Current Cardiology Reports最新文献_第8页

Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis. 心脏肉样瘤病的炎症和心肌血流

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-22 DOI: 10.1007/s11886-024-02070-1

Ashwin Singh Parihar, Ines Valenta, Salwa Mikhail, Alessio Imperiale, Thomas H Schindler

{"title":"Inflammation and Myocardial Blood Flow in Cardiac Sarcoidosis.","authors":"Ashwin Singh Parihar, Ines Valenta, Salwa Mikhail, Alessio Imperiale, Thomas H Schindler","doi":"10.1007/s11886-024-02070-1","DOIUrl":"10.1007/s11886-024-02070-1","url":null,"abstract":"Purpose of the review: Cardiac involvement in systemic sarcoidosis or isolated cardiac sarcoidosis plays a pivotal role in the clinical manifestation and prognostication. Active-inflammatory cardiac sarcoidosis is associated with a regional impairment of coronary microvascular function that may confer further detrimental effects on myocardial function needing further characterization.Recent findings: Clinical investigations with cardiac positron emission tomography/computed tomography in conjunction with 18F-fluorodeoxyglucose to determine myocardial inflammation and 13N-ammonia to quantify myocardial blood flow (MBF) in patients with known or suspected cardiac sarcoidosis outlined that sarcoidosis-induced myocardial inflammation was associated with adverse effects on corresponding regional coronary microvascular function. Notably, immune-suppressive treatment caused reductions in myocardial inflammation were paralleled by improvements of coronary microvascular dysfunction outlining direct adverse effect of inflammation on coronary arteriolar function. This review summarizes contributions of cardiac PET imaging in the identification and characterization of active-inflammatory cardiac sarcoidosis, its effect on coronary microvascular function, treatment responses, and prognostic implications.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Cyp2c19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention. 经皮冠状动脉介入治疗后 Cyp2c19 基因型引导的抗血小板疗法的作用

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s11886-024-02071-0

Manu Rajachandran, Richard A Lange

引用次数: 0

Left Ventricular Unloading in Extracorporeal Membrane Oxygenation: A Clinical Perspective Derived from Basic Cardiovascular Physiology. 体外膜氧合中的左心室卸荷：基础心血管生理学的临床视角。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-07 DOI: 10.1007/s11886-024-02067-w

I Protti, M P J van Steenwijk, P Meani, L Fresiello, C L Meuwese, D W Donker

{"title":"Left Ventricular Unloading in Extracorporeal Membrane Oxygenation: A Clinical Perspective Derived from Basic Cardiovascular Physiology.","authors":"I Protti, M P J van Steenwijk, P Meani, L Fresiello, C L Meuwese, D W Donker","doi":"10.1007/s11886-024-02067-w","DOIUrl":"10.1007/s11886-024-02067-w","url":null,"abstract":"Purpose of review: To present an abridged overview of the literature and pathophysiological background of adjunct interventional left ventricular unloading strategies during veno-arterial extracorporeal membrane oxygenation (V-A ECMO). From a clinical perspective, the mechanistic complexity of such combined mechanical circulatory support often requires in-depth physiological reasoning at the bedside, which remains a cornerstone of daily practice for optimal patient-specific V-A ECMO care.Recent findings: Recent conventional clinical trials have not convincingly shown the superiority of V-A ECMO in acute myocardial infarction complicated by cardiogenic shock as compared with medical therapy alone. Though, it has repeatedly been reported that the addition of interventional left ventricular unloading to V-A ECMO may improve clinical outcome. Novel approaches such as registry-based adaptive platform trials and computational physiological modeling are now introduced to inform clinicians by aiming to better account for patient-specific variation and complexity inherent to V-A ECMO and have raised a widespread interest. To provide modern high-quality V-A ECMO care, it remains essential to understand the patient's pathophysiology and the intricate interaction of an individual patient with extracorporeal circulatory support devices. Innovative clinical trial design and computational modeling approaches carry great potential towards advanced clinical decision support in ECMO and related critical care.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic Review on Role of Drug Eluting Stent (DES) Versus Drug-Coated Balloon (DCB) in Small Vessel Coronary Artery Disease. 药物洗脱支架 (DES) 与药物涂层球囊 (DCB) 在小血管冠状动脉疾病中的作用的系统性综述。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-06-08 DOI: 10.1007/s11886-024-02077-8

