Current Medical Science最新文献

{"title":"Mixed Infections in the Female Lower Genital Tract: Unlocking the Current Landscape and Future Directions.","authors":"Wen-Hua Jiang, Xin-Wei Zhao, Xi-Ming Jin, Wen-Jia Wang, Zhuo Chen","doi":"10.1007/s11596-025-00058-8","DOIUrl":"10.1007/s11596-025-00058-8","url":null,"abstract":"<p><p>Understanding mixed infections in the female lower genital tract is a critical challenge in modern infection research. The interplay of multiple pathogens complicates disease progression, often resulting in treatment failure, recurrent infections, and significant public health and economic burdens. These infections are further exacerbated by disrupted host immune responses, which hinder the recovery of the vaginal microecosystem. Additionally, microbial biofilms-a fundamental mode of pathogen coexistence-contribute to the persistence and drug resistance of these infections, complicating management strategies. This review examines the pathogenesis, diagnosis, and treatment of mixed infections in the female lower genital tract while exploring potential avenues for future research. These findings emphasize the need for greater focus on these infections and offer insights to enhance further research in this area.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"438-448"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Haploidentical Hematopoietic Stem Cell Transplantation for AML Patients with Persistent Molecular MRD.","authors":"Shan Jiang, Ao Zhang, Ya-Jie Ding, Ruo-Wen Wei, Xuan Lu, Fen Chen, Wei Shi, Ling-Hui Xia","doi":"10.1007/s11596-025-00054-y","DOIUrl":"10.1007/s11596-025-00054-y","url":null,"abstract":"<p><strong>Objective: </strong>The combined use of quantitative real-time polymerase chain reaction (qPCR) and next-generation sequencing (NGS) to detect molecular measurable residual disease (mMRD) has been shown to have prognostic value for patients undergoing matched-hematopoietic stem cell transplantation (HSCT). However, there have been no related studies in the context of haploidentical HSCT (haplo-HSCT).</p><p><strong>Methods: </strong>We included 148 acute myeloid leukemia (AML) patients who were in first complete remission (CR1) and underwent HSCT at Union Hospital (Wuhan, China) between 2019 and 2023. Among them, 28 patients were mMRD (+) before transplantation according to PCR/NGS. Then, on the basis of the 2017 European Leukemia Net (ELN) risk stratification, we randomly enrolled 56 mMRD (-) patients at a 1:2 ratio. Finally, we compared the outcomes, including overall survival (OS), cumulative incidence of relapse (CIR), leukemia-free survival (LFS), and nonrelapse mortality (NRM), between the two groups.</p><p><strong>Results: </strong>Persisting mMRD predicts worse long-term clinical outcomes in AML patients who received haplo-HSCT. The 2-year OS and LFS between the mMRD (+) and mMRD (-) groups were 77.1% (95%CI 62.5-95.2) versus 92.3% (95%CI 85.3-99.9) (P = 0.044) and 72.7% (95%CI 56.9-92.8) versus 90.7% (95%CI 83.2-98.8) (P = 0.003), respectively. The results of multivariate analysis revealed that mMRD (+) patients had worse OS and LFS than control patients did and that the mMRD (+) score was an independent prognostic factor for OS and LFS.</p><p><strong>Conclusion: </strong>Pre-HSCT mMRD has predictive value for haplo-HSCT outcomes in AML patients. Patients who are mMRD (+) before transplantation have poorer OS and LFS. For these patients, intensified myeloablative conditioning (MAC), rapid reduction in immunosuppressive agents after 30 days, and pro-donor lymphocyte infusion (DLI) can improve post-transplant outcomes.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"513-524"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological Evidence of the Great Obstetrical Syndromes and Short-Term Neonatal Outcomes.","authors":"Dan Lv, Xu-Fang Li, Shi-Yao Chen, Praseth Leakana, Jia-Qi Han, Jun-Rong Xian, Fan-Fan Li, Meng-Zhou He, Yao Fan, He-Ze Xu, Li Liu, Wei Li, Xing-Guang Lin, Fang Ye, Dong-Rui Deng","doi":"10.1007/s11596-025-00062-y","DOIUrl":"10.1007/s11596-025-00062-y","url":null,"abstract":"<p><strong>Objective: </strong>Great obstetrical syndrome (GOS) represents a group of pregnancy-related diseases that result in inadequate placentation. Most GOS cases end in preterm, either spontaneously or indicatively, and the use of antenatal corticosteroids (ACS) is inevitably discussed. The placenta is an important, transient fetal-derived organ and is the embodiment of maternal or fetal well-being. However, few studies provide histological evidence of the placenta in GOS. This study aims to address these issues.