Current Medical Science最新文献

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Mixed Infections in the Female Lower Genital Tract: Unlocking the Current Landscape and Future Directions. 女性下生殖道混合性感染:解锁当前景观和未来方向。
IF 2 4区 医学
Current Medical Science Pub Date : 2025-05-06 DOI: 10.1007/s11596-025-00058-8
Wen-Hua Jiang, Xin-Wei Zhao, Xi-Ming Jin, Wen-Jia Wang, Zhuo Chen
{"title":"Mixed Infections in the Female Lower Genital Tract: Unlocking the Current Landscape and Future Directions.","authors":"Wen-Hua Jiang, Xin-Wei Zhao, Xi-Ming Jin, Wen-Jia Wang, Zhuo Chen","doi":"10.1007/s11596-025-00058-8","DOIUrl":"https://doi.org/10.1007/s11596-025-00058-8","url":null,"abstract":"<p><p>Understanding mixed infections in the female lower genital tract is a critical challenge in modern infection research. The interplay of multiple pathogens complicates disease progression, often resulting in treatment failure, recurrent infections, and significant public health and economic burdens. These infections are further exacerbated by disrupted host immune responses, which hinder the recovery of the vaginal microecosystem. Additionally, microbial biofilms-a fundamental mode of pathogen coexistence-contribute to the persistence and drug resistance of these infections, complicating management strategies. This review examines the pathogenesis, diagnosis, and treatment of mixed infections in the female lower genital tract while exploring potential avenues for future research. These findings emphasize the need for greater focus on these infections and offer insights to enhance further research in this area.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting miR-144-5p/ACSM1 Axis Alleviates Doxorubicin-Induced Heart Failure by Inhibiting Lipid Peroxidation. 靶向miR-144-5p/ACSM1轴通过抑制脂质过氧化减轻阿霉素诱导的心力衰竭
IF 2 4区 医学
Current Medical Science Pub Date : 2025-05-05 DOI: 10.1007/s11596-025-00053-z
Guo-Ying Kao, Yi Xu, Ying Zhang, Gang Xu
{"title":"Targeting miR-144-5p/ACSM1 Axis Alleviates Doxorubicin-Induced Heart Failure by Inhibiting Lipid Peroxidation.","authors":"Guo-Ying Kao, Yi Xu, Ying Zhang, Gang Xu","doi":"10.1007/s11596-025-00053-z","DOIUrl":"https://doi.org/10.1007/s11596-025-00053-z","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the role of miR-144-5p in doxorubicin (DOX)-induced heart failure and explores its potential mechanisms by targeting ACSM1 and inhibiting lipid peroxidation.</p><p><strong>Methods: </strong>Bioinformatics analysis was performed using the gene expression omnibus dataset GSE136547 to identify differentially expressed miRNAs in heart failure. DOX-induced in vitro and in vivo heart failure models were used to study the effects of miR-144-5p on cardiomyocyte viability, apoptosis, and lipid peroxidation. The targeting relationship between miR-144-5p and ACSM1 was verified using dual-luciferase reporter assays. Cardiac function was assessed by echocardiography, and biochemical markers of heart failure were measured using ELISA. The GO and KEGG enrichment analyses of ACSM1 were performed via the bioinformatic tools GeneMANIA and STRING.</p><p><strong>Results: </strong>miR-144-5p was significantly upregulated in DOX-treated cardiomyocytes and mouse hearts. Inhibition of miR-144-5p attenuated DOX-induced cardiomyocyte apoptosis, lipid peroxidation, and cardiac dysfunction. ACSM1 was identified as a direct target of miR-144-5p, and its expression was downregulated by DOX. Silencing ACSM1 abolished the protective effects of the miR-144-5p inhibitor on the viability, apoptosis, and lipid peroxidation of cardiomyocytes. Furthermore, miR-144-5p inhibition improved cardiac function in DOX-treated mice, as evidenced by reduced left ventricular dysfunction and decreased levels of heart failure markers (BNP, LDH, Ang II, and ALD).