Current Eye Research最新文献

{"title":"Management of Refractory Glaucoma, a New Surgical Paradigm: Review of the Literature.","authors":"Victoria Heintz, Paul Bastelica, Christophe Baudouin, Yves Lachkar, Antoine Labbé","doi":"10.1080/02713683.2025.2494799","DOIUrl":"https://doi.org/10.1080/02713683.2025.2494799","url":null,"abstract":"<p><strong>Purpose: </strong>To review current therapeutic strategies and innovations in the management of refractory glaucoma, with a focus on recent advancements in implantable surgical devices.</p><p><strong>Methods: </strong>A comprehensive literature search across PubMed, Embase, and Cochrane Library, included terms such as \"refractory glaucoma,\" \"posterior drainage implants,\" \"cyclodestruction,\" and \"minimally invasive glaucoma surgery.\" Articles discussing surgical and medical interventions, as well as device innovations, were included.</p><p><strong>Results: </strong>Therapeutic options include creating new sites for filtering surgery, posterior drainage implants, minimally invasive devices, cyclodestruction, or continuing medical management without surgery.</p><p><strong>Conclusion: </strong>Therapeutic decisions regarding refractory glaucoma should be made on a thoughtful, individualized basis, carefully weighing the expected benefits against the potential risks for the patient. Recent innovations in implantable devices expand the range of surgical possibilities.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the Study of \"Expression of PAX6 and Keratocyte-Characteristic Markers in Human Limbal Stromal Cells of Congenital Aniridia and Healthy Subjects, In Vitro\".","authors":"Sücattin İlker Kocamış, Bedia Kesimal","doi":"10.1080/02713683.2025.2494797","DOIUrl":"https://doi.org/10.1080/02713683.2025.2494797","url":null,"abstract":"","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-2"},"PeriodicalIF":1.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vivo</i> Dose-Response Effect of 300 nm UV Radiation on the Ocular Lens Epithelial Cells Count.","authors":"Zhaohua Yu","doi":"10.1080/02713683.2025.2490771","DOIUrl":"https://doi.org/10.1080/02713683.2025.2490771","url":null,"abstract":"<p><strong>Purpose: </strong>To assess how varying doses of ultraviolet radiation affect the distribution of lens epithelial cells.</p><p><strong>Methods: </strong>Forty Sprague Dawley rats were exposed unilaterally to ultraviolet radiation-300 nm at doses of 1, 3, 6, and 8 kJ/m². One week after exposure, lenses from both the exposed and the unexposed contralateral eyes were collected for analysis. A midsagittal section from each lens was stained with 4',6-diamidino-2-phenylindole and examined using fluorescence microscopy to evaluate lens epithelial cell distribution.</p><p><strong>Results: </strong>The difference in lens epithelial cell density between exposed and non-exposed eyes at doses of 1, 3, 6, and 8 kJ/m² was measured as 95% confidence interval values of -0.1 ± 2.1, 0.1 ± 3.0, -4.1 ± 1.4, and -2.9 ± 2.7 cell·μm^-1·10^-2, respectively. Data were analyzed using a linear model with the initial density difference set to zero. The slope of the dose-response relationship was estimated as 95% confidence interval -0.4 ± 0.1 cell·μm·kJ^-1·10¹⁰.</p><p><strong>Conclusion: </strong>Exposure to ultraviolet radiation-300 nm reduces lens epithelial cell density. The linear model provides a quantitative understanding of the relationship between ultraviolet radiation dose and cell density.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of the 360° Versus 180° of Selective Laser Trabeculoplasty (SLT) in the Treatment of Open Angle Glaucoma (OAG) and Ocular Hypertension (OHT): A Comprehensive Systematic Review and Meta-Analysis.","authors":"Dillan Cunha Amaral, Jaime Guedes, Pedro Henrique Santana Moreira, Sacha Pereira, Lucas Neves de Oliveira, Ana Luiza Machado Ribeiro Pimentel, Karina de Oliveira Caneca, Mário Luiz Ribeiro Monteiro, Ricardo Noguera Louzada","doi":"10.1080/02713683.2025.2485223","DOIUrl":"https://doi.org/10.1080/02713683.2025.2485223","url":null,"abstract":"<p><strong>Purpose: </strong>There are several divergences in the literature regarding the safety and effectiveness of selective laser trabeculoplasty application at 360° vs. 180°. This systematic review and meta-analysis aimed to compare the efficacy and safety of selective laser trabeculoplasty at 180° and 360° in open-angle glaucoma and ocular hypertension.</p><p><strong>Methods: </strong>This systematic review and meta-analysis, registered with International Prospective Register of Systematic Reviews (CRD42024501311), conducted searches in PubMed, Embase, Web of Science, and Cochrane Library from inception to January 2024. The protocol is registered in International Prospective Register of Systematic Reviews under the same registration number. Primary outcomes included mean intraocular pressure change at 1, 6, 12, and 24 months, success ratio, and adverse events. Statistical analysis utilized R version 4.3.2 (R Foundation for Statistical Computing, Vienna, Austria).