Current Medical Science最新文献

Application of Optogenetic Neuromodulation in Regulating Depression.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-27 DOI: 10.1007/s11596-025-00037-z

Jin Zhang, Xiang Peng, Man Li, Xiao-Ming Zhang, Hong-Chun Xiang

{"title":"Application of Optogenetic Neuromodulation in Regulating Depression.","authors":"Jin Zhang, Xiang Peng, Man Li, Xiao-Ming Zhang, Hong-Chun Xiang","doi":"10.1007/s11596-025-00037-z","DOIUrl":"https://doi.org/10.1007/s11596-025-00037-z","url":null,"abstract":"Depression is a multifaceted disorder with a largely unresolved etiology influenced by a complex interplay of pathogenic factors. Despite decades of research, it remains a major condition that significantly diminishes patients' quality of life. Advances in optogenetics have introduced a powerful tool for exploring the neural mechanisms underlying depression. By selectively expressing optogenes in specific cell types in mice, researchers can study the roles of these cells through targeted light stimulation, offering new insights into central nervous system disorders. The use of viral vectors to express opsins in distinct neuronal subtypes enables precise activation or inhibition of these neurons via light. When combined with behavioral, morphological, and electrophysiological analyses, optogenetics provides an invaluable approach to investigating the neural mechanisms of psychiatric conditions. This review synthesizes current research on the application of optogenetics to understand the mechanisms of depression. This study aims to enhance our knowledge of optogenetic strategies for regulating depression and advancing antidepressant research.","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogen Detection in Spinal Infections: Next-Generation Sequencing Versus Conventional Microbiological Methods.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-26 DOI: 10.1007/s11596-025-00040-4

Khan Akhtar Ali, Ling-Xiao He, Fang Gao, Ze-An Xia, Hui Huang, Heng Zeng, Wei-Hua Hu

{"title":"Pathogen Detection in Spinal Infections: Next-Generation Sequencing Versus Conventional Microbiological Methods.","authors":"Khan Akhtar Ali, Ling-Xiao He, Fang Gao, Ze-An Xia, Hui Huang, Heng Zeng, Wei-Hua Hu","doi":"10.1007/s11596-025-00040-4","DOIUrl":"https://doi.org/10.1007/s11596-025-00040-4","url":null,"abstract":"Objective and background: Early and accurate diagnosis of spinal infections, including spinal tuberculosis, is pivotal for effective treatment but remains challenging. This study aims to assess the diagnostic yield of metagenomic next-generation sequencing (mNGS) compared with that of conventional microbiological tests (CMTs) in identifying pathogens associated with spinal pathologies, with a special focus on infections leading to surgical interventions.Methods: We enrolled 85 patients who underwent spinal surgery, comprising 63 patients with clinically diagnosed spinal infections, including patients with spinal tuberculosis, and 22 patients with noninfectious spinal conditions. The procedures involved irrigation and debridement for persistent wound drainage, with subsequent DNA extraction from plasma and joint fluid for mNGS and CMT analysis.Results: Significantly increased C-reactive protein (CRP) levels were observed in patients with infections. The mNGS approach showed greater diagnostic sensitivity (92.06%) for detecting pathogens, including Mycobacterium tuberculosis, than did CMTs (36.51%). Despite its low specificity, mNGS had considerable negative predictive value (70.59%), underscoring its utility in ruling out infections.Conclusions: The mNGS offers superior sensitivity over CMTs in the diagnosis of a variety of spinal infections, notably spinal tuberculosis. This study highlights the potential of mNGS in enhancing the diagnosis of complex spinal infections, thereby informing targeted treatment strategies.","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicities Associated with Sacituzumab Govitecan: Data from Clinical Trials and a Real-World Pharmacovigilance Database.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-25 DOI: 10.1007/s11596-025-00030-6

Qiao-Yun Tan, Xiang-Ping Mei, Yue Hu, Hong-Ge Wu, Lin-Ka Xie, Jie Xiong, Jing Yao