</p><p><strong>Conclusions: </strong>Our findings demonstrate that inhibiting miR-144-5p alleviates DOX-induced heart failure by targeting ACSM1 and suppressing lipid peroxidation. The miR-144-5p/ACSM1 axis may represent a novel therapeutic target for heart failure. Future studies should focus on further elucidating the mechanisms underlying this axis and exploring its potential clinical applications.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarker-Based Models Utilizing the Albumin-Fibrinogen Ratio Effectively Predict Peritoneal Metastasis in Patients with Gastric Cancer: A Retrospective Study. 基于生物标志物的模型利用白蛋白-纤维蛋白原比率有效预测胃癌患者腹膜转移:一项回顾性研究。
IF 2 4区 医学
Current Medical Science Pub Date : 2025-04-30 DOI: 10.1007/s11596-025-00052-0
Chun-Yang Shang, Xue-Pu Sun, Xue-Song Dong, Yang-Shuai Wang, Xiao Chen, Hai-Quan Qiao
{"title":"Biomarker-Based Models Utilizing the Albumin-Fibrinogen Ratio Effectively Predict Peritoneal Metastasis in Patients with Gastric Cancer: A Retrospective Study.","authors":"Chun-Yang Shang, Xue-Pu Sun, Xue-Song Dong, Yang-Shuai Wang, Xiao Chen, Hai-Quan Qiao","doi":"10.1007/s11596-025-00052-0","DOIUrl":"https://doi.org/10.1007/s11596-025-00052-0","url":null,"abstract":"<p><strong>Objective: </strong>Peritoneal carcinomatosis (PC) is a common pattern of recurrence in gastric cancer patients and is associated with a poor prognosis. This study aimed to evaluate the predictive value of the albumin-fibrinogen ratio (AFR) for PC in patients with gastric cancer and to develop two preoperative prediction models.</p><p><strong>Methods: </strong>A total of 745 gastric cancer patients were included in this study. Preoperative AFR, along with other serum markers and clinical tumor characteristics, was assessed. Univariate and multivariate logistic regression analyses were performed to determine the odds ratios (ORs) and 95% confidence intervals (CIs) of the independent variables. Propensity score matching (PSM) was used to control for potential confounders, and one-way ANOVA was conducted to evaluate differences in distribution between groups. Two prediction models incorporating the independent predictive indicators were constructed and validated via receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Poorly differentiated type (OR 2.679; P = 0.001), nondiffuse morphological type (OR 2.123; P = 0.040), BMI < 23.550 kg/m<sup>2</sup> (OR 4.635; P = 0.001), AFR < 11.275 (OR 2.895; P = 0.003) and CA199 ≥ 73.615 U/mL (OR 2.040; P = 0.037) were identified as independent risk factors for PC in patients with gastric cancer. After PSM, the AFR remained the only inflammatory marker that was independently associated with PC (P = 0.003). AFR demonstrated consistent robustness in predicting PC across multiple sample sets. Among all the independent risk factors, the AFR had the highest area under the curve (AUC) for ROC analysis (AUC 0.648; 95% CI 0.580-0.715). Two combination models incorporating the AFR demonstrated enhanced predictive ability: Combination Model 1 (AUC 0.759; 95% CI 0.699-0.820) and Combination Model 2 (AUC 0.801; 95% CI 0.744-0.859).</p><p><strong>Conclusions: </strong>The preoperative AFR serves as a useful indicator for predicting PC. Two reliable prediction models based on the AFR have been developed.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unraveling the Molecular Underpinnings: The Therapeutic Impact of Aerobic Exercise on Anxiety Disorders. 揭开分子基础:有氧运动对焦虑症的治疗作用。
IF 2 4区 医学
Current Medical Science Pub Date : 2025-04-28 DOI: 10.1007/s11596-025-00048-w
Yi-Qing Rao, Zi-Yu Zhou, Zi-Qi Yang, Meng-Xin Liu, Xiao-Yu Gan, Xue-Fei Hu, Hong-Yang Wang, Hao Li, Man Li
