Critical Reviews in Biotechnology最新文献_第6页

miRNAs in cardiovascular disease and an update on emerging trend in electrochemical biosensors for miRNA detection. 心血管疾病中的miRNA和电化学生物传感器miRNA检测的最新趋势。

IF 7.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-03-01 Epub Date: 2025-11-23 DOI: 10.1080/07388551.2025.2584689

Peyman HalvaeiKhanekahdani, Yuao Wu, Hang Thu Ta

{"title":"miRNAs in cardiovascular disease and an update on emerging trend in electrochemical biosensors for miRNA detection.","authors":"Peyman HalvaeiKhanekahdani, Yuao Wu, Hang Thu Ta","doi":"10.1080/07388551.2025.2584689","DOIUrl":"10.1080/07388551.2025.2584689","url":null,"abstract":"Cardiovascular disease (CVD) is a leading global cause of death and strains healthcare systems significantly. Early diagnosis is crucial and can be achieved through cardiac biomarker assessment, which enables timely treatment and reduces mortality rates. Traditional diagnostic methods require large hospital equipment for electrocardiography and laboratory analysis, leading to lengthy procedures. To address this, there is increasing interest in advanced biosensing technologies for rapid CVD marker screening. Advances in nanotechnology and bioelectronics have led to new biosensor platforms that offer rapid detection, accurate quantification, and continuous monitoring. This comprehensive review focuses on blood-based RNA cardiac biomarkers, which are widely used in clinical settings, and examines the development of electrochemical nanobiosensors for detecting RNA biomarkers. It provides a thorough evaluation of the benefits and drawbacks of these biosensing devices and offers insights into future research directions for electrochemical nanobiosensors in CVD, particularly those based on RNA markers.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"269-296"},"PeriodicalIF":7.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145585901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of novel enzymes with the incorporation of noncanonical amino acids. 结合非规范氨基酸的新型酶的设计。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1080/07388551.2025.2612060

Liang Cheng, Lirong Yang, Zhongdi Song, Haoran Yu

{"title":"Design of novel enzymes with the incorporation of noncanonical amino acids.","authors":"Liang Cheng, Lirong Yang, Zhongdi Song, Haoran Yu","doi":"10.1080/07388551.2025.2612060","DOIUrl":"10.1080/07388551.2025.2612060","url":null,"abstract":"Enzymes are highly efficient biocatalysts known for their chemical, regio-, and stereoselectivity, making them valuable in industrial applications. While directed evolution has expanded the scope of enzyme-catalyzed reactions, the range of enzymatic reactions remains limited compared to reactions catalyzed by chemical catalysts. Computational enzyme design has achieved de novo enzyme design, but the approach is often complex, time-intensive, and has a low success rate. A promising strategy to design novel enzymes involves developing noncanonical amino acids (ncAAs) with catalytic potential and integrating them into protein scaffolds via genetic codon expansion technology. This method combines the novel reactivity of ncAAs with the high selectivity provided by protein scaffolds, significantly enhancing the diversity of enzyme-catalyzed reactions. This review discusses recent advancements in novel enzyme design using ncAAs, including those being used as catalytic groups, metal-coordinating groups, heme ligands, and photocatalytic groups. The article emphasizes the broad potential of using ncAAs in enzyme design to expand the diversity of enzyme-catalyzed reactions, and outlooks the potential applications of artificial intelligence technology in this area.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"161-182"},"PeriodicalIF":8.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global advances in magnetotactic bacteria: ecology, evolution and biotechnological applications of BioMagnets with a focus on magnetic hyperthermia. 趋磁细菌的全球进展：生物磁体的生态学、进化和生物技术应用，重点是磁热疗。

IF 7.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-03-01 Epub Date: 2025-11-19 DOI: 10.1080/07388551.2025.2583455

Kruti J Mistry, Anoop R Markande, Prabhin Sukumaran, Janki K Patel

{"title":"Global advances in magnetotactic bacteria: ecology, evolution and biotechnological applications of BioMagnets with a focus on magnetic hyperthermia.","authors":"Kruti J Mistry, Anoop R Markande, Prabhin Sukumaran, Janki K Patel","doi":"10.1080/07388551.2025.2583455","DOIUrl":"10.1080/07388551.2025.2583455","url":null,"abstract":"Magnetotactic bacteria (MTB) are an ecologically and physiologically diverse group that synthesizes intracellular nanoparticles, known as magnetosomes (biomagnetic minerals), enabling them to navigate along geomagnetic field lines through microbial magnetoreception. This review provides a comprehensive overview of MTB research from 1979 to 2024, encompassing (i) the cultivation approach, (ii) diverse ecosystems, such as: volcanic lakes, coral reefs, paleosols, acidic peatland, and deep-sea hydrothermal fields, and (iii) ecological and evolutionary studies. To date only two phyla, Pseudomonadota (specifically Alphaproteobacteria, Desulfobacterota, and Gammaproteobacteria) and Nitrospirota have been reported for magnetosomes based biomineralization. Recent advancements in methodologies, including: cultivation-independent approach to survey Magnetosome Gene Cluster (MGCs), 16S rRNA gene characterization, and Cultivation dependent approach for successful isolation of an axenic culture/s of novel MTB strains from diverse ecosystems. The review also highlights the significance of MTB-derived Magnetofossils from paleoenvironmental sediments and emphasizes the importance of Cultivation-independent approach using group-specific primers and alphaproteobacterial sets of primers for direct detection of MTB from the environmental samples. Furthermore, the expanding application of magnetosomes in biotechnology, such as: magnetic hyperthermia for cancer treatment, targeted drug delivery, MTB-based microrobots for isolation of pathogens, and environmental remediation (e.g., pollutant and heavy metal removal from waste water), are discussed.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"245-268"},"PeriodicalIF":7.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145556485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural diversity, biosynthesis, and extraction of brown algae fucoidan and its bio-stimulant applications in crop improvement. 褐藻褐藻聚糖的结构多样性、生物合成、提取及其在作物改良中的应用。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-03-01 Epub Date: 2026-01-11 DOI: 10.1080/07388551.2025.2582742

