Current Medical Science最新文献

{"title":"Current Status and Advances in Anti-Androgen Therapy for Triple-Negative Breast Cancer.","authors":"Jing-Bo Li, Wen-Fei Xia","doi":"10.1007/s11596-025-00094-4","DOIUrl":"https://doi.org/10.1007/s11596-025-00094-4","url":null,"abstract":"<p><p>The heterogeneity of triple-negative breast cancer (TNBC) has spurred the exploration of precision therapies based on molecular subtypes, with the androgen receptor (AR)-positive subtype emerging as a potential therapeutic target. The treatment of AR-positive TNBC relies primarily on androgen receptor antagonists, such as enobosarm, bicalutamide, and enzalutamide. To enhance efficacy, researchers are investigating combination therapies that integrate anti-androgen agents with chemotherapy, immunotherapy, or PARP inhibitors. Additionally, studies have revealed that the AR signaling pathway regulates the tumor microenvironment, and AR inhibition may potentiate the efficacy of immune checkpoint inhibitors. However, anti-AR therapies face significant limitations and challenges due to multifaceted factors, necessitating further resolution. With continued advancements, AR-targeted therapy holds promise as a critical component of personalized treatment strategies for TNBC.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological and Molecular Characterization of Uterine Tumors Resembling Ovarian Sex Cord Tumors: An Eight-Case Series with Novel Fusion Gene Insights and Literature Review.","authors":"Shu-Hao Yang, Dong Kuang, Ya Li, Shu-Hong Yang","doi":"10.1007/s11596-025-00099-z","DOIUrl":"https://doi.org/10.1007/s11596-025-00099-z","url":null,"abstract":"<p><p>Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are characterized by an uncertain malignant potential and exhibit prominent sex cord-like differentiation. The purpose of this study was to comprehensively review the clinicopathological characteristics of UTROSCTs and analyze eight cases of UTROSCTs treated at our hospital. We conducted an extensive review of the relevant literature and gathered pertinent data. In addition, we identified eight patients with UTROSCTs and analyzed their clinical and pathological features, diagnosis, treatment, and prognosis. Patients presented with symptoms such as abnormal vaginal bleeding or uterine mass detection. Surgical interventions varied, including total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy, with adjuvant therapy given to one patient. All eight patients are currently disease-free, with the longest follow-up period being nearly 10 years. Our systematic review of UTROSCTs summarized the clinical and pathological features and revealed several novel markers, including ESR1-NCOA2-3, GREB1-NCOA1-3, GREB1-CTNNB1, and GREB1-NR4A3. UTROSCTs are rare mesenchymal tumors with unclear histogenesis and uncertain malignant potential. Although our understanding of UTROSCTs remains incomplete, the promising findings and increasing availability of clinical data will contribute to the further understanding and development of this rare neoplasm.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Traditional Chinese Medicine: Multimodal Fusion and Machine Learning for Enhanced Diagnosis and Treatment Efficacy.","authors":"Jie Wang, Yong-Mei Liu, Jun Li, Hao-Qiang He, Chao Liu, Yi-Jie Song, Su-Ya Ma","doi":"10.1007/s11596-025-00103-6","DOIUrl":"https://doi.org/10.1007/s11596-025-00103-6","url":null,"abstract":"<p><p>Artificial intelligence (AI) serves as a key technology in global industrial transformation and technological restructuring and as the core driver of the fourth industrial revolution. Currently, deep learning techniques, such as convolutional neural networks, enable intelligent information collection in fields such as tongue and pulse diagnosis owing to their robust feature-processing capabilities. Natural language processing models, including long short-term memory and transformers, have been applied to traditional Chinese medicine (TCM) for diagnosis, syndrome differentiation, and prescription generation. Traditional machine learning algorithms, such as neural networks, support vector machines, and random forests, are also widely used in TCM diagnosis and treatment because of their strong regression and classification performance on small structured datasets. Future research on AI in TCM diagnosis and treatment may emphasize building large-scale, high-quality TCM datasets with unified criteria based on syndrome elements; identifying algorithms suited to TCM theoretical data distributions; and leveraging AI multimodal fusion and ensemble learning techniques for diverse raw features, such as images, text, and manually processed structured data, to increase the clinical efficacy of TCM diagnosis and treatment.