Croatian Medical Journal最新文献_第5页

Transurethral drainage of prostatic abscess using pulsed Tm:YAG laser: a case report. 脉冲Tm:YAG激光经尿道前列腺脓肿引流术1例。

IF 2.1 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Branimir Lodeta

引用次数: 0

Ancient DNA studies performed in the forensic genetic laboratory in Slovenia: a narrative review. 在斯洛文尼亚法医遗传实验室进行的古代DNA研究：叙述性回顾。

IF 2.1 4区医学

Croatian Medical Journal Pub Date : 2026-03-20

Irena Zupanič Pajnič

{"title":"Ancient DNA studies performed in the forensic genetic laboratory in Slovenia: a narrative review.","authors":"Irena Zupanič Pajnič","doi":"","DOIUrl":"","url":null,"abstract":"Ancient DNA research is typically conducted in dedicated clean-room facilities; however, recent work in Slovenia has demonstrated that standard forensic technologies can also be successfully applied to archaeological remains. This article reviews studies conducted by our group on skeletal samples from different Slovenian sites. Comparative analyses of petrous bones from two archaeological contexts revealed how environmental conditions affect DNA preservation. Long-term storage effects were assessed by comparing freshly excavated remains with samples stored for 12 years under unregulated museum conditions. Intra-skeletal variability was examined through petrous bones, femurs, tali, calcanei, patellae, and teeth, and the potential of tooth cementum for minimally destructive extraction was evaluated. Differences in DNA quality between adult and non-adult skeletons were investigated. Genetic sexing was performed on 83 subadult skeletons to test the reliability of morphological methods, which often fail at this age. For optimized analyses, a DNA extraction protocol was developed that requires minimal bone powder. The PowerQuant real-time polymerase chain reaction (PCR) system proved a cost-effective predictor of successful short tandem repeat (STR) typing in degraded remains. Kinship studies, including that of four individuals from the 5th-6th century, demonstrated the utility of combining STR, single nucleotide polymorphism (SNP), and PCR-based massive parallel sequencing approaches, which improved statistical power and confirmed relatedness. Additionally, eye and hair color were predicted for skeletons dated to the 3rd-18th centuries. Overall, these results highlight that combining conventional forensic approaches with strict contamination control can generate reliable genetic data from archaeological samples and offer valuable insights into past populations.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"67 1","pages":"30-38"},"PeriodicalIF":2.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13014292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In reply to: "Post-COVID lung injury and the need for longitudinal histology". 回复：“covid - 19后肺损伤和纵向组织学的需要”。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Grgur Salai, Xxx Yyy, Jasna Tekavec-Trkanjec

引用次数: 0

Assuming the right approach in cerebrofacial arteriovenous metameric syndrome: a case report. 脑面动静脉异长综合征的正确入路推定1例。

IF 2.1 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Maša Malenica, Vladimir Kalousek, Ana Smolić, Monika Kukuruzović, Tena Trbojević, Tomislav Sajko

{"title":"Assuming the right approach in cerebrofacial arteriovenous metameric syndrome: a case report.","authors":"Maša Malenica, Vladimir Kalousek, Ana Smolić, Monika Kukuruzović, Tena Trbojević, Tomislav Sajko","doi":"","DOIUrl":"","url":null,"abstract":"Cerebrofacial arteriovenous metameric syndrome (CAMS) is a rare nonhereditary disease, amounting to only 0.5% of all cerebral vascular malformations. It is characterized by vascular malformations in a metameric distribution involving the cerebrofacial region. We present a case of a 14-year-old girl in whom the first vascular lesion appeared on the tip of her nose at the age of 18 months. This lesion reoccurred on several occasions during her childhood, with exacerbations coinciding with common rhinitis and several nose bleeds. She was unsuccessfully treated with laser therapy and topical selective beta-blockers prior to further investigations. Combined cerebrofacial arteriovenous malformation (CAMS I+II) was diagnosed by magnetic resonance imaging of the paranasal sinuses, orbits, and brain with cerebral angiography and confirmed by digital subtraction angiography. Clarifying the correct diagnosis enabled us to abort a potential surgical approach and to assume an expectant approach unless the patient develops neurological symptoms. Timely, complete, and adequate imaging investigations are necessary in cases of facial vascular malformations. This report for the first time describes the specific angioarchitecture involving two types of CAMS.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 6","pages":"456-459"},"PeriodicalIF":2.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-perceived quality of life, health, and physical activity among older adults: the roles of marital status and residence during the COVID-19 pandemic. 老年人自我感知的生活质量、健康和身体活动：婚姻状况和居住地在COVID-19大流行期间的作用