Motisola Mutema, Vishnu Shenoy, Partha Sardar, Sahil Parikh, Saurav Chatterjee

{"title":"Systematic Review on Role of Drug Eluting Stent (DES) Versus Drug-Coated Balloon (DCB) in Small Vessel Coronary Artery Disease.","authors":"Motisola Mutema, Vishnu Shenoy, Partha Sardar, Sahil Parikh, Saurav Chatterjee","doi":"10.1007/s11886-024-02077-8","DOIUrl":"10.1007/s11886-024-02077-8","url":null,"abstract":"PURPOSE OF REVIEW: This review aims to explain the current advancements in the treatment modalities for small vessel coronary artery disease (SVCAD) and de novo lesions post-percutaneous coronary intervention (PCI), focusing on drug-coated stents (DES) and drug-coated balloons (DCB). Its goal is to address the lack of standards in the management of these lesions and to assess the potential of DCB as a preferential treatment strategy over DES in the long term. RECENT FINDINGS: Technological advancements have improved drug-eluting stents (DES) and drug-coated balloons (DCB) which offer a more promising avenue for managing SVCAD. According to new data, DCBs, initially recognized for their efficacy in preventing restenosis within three to five years of stent placement, may offer superior outcomes compared to DES in certain clinical scenarios. This review shows that DCBs have a favorable therapeutic profile in the treatment of SVCAD, and they could be considered as an alternative to DES. Although the initial data is compelling, definitive conclusions cannot be met without further large-scale, long-term clinical trials. The implication of these findings suggests a shift in the future of SVCAD management and requires additional research to substantiate the long-term benefits of DCB use in SVCAD. Should ongoing and future studies corroborate the current evidence, DCB could emerge as the standard of care for SVCAD, significantly influencing clinical practices and future research.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation and Management of Mechanical Heart Valve Dysfunction and Thrombosis. 机械心脏瓣膜功能障碍和血栓形成的评估与管理。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-24 DOI: 10.1007/s11886-024-02074-x

Gary Parizher, Ambreen Ali, Paul C Cremer

引用次数: 0

Infection of Transcatheter Valvular Devices. 经导管瓣膜装置感染。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s11886-024-02076-9

Taha Hatab, Syed Zaid, Samarthkumar J Thakkar, Rody G Bou Chaaya, Sachin S Goel, Michael J Reardon

{"title":"Infection of Transcatheter Valvular Devices.","authors":"Taha Hatab, Syed Zaid, Samarthkumar J Thakkar, Rody G Bou Chaaya, Sachin S Goel, Michael J Reardon","doi":"10.1007/s11886-024-02076-9","DOIUrl":"10.1007/s11886-024-02076-9","url":null,"abstract":"Purpose of review: This review explores the epidemiology, clinical traits, and diagnosis of Transcatheter Aortic Valve Replacement-Associated Infective Endocarditis (TAVR-IE) and mitral transcatheter edge-to-edge repair infective endocarditis (TEER-IE), focusing on a multimodal imaging approach. It addresses the rising prevalence of TAVR and TEER, emphasizing the need to understand long-term complications and clinical consequences, which poses significant challenges despite advancements in valve technology.Recent findings: Studies report a variable incidence of TAVR-IE and TEER-IE influenced by diverse patient risk profiles and procedural factors. Younger age, male gender, and certain comorbidities emerge as patient-related risk factors. Procedure-related factors include intervention location, valve type, and technical aspects. Microbiologically, Staphylococcus aureus, Viridans Group Streptococcus, and Enterococcus are frequently encountered pathogens. TAVR-IE and TEER-IE diagnosis involves a multimodal imaging approach due to limitations in echocardiography. Blood cultures and imaging aid identification, with Fluorescence in situ hybridization is showing promise. Treatment encompasses medical management with antibiotics and, when necessary, surgical intervention. The management approach requires a multidisciplinary \"Endocarditis Team.\" This review underscores the need for continued research to refine risk prediction, enhance diagnostic accuracy, and optimize management strategies for TAVR-IE, considering the evolving landscape of transcatheter interventions.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updates on Patent Foramen Ovale (PFO) Closure. 闭塞大孔 (PFO) 的最新进展。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-06-24 DOI: 10.1007/s11886-024-02073-y