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interplay Between Vestibular Dysfunction and Sleep Disorders.","authors":"Xi-Xi Yu, E Tian, Jun Wang, Ouk Synadet, Zhao-Qi Guo, Jing-Yu Chen, Jia-Qi Guo, Zhang-Hong Zhou, Shi-Yu Shi, Hua-Jing Yang, Yi-Sheng Lu, Su-Lin Zhang","doi":"10.1007/s11596-025-00085-5","DOIUrl":"10.1007/s11596-025-00085-5","url":null,"abstract":"<p><p>Recent years have seen a burgeoning interest in elucidating the intricate relationship between vestibular dysfunction and sleep disorders, owing to their substantial impact on daily functioning and overall health. Despite significant advancements, the precise mechanisms underpinning this interplay remain elusive. This review aims to synthesize the current literature on the association between vestibular dysfunction and sleep disorders, focusing on potential causal mechanisms and therapeutic implications. We systematically examine various sleep disorders, including insomnia, circadian rhythm disorders, and sleep apnea, in association with specific vestibular dysfunctions, such as Meniere's disease (MD), vestibular migraine (VM), benign paroxysmal positional vertigo (BPPV), vestibular neuritis (VN), and persistent postural perceptual dizziness (PPPD). By exploring these complex interactions, our goal is to provide a comprehensive understanding that contributes to the ongoing discourse in this field. We seek to encourage further investigations into innovative diagnostic and therapeutic strategies, ultimately aiming to improve the clinical management and enhance the quality of life for patients affected by both vestibular dysfunction and sleep disorders.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"699-714"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Nomogram Prediction Model for Sepsis-Induced Coagulopathy: A Multicenter Retrospective Study.","authors":"Wen-Hao Ma, Ze-Yu Yang, Xing-Xing Fan, Lei Tian, Tuo Zhang, Ming-da Wang, Ji-Yuan Gao, Jian-le Xu, Wei Fang, Hui-Min Hou, Man Chen","doi":"10.1007/s11596-025-00093-5","DOIUrl":"10.1007/s11596-025-00093-5","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to develop a prediction model to assess the risk of sepsis-induced coagulopathy (SIC) in sepsis patients.</p><p><strong>Methods: </strong>We conducted a retrospective study of septic patients admitted to the Intensive Care Units of Shandong Provincial Hospital (Central Campus and East Campus), and Shenxian People's Hospital from January 2019 to September 2024. We used Kaplan-Meier analysis to assess survival outcomes. LASSO regression identified predictive variables, and logistic regression was employed to analyze risk factors for pre-SIC. A nomogram prediction model was developed via R software and evaluated via receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).</p><p><strong>Results: </strong>Among 309 patients, 236 were in the training set, and 73 were in the test set. The pre-SIC group had higher mortality (44.8% vs. 21.3%) and disseminated intravascular coagulation (DIC) incidence (56.3% vs. 29.1%) than the non-SIC group. LASSO regression identified lactate, coagulation index, creatinine, and SIC scores as predictors of pre-SIC. The nomogram model demonstrated good calibration, with an AUC of 0.766 in the development cohort and 0.776 in the validation cohort. DCA confirmed the model's clinical utility.</p><p><strong>Conclusion: </strong>SIC is associated with increased mortality, with pre-SIC further increasing the risk of death. The nomogram-based prediction model provides a reliable tool for early SIC identification, potentially improving sepsis management and outcomes.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"867-876"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ZWINT Expression with Clinicopathologic Characteristics and Prognosis in Breast Cancer Patients.","authors":"Bei Liu, Qin Wang, Xiao-Hong Min, Han-Han Liu, Huan Wu, Hui Xu, Jun-Bo Hu, Yong-Qing Tong, Zi-Ming Huang","doi":"10.1007/s11596-025-00081-9","DOIUrl":"10.1007/s11596-025-00081-9","url":null,"abstract":"<p><strong>Objective: </strong>ZW10 interacting kinetochore protein (ZWINT) has been demonstrated to play a pivotal role in the growth, invasion, and migration of cancers. Nevertheless, whether the expression levels of ZWINT are significantly correlated with clinicopathological characteristics and prognostic outcomes of patients with breast cancer remains elusive. This study systematically investigated the clinical significance of ZWINT expression in breast cancer through integrated molecular subtyping and survival analysis.</p><p><strong>Methods: </strong>We systematically characterized the spatial expression pattern of ZWINT across various breast cancer subtypes and assessed its prognostic significance using an integrated bioinformatics approach that involved multi-omics analysis. The approach included the Breast Cancer Gene-Expression Miner v5.1 (bc-GenExMiner v5.1), TNMplot, MuTarget, PrognoScan database, and Database for Annotation, Visualization, and Integrated Discovery (DAVID).