Current Cardiology Reports最新文献_第7页

Primary Graft Dysfunction after Heart Transplantation: Current Evidence and Implications for Clinical Practice. 心脏移植后的原发性移植物功能障碍：当前证据及对临床实践的影响》。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-15 DOI: 10.1007/s11886-024-02153-z

Elena I Gavrila, Jonathan S Dowell, Ananya Gorrai, Christopher Wrobel, Nicholas Hendren, E Ashley Hardin, Yasbanoo Moayedi, Natalie Tapaskar, Matthias Peltz, Maryjane Farr, Lauren K Truby

{"title":"Primary Graft Dysfunction after Heart Transplantation: Current Evidence and Implications for Clinical Practice.","authors":"Elena I Gavrila, Jonathan S Dowell, Ananya Gorrai, Christopher Wrobel, Nicholas Hendren, E Ashley Hardin, Yasbanoo Moayedi, Natalie Tapaskar, Matthias Peltz, Maryjane Farr, Lauren K Truby","doi":"10.1007/s11886-024-02153-z","DOIUrl":"https://doi.org/10.1007/s11886-024-02153-z","url":null,"abstract":"Purpose of review: This review summarizes the current literature on primary graft dysfunction highlighting the current definition, reviewing epidemiology, and describing donor, recipient, and perioperative risk factors in the contemporary era.Recent findings: PGD, in its most severe form, complicates 8% of heart transplants and portends a 1-year mortality of close to 40%. PGD is multifactorial and heterogeneous with contributions from donor and recipient risk as well as organ recovery and preservation modalities. Biomarkers may enhance risk stratification and lend insight into the underlying mechanism of PGD. Temperature-controlled storage and hypothermic oxygenation perfusion systems, in particular, may have significant potential to mitigate PGD risk. PGD is a devastating early complication of heart transplantation that is both complex and multifactorial. Despite its incidence and impact the underlying biology of PGD remains poorly understood. Future studies mechanistic studies are needed to address the underlying pathophysiology of PGD to develop targeted prophylactic and/or therapeutic interventions.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"24"},"PeriodicalIF":3.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Modality Imaging in Cardio-Rheumatology. 心脏风湿病的多模态成像。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-14 DOI: 10.1007/s11886-024-02160-0

Vasiliki Vartela, Alessia Pepe, Ioannis Fragos, Sophie I Mavrogeni

{"title":"Multi-Modality Imaging in Cardio-Rheumatology.","authors":"Vasiliki Vartela, Alessia Pepe, Ioannis Fragos, Sophie I Mavrogeni","doi":"10.1007/s11886-024-02160-0","DOIUrl":"https://doi.org/10.1007/s11886-024-02160-0","url":null,"abstract":"Purpose of review: Our purpose was to discuss the advantages and disadvantages of various noninvasive imaging modalities in the evaluation of cardiovascular disease (CVD) in patients with autoimmune rheumatic diseases (ARDs). The detailed knowledge of imaging modalities will facilitate the diagnosis and follow up of CVD in ARDs.Recent findings: Autoimmune Rheumatic Diseases (ARDs) are characterized by alterations in immunoregulatory system of the body. Although there is great progress in anti-rheumatic treatment, ARD patients are still at a higher risk for reduced life expectancy, compared with the general population, which is mainly due to the high incidence of CVD. Cardiovascular imaging holds the promise of early, noninvasive diagnosis and follow up of these patients. Echocardiography (echo), a cost effective, widely available imaging modality, can provide valuable early information about CVD in ARDs and motivate the use of more sophisticated investigations, if needed. Single Photon Emission tomography (SPECT) gives information about myocardial perfusion, while positron emission tomography (PET) gives information about both myocardial perfusion and inflammation with better spatial resolution and less radiation but at a higher financial cost, compared to SPECT. Computed Tomography Coronary Angiography (CTCA) is a reliable tool to rule out the presence of coronary artery disease, which has high incidence in ARD population. Lastly, Cardiovascular Magnetic Resonance (CMR) can perform function and tissue characterization evaluation in the same scan without using radiation and represents the ideal tool for serial evaluation of ARD patients. Lastly, molecular imaging holds the promise for individualized treatment in various ARDs. Cardiovascular imaging is the modern \"stethoscope\" of the clinicians and therefore they should be familiar with pro and contra of these modalities in order to achieve the best diagnostic and therapeutic target in ARD patients.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"21"},"PeriodicalIF":3.1,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promotion of Cardiometabolic Health: A Personal Journey. 促进心脏代谢健康：个人旅程。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-14 DOI: 10.1007/s11886-024-02165-9