{"title":"Unraveling the Molecular Underpinnings: The Therapeutic Impact of Aerobic Exercise on Anxiety Disorders.","authors":"Yi-Qing Rao, Zi-Yu Zhou, Zi-Qi Yang, Meng-Xin Liu, Xiao-Yu Gan, Xue-Fei Hu, Hong-Yang Wang, Hao Li, Man Li","doi":"10.1007/s11596-025-00048-w","DOIUrl":"https://doi.org/10.1007/s11596-025-00048-w","url":null,"abstract":"<p><p>Anxiety disorders, characterized by persistent apprehension, somatic symptoms and fatigue, are leading causes of disability worldwide. The burgeoning therapeutic potential of aerobic exercise has gained prominence as a leading non-pharmacological strategy, with evidence supporting its effectiveness in alleviating anxiety across diverse conditions. This review synthesizes current research to clarify the molecular mechanisms through which aerobic exercise ameliorates anxiety in terms of the effects of exercise on the hypothalamic-pituitary-adrenal (HPA) axis, the hepatic-brain axis and epigenetics; electroencephalographic alterations; inflammatory pathways; the balance between oxidative and nitrogenous stress; various substances, such as brain-derived neurotrophic factor (BDNF), atrial natriuretic peptide (ANP), and opioid peptides; and the 5-HT2C receptor and cannabinoid receptor type-1 (CB1R), among others, reflecting the positive modulatory effects of aerobic exercise on anxiety. As a non-pharmacological intervention, aerobic exercise has been demonstrated to be useful in a variety of medical applications and has considerable potential for ameliorating symptoms of anxiety.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Decreased Fecal Microbiota Akkermansia with Increased High-Sensitivity C-Reactive Protein Levels in Patients with Unstable Angina. 不稳定心绞痛患者粪便微生物群Akkermansia减少与高敏c反应蛋白水平升高的关系
IF 2 4区 医学
Current Medical Science Pub Date : 2025-04-24 DOI: 10.1007/s11596-025-00050-2
Yuan-Fan Yuan, Ji-Yu Zhang, Jia-Hao Xu, Xin-Yi Xia, Miao Yu, Ling-Feng Zha, De-Sheng Hu, Wei-Min Wang, Chao-Long Wang, Qing Wang, Chen Chen, Zhi-Lei Shan, Fen Yang, Xiang Cheng
{"title":"Association of Decreased Fecal Microbiota Akkermansia with Increased High-Sensitivity C-Reactive Protein Levels in Patients with Unstable Angina.","authors":"Yuan-Fan Yuan, Ji-Yu Zhang, Jia-Hao Xu, Xin-Yi Xia, Miao Yu, Ling-Feng Zha, De-Sheng Hu, Wei-Min Wang, Chao-Long Wang, Qing Wang, Chen Chen, Zhi-Lei Shan, Fen Yang, Xiang Cheng","doi":"10.1007/s11596-025-00050-2","DOIUrl":"https://doi.org/10.1007/s11596-025-00050-2","url":null,"abstract":"<p><strong>Background and objective: </strong>Inflammation plays a pivotal role in the progression of coronary artery disease (CAD). High-sensitivity C-reactive protein (hsCRP) serves as a well-established biomarker for assessing cardiovascular inflammation risk. However, the specific intestinal microbiota alteration contributing to increased inflammation remains unclear. Therefore, the present study investigated the correlation between the intestinal microbiota and inflammation in patients with unstable angina (UA).</p><p><strong>Methods: </strong>A cohort of 92 patients with UA was recruited for this study. The plasma hsCRP level was measured via a CardioPhase hsCRP assay, fecal samples were collected after admission, and 16S rRNA sequencing was conducted to identify the fecal microbial profile. The participants were classified into two groups according to the median hsCRP level (1.11 mg/L). The composition of the fecal microbiota was compared between patients with hsCRP ≥ 1.11 mg/L and those with hsCRP < 1.11 mg/L. Additionally, the correlations between the fecal microbiota and clinical characteristics were analyzed.