Unraveling the Molecular Underpinnings: The Therapeutic Impact of Aerobic Exercise on Anxiety Disorders.

IF 2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Current Medical Science Pub Date : 2025-04-28 DOI:10.1007/s11596-025-00048-w

Yi-Qing Rao, Zi-Yu Zhou, Zi-Qi Yang, Meng-Xin Liu, Xiao-Yu Gan, Xue-Fei Hu, Hong-Yang Wang, Hao Li, Man Li

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Abstract

Anxiety disorders, characterized by persistent apprehension, somatic symptoms and fatigue, are leading causes of disability worldwide. The burgeoning therapeutic potential of aerobic exercise has gained prominence as a leading non-pharmacological strategy, with evidence supporting its effectiveness in alleviating anxiety across diverse conditions. This review synthesizes current research to clarify the molecular mechanisms through which aerobic exercise ameliorates anxiety in terms of the effects of exercise on the hypothalamic-pituitary-adrenal (HPA) axis, the hepatic-brain axis and epigenetics; electroencephalographic alterations; inflammatory pathways; the balance between oxidative and nitrogenous stress; various substances, such as brain-derived neurotrophic factor (BDNF), atrial natriuretic peptide (ANP), and opioid peptides; and the 5-HT2C receptor and cannabinoid receptor type-1 (CB1R), among others, reflecting the positive modulatory effects of aerobic exercise on anxiety. As a non-pharmacological intervention, aerobic exercise has been demonstrated to be useful in a variety of medical applications and has considerable potential for ameliorating symptoms of anxiety.

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揭开分子基础：有氧运动对焦虑症的治疗作用。

以持续忧虑、躯体症状和疲劳为特征的焦虑症是全世界致残的主要原因。有氧运动作为一种领先的非药物策略，其新兴的治疗潜力已经获得了突出的地位，有证据支持它在缓解各种情况下的焦虑方面的有效性。本文从运动对下丘脑-垂体-肾上腺（HPA）轴、肝-脑轴和表观遗传学的影响等方面综述了有氧运动改善焦虑的分子机制；脑电图仪的改变;炎症通路;氧化和氮胁迫之间的平衡；脑源性神经营养因子（BDNF）、房利钠肽（ANP）、阿片肽等多种物质；以及5-HT2C受体和大麻素受体1型（CB1R）等，反映了有氧运动对焦虑的正调节作用。作为一种非药物干预，有氧运动已被证明在各种医学应用中是有用的，并且在改善焦虑症状方面具有相当大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Medical Science Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

4.70

自引率

0.00%

发文量

126

期刊介绍： Current Medical Science provides a forum for peer-reviewed papers in the medical sciences, to promote academic exchange between Chinese researchers and doctors and their foreign counterparts. The journal covers the subjects of biomedicine such as physiology, biochemistry, molecular biology, pharmacology, pathology and pathophysiology, etc., and clinical research, such as surgery, internal medicine, obstetrics and gynecology, pediatrics and otorhinolaryngology etc. The articles appearing in Current Medical Science are mainly in English, with a very small number of its papers in German, to pay tribute to its German founder. This journal is the only medical periodical in Western languages sponsored by an educational institution located in the central part of China.