Konstantinos V Voudris, Marie-France Poulin, Clifford J Kavinsky

{"title":"Updates on Patent Foramen Ovale (PFO) Closure.","authors":"Konstantinos V Voudris, Marie-France Poulin, Clifford J Kavinsky","doi":"10.1007/s11886-024-02073-y","DOIUrl":"10.1007/s11886-024-02073-y","url":null,"abstract":"Purpose of review: Patent foramen ovale (PFO) has been previously linked to left circulation thromboembolism and stroke. This review article aims to discuss the latest evidence, updated societal guidelines, diagnostic algorithms and novel therapeutic devices for PFO closure.Recent findings: PFO closure for cryptogenic stroke and systemic embolization is supported by a large body of evidence and has a strong societal recommendation. Limited data are available for platypnea-orthodeoxia syndrome, although closure appears to be beneficial. Current data do not support routine closure for migraines and decompression Illness. Development of heart-brain teams can improve identification of patients most likely to benefit from closure, utilizing a combination of imaging test and risk score algorithms. Multiple novel devices aiming at reducing complications and improving the long-term impact of current available devices are being evaluated. PFO closure has significantly progressed over the last years, with new data supporting its superiority in reducing risk of recurrent embolic stroke in patients with PFO-related stroke. Additional clinical data are required to provide further refinements on patient selection and guidance on treatment of specific subgroups.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. 阻塞性睡眠呼吸暂停与影响不良心血管疾病相关结果的心肌血流变化之间的联系

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-28 DOI: 10.1007/s11886-024-02072-z

Ehimen C Aneni, Albert J Sinusas, Morgan C Emokpae, Stephanie L Thorn, H Klar Yaggi, Edward J Miller

{"title":"Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes.","authors":"Ehimen C Aneni, Albert J Sinusas, Morgan C Emokpae, Stephanie L Thorn, H Klar Yaggi, Edward J Miller","doi":"10.1007/s11886-024-02072-z","DOIUrl":"10.1007/s11886-024-02072-z","url":null,"abstract":"Purpose of review: Recent studies have demonstrated an association between obstructive sleep apnea (OSA) and abnormal myocardial blood flow (MBF), myocardial flow reserve (MFR), and coronary microvascular dysfunction (CMD). Here, we review the evidence and describe the potential underlying mechanisms linking OSA to abnormal MBF. Examining relevant studies, we assess the impact of OSA-specific therapy, such as continuous positive airway pressure (CPAP), on MBF.Recent findings: Recent studies suggest an association between moderate to severe OSA and abnormal MBF/MFR. OSA promotes functional and structural abnormalities of the coronary microcirculation. OSA also promotes the uncoupling of MBF to cardiac work. In a handful of studies with small sample sizes, CPAP therapy improved MBF/MFR. Moderate to severe OSA is associated with abnormal MFR, suggesting an association with CMD. Evidence suggests that CPAP therapy improves MBF. Future studies must determine the clinical impact of improved MBF with CPAP.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Multimodality Imaging in Cardiomyopathy. 多模态成像在心肌病中的作用。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1007/s11886-024-02068-9