</p><p><strong>Methods: </strong>A total of 831 pregnant women were prospectively recruited. Placenta tissue was collected immediately and fixed with 4% paraformaldehyde solution for future H&E analysis. A novel checklist was devised to evaluate maternal vascular malperfusion sections on the basis of the commonly accepted Amsterdam placental workshop group consensus statement.</p><p><strong>Results: </strong>A total of 131 patients were classified as having GOS. Comparisons between those with and without GOS revealed significant differences, including higher levels of distal villous hypoplasia, increased syncytial knots, accelerated villous maturation, and higher total scores in GOS. We found significant negative associations between GOS and neonatal weight, neonatal height, head circumference, placental surface area, placental volume, and placenta gross examination score. GOS neonates were 1.25 times more likely to have hyperbilirubinemia. Regarding the effect of ACS, a significant reduction in birthweight, height, and head circumference was observed, along with an increased risk of hyperbilirubinemia.</p><p><strong>Conclusion: </strong>This study provides histological evidence of the GOS that supports the defective deep placentation hypothesis. Our research also contributes to benefit-risk consultation in the GOS, such as in cases of PE and FGR, where a balance between fetal lung maturation and short-term neonatal outcomes is crucial.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"585-593"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HNMT Promotes the Occurrence and Progression of Nasopharyngeal Carcinoma by Inhibiting the IFN/TXNIP/p53 Axis.","authors":"Sheng Cheng, Xi-Fang Wu, Wei-di Sun, Hong Zhai, Xin Liu, Chao-Wu Jiang, Biao Ruan","doi":"10.1007/s11596-025-00072-w","DOIUrl":"10.1007/s11596-025-00072-w","url":null,"abstract":"<p><strong>Objective: </strong>Histamine N-methyltransferase (HNMT) is involved primarily in histamine metabolism, but emerging evidence suggests its potential role in cancer progression. This study investigated the role of HNMT in nasopharyngeal carcinoma (NPC) and its impact on interferon (IFN) signaling, thioredoxin-interacting protein (TXNIP), and p53 tumor suppressor pathways.</p><p><strong>Methods: </strong>HNMT expression in NPC tissues and cell lines was analyzed via qPCR and Western blotting. Functional assays, including cell proliferation, migration, invasion, and apoptosis, were performed after HNMT knockdown or overexpression. Transcriptomic sequencing was used to identify differentially expressed genes (DEGs). In addition, we examined the relationship between HNMT and the IFN/TXNIP/p53 axis via rescue experiments in vitro and in vivo models via qPCR and Western blotting.</p><p><strong>Results: </strong>HNMT knockdown reduced cell proliferation, migration, and invasion, and promoted apoptosis in NPC tissues and cell lines. TXNIP was the most significantly upregulated gene following HNMT knockdown. Inhibition of the IFN pathway reversed these effects, confirming the role of HNMT in downregulating the IFN/TXNIP/p53 pathway. An in vivo study revealed that HNMT overexpression correlated with reduced expression of TXNIP and p53 in NCG mice.</p><p><strong>Conclusion: </strong>In NPC, HNMT promotes tumor growth and progression by inhibiting the IFN/TXNIP/p53 axis. These findings suggest that targeting the HNMT axis or restoring its function could provide new therapeutic strategies for NPC.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"661-670"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malperfusion in Acute Type A Aortic Dissection: Development of a Predictive Diagnostic Model.","authors":"Kan-Paatib Barnabo Nampoukime, Adeoumi Esperance Monteiro Igwenandji, You-Min Pan, Lud Merveil Norbely Nouani, Djessica Fortes Gomes, Mustafa Abbas Farhood Sultani, Hai-Hao Wang","doi":"10.1007/s11596-025-00070-y","DOIUrl":"10.1007/s11596-025-00070-y","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical predictors of malperfusion in patients with acute type A aortic dissection (ATAAD) and to construct a diagnostic model to identify high-risk individuals.</p><p><strong>Methods: </strong>A retrospective analysis of 553 ATAAD patients from Tongji Hospital divided into malperfusion and non-malperfusion groups was conducted. Logistic regression was used to identify independent predictors of the outcome. Model performance via the Hosmer-Lemeshow test, decision curve analysis (DCA), the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and predictive values.