Synthesis of novel pyrazolic analogues of chalcones as potential antibacterial and antifungal agents

Q2 Chemistry

Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2023.2.001

C. Kumar, S. Manjunatha, B. Nandeshwarappa

引用次数: 0

Abstract

The present includes the synthesis of pyrazoline derivatives using chalcones and phenyl hydrazine in the presence of ethanol. It also reveals that 2-pyrazoline complexes are physiologically active and may be used in a variety of therapeutic functions. FT-IR, 1H-NMR, 13C-NMR, LC-MS, and elemental analyses were used to characterise newly synthesised phenyl-pyrazoline derivatives. The antimicrobial activity of the synthesised compounds was assessed using the agar well diffusion assay and the Minimum Inhibition Concentration (MIC). Compounds 4b, 4f, and 4h have exhibited remarkable antibiotic action against bacterial strains such as Staphylococcus aureus, Bacillus subtilis, Salmonella. Typhi, and Shigella sp. On the other hand, compound 4h had significant antifungal activity against Candida albicans and Aspergillus fusarium and was a highly promising agent when compared to standard nystatin.

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新型吡唑类查尔酮潜在抗菌抗真菌药物的合成

本发明包括在乙醇存在下用查尔酮和苯基肼合成吡唑啉衍生物。它还揭示了2-吡唑啉配合物具有生理活性，可用于多种治疗功能。采用FT-IR、1H-NMR、13C-NMR、LC-MS和元素分析对新合成的苯基吡唑啉衍生物进行表征。采用琼脂孔扩散法和最小抑制浓度(MIC)对合成化合物的抗菌活性进行了评价。化合物4b、4f和4h对金黄色葡萄球菌、枯草芽孢杆菌、沙门氏菌等细菌具有显著的抗菌作用。另一方面，化合物4h对白色念珠菌和镰刀曲霉具有显著的抗真菌活性，与标准制霉菌素相比具有很高的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Chemistry Letters Chemistry-Chemistry (all)

CiteScore

4.90

自引率

0.00%

发文量

审稿时长

20 weeks

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