</p><p><strong>Results: </strong>The meta-analysis included nine studies, involving 1065 eyes. Compared to 180° selective laser trabeculoplasty, 360° selective laser trabeculoplasty demonstrated superior success ratios (odds ratio 1.63; <i>p</i> = .002) and intraocular pressure reduction at 1 (mean difference -0.99; <i>p</i> < .01), 6 (mean difference -1.37; <i>p</i> < .01), and 12 (mean difference -1.41; <i>p</i> < .01) months. Although the intraocular pressure difference at 24 months was not statistically significant, a subgroup analysis showed that one study influenced heterogeneity and effect size. Adverse event rates did not significantly differ between the groups.</p><p><strong>Conclusion: </strong>360° selective laser trabeculoplasty is preferred for initial laser therapy in open-angle glaucoma and ocular hypertension. It achieves maximal intraocular pressure reduction while maintaining an excellent safety profile.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waveform Score Influences the Outcome Metrics of the Ocular Response Analyzer in Patients with Keratoconus and in Healthy Controls.","authors":"Phillip T Yuhas, Maddison M Fortman, Michael Nye, Ashraf M Mahmoud, Cynthia J Roberts","doi":"10.1080/02713683.2025.2489607","DOIUrl":"https://doi.org/10.1080/02713683.2025.2489607","url":null,"abstract":"<p><strong>Purpose: </strong>To test whether the intraocular-pressure (IOP) and biomechanical outcome metrics from the Ocular Response Analyzer (ORA) differ between the measurement with the highest waveform score and the average of four measurements of any waveform score in participants with keratoconus and in controls.</p><p><strong>Methods: </strong>Patients with diagnosed keratoconus and healthy controls were recruited prospectively. Four measurements were made using a third-generation ORA. Goldmann-correlated IOP (IOPg), corneal-compensated IOP (IOPcc), corneal hysteresis (CH), corneal resistance factor (CRF), waveform score, and six waveform parameters (p1area, p2area, w1, w2, h1, and h2) were considered as outcome metrics. In the left eye, outcomes from the measurement with the highest waveform score were compared against averaged outcomes from four measurements of any waveform score using either paired t-tests or Wilcoxon signed-rank tests. Receiver operating characteristic (ROC) curves tested ability of both data-selection approaches to differentiate the cohorts.</p><p><strong>Results: </strong>One-hundred ninety-two (<i>N</i> = 192) participants were enrolled. In the control cohort (<i>n</i> = 145), waveform score, CH, p2area, and h2 were all significantly greater for the best-waveform-score measurement than for the average-waveform-score measurement. IOPcc and w2 were significantly less for the best-waveform-score measurement than for the average-waveform-score measurement. In the keratoconus cohort (<i>n</i> = 47), waveform score, p1area, p2area, h1, and h2 were all significantly greater for the best-waveform-score measurement than for the average-waveform-score measurement. W2 was significantly less for the best-waveform-score measurement than for the average-waveform-score measurement. The area under the ROC curve was high for both data-selection approaches.</p><p><strong>Conclusion: </strong>In general, the best measurement had higher and narrower waveform peaks than the averaged measurement, which suggests better alignment between the device and the eye in the former than in the latter. Thus, making multiple measurements and then analyzing the one with the single highest quality may be preferred to analyzing the average of the group.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of Thioredoxin and Thioredoxin Interacting Protein with Type 2 Diabetes Mellitus Complicated with Diabetic Retinopathy.","authors":"Jiasu Liu, Xuebin Yu, Maryam Chudhary, Hui Qi, Na Zhang, Shiwen Zhong, Qi Zhao, Xiang Ren, Hui Kong, Li Kong","doi":"10.1080/02713683.2025.2487069","DOIUrl":"https://doi.org/10.1080/02713683.2025.2487069","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between Thioredoxin (Trx), Thioredoxin interacting protein (Txnip), and the severity of diabetic retinopathy (DR).</p><p><strong>Methods: </strong>The study involved a total of 101 eyes, comprising of 31 healthy controls, 24 diabetic patients with no clinically detectable retinopathy (NDR group), 26 patients with non-proliferative DR (NPDR group), and 20 patients with proliferative DR (PDR group), including 62 males and 49 females, average aged 61.65 ± 9.4. Retinal morphology was evaluated using spectral domain optical coherence tomography (SD-OCT), while retinal function was assessed using full-field electroretinogram (ffERG) to record the amplitudes and implicit time. The correlation between serum Trx, Txnip, and DR was analyzed using Spearman correlation analysis.