{"title":"Toxicities Associated with Sacituzumab Govitecan: Data from Clinical Trials and a Real-World Pharmacovigilance Database.","authors":"Qiao-Yun Tan, Xiang-Ping Mei, Yue Hu, Hong-Ge Wu, Lin-Ka Xie, Jie Xiong, Jing Yao","doi":"10.1007/s11596-025-00030-6","DOIUrl":"https://doi.org/10.1007/s11596-025-00030-6","url":null,"abstract":"Objective: This study aimed to analyze the adverse effects (AEs) of sacituzumab govitecan (SG) through multiple sources of data to provide a reference for clinical safety management.Methods: Clinical trials of SG with available safety data were retrieved and included in the pooled analysis. The adverse drug reaction (ADR) signals of SG were collected from the FDA Adverse Event Reporting System (FAERS) database. Drug interactions with SG in the DDInter database were summarized.Results: A total of 6 clinical trials involving 1737 patients were included in the pooled analysis, and the most common AEs of ≥ grade 3 were neutropenia (46%), leukopenia (13%), and anemia (8%). In the pharmacovigilance study, 1024 AE reports were extracted, and the most common toxicities of SG were hematologic and gastrointestinal. AEs not included in the drug instructions also presented high signals, such as meningitis, colitis and lymphedema. A total of 40 drugs identified could induce drug-drug interactions when they were concomitantly administered with SG.Conclusions: This study provides the most comprehensive profile of SG toxicity on the basis of data from clinical trials and the FRAES and DDInter databases. Attention should be given not only to common ADRs but also to ADRs not reported in drug instructions, and potential drugs that can induce drug-drug interactions.","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Naringin and Naringenin: Potential Multi-Target Agents for Alzheimer's Disease.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-19 DOI: 10.1007/s11596-025-00039-x

Jing Lu, Jie Chen, Shu-Yue Li, Guang-Jie Pan, Yi Ou, Li-Fu Yuan, Jian-Ping Jiang, Ling-Hui Zeng, Jie Zhao

引用次数: 0

Construction of a Multimodal 3D Atlas for a Micrometer-Scale Brain-Computer Interface Based on Mixed Reality.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-18 DOI: 10.1007/s11596-025-00033-3

Hong Zhou, Zi-Neng Yan, Wei-Hang Gao, Xiang-Xin Lv, Rui Luo, Jason Shih Hoellwarth, Lei He, Jia-Ming Yang, Jia-Yao Zhang, Hong-Lin Wang, Yi Xie, Xiao-Liang Chen, Ming-di Xue, Ying Fang, Yu-Yu Duan, Rui-Yuan Li, Xu-Dong Wang, Rui-Lin Wang, Mao Xie, Li Huang, Peng-Ran Liu, Zhe-Wei Ye

{"title":"Construction of a Multimodal 3D Atlas for a Micrometer-Scale Brain-Computer Interface Based on Mixed Reality.","authors":"Hong Zhou, Zi-Neng Yan, Wei-Hang Gao, Xiang-Xin Lv, Rui Luo, Jason Shih Hoellwarth, Lei He, Jia-Ming Yang, Jia-Yao Zhang, Hong-Lin Wang, Yi Xie, Xiao-Liang Chen, Ming-di Xue, Ying Fang, Yu-Yu Duan, Rui-Yuan Li, Xu-Dong Wang, Rui-Lin Wang, Mao Xie, Li Huang, Peng-Ran Liu, Zhe-Wei Ye","doi":"10.1007/s11596-025-00033-3","DOIUrl":"https://doi.org/10.1007/s11596-025-00033-3","url":null,"abstract":"Objective: To develop a multimodal imaging atlas of a rat brain-computer interface (BCI) that incorporates brain, arterial, bone tissue and a BCI device using mixed reality (MR) for three-dimensional (3D) visualization.Methods: An invasive BCI was implanted in the left visual cortex of 4-week-old Sprague-Dawley rats. Multimodal imaging techniques, including micro-CT and 9.0 T MRI, were used to acquire images of the rat cranial bone structure, vascular distribution, brain tissue functional zones, and BCI device before and after implantation. Using 3D-slicer software, the images were fused through spatial transformations, followed by image segmentation and 3D model reconstruction. The HoloLens platform was employed for MR visualization.Results: This study constructed a multimodal imaging atlas for rats that included the skull, brain tissue, arterial tissue, and BCI device coupled with MR technology to create an interactive 3D anatomical model.Conclusions: This multimodal 3D atlas provides an objective and stable reference for exploring complex relationships between brain tissue structure and function, enhancing the understanding of the operational principles of BCIs. This is the first multimodal 3D imaging atlas related to a BCI created using Sprague-Dawley rats.","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scoring the Clinical Application of a Novel Scale in a Hybrid Operating Room for Neurosurgery.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-18 DOI: 10.1007/s11596-025-00015-5

Wei-Yu Sun, Yu Feng, Jin Yu, Ting-Bao Zhang, Yi-Hui Ma, Kun-Xian Zhang, Xi-Qian Gu, Min Niu, Xiang Li, Jin-Cao Chen, Wen-Yuan Zhao