</p><p><strong>Results: </strong>Malperfusion was observed in 28.4% of ATAAD patients. Significant predictors included elevated lactate dehydrogenase (LDH) (OR: 1.0019, 95% CI: 1.0002-1.0036, P = 0.027), alanine aminotransferase (ALT) (OR: 0.9936, 95% CI: 0.987-1.000, P = 0.046) and estimated glomerular filtration rate (eGFR) (OR: 0.9877, 95% CI: 0.977-0.998, P = 0.021), suggesting roles for tissue ischemia and impaired renal or hepatic function. Other variables, such as D-dimer, uric acid, creatinine, and NT-proBNP, showed trends toward significance but did not reach the 0.05 threshold. The model demonstrated good calibration (Hosmer-Lemeshow P = 0.318), moderate discriminatory power (AUC = 0.725), high specificity (93.62%), and low sensitivity (26.75%).</p><p><strong>Conclusion: </strong>The model based on routine biochemical markers provides a practical approach for the early identification of malperfusion in ATAAD patients. It shows strong specificity and clinical utility, although its limited sensitivity highlights the need for further refinement. Future improvements should focus on incorporating additional clinical or imaging data to increase diagnostic accuracy.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"651-660"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Activates Nrf2 to Prevent Nerve Injury and Reduce Brain Damage in Acute Cerebral Infarction.","authors":"Hong-Min Zhao, Li-Qin Mu, Jing Wang, Run-Zhi Chen, Yang Li, Lin Zhao, Yu Zhao, Li-Na Liu","doi":"10.1007/s11596-025-00043-1","DOIUrl":"10.1007/s11596-025-00043-1","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the neuroprotective effects of cholecalciferol cholesterol emulsion (CCE), a vitamin D (VD) precursor, in a murine model of acute cerebral infarction (ACI) and to elucidate the role of the Nrf2 signaling pathway in mediating these effects.</p><p><strong>Methods: </strong>Forty C57BL/6J mice (male and female) were divided into five groups (n = 10 per group): control, control + CCE, ACI, ACI + CCE, and ACI + CCE + ML385 (an Nrf2 inhibitor). ACI was induced by middle cerebral artery occlusion (MCAO). CCE was administered for three weeks prior to ACI induction, and ML385 was administered intravenously to inhibit Nrf2. Neurological function, brain edema, and infarct size, as well as inflammatory and apoptotic marker levels, were assessed post-ACI. Statistical analyses were conducted via one-way ANOVA and Student's t test, with P < 0.05 considered significant.</p><p><strong>Results: </strong>Compared to ACI group, CCE significantly reduced neurological deficits, brain edema, and infarct size (P < 0.01). The ACI + CCE group presented improved short-term memory retention, as evidenced by shorter avoidance latency in shuttle avoidance tests (P < 0.01). CCE administration attenuated the expression of inflammatory markers (IL-6, MIF, Lp-PLA2) while increasing IL-10 levels (P < 0.001). Furthermore, CCE increased Nrf2 and HO-1 expression and reduced apoptosis by decreasing the Bax/Bcl-2 ratio in brain tissue (P < 0.001). ML385 abolished these neuroprotective effects, confirming the role of the Nrf2 pathway in mediating the benefits of VD.</p><p><strong>Conclusion: </strong>VD, via VD receptor-mediated activation of the Nrf2/HO-1 pathway, reduces inflammation, apoptosis, and neurological damage following ACI. These findings support the therapeutic potential of VD in the treatment of ischemic stroke and highlight the importance of Nrf2 in mediating these effects.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"469-480"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELMOD2 Overexpression Predicts Adverse Outcomes and Regulates Tumor Progression in Gliomas.","authors":"Rui-Chao Li, Chang Liu, Guo-Jian Wang, Zi Wang, Rong-Lin Li, Hao-Tian Lu, Xiao-Xun Xie, Qing-Mei Zhang, Da-Qin Feng, Xiang Yun, Bin Luo","doi":"10.1007/s11596-025-00057-9","DOIUrl":"10.1007/s11596-025-00057-9","url":null,"abstract":"<p><strong>Objective: </strong>Glioma is a highly heterogeneous and malignant intracranial tumor that presents challenges for clinical treatment. ELMO domain containing 2 (ELMOD2) is a GTPase-activating protein that regulates a range of cellular biological processes. However, its specific role and prognostic value in tumorigenesis are still unknown. This study aimed to assess the prognostic relevance and signaling function of ELMOD2 in gliomas.