Current Cardiology Reports最新文献

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A Narrative Review of Cardiometabolic Profiles among U.S. Adults: Temporal Trends and Implications. 美国成年人心脏代谢概况的叙述性回顾:时间趋势和意义。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-23 DOI: 10.1007/s11886-024-02179-3
Junxiu Liu, Lei Hao, Carl J Lavie
{"title":"A Narrative Review of Cardiometabolic Profiles among U.S. Adults: Temporal Trends and Implications.","authors":"Junxiu Liu, Lei Hao, Carl J Lavie","doi":"10.1007/s11886-024-02179-3","DOIUrl":"10.1007/s11886-024-02179-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>To provide a narrative overview of trends and disparities in the cardiometabolic profiles of U.S. adults by synthesizing findings from nationally representative studies conducted between 1999 and 2020.</p><p><strong>Recent findings: </strong>During the study period, the cardiometabolic profiles of U.S. adults displayed a complex mix of trends. While there were notable improvements in specific risk factors, such as reductions in total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, other aspects of cardiometabolic health worsened. The mean body mass index and hemoglobin A1c levels increased, accompanied by significant rises in the prevalence of obesity, type 2 diabetes, and metabolic syndrome. Despite some progress in blood pressure and lipid profiles, the overall cardiometabolic health of the population declined, with only a small percentage of adults maintaining optimal health by 2018. Furthermore, significant disparities persisted across racial and socioeconomic groups, with non-Hispanic Black participants and those with lower education and income facing higher cardiometabolic risks compared to their counterparts. Despite improvements in certain aspects of cardiometabolic profiles among U.S. adults, significant challenges remain, particularly with the rising rates of obesity, type 2 diabetes, and metabolic syndrome. Persistent disparities in cardiometabolic health across sociodemographic groups emphasize the need for comprehensive public health strategies that address medical care, lifestyle factors, and social determinants of health. Future efforts should prioritize reducing these disparities and enhancing health equity to mitigate the overall burden of cardiometabolic disease.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"36"},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Accuracy of Technetium-99 m Pyrophosphate Imaging in Diagnosing Transthyretin Cardiac Amyloidosis and Its Impact on Patient Management. 锝- 99m焦磷酸显像诊断甲状腺素型心脏淀粉样变性的准确性及其对患者管理的影响。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-23 DOI: 10.1007/s11886-025-02202-1
Zainab Altaha, Robert J H Miller
{"title":"The Accuracy of Technetium-99 m Pyrophosphate Imaging in Diagnosing Transthyretin Cardiac Amyloidosis and Its Impact on Patient Management.","authors":"Zainab Altaha, Robert J H Miller","doi":"10.1007/s11886-025-02202-1","DOIUrl":"10.1007/s11886-025-02202-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review evaluates recent advancements in Technetium-99 m pyrophosphate (99mTc-PYP) imaging for transthyretin amyloid cardiomyopathy (ATTR-CM). We summarize the advantages of single-photon emission computed tomography (SPECT) over planar imaging, the potential impact of quantitative methods, and emerging data for quantifying response to therapy.</p><p><strong>Recent findings: </strong>The current literature demonstrates the superior diagnostic accuracy of SPECT compared with planar imaging in 99mTc-PYP studies. Emerging quantitative methods, using hybrid SPECT/CT and artificial intelligence, show promise for enhancing diagnostic precision and risk assessment. Recent studies have also highlighted the potential of 99mTc-PYP quantification for monitoring treatment response. 99mTc-PYP SPECT imaging has exceptional diagnostic accuracy for ATTR-CM. Quantitative techniques, which can be facilitated by artificial intelligence, improve risk stratification and may aid in treatment monitoring. Future research should focus on clarifying the clinical role and optimal approach for quantification.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"37"},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eosinophilic Myocarditis: A Concise Review. 嗜酸性心肌炎:简要回顾。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-23 DOI: 10.1007/s11886-024-02184-6
Ashlee M Asada, Rami Kahwash, Vincenzo Trovato