</p><p><strong>Results: </strong>Our analysis revealed consistent upregulation of ZWINT mRNA and protein expression across distinct clinicopathological subtypes of breast cancer. ZWINT overexpression demonstrated significant co-occurrence with truncating mutations in cadherin 1 (CDH1) and tumor protein p53 (TP53), suggesting potential functional crosstalk in tumor progression pathways. The overexpression of ZWINT correlated with adverse clinical outcomes, showing 48% increased mortality risk (overall survival: HR 1.48, 95% CI 1.23-1.79), 66% higher recurrence probability (relapse-free survival: 1.66, 95% CI 1.50-1.84), and 63% elevated metastasis risk (distant metastasis-free survival: HR 1.63, 95% CI 1.39-1.90). Multivariate Cox regression incorporating TNM staging and molecular subtypes confirmed ZWINT as an independent prognostic determinant (P < 0.001, Harrell's C-index = 0.7827), which was validated through bootstrap resampling (1000 iterations).</p><p><strong>Conclusion: </strong>ZWINT may serve as a potential biomarker for prognosis and a possible therapeutic target alongside TP53/CDH1 in breast cancer.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"775-788"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating T Regulatory Cells Are Persistently Reduced in Non-Severe Acquired Aplastic Anemia.","authors":"Pasqualina Scala, Valentina Giudice, Denise Morini, Anna Maria Della Corte, Carmine Selleri, Bianca Serio","doi":"10.1007/s11596-025-00100-9","DOIUrl":"10.1007/s11596-025-00100-9","url":null,"abstract":"<p><strong>Objective: </strong>Acquired aplastic anemia (aAA) is characterized by an autologous immunological attack against hematopoietic stem and progenitor cells, and immunotolerance disruption is frequent, with reduced T regulatory cells (Tregs) frequencies and increased effector cytotoxic cells. Tregs are reduced in aAA and increase in number after successful immunosuppressive therapies.</p><p><strong>Methods: </strong>In this retrospective study, we investigated the frequency of circulating Tregs by multiparametric flow cytometry immunophenotyping in non-severe aAA patients before and after immunosuppressive therapy. The samples were stained with the following antibodies: ECD anti-CD3, PE or PC5 anti-CD4, FITC anti-CD8, and PE anti-CD25, and Tregs were identified by first gating on linear parameters for lymphocyte identification and then for CD3 expression. In CD3⁺CD4⁺ cells, Tregs were further identified on the basis of CD25 and FOXP3 expression.</p><p><strong>Results: </strong>Although the number of Tregs tended to increase after immunosuppressive treatments, their circulating frequency remained lower than that of healthy subjects, regardless of their responsiveness to therapies. Moreover, the relative frequency combined with absolute Treg counts might be more informative in the differential diagnosis of bone marrow failure syndromes.</p><p><strong>Conclusions: </strong>The persistent decrease in circulating Tregs could be the result of immunosuppressive agents that could preferentially expand other T-cell subsets. At the same time, an imbalance in immunotolerance might persist, which is also favored by chronic antigen stimulation.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"977-984"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEP1-40 Regulates the Development of Hippocampal Neural Stem Cells in Schizophrenic Mice.","authors":"Yu Shao, Yan-Bo Liu, Dong-Kun Yu, Zhi-Lun Yang, Zi-Qi Feng, Xiao-Juan Mi, Juan Liu","doi":"10.1007/s11596-025-00078-4","DOIUrl":"10.1007/s11596-025-00078-4","url":null,"abstract":"<p><strong>Objective: </strong>Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive, affective, and behavioral abnormalities. Existing treatments have yielded limited effects on improving cognitive function. Recent studies have identified the abnormal differentiation of hippocampal neural stem cells (NSCs), neuronal loss, and dysregulated proliferation of astrocytes as significant pathological mechanisms contributing to the symptoms of schizophrenia. Impaired hippocampal neurogenesis may lead to emotional and cognitive deficits and biases in learning and memory, indicating that NSC differentiation is critical. NEP1-40, a Nogo-A receptor inhibitor, has shown promise for nerve protection and repair promotion. However, the effects of NEP1-40 on stem cell differentiation, the reduction in neuronal apoptosis, and the amelioration of schizophrenia-like behaviors have not been adequately investigated. This study examined the influence of NEP1-40 on NSC differentiation, hippocampal neuronal apoptosis, and proliferation in adolescent mice, along with its potential to enhance cognitive and behavioral outcomes in MK-801-induced schizophrenia mouse models.</p><p><strong>Methods: </strong>In in vivo experiments, a schizophrenia mouse model was successfully established. Subsequently, behavioral tests were conducted, followed by Western blotting (WB) and immunofluorescence (IF) analyses. In in vitro settings, NSCs were cultured and transfected. Flow cytometry, along with WB and IF assays, was employed to evaluate the effects of NEP1-40.