Jean-Pierre Després

引用次数: 0

Metabolic Dysfunction Associated-Steatotic Liver Disease (MASLD) and Cardiovascular Risk: Embrace All Facets of the Disease. 代谢功能障碍相关的脂肪变性肝病（MASLD）和心血管风险：包括疾病的所有方面。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-13 DOI: 10.1007/s11886-024-02181-9

Niki Katsiki, Genovefa Kolovou, Michal Vrablik

引用次数: 0

Role of Trained Immunity in Heath and Disease. 训练免疫在健康和疾病中的作用。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-13 DOI: 10.1007/s11886-024-02167-7

Shibali Das, Kory J Lavine

{"title":"Role of Trained Immunity in Heath and Disease.","authors":"Shibali Das, Kory J Lavine","doi":"10.1007/s11886-024-02167-7","DOIUrl":"https://doi.org/10.1007/s11886-024-02167-7","url":null,"abstract":"Purpose of review: This review aims to explore the role of immune memory and trained immunity, focusing on how innate immune cells like monocytes, macrophages, and natural killer cells undergo long-term epigenetic and metabolic rewiring. Specifically, it examines the mechanisms by which trained immunity, often triggered by infection or vaccination, could impact cardiac processes and contribute to both protective and pathological responses within the cardiovascular system.Recent findings: Recent research demonstrates that vaccination and infection not only activate immune responses in circulating monocytes and tissue macrophages but also affect immune progenitor cells within the bone marrow environment, conferring lasting protection against heterologous infections. These protective effects are attributed to epigenetic and metabolic reprogramming, which enable a heightened immune response upon subsequent encounters with pathogens. However, while trained immunity is beneficial in combating infections, it has been linked to exacerbated inflammation, which may increase susceptibility to cardiovascular diseases, including atherosclerosis and heart failure. Our review highlights the dual nature of trained immunity: while it offers protective advantages against infections, it also poses potential risks for cardiovascular health by promoting chronic inflammation. Understanding the molecular mechanisms underlying immune memory's impact on cardiac processes could lead to new therapeutic strategies to mitigate cardiovascular diseases, such as atherosclerosis, heart failure, and diabetes. These insights build the grounds for future research to balance the benefits of trained immunity with its potential risks in cardiovascular disease management.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"18"},"PeriodicalIF":3.1,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Old and New Biomarkers in Idiopathic Recurrent Acute Pericarditis (IRAP): Prognosis and Outcomes. 特发性复发性急性心包炎（IRAP）的新旧生物标志物：预后和结局。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-11 DOI: 10.1007/s11886-024-02170-y

Ruggiero Mascolo, Emanuele Bizzi, Martina Martelli, Chiara Facoetti, Giulia Colazzo, Fabio Barone, Antonio Brucato

{"title":"Old and New Biomarkers in Idiopathic Recurrent Acute Pericarditis (IRAP): Prognosis and Outcomes.","authors":"Ruggiero Mascolo, Emanuele Bizzi, Martina Martelli, Chiara Facoetti, Giulia Colazzo, Fabio Barone, Antonio Brucato","doi":"10.1007/s11886-024-02170-y","DOIUrl":"10.1007/s11886-024-02170-y","url":null,"abstract":"Purpose of review: To outline the latest discoveries regarding the utility and reliability of serum biomarkers in idiopathic recurrent acute pericarditis (IRAP), considering recent findings on its pathogenesis. The study highlights the predictive role of these biomarkers in potential short- (cardiac tamponade, recurrences) and long-term complications (constrictive pericarditis, death).Recent findings: The pathogenesis of pericarditis has been better defined in recent years, focusing on the autoinflammatory pathway. New studies have demonstrated the pivotal role of the classical inflammatory biomarkers in distinguishing pericarditis phenotypes (high-grade vs. low-grade inflammation) and in defining outcomes of this condition. Pericarditis involves intense inflammatory activity, which causes elevation of different markers, such as C-reactive protein, erythrocyte sedimentation rate, neutrophils and platelets, serum amyloid A and D-Dimer. Conversely, lymphocytes are often reduced, as well as hemoglobin during the acute phase. Cardiac troponins T and I are elevated in up to 30% of cases. A Biomarker for CRP-negative cases is needed. Other markers have been proposed for diagnosis and prognosis in IRAP, such as anti-heart antibodies and anti-intercalated disk antibodies, but we need further studies to validate them.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"17"},"PeriodicalIF":3.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142963293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atrial Functional Mitral Regurgitation: Definition, Mechanisms, and Treatment Perspectives. 心房功能性二尖瓣返流：定义、机制和治疗前景。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-11 DOI: 10.1007/s11886-024-02188-2