{"title":"Eosinophilic Myocarditis: A Concise Review.","authors":"Ashlee M Asada, Rami Kahwash, Vincenzo Trovato","doi":"10.1007/s11886-024-02184-6","DOIUrl":"10.1007/s11886-024-02184-6","url":null,"abstract":"<p><strong>Purpose of review: </strong>Eosinophilic myocarditis (EM) is a rare and heterogeneous form of inflammatory heart disease that can present with a wide range of severity. Current literature is limited to case reports or small case series that outline the evaluation process, disease course, and the nonstandardized treatments trialed. This review aims to concisely summarize the current literature on EM including an update on maintenance therapy for refractory or recurrent disease.</p><p><strong>Recent findings: </strong>In the last several years, several observational studies have reported the clinical benefit of mepolizumab and benralizumab in refractory EM. EM is a complex and heterogenous cause of inflammatory heart disease with a wide range of etiologies and presentations. Treatment of this disease has not been standardized as there are no large scale trials quantifying benefit of any specific therapy regimen. Targeted biologics show promise in observational studies; therefore, prospective studies are needed to quantify this benefit in EM.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"38"},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transthyretin Cardiac Amyloidosis: Current and Emerging Therapies. 转甲状腺素型心脏淀粉样变性:当前和新出现的治疗方法。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-22 DOI: 10.1007/s11886-024-02172-w
Aditi G M Patel, Pengyang Li, Narotham Badrish, Aditya Kesari, Keyur B Shah
{"title":"Transthyretin Cardiac Amyloidosis: Current and Emerging Therapies.","authors":"Aditi G M Patel, Pengyang Li, Narotham Badrish, Aditya Kesari, Keyur B Shah","doi":"10.1007/s11886-024-02172-w","DOIUrl":"10.1007/s11886-024-02172-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>In this article, we describe current and newer TTR stabilizers, TTR silencers which include small interfering RNA agents (siRNA), antisense oligonucleotides (ASO) and CRISPR-Cas9 gene editing, and TTR depleters, which investigates the use of monoclonal antibodies to remove amyloid fibril deposits for patients with advanced disease.</p><p><strong>Recent findings: </strong>Once thought to be a rare and fatal condition, increased recognition, improved non-invasive diagnostic tools, and the explosive development of novel therapies, has transformed the landscape of transthyretin amyloid cardiomyopathy (ATTR-CM). Advances in cardiac imaging with respect to echocardiography, cardiac magnetic resonance imaging (CMR), and radionuclide bone scintigraphy has increased the diagnosis of ATTR-CM over the last twenty years. Ongoing clinical trials are evaluating several novel therapies at several mechanistic targets in the transthyretin (TTR) amyloidogenesis cascade, including the recently published findings from the study of vutrisiran, a siRNA agent. Our review provides a comprehensive summary of current and emerging therapies for ATTR-CM. While these are promising, disease-modifying treatments, reaching vulnerable populations early in the disease course should be a focus for future studies and interventions.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"33"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Echocardiographic Updates in the Assessment of Cardiomyopathy. 超声心动图评价心肌病的最新进展。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-22 DOI: 10.1007/s11886-024-02159-7
Baoqiong Liu, Kandarp Suthar, Christine M Gerula
{"title":"Echocardiographic Updates in the Assessment of Cardiomyopathy.","authors":"Baoqiong Liu, Kandarp Suthar, Christine M Gerula","doi":"10.1007/s11886-024-02159-7","DOIUrl":"10.1007/s11886-024-02159-7","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to provide an updated overview of the role of echocardiography in the assessment of cardiomyopathies, highlighting recent findings and technological advancements.</p><p><strong>Recent findings: </strong>Over the past few years, significant advancements in echocardiographic techniques have improved diagnostic accuracy and provided important prognostic value in the assessment of cardiomyopathies. Cardiomyopathy is a group of diseases affecting the heart muscle. Echocardiography, a non-invasive imaging modality provides crucial information on cardiac structure, function, and hemodynamics. Recent advancements, including strain imaging, speckle-tracking, and 3D echocardiography enhance the precision of structural and functional assessments, while artificial intelligence integration improves diagnostic accuracy and workflow efficiency. These advancements not only refine diagnostic capabilities but also provide prognostic insights and facilitate better patient outcomes.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"34"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vascular Access and Closure Management for Electrophysiological Interventions: Small Interventions Big Impact. 电生理干预的血管通路和关闭管理:小干预大影响。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-22 DOI: 10.1007/s11886-024-02156-w