</p><p><strong>Results: </strong>A notable reduction in the relative abundance of Akkermansia was observed in patients with hsCRP ≥ 1.11 mg/L, whereas the diversity of the fecal microbiota was not significantly different between patients with hsCRP ≥ 1.11 mg/L and those with hsCRP < 1.11 mg/L. Furthermore, the abundance of Akkermansia was negatively correlated with hsCRP levels.</p><p><strong>Conclusion: </strong>This study suggested a significant association between decreased levels of Akkermansia and inflammatory risk in patients with UA. These findings underscore the potential role of the intestinal microbiota in contributing to inflammation in UA patients. Further work is needed on the mechanism by which the microbiota contributes to inflammatory risk.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Calprotectin S100A8/A9 to Overcome AML Progression in DNMT3A-Mutant Cells. 靶向钙保护蛋白S100A8/A9在dnmt3a突变细胞中克服AML进展
IF 2 4区 医学
Current Medical Science Pub Date : 2025-04-23 DOI: 10.1007/s11596-025-00042-2
Xiao-Ya Cai, Gui-Qin Huang, Ye-Ming Zhou, Deng-Ju Li
{"title":"Targeting Calprotectin S100A8/A9 to Overcome AML Progression in DNMT3A-Mutant Cells.","authors":"Xiao-Ya Cai, Gui-Qin Huang, Ye-Ming Zhou, Deng-Ju Li","doi":"10.1007/s11596-025-00042-2","DOIUrl":"https://doi.org/10.1007/s11596-025-00042-2","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of calprotectin (S100A8/A9) on the biological activity of acute myeloid leukemia (AML) cells harboring a DNA methyltransferase 3A (DNMT3A) mutation and to explore the underlying molecular mechanisms involved.</p><p><strong>Methods: </strong>AML monoclonal cell lines harboring the DNMT3A<sup>R882H</sup> mutation were generated via lentiviral transduction and limiting dilution. RNA sequencing was used for differential gene expression analysis, followed by bioinformatic pathway enrichment and gene correlation analyses. The biological effects of paquinimod, a selective S100A8/A9 inhibitor, on DNMT3A<sup>R882H</sup> AML cells were assessed via Cell Counting Kit (CCK-8) proliferation assays, Annexin V/PI staining, cell cycle analysis, cell adhesion assays, and transwell migration assays.</p><p><strong>Results: </strong>Differential gene expression analysis revealed 442 upregulated and 535 downregulated genes in DNMT3A-mutated (DNMT3A<sup>mut</sup>) cells compared with those in DNMT3A wild-type (DNMT3A<sup>wt</sup>) cells, with the S100A8/A9 complex recurrently enriched in Reactome pathway analysis. Compared with healthy controls, patients with AML presented increased expression of S100A8 and S100A9 and increased expression of DNMT3A<sup>mut</sup> cells relative to DNMT3A<sup>wt</sup> cells, which was correlated with poor prognosis in patients with AML. There were no notable differences in proliferation among the DNMT3A<sup>mut</sup>, DNMT3A<sup>wt</sup>, and empty vector cells under normal or starvation conditions. However, paquinimod treatment notably inhibited the proliferation, migration, and adhesion of DNMT3A<sup>mut</sup> AML cells in a dose-dependent manner, causing G0/G1 cell cycle arrest, whereas no significant effects on apoptosis were observed. Paquinimod also downregulated key adhesion molecules, including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), and matrix metalloproteinase-2 (MMP-2). Additionally, S100A8 and S100A9 expression was upregulated in a dose-dependent manner in response to cytarabine treatment.</p><p><strong>Conclusion: </strong>Elevated S100A8/A9 expression contributes to the abnormal proliferation, migration, adhesion, and chemoresistance of DNMT3A<sup>mut</sup> AML cells. Targeting S100A8/A9 alone or in combination with other treatments represents a promising therapeutic strategy for DNMT3A<sup>mut</sup> AML.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Lymph Node Metastasis in Stage pT1 Invasive Lung Adenocarcinoma. pT1期浸润性肺腺癌淋巴结转移的危险因素分析。
