Current NanomedicinePub Date : 2024-07-18DOI: 10.2174/0124681873304985240627061125
Aakriti Patel, Astha Singh, Neha Minocha
{"title":"Contemporary Nanoemulsion Research: Extensive Examination of Self-Nanoemulsifying Drug Delivery Systems","authors":"Aakriti Patel, Astha Singh, Neha Minocha","doi":"10.2174/0124681873304985240627061125","DOIUrl":"https://doi.org/10.2174/0124681873304985240627061125","url":null,"abstract":"\u0000\u0000The administration of new pharmaceutical compounds orally can pose certain challenges\u0000in terms of drug absorption, bioavailability, and pharmacokinetic profile. However, a widely\u0000recognized method for enhancing bioavailability involves lipid-based drug delivery systems.\u0000Lipid-based drug delivery systems (LBDDS) are the most favourable method for formulating\u0000medicines that have low solubility in water. Nanotechnology exerts a significant impact on the\u0000therapeutic efficacy of hydrophobic medicines and has emerged as a crucial method in the field of\u0000drug delivery research. Self-nanoemulsifying drug delivery systems (SNEDDs) are an important\u0000approach that combines the advantages of lipid-based drug delivery systems (LBDDS) and nanotechnology.\u0000SNEDDs are currently the favoured method for enhancing the formulation of pharmaceuticals\u0000that have low solubility in water. SNEDDs are homogenous mixtures that can self-emulsify\u0000spontaneously with gentle stirring, forming an oil-in-water emulsion that conveniently protects\u0000and creates a pathway for the lipophilic drug. The small particle size of <200nm increases\u0000the solubilisation capacity of the drug by increasing its surface area. SNEDDs have demonstrated\u0000the ability to enhance the bioavailability of medicines that are not easily soluble in water.\u0000SNEDDs stand apart from other solubility enhancement approaches due to their inclusion of\u0000biodegradable components, their ease of large-scale manufacture, and their numerous potential for\u0000drug targeting. The aim of the present review was to provide basic knowledge about formulation,\u0000applications, and benefits of using SNEDDs. A detailed manuscript has been prepared by doing a\u0000literature survey on databases like Google Scholar, SCOPUS, and Pubmed to review the current\u0000state of nanotechnology applications, industrial developments, and challenges for using SNEDDS\u0000as a novel delivery system is provided in this manuscript.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Current NanomedicinePub Date : 2024-07-05DOI: 10.2174/0124681873312057240622175745
Archna Singh, Avijit Mazumder, Saumya Das, Rashmi Mishra, M. Chaitanya
{"title":"Nanomedicine in Alzheimer’s Therapy: Enhancing Drug Delivery\u0000Strategies","authors":"Archna Singh, Avijit Mazumder, Saumya Das, Rashmi Mishra, M. Chaitanya","doi":"10.2174/0124681873312057240622175745","DOIUrl":"https://doi.org/10.2174/0124681873312057240622175745","url":null,"abstract":"\u0000\u0000Alzheimer's disease (AD), a progressive neurodegenerative disorder, arises from the\u0000buildup of beta-amyloid plaques within the intricate neural networks of the brain. A lasting remedy\u0000for Alzheimer's disease remains elusive, as current pharmaceutical options merely offer the potential\u0000to decelerate its advancement. Nevertheless, nanotechnology has demonstrated its efficacy\u0000in the realm of medical interventions. Nanotechnology holds immense promise for the treatment\u0000of Alzheimer's disease, particularly in the realms of disease detection and providing alternative\u0000therapeutic approaches. With its demonstrated superiority in medical applications, nanotechnology\u0000emerges as a potent tool with significant potential in addressing the complexities of\u0000Alzheimer's disease, offering enhanced diagnostics and novel treatment strategies. This feat is\u0000achieved by augmenting the efficacy of drug administration through the penetration and surmounting\u0000of the BBB.\u0000Nonetheless, it is crucial to thoroughly investigate and explore the limitations at hand, aiming to\u0000minimize undesired side effects and potential toxicity while enhancing medication absorption,\u0000thereby optimizing the overall therapeutic outcome. Cutting-edge breakthroughs in Alzheimer's\u0000disease treatment utilizing nanotechnology encompass a spectrum of remarkable advancements, including\u0000stem cell regeneration, nanomedicine, and neuroprotection. The present investigation\u0000delves into the remarkable strides made in nanotechnology, specifically examining its pivotal role\u0000in detecting and treating neurodegenerative disorders such as Alzheimer's while shedding light on\u0000the challenges ahead.\u0000","PeriodicalId":10818,"journal":{"name":"Current Nanomedicine","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141674547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}