Davide Fabbricatore, Katarzyna Malaczynska-Rajpold
{"title":"Vascular Access and Closure Management for Electrophysiological Interventions: Small Interventions Big Impact.","authors":"Davide Fabbricatore, Katarzyna Malaczynska-Rajpold","doi":"10.1007/s11886-024-02156-w","DOIUrl":"10.1007/s11886-024-02156-w","url":null,"abstract":"<p><strong>Purpose of the review: </strong>This review examines the role of vascular access and closure management in cardiac electrophysiology (EP) procedures, emphasising their impact on patient outcomes and safety. It synthesises current evidence and highlights advancements, challenges, and opportunities in this critical area of EP practice.</p><p><strong>Recent findings: </strong>Ultrasound-guided vascular access has significantly reduced complications and improved success rates compared to traditional methods. Vascular closure devices (VCDs) enable faster recovery and same-day discharge, becoming superior alternatives to manual compression. The \"4P framework\"- Plan, Prepare, Puncture, Protect- offers a structured approach to optimising vascular access. Alternative techniques, such as transhepatic and jugular access, are feasible in complex cases, though large-scale evidence is limited. Vascular access management is essential for EP procedures, demanding adequate planning and execution. While advancements in imaging and closure techniques enhance outcomes, further research is needed to standardise practices and evaluate long-term results. A personalised, systematic approach ensures optimal procedural success and patient care.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"35"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Regulation of Cardiomyocyte Maturation. 心肌细胞成熟的分子调控。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-21 DOI: 10.1007/s11886-024-02189-1
Bhavana Shewale, Tasneem Ebrahim, Arushi Samal, Nicole Dubois
{"title":"Molecular Regulation of Cardiomyocyte Maturation.","authors":"Bhavana Shewale, Tasneem Ebrahim, Arushi Samal, Nicole Dubois","doi":"10.1007/s11886-024-02189-1","DOIUrl":"10.1007/s11886-024-02189-1","url":null,"abstract":"<p><strong>Purpose of the review: </strong>This review aims to discuss the process of cardiomyocyte maturation, with a focus on the underlying molecular mechanisms required to form a fully functional heart. We examine both long-standing concepts associated with cardiac maturation and recent developments, and the overall complexity of molecularly integrating all the processes that lead to a mature heart.</p><p><strong>Recent findings: </strong>Cardiac maturation, defined here as the sequential changes that occurring before the heart reaches full maturity, has been a subject of investigation for decades. Recently, there has been a renewed, highly focused interest in this process, driven by clinically motivated research areas where enhancing maturation may lead to improved therapeutic opportunities. These include using pluripotent stem cell models for cell therapy and disease modeling, as well as recent advancements in adult cardiac regeneration approaches. We highlight key processes underlying maturation of the heart, including cellular and organ growth, and electrophysiological, metabolic, and contractile maturation. We further discuss how these processes integrate and interact to contribute to the overall complexity of the developing heart. Finally, we emphasize the transformative potential for translating relevant maturation concepts to emerging models of heart disease and regeneration.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"32"},"PeriodicalIF":3.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Key Concepts in Machine Learning and Clinical Applications in the Cardiac Intensive Care Unit. 机器学习的关键概念及其在心脏重症监护病房的临床应用。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-20 DOI: 10.1007/s11886-024-02149-9
Dhruv Sarma, Aniket S Rali, Jacob C Jentzer