</p><p><strong>Methods: </strong>The Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases were utilized to conduct a comprehensive analysis of the expression profile of ELMOD2 in gliomas, elucidating its associations with clinicopathological parameters and patient prognosis. Single-cell analysis was performed to characterize ELMOD2 expression across distinct glioma cell subpopulations. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses, and Gene Set Variation Analysis (GSVA) were employed to evaluate the potential biological functions of ELMOD2 in gliomagenesis. Specific small interfering RNAs (siRNAs) were used to knock down ELMOD2 in the glioma cell lines U251 and A172 to assess their cellular behaviors and examine the levels of multiple key signaling molecules associated with the occurrence of gliomas.</p><p><strong>Results: </strong>ELMOD2 was overexpressed in gliomas, and this upregulation was correlated with tumor grade, isocitrate dehydrogenase mutation, and 1p/19q codeletion status. Notably, ELMOD2 expression was elevated in classical and mesenchymal subtypes, and single-cell resolution analysis revealed predominant enrichment within malignant cells. Functionally, ELMOD2 regulated cell cycle progression, and its overexpression was related to independent adverse outcomes. In vitro experiments revealed that ELMOD2 was located in the cytoplasm and nucleoplasm. Furthermore, ELMOD2 knockdown reduced proliferation, migration, and invasion and increased apoptosis in U251 and A172 cell lines. Finally, ELMOD2 knockdown significantly decreased p-Erk1/2.</p><p><strong>Conclusions: </strong>ELMOD2 expression in glioma is positively correlated with tumorigenesis and is a crucial independent prognostic marker. Thus, ELMOD2 is a promising biomarker and therapeutic target for glioma treatment.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"549-561"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and Country-Level Analysis of Liver Cancer: Disease Burden and Recent Trends.","authors":"Luan Chen, Jie Zhang, Jing-Yi Peng, Yuan Yuan, Yang Ding, Yi Wang, Xing-Xing He","doi":"10.1007/s11596-025-00064-w","DOIUrl":"10.1007/s11596-025-00064-w","url":null,"abstract":"<p><strong>Background: </strong>Liver cancer is the sixth most prevalent cancer globally and the third leading cause of cancer-related mortality, with more than three-quarters of a million deaths. This has presented a significant challenge and imposed considerable strain on global public health systems. Therefore, evaluating the updated global burden of liver cancer and its recent trends in incidence and mortality is highly important, as it provides valuable insights for shaping public health policies and improving clinical practices.</p><p><strong>Methods: </strong>The data in our article were obtained from the Global Burden of Disease Study 2021 (GBD 2021), which is available at https://vizhub.healthdata.org/gbd-results/ . In this study, liver cancer mortality and incidence were estimated via the cause of death ensemble (CODEm) model for every combination of sex, age, location, and year. The incidence was modelled with DisMod-MR 2.1, a Bayesian meta-regression tool. A linear regression model was employed to explore the temporal trend of these rates, formulated as y = α + βx + ε, where x represents the calendar year and y signifies the natural logarithm of the rate. For both incidence and mortality, the estimated annual percentage change (EAPC) was computed via the formula 100 × (e^β - 1), accompanied by a 95% confidence interval (CI).</p><p><strong>Results: </strong>First, 529,000 cases were newly diagnosed, with an age-standardized incidence rate (ASIR) of 6.15 per 100,000 people. In terms of etiology, the incidence of liver cancer caused by metabolic factors has tended to increase. Additionally, the incidence of liver cancer was greater in males and older populations. Several specific regions presented liver cancer burdens that overwhelmingly surpassed the expected age-standardized rates (ASRs) each year from 1990 to 2021, regardless of their respective sociodemographic index (SDI) scores.</p><p><strong>Conclusion: </strong>Our findings reveal that liver cancer continues to pose a significant public health challenge. These findings suggest that targeted interventions are needed to address both the infectious and non-infectious drivers of liver cancer in different socioeconomic settings. Hence, continued efforts in prevention through vaccination, antiviral therapies, and strategies to combat metabolic diseases are crucial for reducing the global burden of liver cancer in the coming decades.