The Durability of Simvastatin Nanoparticle Coatings on Dental Implant Healing-Abutments

Considering the success of dental implant treatments and their long-term effectiveness, it is important to prevent a series of biological complications such as peri-implant diseases. The development of antimicrobial coatings is known as a promising strategy to overcome these challenges. This study aimed to investigate the durability of simvastatin-loaded gelatin nanoparticle coating on titanium healing abutments. 40 titanium healing abutments were prepared in two groups, including the test group (titanium healing abutments coated with simvastatin nanoparticles, n=20) and the control group (titanium healing abutments without simvastatin nanoparticle coating, n=20). The dip-coating process was then applied to cover the surface of the healing-abutments. The morphology and composition of coatings were evaluated by Scanning Electron Microscope (SEM) and X-Ray Diffraction analysis (XRD), respectively. The resulting data from SEM and XRD confirmed the successful coating of simvastatin- loaded gelatin nanoparticles on the implant. Based on the Sidak test results, it was observed that the average weight before coating and immediately after coating had a significant difference. Also, the average weight between the initial time (after coating) and the time of 1 day after coating and 30 days after coating was not statistically significant. It means that the coating has been stable for at least 30 days. The difference between the initial weight (after coating) and 60 days after plating was significant. This means that the durability of the coating has decreased until the 60th day. The resulting data showed that the coating of gelatinous nanoparticles containing simvastatin on the titanium healing abutments was successful, and the durability of the coating lasted for at least 1 month.