</p><p><strong>Results: </strong>Schizophrenia-like behaviors in mice were significantly improved with the overexpression of NEP1-40. Compared with the model group, the NEP1-40 treatment group presented increased expression of a neuronal marker (Tuj1), reduced expression of an astroglial marker (GFAP), and decreased hippocampal neuronal apoptosis. NSC differentiation was assessed by quantifying the number of BrdU-positive cells coexpressing Tuj1 and GFAP in the hippocampal dentate gyrus. NEP1-40 treatment led to an increase in BrdU/Tuj1-positive cells and a reduction in BrdU/GFAP-positive cells. In cellular studies, NEP1-40 overexpression similarly increased the number of Tuj1-positive cells, reduced the number of GFAP-positive cells, decreased the degree of neuronal apoptosis, and promoted neuronal proliferation.</p><p><strong>Conclusion: </strong>These findings demonstrated the neurogenic effects of NEP1-40 on NSCs and their potential to mitigate schizophrenia-like behaviors in vivo.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"930-943"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dapagliflozin Suppressed Cuproptosis and Myocardial Fibrosis in Myocardial Infarction Through HIF-1α/TGF-β Pathway.","authors":"Yu-Ze Zhang, Ting-Ting Lin, Shu-Min Fan, Yan-Qing Wu","doi":"10.1007/s11596-025-00076-6","DOIUrl":"10.1007/s11596-025-00076-6","url":null,"abstract":"<p><strong>Background: </strong>Myocardial infarction (MI) and postmyocardial remodeling are the most common causes of heart failure worldwide and seriously affect the quality of life and prognosis of patients. Dapagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, is a novel class of hypoglycemic drug that has been proven to have cardiovascular protective effects. However, the underlying mechanisms by which dapagliflozin affects MI have yet to be elucidated.</p><p><strong>Methods: </strong>An MI mouse model was created by ligating the left anterior descending branch of the coronary artery. Hematoxylin‒eosin (HE) and Masson's trichrome (Masson) staining were used to assess myocardial damage. The levels of fibrosis-related and cuproptosis-related markers were assessed via Western blot analysis. A hypoxia-induced cardiomyocyte fibrosis model was constructed in vitro. The DCFH-DA probe was used to measure the levels of reactive oxygen species (ROS), and flow cytometry was used to identify cell apoptosis.</p><p><strong>Results: </strong>Dapagliflozin improved heart function, ameliorated fibrosis in the myocardium, and alleviated myocardial injury. Moreover, dapagliflozin reduced the copper ion concentration and ROS accumulation and inhibited the expression of cuproptosis-related markers. Dapagliflozin suppressed the expression of HIF-1α/TGF-β signal and the overexpression of HIF-1α effectively reversed the dapagliflozin-mediated myocardial protective effects.</p><p><strong>Conclusion: </strong>Dapagliflozin reduced myocardial fibrosis by suppressing HIF-1α/TGF-β-mediated cuproptosis.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"831-840"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological Reconstruction for Moderate-Severe Pelvic Organ Prolapse: A Multicenter Retrospective Self-Controlled Study.","authors":"Zhen-Hua Gao, Xing-Qi Wang, Kun-Bin Ke, Quan Zhang, Ling Li, Ji-Hong Shen","doi":"10.1007/s11596-025-00095-3","DOIUrl":"10.1007/s11596-025-00095-3","url":null,"abstract":"<p><strong>Objective: </strong>This is a self-controlled multicenter retrospective study based on the clinical efficacy and complications of physiological reconstruction in the treatment of moderate and severe pelvic organ prolapse.</p><p><strong>Methods: </strong>From December 2014 to August 2021, 517 women were included and registered for physiological reconstruction at four Chinese urogynecology institutions. We enrolled 364 women with POP-Q stage ≥ 3. The degree of POP was quantified via a POP-Q system. The surgical purpose of physiological reconstruction is to repair the vagina, levator ani muscle, perineum, and urogenital hiatus and adopt a repair method in accordance with the axial direction of physiology. All 330 evaluable participants were followed for 2 years. The evaluation indices included the PFDI-20, PGI-I, PFIQ-7, PISQ-12, PGI-I, and PGI-S. All complications were coded according to the category-time-site system proposed by the International Urogynecological Association (IUGA) and International Continence Society (ICS).</p><p><strong>Results: </strong>Compared with the preoperative POP-Q scores, statistically significant improvements were observed at the 6-month, 1-year and 2-year time points (P < 0.001). Statistically significant improvements in quality of life were observed across all time points.</p><p><strong>Conclusions: </strong>Physiologic reconstructive surgical techniques combined with modified anterior pelvic floor mesh implantation could help restore the physiologic axis and vaginal shape, which may be the most important factors in maintaining the functional position of pelvic floor organs and is the most effective method for repairing the pelvic fascia tendon arch. This surgical method is safe, feasible, and effective in patients with severe prolapse.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"909-916"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12364984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}