{"title":"Scoring the Clinical Application of a Novel Scale in a Hybrid Operating Room for Neurosurgery.","authors":"Wei-Yu Sun, Yu Feng, Jin Yu, Ting-Bao Zhang, Yi-Hui Ma, Kun-Xian Zhang, Xi-Qian Gu, Min Niu, Xiang Li, Jin-Cao Chen, Wen-Yuan Zhao","doi":"10.1007/s11596-025-00015-5","DOIUrl":"https://doi.org/10.1007/s11596-025-00015-5","url":null,"abstract":"Objective: The lack of clarity regarding the application performance of a hybrid operating room (HOR) and the uncertainty of surgical scheduling often lead to its inefficient application. This study aimed to review the clinical application of our neurosurgical HOR and propose a scale to score cases clearly.Methods: We reviewed the operating procedures and duration of stay in 1865 HOR cases. The actual procedures of each case were summarized into 5 application types, and numerical assignment was used to distinguish the dependence of each type on our HOR: surgical procedures combined with interventional procedures (4 points, the highest dependence), surgical procedures combined with imaging procedures (3 points), interventional procedures (2 points), imaging procedures (1 point), and surgical procedures (0 points, the lowest dependence).Results: A novel scale that could score 1865 cases into those 5 grades was developed. The percentages by grade were as follows: 4 points, 4.24%; 3 points, 4.88%; 2 points, 20.75%; 1 point, 69.38%; and 0 points, 0.75%. The cumulative usage time was 4241.9 h, the duration of which was as follows: 4 points, 16.17%; 3 points, 15.50%; 2 points, 31.32%; 1 point, 35.62%; and 0 points, 1.39%.Conclusions: The HOR serves as a multifunctional room to treat neurosurgical diseases. The scale helps to quickly prioritize cases that rely more on HOR, providing guidelines for surgical scheduling. Although our HOR is unsuitable for emergency cases, it clearly shows the application performance of our HOR to provide a reference for promoting its efficient application.","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Third-Generation EGFR-TKIs Combined with Radiotherapy for Advanced NSCLC with Typical EGFR Mutations: A Retrospective Study. 第三代表皮生长因子受体-TKIs 联合放疗治疗典型表皮生长因子受体突变的晚期 NSCLC 的有效性和安全性：一项回顾性研究。

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-11 DOI: 10.1007/s11596-025-00032-4

Wen-Xuan Zhang, Hui-Chan Xue, Ye Zhao, Shuang-Bing Xu

{"title":"Efficacy and Safety of Third-Generation EGFR-TKIs Combined with Radiotherapy for Advanced NSCLC with Typical EGFR Mutations: A Retrospective Study.","authors":"Wen-Xuan Zhang, Hui-Chan Xue, Ye Zhao, Shuang-Bing Xu","doi":"10.1007/s11596-025-00032-4","DOIUrl":"https://doi.org/10.1007/s11596-025-00032-4","url":null,"abstract":"Objective: To evaluate the efficacy and safety of third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in combination with radiotherapy (RT) for patients with advanced non-small cell lung cancer (NSCLC) harboring typical EGFR mutations.Methods: Patients who received treatment with third-generation EGFR-TKIs alone or in combination with RT were retrospectively enrolled at a single center. The primary endpoint was progression-free survival (PFS). Differences in PFS between the two groups were assessed via the Kaplan-Meier method. Additionally, a subgroup analysis was conducted to further explore the effect of thoracic RT combined with EGFR-TKIs.Results: This study included a total of 260 patients, among whom 81 patients received third-generation EGFR-TKIs and 179 patients received third-generation EGFR-TKIs plus RT. There was a significant difference in median PFS (mPFS) (13.0 versus 18.1 months, P = 0.0003) between the two groups. Moreover, third-generation EGFR-TKIs plus thoracic RT significantly improved the mPFS (13.0 versus 23.7 months, P < 0.0001). We observed that third-generation EGFR-TKIs plus RT increased the incidence of pneumonia, but all the cases were grade 1 or 2.Conclusion: The addition of RT can delay the occurrence of acquired resistance to third-generation EGFR-TKIs, thereby significantly prolonging PFS in advanced NSCLC patients. RT for primary lung lesions exhibited a significant synergistic effect with EGFR-TKI treatment, and the adverse events of the combination therapy were acceptable.","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to: Early Aerobic Exercise Promotes Neurological Function Recovery of Rats after Cerebral Ischemia/Reperfusion by Upregulating the Expression of Heat Shock Protein A5.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-11 DOI: 10.1007/s11596-025-00029-z

Zhi-Feng Peng, Nai-Bao Zhang, Jian Meng, Ji-Hong Zhang

引用次数: 0

Clinical Manifestations of Ocular Toxoplasmosis in Hubei, China: Case Series.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-07 DOI: 10.1007/s11596-025-00028-0