IF 2.1 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Nada Pjevač Keleminić, Venija Cerovečki, Mirjana Kujundžić Tiljak

{"title":"Self-perceived quality of life, health, and physical activity among older adults: the roles of marital status and residence during the COVID-19 pandemic.","authors":"Nada Pjevač Keleminić, Venija Cerovečki, Mirjana Kujundžić Tiljak","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To examine the associations between marital status, place of residence, self-reported health status, quality of life, and physical activity among older adults during the COVID-19 pandemic.Methods: This cross-sectional study enrolled 962 participants aged 65 and older, surveyed between March 2020 and May 2023. Respondents were categorized according to marital status (married/living with a partner, single, divorced, widowed) and place of residence (own home vs nursing home). Standardized instruments were used: the Short Form Health Survey-36 for health status, the Personal Well-being Index for quality of life, and the Croatian short version of the International Physical Activity Questionnaire.Results: Respondents who were married or living with a partner reported significantly higher levels of physical activity, better physical and mental health, and greater life satisfaction than single, divorced, or widowed respondents (P<0.001). Community-dwelling respondents scored significantly higher on most health and quality-of-life indicators than nursing home residents, except for perceived future security.Conclusion: Marital status and living arrangements significantly affected the self-perceived health, physical activity, and quality of life of older adults during the COVID-19 pandemic. The results emphasize the importance of social support and residential context in promoting healthy aging.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 6","pages":"390-398"},"PeriodicalIF":2.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health economic evaluations of myasthenia gravis: a systematic review. 重症肌无力的健康经济评价：系统综述。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Frenki Çipi, Chantal Koloneci, Artejana Marku, Kamila Domi, Xhoana Tahiraj, Visar Malaj, Malvina Hoxha

{"title":"Health economic evaluations of myasthenia gravis: a systematic review.","authors":"Frenki Çipi, Chantal Koloneci, Artejana Marku, Kamila Domi, Xhoana Tahiraj, Visar Malaj, Malvina Hoxha","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To systematically review the latest pharmacoeconomic evidence regarding the costs associated with myasthenia gravis (MG) care and treatment.Methods: We searched the National Health Service Economic Evaluation Database and PubMed for articles in English from any country reporting health economic analyses of pharmacological treatments, hospitalization, or surgical procedures related to MG.Results: The study included 31 articles showing a considerable variability in the costs and cost-effectiveness of MG treatments across regions, therapies, and health care settings. Traditional therapies such as plasma exchange (PLEX) and intravenous immunoglobulin (IVIg) differ notably in cost, with PLEX generally being less expensive. Newer clinically effective treatments such as efgartigimod and eculizumab raise concerns about their economic sustainability, whereas rituximab might be a more affordable alternative in certain contexts.Conclusion: Future research should compare cost-effectiveness across health care systems, incorporating local pricing and reimbursement, and collecting real-world data.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 6","pages":"436-445"},"PeriodicalIF":2.3,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ChatGPT and Gemini in warfarin counseling. ChatGPT和Gemini在华法林咨询。

IF 2.1 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Muhammet Hüseyin Erkan, Ömer Faruk Rahman, Abdullah Güner, Fevzi Ayyıldız, Emin Barbarus

{"title":"ChatGPT and Gemini in warfarin counseling.","authors":"Muhammet Hüseyin Erkan, Ömer Faruk Rahman, Abdullah Güner, Fevzi Ayyıldız, Emin Barbarus","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To compare the accuracy, scientific adequacy, and clarity of responses provided by ChatGPT-4o and Gemini to frequently asked patients' questions about warfarin use.Methods: Forty patients' questions were posed to ChatGPT and Gemini using the zero-shot method. Four cardiovascular surgeons evaluated the responses for adequacy, scientific accuracy, and clarity on a 5-point Likert scale. The first and second set of data evaluations were separated by seven days to minimize any memory effect. The experts were blinded to the type of LLM that created the response.Results: ChatGPT responses were significantly shorter (187.3±47.6 vs 291.4±98.1 words; P<0.001) but scientifically more adequate (4.38±0.30 vs 4.17±0.35; P=0.004). Gemini scored higher in terms of clarity (4.69±0.24 vs 4.48±0.33; P<0.001). The two models did not significantly differ in terms of accuracy (P = 0.606).Conclusion: Both LLMs provide reliable and understandable information for warfarin counseling. While ChatGPT provides dense and scientifically detailed responses, Gemini excels in clarity and user-friendly communication. However, expert supervision and appropriate clinical guidance are critical for safe and comprehensive guidance.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 6","pages":"399-405"},"PeriodicalIF":2.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12856749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Feasibility and first-year findings of a pilot program of prostate cancer screening in Croatia (CROState). 克罗地亚前列腺癌筛查试点方案的可行性和第一年的结果（CROState）。