Sebastiaan Dhont, Sébastien Deferm, Philippe B Bertrand, Pieter M Vandervoort

{"title":"Atrial Functional Mitral Regurgitation: Definition, Mechanisms, and Treatment Perspectives.","authors":"Sebastiaan Dhont, Sébastien Deferm, Philippe B Bertrand, Pieter M Vandervoort","doi":"10.1007/s11886-024-02188-2","DOIUrl":"10.1007/s11886-024-02188-2","url":null,"abstract":"Purpose of review: This review aims to explore the complex interplay between atrial functional mitral regurgitation (AFMR), atrial fibrillation (AF), and heart failure with preserved ejection fraction (HFpEF). The goal is to define these conditions, examine their underlying mechanisms, and discuss treatment perspectives, particularly addressing diagnostic challenges.Recent findings: Recent research highlights the rising prevalence of AFMR, now accounting for nearly one-third of significant mitral regurgitation cases. Advances in percutaneous treatment options have improved management for vulnerable HFpEF patients, but long-term outcomes remain unclear, and symptom relief is inconsistent. AF and HFpEF share the left atrium as a common pathological substrate, with progressive LA remodeling contributing to AFMR. Diagnostic limitations hinder effective symptom management with current mitral valve interventions. Future research should focus on better diagnostic tools to determine the contributions of valvular disease, arrhythmia, or myocardial dysfunction to clinical outcomes, as we currently lack definitive tests to establish this connection.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"16"},"PeriodicalIF":3.1,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac Regeneration in Adult Zebrafish: A Review of Signaling and Metabolic Coordination. 成年斑马鱼的心脏再生：信号和代谢协调的综述。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-10 DOI: 10.1007/s11886-024-02162-y

Arkadeep Mitra, Subhadeep Mandal, Kalyan Banerjee, Nilanjan Ganguly, Pramit Sasmal, Durba Banerjee, Shreyasi Gupta

{"title":"Cardiac Regeneration in Adult Zebrafish: A Review of Signaling and Metabolic Coordination.","authors":"Arkadeep Mitra, Subhadeep Mandal, Kalyan Banerjee, Nilanjan Ganguly, Pramit Sasmal, Durba Banerjee, Shreyasi Gupta","doi":"10.1007/s11886-024-02162-y","DOIUrl":"10.1007/s11886-024-02162-y","url":null,"abstract":"Purpose of review: This review investigates how post-injury cellular signaling and energy metabolism are two pivotal points in zebrafish's cardiomyocyte cell cycle re-entry and proliferation. It seeks to highlight the probable mechanism of action in proliferative cardiomyocytes compared to mammals and identify gaps in the current understanding of metabolic regulation of cardiac regeneration.Recent findings: Metabolic substrate changes after birth correlate with reduced cardiomyocyte proliferation in mammals. Unlike adult mammalian hearts, zebrafish can regenerate cardiomyocytes by re-entering the cell cycle, characterized by a metabolic switch from oxidative metabolism to increased glycolysis. Zebrafish provide a valuable model for studying metabolic regulation during cell cycle re-entry and cardiac regeneration. Proliferative cardiomyocytes have upregulated Notch, hippo, and Wnt signaling and decreased ROS generation, DNA damage in different zebrafish cardiac regeneration models. Understanding the correlation between metabolic switches during cell cycle re-entry of already differentiated zebrafish cardiomyocytes is being increasingly recognized as a critical factor in heart regeneration. Zebrafish studies provide insights into metabolic adaptations during heart regeneration, emphasizing the importance of a metabolic switch. However, there are mechanistic gaps, and extensive studies are required to aid in formulating therapeutic strategies for cardiac regenerative medicine.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"15"},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tailored Approach to Temporary Mechanical Circulatory Support for Cardiogenic Shock: Strategies to Facilitate Patient Mobilization. 心源性休克临时机械循环支持的量身定制方法：促进患者活动的策略。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-10 DOI: 10.1007/s11886-024-02152-0