Mu Li, Xian Zhang, Xiao-Qin Yan, Peng-Cheng Li

{"title":"Clinical Manifestations of Ocular Toxoplasmosis in Hubei, China: Case Series.","authors":"Mu Li, Xian Zhang, Xiao-Qin Yan, Peng-Cheng Li","doi":"10.1007/s11596-025-00028-0","DOIUrl":"https://doi.org/10.1007/s11596-025-00028-0","url":null,"abstract":"Objective: The clinical features, disease course and visual outcomes of toxoplasmosis are less commonly reported in China than in other countries. To reduce misdiagnosis and improve visual function, the clinical characteristics, management and visual outcomes of 13 cases of ocular toxoplasmosis (OT) were described.Methods: This retrospective study included 14 eyes of 13 patients who were diagnosed with OT in Hubei, China. The clinical characteristics, course of treatment and outcomes are presented. There were 7 males and 6 females.Results: The main form of OT was retinochoroiditis with vitritis or anterior uveitis. Next-generation sequencing was applied to 3 eyes, and positive results were found in those eyes. Thirteen patients were positive for Toxoplasma gondii IgG antibodies, and 3 of them were also positive for IgM T. gondii antibodies. One patient with acquired immune deficiency syndrome was diagnosed with coinfection with OT and cytomegalovirus, as evidenced by an aqueous humor etiological test. Three patients were misdiagnosed with noninfectious uveitis. Recurrence occurred in 3 eyes during the follow-up periods. One patient who received vitreous implantation of Ozurdex therapy at another hospital before referral relapsed. One patient who received sulfadiazine, azithromycin and glucocorticoid therapy relapsed. One patient who received sulfadiazine therapy experienced relapse. Patients who received clindamycin and sulfadiazine or who received clindamycin only did not experience recurrence during the follow-up period. The best corrected visual acuity was improved in 6 eyes after inflammation resolved.Conclusions: Primary active retinochoroiditis is the main form of OT in Hubei, China. Timely correct diagnosis on the basis of ocular characteristics and aetiological test results and effective treatment should be adopted to prevent poor visual outcomes and recurrence.","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Histone Demethylase Inhibitor GSK-J4 Attenuates Periodontal Bone Loss and Inflammation in a Rat Model of Periodontitis.

IF 2 4区医学

Current Medical Science Pub Date : 2025-03-06 DOI: 10.1007/s11596-025-00018-2

Jian Kang, Huan Yu, Xu Xiang, Yong-Qiang Ma, Le Zhang, Yuan Zhang, Zhi-Tao Wang, Jing Yang, Zheng Zhang, Hui-Ru Zou, Yue Wang

{"title":"The Histone Demethylase Inhibitor GSK-J4 Attenuates Periodontal Bone Loss and Inflammation in a Rat Model of Periodontitis.","authors":"Jian Kang, Huan Yu, Xu Xiang, Yong-Qiang Ma, Le Zhang, Yuan Zhang, Zhi-Tao Wang, Jing Yang, Zheng Zhang, Hui-Ru Zou, Yue Wang","doi":"10.1007/s11596-025-00018-2","DOIUrl":"https://doi.org/10.1007/s11596-025-00018-2","url":null,"abstract":"Objective: To investigate the treatment effect of the histone demethylase inhibitor GSK-J4, a small molecule that inhibits the demethylase activity of Jumonji domain-containing protein 3 (JMJD3), in the treatment of periodontitis.Methods: Gingival tissues from patients with moderate to severe chronic periodontitis and healthy controls were collected to evaluate JMJD3 expression via real-time quantitative reverse transcription PCR (RT-qPCR) and immunohistochemistry (IHC). Next, Sprague-Dawley (SD) rats were used to investigate the effect of GSK-J4 in vivo. The experimental periodontitis model was induced by upper first molar ligation and gingival sulcus injection of Porphyromonas gingivalis. The rats were divided into a healthy group, a periodontitis group, periodontitis plus GSK-J4 treatment groups (P + GSK-J4 15 mg/kg or 25 mg/kg), and a periodontitis plus dimethyl sulfoxide (DMSO) group (P + DMSO). After 4 weeks, maxillary molar segments were assessed via micro-computed tomography (CT) and hematoxylin and eosin (HE) staining. Serum tumor necrosis factor-α (TNF-α) levels were measured by enzyme-linked immunosorbent assay (ELISA).Results: Higher expression of the Jmjd3 gene and JMJD3 protein was detected in human inflamed gingiva than in healthy gingiva (P < 0.05). GSK-J4 administration reversed alveolar bone absorption [i.e., reduced alveolar bone crest (ABC)-cementoenamel junction (CEJ) distance], reduced inflammatory cell accumulation at the crest of the alveolar bone, and alleviated serum TNF-α levels in rats with periodontitis. Moreover, the number of H3K27me3-positive nuclei was greater in model rats treated with GSK J4 than in model rats.Conclusions: The histone demethylase inhibitor GSK-J4 attenuated periodontal bone loss and inflammation in a rat periodontitis model by targeting JMJD3.","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0