</p><p><strong>Results: </strong>In the early stage of DR, there was no significant difference in macular retinal thickness between groups; in the PDR group, there was a significant increase compared to both the NDR and control groups, particularly in the central fovea (<i>p</i> < 0.0001). Additionally, the amplitude and implicit time of oscillatory potentials exhibited a significant difference between the NDR and control groups at an early stage of DR (<i>p</i> < 0.001). Furthermore, the amplitude of rod and cone ERG decreased significantly in the early stage of DR, while the implicit time began to decline in the NPDR stage. The serum levels of Trx and Txnip exhibited a positive correlation with the progression of DR (<i>r</i> = 0.851, 0.762). Conversely, a negative correlation was observed between the serum levels of Trx and Txnip and the amplitudes of ERG, while a positive correlation was observed with the implicit time of ERG.</p><p><strong>Conclusions: </strong>The serum levels of Trx and Txnip exhibit a positive correlation with retinopathy associated with type 2 diabetes mellitus (T2DM), and thus may be utilized as a potential target for the timely diagnosis and treatment of DR.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Pterygium Extended Removal Combined with Conjunctival Autograft and Amniotic Membrane Transplantation.","authors":"Kuanshu Li, Kehua Wang, Guihua Zou, Congxiang Wang, Wei Huang","doi":"10.1080/02713683.2025.2488022","DOIUrl":"https://doi.org/10.1080/02713683.2025.2488022","url":null,"abstract":"<p><strong>Purpose: </strong>To observe the Long-term results of pterygium extended removal combined conjunctival autograft and amniotic membrane transplantation.</p><p><strong>Methods: </strong>This is a prospective study of 666 eyes (606 patients, 332 right eyes and 336 left eyes). All patients underwent pterygium extended removal combined conjunctival autograft and amniotic membrane transplantation in a same hospital. The primary outcome measures included the cosmetic appearances and recurrence rate; the secondary outcome measures were some serious complications, like Keratitis, conjunctival cyst and conjunctival granuloma.</p><p><strong>Results: </strong>606 patients (82.34% of surviving) were able to be followed up. The mean follow-up period was 29.96 ± 13.34 months. Recurrence was noted in 7 eyes (1.05%), and there were no serious complications. 89.04% of eyes were graded as having excellent cosmetic appearance.</p><p><strong>Conclusions: </strong>The long-term recurrence rate of pterygium extended removal combined conjunctival autograft and amniotic membrane Graft is very low, and the long-term cosmetic appearance is excellent. And also, there were no other serious complications.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM2.5 Stimulates Macrophage-Derived Thymic Stromal Lymphopoietin (TSLP) to Induce a Mouse Model of Allergic Conjunctivitis.","authors":"Yazhou Qin, Yue Bian, Jingbo Hu, Yuyao Qu, Ruoying Liu, Jixian Ma, Jingming Li, Bo Ma, Cheng Pei, Ning Gao","doi":"10.1080/02713683.2025.2487066","DOIUrl":"https://doi.org/10.1080/02713683.2025.2487066","url":null,"abstract":"<p><strong>Purpose: </strong>Increasing epidemiologic evidence has indicated that PM2.5 exposure is strongly correlated with the prevalence of allergic conjunctivitis (AC), but there is no experimental model for elucidating the underlying mechanism involved. We established a stable PM2.5-induced mouse model of AC to explore the adverse effects of PM2.5 on the ocular surfaces and the underlying mechanisms involved.</p><p><strong>Methods: </strong>BALB/c mice were sensitized by intraplanar injection of 200 μg PM2.5 on day 0 and challenged for 10 consecutive days, beginning on day 9, with eye drops containing 12.5 mg/mL PM2.5. Assessments of the ocular surfaces, eye blink counts, and tear secretion were performed to evaluate clinical symptoms. The whole eyes were harvested for histopathological and immunofluorescence analyses, the conjunctiva was isolated for Western blotting, and the sera were subjected to IgE ELISA to evaluate the immune characteristics and TSLP-related pathway expression. Furthermore, mouse bone marrow-derived macrophages (BMDMs) were incubated with 25 μg/mL PM2.5 for 24 h. Cellular protein and RNA were extracted for Western blotting and RNA sequencing.</p><p><strong>Results: </strong>PM2.5 exposure induced clinical manifestations and pathological changes similar to those in human AC. The sensitization and challenge evoked Th2 responses and serum IgE production. PM2.5 exposure mediated TSLP production in macrophages and aggravated allergic inflammation through the TSLP-TSLPR and TSLP-OX40L signaling pathways <i>in vivo</i>. Macrophages produced TSLP and polarized to the M1 phenotype after PM2.5 administration <i>in vitro</i>.