Jean-Luc A Maigrot, Brett J Wakefield, Chase M Donaldson, Aaron J Weiss

{"title":"Tailored Approach to Temporary Mechanical Circulatory Support for Cardiogenic Shock: Strategies to Facilitate Patient Mobilization.","authors":"Jean-Luc A Maigrot, Brett J Wakefield, Chase M Donaldson, Aaron J Weiss","doi":"10.1007/s11886-024-02152-0","DOIUrl":"10.1007/s11886-024-02152-0","url":null,"abstract":"Purpose of review: This article discusses a tailored approach to managing cardiogenic shock and temporary mechanical circulatory support (tMCS). We also outline specific mobilization strategies for patients with different tMCS devices and configurations, which can be enabled by this tailored approach to cardiogenic shock management.Recent findings: Safe and effective mobilization of patients with cardiogenic shock receiving tMCS can be accomplished. Appropriate patient selection, tailored device management, and dynamic multidisciplinary approaches to mobilization are critical to success. Cardiogenic shock is a heterogeneous condition characterized by end-organ dysfunction due to hypoperfusion and low cardiac output. Temporary mechanical circulatory support (tMCS) is an increasingly valuable tool in managing these patients, with various devices and configurations available. Critically ill patients receiving tMCS are at risk for complications and deconditioning associated with prolonged bed rest, making it essential to implement strategies that promote mobility when feasible. We advocate for a tailored approach to the selection and management of tMCS in patients with cardiogenic shock. This approach focuses on the early identification of patients who may benefit from tMCS before further deterioration, alongside the selection of devices that provide ventricular-specific support and facilitate upper-body cannulation to enhance mobilization while also considering patients' potential exit strategies from tMCS. Understanding this approach is vital to appropriately facilitating safe and effective mobilization.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"14"},"PeriodicalIF":3.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hot Phases Cardiomyopathy: Pathophysiology, Diagnostic Challenges, and Emerging Therapies. 热期心肌病：病理生理学、诊断挑战和新兴疗法。

IF 3.1 3区医学

Current Cardiology Reports Pub Date : 2025-01-09 DOI: 10.1007/s11886-024-02168-6

Giulia Bassetto, Federico Angriman, Carola Pio Loco Detto Gava, Alessia Paldino, Maria Perotto, Luca Bordignon, Marta Gigli, Matteo Dal Ferro, Laura Massa, Alessandro Altinier, Antonio De Luca, Gianfranco Sinagra, Marco Merlo

{"title":"Hot Phases Cardiomyopathy: Pathophysiology, Diagnostic Challenges, and Emerging Therapies.","authors":"Giulia Bassetto, Federico Angriman, Carola Pio Loco Detto Gava, Alessia Paldino, Maria Perotto, Luca Bordignon, Marta Gigli, Matteo Dal Ferro, Laura Massa, Alessandro Altinier, Antonio De Luca, Gianfranco Sinagra, Marco Merlo","doi":"10.1007/s11886-024-02168-6","DOIUrl":"10.1007/s11886-024-02168-6","url":null,"abstract":"Purpose of review: Hot phases are a challenging clinical presentation in arrhythmogenic cardiomyopathy (ACM), marked by acute chest pain and elevated cardiac troponins in the absence of obstructive coronary disease. These episodes manifest as myocarditis and primarily affect young patients, contributing to a heightened risk of life-threatening arrhythmias and potential disease progression. This review aims to synthesize recent research on the pathophysiology, diagnostic challenges, and therapeutic management of hot phases in ACM.Recent findings: Hot phases have been linked to genetic mutations, particularly in desmosomal proteins such as Desmoplakin (DSP). Diagnostic challenges include differentiating hot phases from isolated acute myocarditis, through identification of red flags and a multimodal approach, including CMR, FDG-PET, endomyocardial biopsy and genetic testing. Emerging therapies, such as immunosuppressive and anti-inflammatory treatments, show promise in managing hot-phase episodes. Hot phases in ACM present a significant risk for arrhythmias and disease progression, necessitating a comprehensive diagnostic and therapeutic management. A multimodal diagnostic approach is essential for accurate diagnosis, but further research is needed to refine these strategies and improve prognosis for affected patients.","PeriodicalId":10829,"journal":{"name":"Current Cardiology Reports","volume":"27 1","pages":"11"},"PeriodicalIF":3.1,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0