IF 2 4区 医学
Current Medical Science Pub Date : 2025-04-17 DOI: 10.1007/s11596-025-00016-4
Shou-Kang Li, Nai-Cheng Song, Quan Liu, Zhi-Kun Zheng, Jin-Song Li
{"title":"Risk Factors for Lymph Node Metastasis in Stage pT1 Invasive Lung Adenocarcinoma.","authors":"Shou-Kang Li, Nai-Cheng Song, Quan Liu, Zhi-Kun Zheng, Jin-Song Li","doi":"10.1007/s11596-025-00016-4","DOIUrl":"https://doi.org/10.1007/s11596-025-00016-4","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the risk factors for lymph node metastasis (LNM) in patients with stage pT1 lung adenocarcinoma to select a more appropriate surgical option.</p><p><strong>Methods: </strong>In this retrospective study, 294 patients with postoperative pathologically confirmed stage pT1 invasive lung adenocarcinoma were collected and divided into two groups according to whether they had mediastinal or hilar LNM. Patient tumor imaging, pathological features and gene mutations were analyzed, and risk factors that might predict LNM were derived via univariate and multivariate logistic analyses. LNM-related variables were screened by Boruta and least absolute shrinkage and selection operator regression analysis.</p><p><strong>Results: </strong>Among the 294 patients, 45 (15.3%) had positive mediastinal or hilar lymph nodes. There were no significant differences between the two groups in terms of sex, age, or underlying disease. The difference in the percentage of solidity between the two groups was significant, with the higer percentage group showing a more significant difference. The results of multivariate logistic analysis revealed that a high percentage of solid components and wild-type epidermal growth factor receptor (EGFR) were risk factors for LNM. The nomogram for predicting LNM included the consolidation tumor ratio, tumor size, micropapillary and EGFR, with an area under the curve of 93.4% (95% CI: 88.7-99.1) in the derivation cohort and 92.3% (95% CI: 84.6-99.9) in the validation cohort.</p><p><strong>Conclusions: </strong>A high proportion of solid components and wild-type EGFR were risk factors for pT1 stage lung adenocarcinoma, suggesting that the choice of lung segmentectomy needs to be evaluated and selected more cautiously.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aberrant Sialylation in Ovarian Cancer: Orchestrating Progression, Metastasis, and Therapeutic Hurdles. 异常唾液酰化在卵巢癌:协调进展,转移和治疗障碍。
IF 2 4区 医学
Current Medical Science Pub Date : 2025-04-17 DOI: 10.1007/s11596-025-00041-3
Yu-Xin Chen, Guang-Nian Zhao, Qing-Lei Gao
{"title":"Aberrant Sialylation in Ovarian Cancer: Orchestrating Progression, Metastasis, and Therapeutic Hurdles.","authors":"Yu-Xin Chen, Guang-Nian Zhao, Qing-Lei Gao","doi":"10.1007/s11596-025-00041-3","DOIUrl":"https://doi.org/10.1007/s11596-025-00041-3","url":null,"abstract":"<p><p>Ovarian cancer (OC), a highly lethal gynaecological malignancy, is often diagnosed at advanced stages, resulting in a poor prognosis. Sialylation, an important form of glycosylation, significantly contributes to the progression of various solid tumours, including OC. Aberrant sialylation promotes tumour progression and metastasis by altering the structure and function of glycoproteins. Although its role in several solid tumours is well documented, the role of abnormal sialylation in OC and its potential as a therapeutic target remain poorly understood. This review highlights sialylation as a key regulator of the progression, metastasis, and drug resistance of OC. A deeper understanding of altered sialylation can contribute to the identification of novel therapeutic strategies for OC.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prognostic Value of the Systemic Immune-Inflammation Index in Glioblastoma Patients and the Establishment of a Nomogram. 胶质母细胞瘤患者全身免疫炎症指数的预后价值及影像学的建立。