</p><p><strong>Conclusions: </strong>These results demonstrate a reproducible method for establishing a PM2.5-induced AC model. In addition, PM2.5 exposure stimulated macrophages to secrete TSLP and enhance allergic inflammation.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Powered Revision Endoscopic DCR and Utility of Three-Dimensional Computed Tomography Dacryocystography (3D CT-DCG).","authors":"Ayushi Agarwal, Sumer Doctor, E Ravindra Mohan, Mohammad Javed Ali, Nandini Bothra","doi":"10.1080/02713683.2025.2487067","DOIUrl":"https://doi.org/10.1080/02713683.2025.2487067","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the causes of failure in primary external dacryocystorhinostomy versus endoscopic dacryocystorhinostomy and surgical outcomes of powered revision endoscopic dacryocystorhinostomy and the role of pre-operative lacrimal imaging in surgical planning.</p><p><strong>Methods: </strong>Retrospective, interventional study on patients with an earlier failed dacryocystorhinostomy who underwent revision endoscopic dacryocystorhinostomy surgery from January 2016 to June 2024. Data collected included the demographic profile, clinical presentation, details of prior intervention, pre- and intra-operative endoscopic findings, adjunctive procedures, and the computed tomography dacryocystography characteristics. Successful outcomes were anatomic success (patent irrigation) and functional success (resolution of epiphora).</p><p><strong>Results: </strong>Two hundred and ten lacrimal drainage systems of 205 patients who underwent revision endoscopic dacryocystorhinostomy were analyzed. The mean age at the presentation was 45 years. Of the 210 lacrimal surgeries, 17 (8%) had multiple surgeries, 129 (61%) underwent prior endoscopic dacryocystorhinostomy, and 81 (39%) had external dacryocystorhinostomy. One hundred and eight (51%) primary surgeries were performed by an ophthalmologist, 94 (45%) by an ear nose throat surgeon, and eight (3.8%) were unknown. The most common cause of failure was complete cicatricial closure (73%) followed by interfering osteo-septal synechiae (20%). The most common location of previous osteotomy was inferior (37%). Preoperative three-dimensional computed tomography-dacryocystography showed inadequate superior osteotomy in 62.5%, and sac displacement in 57%. Three-dimensional computed tomography-dacryocystography correlated with intra-operative findings in 96% cases. Adjunct procedures were performed in 42% of revision endoscopic dacryocystorhinostomy's. Successful outcome was achieved in 199 (94.7%), regardless of nature of primary surgery (<i>p</i> = .63), at 3-months follow-up.</p><p><strong>Conclusion: </strong>With proper planning, comparable success to external approach can be achieved with a revision endoscopic dacryocystorhinostomy. Computed tomography dacryocystography in select cases can guide surgical planning and anticipate intra-operative challenges.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Production and Study of Flexible Acrylic Keratoprosthesis.","authors":"Victoria H Fan, Michael G Sun, Ahmed F Al-Qahtani, Ibraim V Vieira, Charles Q Yu","doi":"10.1080/02713683.2025.2485186","DOIUrl":"https://doi.org/10.1080/02713683.2025.2485186","url":null,"abstract":"<p><strong>Purpose: </strong>To design, produce and implant one-piece flexible acrylic keratoprostheses for the treatment of corneal blindness.</p><p><strong>Methods: </strong>A protocol was developed to produce flexible acrylic sheets of differing properties, and their mechanical characteristics were evaluated. To assess <i>in vitro</i> toxicity, an MTT assay was performed. 3D-printed injection molding technique of this material was designed to fabricate flexible keratoprostheses with complex shapes. A pilot study involving a 3-month implantation in a rabbit was conducted, including histological analysis.</p><p><strong>Results: </strong>Flexible acrylic copolymer sheets of high clarity were produced by free radical polymerization. Their mechanical properties and refractive indices could be altered with different material formulations. They demonstrated no <i>in vitro</i> toxicity in human corneal cells <i>via</i> MTT assay. 3D printed silver molds allowed for the production of keratoprostheses of complex shapes made from these materials. Surgical implantation resulted in clear implant at 3 months.</p><p><strong>Conclusions: </strong>Molding of flexible acrylic allows for production of one-piece keratoprostheses of a complex shape and opens new possibilities for the treatment of corneal blindness.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}