免疫检查点抑制剂心肌炎的诊断和治疗进展。

IF 3.1 3区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Anthony M Hachem, Aditya Desai, Noah Beinart, Keila C Ostos-Mendoza, Ana Sofia Lopez Rodriguez, Regina Diaz de Leon Derby, Sara Ebrahimi, Nicolas L Palaskas
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引用次数: 0

摘要

综述的目的:提供有关免疫检查点抑制剂心肌炎诊断和治疗的最新文献。最近的研究结果:免疫检查点抑制剂心肌炎的诊断已经发展到包括更多地依赖于进行心内膜活检来澄清在选定病例中的诊断。此外,在临床和心内膜肌活检上都有疾病谱的识别,表明其严重程度从轻度到暴发性不等。免疫检查点抑制剂心肌炎的治疗正在转向增加使用额外的免疫抑制药物作为类固醇保留剂。有越来越多的研究,包括两项随机对照试验评估阿巴接受治疗免疫检查点抑制剂心肌炎。本文综述了免疫检查点抑制剂心肌炎的诊断和治疗方面的最新文献,并提供了我们治疗这种罕见但可能致命的疾病的经验和方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Updates in Diagnosis and Treatment of Immune Checkpoint Inhibitor Myocarditis.

Purpose of review: To provide an update on the literature regarding diagnosis and management of immune checkpoint inhibitor myocarditis.

Recent findings: The diagnosis of immune checkpoint inhibitor myocarditis has evolved to include more reliance on performing endomyocardial biopsy to clarify the diagnosis in selected cases. Additionally, there is recognition of a spectrum of disease both clinically and on endomyocardial biopsy suggesting that there is a range of severity from mild to fulminant. The treatment of immune checkpoint inhibitor myocarditis is shifting towards increased use of additional immunosuppressive medications as steroid sparing agents. There are increased studies including two randomized controlled trials evaluating abatacept in the treatment of immune checkpoint inhibitor myocarditis. This review summarizes the latest literature regarding diagnosis and management of immune checkpoint inhibitor myocarditis and provides our experience and approach to this rare but potentially fatal condition.

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来源期刊
Current Cardiology Reports
Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
6.20
自引率
2.70%
发文量
209
期刊介绍: The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.
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