Insecticidal activity and structure activity relationship study of some synthesized hydrazone, dihydropyridine and 3-cyano-1, 4-dihydro-pyradazin-4-one derivatives against Aphis nerii

Q2 Chemistry

Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2023.2.003

M. El-Gaby, Modather F. Hussein, Faraghally A. Faraghally, A. Drar, Mohamed A Gad

引用次数: 2

Abstract

In our work we study the toxic effects of the prepared pyridine and pyradazine derivatives. Five compounds have been synthesized in pure state as reported procedures, and their toxicity as potential insecticidal agents against adult and nymphs of Aphis nerii were screened. The toxicity data in adults, exhibited that compound 6a is more toxic than other synthesized compounds, which LC50 was1.04 ppm while, in nymph compound 4a is more toxic than other synthesized compounds, which LC50 was 0.02 ppm. The other screened compounds showed weak to strong toxicological activity. The structure-activity relationships (SAR) for these compounds were also discussed.

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合成的腙类、二氢吡啶类和3-氰基- 1,4 -二氢吡达嗪-4- 1类衍生物对灰蚜的杀虫活性及构效关系研究

在我们的工作中，我们研究了所制备的吡啶和吡哒嗪衍生物的毒性作用。本文报道了5种化合物的纯合成方法，并对其作为潜在杀虫剂对麻蚜成虫和若虫的毒性进行了筛选。在成虫中，化合物6a毒性较强，LC50为1.04 ppm;在若虫中，化合物4a毒性较强，LC50为0.02 ppm。筛选的其他化合物均表现出弱到强的毒理活性。并讨论了这些化合物的构效关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

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