IF 2.1 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Željko Kaštelan, Tomislav Kuliš, Igor Grubišić, Ivana Brkić Biloš, Maja Prutki, Marija Bubaš, Krunoslav Capak

{"title":"Feasibility and first-year findings of a pilot program of prostate cancer screening in Croatia (CROState).","authors":"Željko Kaštelan, Tomislav Kuliš, Igor Grubišić, Ivana Brkić Biloš, Maja Prutki, Marija Bubaš, Krunoslav Capak","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To evaluate the feasibility, participation rate, diagnostic pathway performance, and early detection outcomes of the first year of the Croatian pilot prostate cancer screening program (CROState) implemented in Zagreb.Methods: This prospective pilot program invited men aged 55-69 years without a prior prostate cancer diagnosis or prostate-specific antigen (PSA) testing in the past 12 months. Recruitment was conducted by general practitioners. Men with PSA>4 ng/mL underwent repeat testing, and if PSA was elevated again, they were referred to one of two university hospitals for further evaluation. The diagnostic pathway included multiparametric magnetic resonance imaging, urological examination, and transperineal fusion biopsy when indicated. All confirmed cancer cases were reviewed by a multidisciplinary team.Results: A total of 5251 men were invited to the program, of whom 4930 (93.9%) participated in PSA testing. Elevated PSA was detected in 419 (8.5%). Only 157 (37.5%) men completed repeat PSA testing, and 123 men were referred for hospital evaluation. Eighty-eight patients completed advanced diagnostics, with 83 undergoing magnetic resonance imaging. Forty-two men proceeded to biopsy, of whom 27 had positive results (64.3%). Most cancers were clinically significant; only two men fulfilled criteria for active surveillance. The main challenge was incomplete adherence to repeat PSA testing.Conclusion: The CROState pilot demonstrated high initial participation and high detection rate of prostate cancer, with a few clinically insignificant tumors, when combining PSA testing with advanced imaging and targeted biopsy. Limited compliance with repeat PSA testing must be addressed before wider national implementation.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 6","pages":"382-389"},"PeriodicalIF":2.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Healthcare professionals' views on training, standards, and resources for extracorporeal membrane oxygenation: a cross-sectional survey. 医疗保健专业人员对体外膜氧合的培训、标准和资源的看法：一项横断面调查。

IF 2.1 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Bekzhan A Permenov, Olena Zimba, Marlen Yessirkepov, Darkhan Suigenbayev, Burhan Fatih Kocyigit

{"title":"Healthcare professionals' views on training, standards, and resources for extracorporeal membrane oxygenation: a cross-sectional survey.","authors":"Bekzhan A Permenov, Olena Zimba, Marlen Yessirkepov, Darkhan Suigenbayev, Burhan Fatih Kocyigit","doi":"","DOIUrl":"","url":null,"abstract":"Aim: To assess health care professionals' knowledge and opinions regarding extracorporeal membrane oxygenation (ECMO) use, training, standards, and resource availability.Methods: This cross-sectional study employed an online self-administered survey to evaluate health care professionals' knowledge and opinions concerning ECMO procedures. The survey consisted of multiple-choice and open-ended questions inquiring about demographics, ECMO practices, training and certification experiences, ECMO use during the COVID-19 pandemic, and obstacles to ECMO implementation.Results: The study enrolled 89 health care professionals from 12 countries. The respondents were most frequently from Kazakhstan (67.4%), Turkey (5.6%), Croatia (5.6%), and Ukraine (5.6%). Notably, 61.8% of respondents supported ECMO procedures performed by certified specialists. The respondents believed that the main ECMO indications were respiratory failure (83.1%), cardiopulmonary failure (69.6%), heart and lung transplantation (64.1%), and cardiogenic shock (58.4%). Major obstacles to ECMO implementation were reported to be high costs (53.9%), inadequately qualified staff (52.8% for physicians, 41.6% for nurses), and restricted availability of ECMO devices (42.7%).Conclusion: The findings emphasize the need for standardized training, wider availability of ECMO standards, and efforts to address resource-related barriers to ECMO access. Our results primarily reflect practices in Kazakhstan and should be interpreted in light of the study's restricted geographical coverage.","PeriodicalId":10796,"journal":{"name":"Croatian Medical Journal","volume":"66 6","pages":"419-428"},"PeriodicalIF":2.1,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12836024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of pharmacogenomics in personalized medicine. 药物基因组学在个体化医疗中的作用。

IF 2.3 4区医学

Croatian Medical Journal Pub Date : 2026-01-05

Nada Božina, Julia Carolin Stingl

引用次数: 0