{"title":"Key Concepts in Machine Learning and Clinical Applications in the Cardiac Intensive Care Unit.","authors":"Dhruv Sarma, Aniket S Rali, Jacob C Jentzer","doi":"10.1007/s11886-024-02149-9","DOIUrl":"10.1007/s11886-024-02149-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>Artificial Intelligence (AI) technology will significantly alter critical care cardiology, from our understanding of diseases to the way in which we communicate with patients and colleagues. We summarize the potential applications of AI in the cardiac intensive care unit (CICU) by reviewing current evidence, future developments and possible challenges.</p><p><strong>Recent findings: </strong>Machine Learning (ML) methods have been leveraged to improve interpretation and discover novel uses for diagnostic tests such as the ECG and echocardiograms. ML-based dynamic risk stratification and prognostication may help optimize triaging and CICU discharge procedures. Latent class analysis and K-means clustering may reveal underlying disease sub-phenotypes within heterogeneous conditions such as cardiogenic shock and decompensated heart failure. AI technology may help enhance routine clinical care, facilitate medical education and training, and unlock individualized therapies for patients in the CICU. However, robust regulation and improved clinician understanding of AI is essential to overcome important practical and ethical challenges.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"30"},"PeriodicalIF":3.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood Pressure Control and Incident Left-Ventricular Conduction Disease. 血压控制与左心室传导疾病的发生。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-20 DOI: 10.1007/s11886-025-02196-w
Emilie K Frimodt-Møller, Gregory M Marcus
{"title":"Blood Pressure Control and Incident Left-Ventricular Conduction Disease.","authors":"Emilie K Frimodt-Møller, Gregory M Marcus","doi":"10.1007/s11886-025-02196-w","DOIUrl":"10.1007/s11886-025-02196-w","url":null,"abstract":"<p><strong>Purpose of review: </strong>Cardiac conduction disease, a harbinger of pacemaker implantation, heart failure, and death, is commonly regarded as immutable. However, emerging research suggests it may be a target for upstream prevention strategies such as blood pressure management. This review summarizes recent evidence regarding blood pressure control and the development of conduction disease.</p><p><strong>Recent findings: </strong>Recent observational studies link hypertension to both prevalent and incident conduction disease. In randomized trials, intensive blood pressure control among hypertensive individuals reduced the incidence of left-ventricular conduction abnormalities in the form of fascicular- and left bundle branch blocks, while treatment with lisinopril independent of blood pressure control appeared to reduce conduction disease risk. Understanding factors that influence conduction system disease development may help inform novel primary prevention strategies. Recent evidence suggests that treatment of hypertension may play a key role in the prevention of conduction disease.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"29"},"PeriodicalIF":3.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular Risk Factor and Atherosclerosis in Rheumatoid Arthritis (RA). 类风湿关节炎(RA)的心血管危险因素和动脉粥样硬化。
IF 3.1 3区 医学
Current Cardiology Reports Pub Date : 2025-01-20 DOI: 10.1007/s11886-025-02198-8
Lakshmi Kattamuri, Shivangini Duggal, John Paul Aparece, Shrilekha Sairam
{"title":"Cardiovascular Risk Factor and Atherosclerosis in Rheumatoid Arthritis (RA).","authors":"Lakshmi Kattamuri, Shivangini Duggal, John Paul Aparece, Shrilekha Sairam","doi":"10.1007/s11886-025-02198-8","DOIUrl":"10.1007/s11886-025-02198-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>To highlight advancements in managing traditional and rheumatoid arthritis (RA) specific risk factors and the impact of RA treatments on cardiovascular outcomes.</p><p><strong>Recent findings: </strong>Advancements in rheumatoid arthritis management have paralleled declining trends in cardiovascular disease risks. Biomarkers like CRP, Lipoprotein(a), Apolipoprotein B 100, and imaging tools such as coronary artery calcium scoring enhance cardiovascular risk stratification, particularly in intermediate-risk RA patients. While effective RA treatments, have demonstrated substantial cardiovascular benefits, subclass differences were noted in high-risk patients. Increased risk of cardiovascular disease is driven by chronic inflammation, altered lipid metabolism, and traditional risk factors. Effective RA treatment significantly lowers cardiovascular events. Standard treatment of hypertension, diabetes and hypercholesterolemia are effective and lowers RA disease activity and inflammatory markers. While RA is considered a risk enhancing state in calculating CV risk scores, currently there exists no RA disease -specific blood pressure, blood sugar or lipid targets.</p>","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"31"},"PeriodicalIF":3.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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