IF 2 4区 医学
Current Medical Science Pub Date : 2025-04-16 DOI: 10.1007/s11596-025-00047-x
Hao Xu, Li-Hao Jiang, Sheng-Nan Yu, Qing-Lan Ren
{"title":"The Prognostic Value of the Systemic Immune-Inflammation Index in Glioblastoma Patients and the Establishment of a Nomogram.","authors":"Hao Xu, Li-Hao Jiang, Sheng-Nan Yu, Qing-Lan Ren","doi":"10.1007/s11596-025-00047-x","DOIUrl":"https://doi.org/10.1007/s11596-025-00047-x","url":null,"abstract":"<p><strong>Objective: </strong>The systemic immune-inflammation index (SII) has recently attracted significant interest as a new biomarker for predicting the prognosis of patients with glioblastoma (GBM). However, the predictive significance of it is still a subject of debate. This study intended to assess the clinical effectiveness of the SII in GBM and establish a nomogram.</p><p><strong>Methods: </strong>Receiver operating characteristic (ROC) curves were utilized to determine the optimal cut-off values of the SII. Kaplan-Meier (KM) survival curves were used to analyze the median overall survival (OS). Cox regression analysis was carried out to evaluate the associations between OS and different clinical factors. Based on the SII and clinical characteristics, a nomogram was constructed, and its value in clinical application was evaluated by means of decision curve analysis.</p><p><strong>Results: </strong>The optimal SII cut-off value was 610.13. KM analysis revealed that GBM patients with higher SII values had shorter OS (15.0 vs. 34.0 months, P = 0.044). Multivariate analysis demonstrated that a high SII was an independent predictor of poor outcome in GBM (HR = 1.79, P = 0.029). The nomogram incorporating the preoperative SII showed good predictive accuracy for GBM patient prognosis (C-index = 0.691).</p><p><strong>Conclusions: </strong>The SII is an independent predictive indicator for GBM. Patients with elevated SII levels tend to have a poorer prognosis. A nomogram combining the SII with clinical and molecular pathological features can assist clinicians in assessing the risk of death in GBM patients, providing a basis for individualized treatment decisions.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-6: Molecular Mechanisms and Therapeutic Perspectives in Atrial Fibrillation. 白细胞介素-6:心房颤动的分子机制和治疗前景。
IF 2 4区 医学
Current Medical Science Pub Date : 2025-04-01 Epub Date: 2025-03-04 DOI: 10.1007/s11596-025-00021-7
Jin-Fang Yu, Qian Dong, Yi-Mei Du
{"title":"Interleukin-6: Molecular Mechanisms and Therapeutic Perspectives in Atrial Fibrillation.","authors":"Jin-Fang Yu, Qian Dong, Yi-Mei Du","doi":"10.1007/s11596-025-00021-7","DOIUrl":"10.1007/s11596-025-00021-7","url":null,"abstract":"<p><p>Atrial fibrillation (AF) is a prevalent cardiac arrhythmia with a multifactorial pathophysiology involving electrical, structural, and autonomic remodeling of the atria. AF is closely associated with elevated interleukin-6 (IL-6) levels, which contribute to atrial remodeling and the progression of AF. This review summarizes the mechanisms by which IL-6 promotes AF through inflammatory pathways, atrial fibrosis, electrical remodeling, and calcium mishandling. Experimental models have demonstrated that IL-6 neutralization reduces the incidence of AF, highlighting its potential as a therapeutic target. Future studies should focus on IL-6 blockade strategies to manage AF, aiming to improve patient outcomes.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"157-168"},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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