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"606-615"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of the Systemic Immune-Inflammation Index in Glioblastoma Patients and the Establishment of a Nomogram.","authors":"Hao Xu, Li-Hao Jiang, Sheng-Nan Yu, Qing-Lan Ren","doi":"10.1007/s11596-025-00047-x","DOIUrl":"10.1007/s11596-025-00047-x","url":null,"abstract":"<p><strong>Objective: </strong>The systemic immune-inflammation index (SII) has recently attracted significant interest as a new biomarker for predicting the prognosis of patients with glioblastoma (GBM). However, the predictive significance of it is still a subject of debate. This study intended to assess the clinical effectiveness of the SII in GBM and establish a nomogram.</p><p><strong>Methods: </strong>Receiver operating characteristic (ROC) curves were utilized to determine the optimal cut-off values of the SII. Kaplan-Meier (KM) survival curves were used to analyze the median overall survival (OS). Cox regression analysis was carried out to evaluate the associations between OS and different clinical factors. Based on the SII and clinical characteristics, a nomogram was constructed, and its value in clinical application was evaluated by means of decision curve analysis.</p><p><strong>Results: </strong>The optimal SII cut-off value was 610.13. KM analysis revealed that GBM patients with higher SII values had shorter OS (15.0 vs. 34.0 months, P = 0.044). Multivariate analysis demonstrated that a high SII was an independent predictor of poor outcome in GBM (HR = 1.79, P = 0.029). The nomogram incorporating the preoperative SII showed good predictive accuracy for GBM patient prognosis (C-index = 0.691).</p><p><strong>Conclusions: </strong>The SII is an independent predictive indicator for GBM. Patients with elevated SII levels tend to have a poorer prognosis. A nomogram combining the SII with clinical and molecular pathological features can assist clinicians in assessing the risk of death in GBM patients, providing a basis for individualized treatment decisions.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"481-493"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spontaneous Abortion of Females is Influenced by Their Male Partner's Heat Wave Exposure During Adolescence: A Nationwide Observational Study in China.","authors":"Yi-Ling Tan, Rui Qu, Wei-Qian Zhang, Dong-Dong Tang, Jing Yang, Xing Li","doi":"10.1007/s11596-025-00063-x","DOIUrl":"10.1007/s11596-025-00063-x","url":null,"abstract":"<p><strong>Objective: </strong>Heat wave exposure significantly impacts human health. Nevertheless, studies on the long-term effects of heat wave exposure during adolescence on adverse pregnancy outcomes (APOs) are rare. This study aimed to investigate the relationship between the long-term effects of heat wave exposure during adolescence and APOs.</p><p><strong>Methods: </strong>We analyzed data from 3,376 female and 3,013 male participants across 31 provinces in China. All adolescents (10-19 years old), early adolescents (10-14), and late adolescents (15-19) were chosen as exposure windows. Heat waves were defined as periods lasting 2‒4 consecutive days with the daily temperature exceeding the 75th, 90th, and 92.5th percentiles. We employed multivariate logistic regression models to assess the associations between exposure to heat waves during adolescence and APOs.</p><p><strong>Results: </strong>The results revealed significant associations between male exposure to heat wave events during late adolescence and spontaneous abortion (P < 0.05), which was more pronounced in South China. In contrast, no statistically significant associations were detected between males' exposure to heat wave events during adolescence and their partners' preterm birth (P > 0.05 for all comparisons). The exposure of females to heat waves during adolescence was not significantly associated with subsequent spontaneous abortion or preterm birth (P > 0.05 for all comparisons).</p><p><strong>Conclusions: </strong>This study demonstrates that spontaneous abortion in females is associated with heat wave exposure in their male partner during adolescence.</p>","PeriodicalId":10820,"journal":{"name":"Current Medical Science","volume":" ","pages":"594-605"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}