Jonathan A Pan, Amit R Patel

{"title":"The Role of Multimodality Imaging in Cardiomyopathy.","authors":"Jonathan A Pan, Amit R Patel","doi":"10.1007/s11886-024-02068-9","DOIUrl":"10.1007/s11886-024-02068-9","url":null,"abstract":"Purpose of review: There has been increasing use of multimodality imaging in the evaluation of cardiomyopathies.Recent findings: Echocardiography, cardiac magnetic resonance (CMR), cardiac nuclear imaging, and cardiac computed tomography (CCT) play an important role in the diagnosis, risk stratification, and management of patients with cardiomyopathies. Echocardiography is essential in the initial assessment of suspected cardiomyopathy, but a multimodality approach can improve diagnostics and management. CMR allows for accurate measurement of volumes and function, and can easily detect unique pathologic structures. In addition, contrast imaging and parametric mapping enable the characterization of tissue features such as scar, edema, infiltration, and deposition. In non-ischemic cardiomyopathies, metabolic and molecular nuclear imaging is used to diagnose rare but life-threatening conditions such amyloidosis and sarcoidosis. There is an expanding use of CCT for planning electrophysiology procedures such as cardioversion, ablations, and device placement. Furthermore, CCT can evaluate for complications associated with advanced heart failure therapies such as cardiac transplant and mechanical support devices. Innovations in multimodality cardiac imaging should lead to increased volumes and better outcomes.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct Challenges of Eruptive and Non-Eruptive Calcified Nodules in Percutaneous Coronary Intervention. 经皮冠状动脉介入治疗中溃疡性和非溃疡性钙化结节的不同挑战。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-29 DOI: 10.1007/s11886-024-02075-w

Keyvan Karimi Galougahi, Doosup Shin, Ali Dakroub, Koshiro Sakai, Mandeep Singh, Sarah Malik, Akiko Maehara, Mitsuaki Matsumura, Gary Mintz, James C Spratt, Omar Khalique, Evan Shlofmitz, Allen Jeremias, Richard Shlofmitz, Ziad A Ali

{"title":"Distinct Challenges of Eruptive and Non-Eruptive Calcified Nodules in Percutaneous Coronary Intervention.","authors":"Keyvan Karimi Galougahi, Doosup Shin, Ali Dakroub, Koshiro Sakai, Mandeep Singh, Sarah Malik, Akiko Maehara, Mitsuaki Matsumura, Gary Mintz, James C Spratt, Omar Khalique, Evan Shlofmitz, Allen Jeremias, Richard Shlofmitz, Ziad A Ali","doi":"10.1007/s11886-024-02075-w","DOIUrl":"10.1007/s11886-024-02075-w","url":null,"abstract":"Purpose of review: To provide a summary of prevalence, pathogenesis, and treatment of coronary calcified nodules (CNs).Recent findings: CNs are most frequently detected at the sites of hinge motion of severely calcified lesions such as in the middle segment of right coronary artery and left main coronary bifurcation. On histopathology, CNs exhibit two distinctive morphologies: eruptive and non-eruptive. Eruptive CNs, which have a disrupted fibrous cap with adherent thrombi, are biologically active. Non-eruptive CNs, which have an intact fibrous cap without thrombi, are biologically inactive, representing either healed eruptive CNs or protrusion of calcium due to plaque progression. Recent studies using optical coherence tomography (OCT) have shown a difference in the mechanism of stent failure in the two subtypes, demonstrating early reappearance of eruptive CNs in the stent (at ~ 6 months) as a unique mechanism of stent failure that does not seem to be preventable by simply achieving adequate stent expansion. The cause of CN reappearance in stent is not known and could be due to acute or subacute intrusion or continued growth of the CN. Whether modification of CN is needed, the most effective calcium modification modality and effectiveness of stent implantation in eruptive CNs has not been elucidated. In this review, we discuss pathogenesis of CNs and how intravascular imaging can help diagnose and manage patients with CNs. We also discuss medical and transcatheter therapies beyond conventional stent implantation for effective treatment of eruptive CNs that warrant testing in prospective studies.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141160077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0