Waseem Ahmad, Poonam Negi
{"title":"N,N-Dimethylaniline and Zno nanoparticles mediated photochemical transformation of metronidazole","authors":"Waseem Ahmad, Poonam Negi","doi":"10.5267/j.ccl.2023.5.002","DOIUrl":"https://doi.org/10.5267/j.ccl.2023.5.002","url":null,"abstract":"The present study evaluates the photochemical behavior of a nitroimidazole derivative drug metronidazole in presence of N,N dimethylaniline and ZnO nanoparticles. The photochemical behavior was examined in a photochemical reactor by irradiating with a light of 254 and 310 nm. After completion of reaction one photoproduct was obtained. The photoproduct was isolated by using column chromatography and the structure of the isolated photoproduct was established by different spectroscopic techniques. This study provides the probable mechanism of the photochemical transformation of metronidazole in presence of an electron donor and in presence of ZnO NPs. During the photochemical transformation the nitro group of metronidazole was reduced in the amine group by a series of electron transfer processes. The ZnO nanoparticles are very efficient catalysts, and they degrade almost 90% metronidazole in the 60 min of UV irradiation. The photocatalytic mechanism of the ZnO nanoparticles is also discussed.","PeriodicalId":10942,"journal":{"name":"Current Chemistry Letters","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135686287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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