Dhanya Punjamgod, Anjana Kurinjery, Muthusamy Annamalai, Raja Rathinam, Arunkumar Kulanthaiyesu

{"title":"Structural diversity, biosynthesis, and extraction of brown algae fucoidan and its bio-stimulant applications in crop improvement.","authors":"Dhanya Punjamgod, Anjana Kurinjery, Muthusamy Annamalai, Raja Rathinam, Arunkumar Kulanthaiyesu","doi":"10.1080/07388551.2025.2582742","DOIUrl":"10.1080/07388551.2025.2582742","url":null,"abstract":"Fucoidan is a sulfate-containing polysaccharide present in the cell wall of brown algae. It ensures the survival of the algae in the marine environment by providing protection against desiccation and osmotic stress. This review explores the structural diversity, synthesis, extraction methods, and application potential of fucoidan of brown algae with a focus on its bio-stimulant activities in plants. The structural variation of fucoidan in brown algae depends on various parameters, and it is the key factor for determining its biological activities. The synthesis of this polysaccharide takes place in the Golgi bodies, and it involves several steps for the polymerization and further modifications. Extraction and purification of this polysaccharide from the algal biomass involve several steps, and choosing the appropriate method is crucial for achieving maximum yield. As a complex heterogeneous polysaccharide, fucoidan possesses diverse biological activities, such as: anticancer, anticoagulant, antioxidant, immunomodulatory effects. Nowadays fucoidan is a topic of intense research, and studies are ongoing to explore its potential applications. This review also focuses on explaining bio-stimulant application in plants along with its potential application in: cancer research, tissue engineering, drug delivery, food coating and as an edible film and storage material for fruits with a particular emphasis on its role in promoting plant growth and enhancing stress tolerance.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"225-244"},"PeriodicalIF":8.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mini revolution: application of mini-bioreactors in adaptive laboratory evolution. 微型革命：微型生物反应器在适应性实验室进化中的应用。

IF 8.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1080/07388551.2025.2608012

Adrián Pedreira, José Antonio Vázquez, Míriam R García

{"title":"The mini revolution: application of mini-bioreactors in adaptive laboratory evolution.","authors":"Adrián Pedreira, José Antonio Vázquez, Míriam R García","doi":"10.1080/07388551.2025.2608012","DOIUrl":"10.1080/07388551.2025.2608012","url":null,"abstract":"Adaptive laboratory evolution (ALE) is a powerful tool for understanding and controlling the evolutionary trajectories of microorganisms. The scope of applications extends widely, including areas such as: biotechnology, synthetic biology, microbial ecology, and fundamental evolutionary research. In this work, we systematically explore the implementation and advantages of mini-bioreactors, defined as reactors with working volumes below 0.5 L, in ALE experiments. Mini-bioreactors offer substantial improvements over traditional large-scale reactors, including: reduced costs, enhanced parallelization capabilities, customizable configurations, and ease of automation. Through the utilization of illustrative case studies, which facilitate a comparative and critical evaluation of: batch, chemostat, turbidostat, and morbidostat operational modes, this review underscores the distinct capabilities of mini-bioreactors in enabling precise, dynamic control of evolutionary pressures. The novelty of this review lies in its comprehensive synthesis of recent advancements in mini-bioreactor technologies and operational strategies, particularly emphasizing innovations, such as: integrated automation, advanced sensors, and novel control algorithms adapted or specially designed for ALE. The ultimate objective is to provide both novices and experienced researchers with an updated, in-depth resource that addresses current technological limitations and future directions of mini-bioreactors in ALE.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"338-356"},"PeriodicalIF":8.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbial enhanced oil recovery in China: progress and prospects. 中国微生物采油技术进展与展望

IF 7.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-02-15 DOI: 10.1080/07388551.2026.2619529

Yi-Fan Liu, Zhao-Wei Hou, Gang-Zheng Sun, Lei Zhou, Jin-Feng Liu, Rui Jin, Gong-Ze Cao, Wan-Qi Qin, Shi-Zhong Yang, Ji-Dong Gu, Wei-Dong Wang, Xiao-Lin Wu, Bo-Zhong Mu

{"title":"Microbial enhanced oil recovery in China: progress and prospects.","authors":"Yi-Fan Liu, Zhao-Wei Hou, Gang-Zheng Sun, Lei Zhou, Jin-Feng Liu, Rui Jin, Gong-Ze Cao, Wan-Qi Qin, Shi-Zhong Yang, Ji-Dong Gu, Wei-Dong Wang, Xiao-Lin Wu, Bo-Zhong Mu","doi":"10.1080/07388551.2026.2619529","DOIUrl":"https://doi.org/10.1080/07388551.2026.2619529","url":null,"abstract":"As an economical and sustainable approach for the enhancement of oil recovery, microbial enhanced oil recovery has gained prominence in residual oil recovery from depleted oil reservoirs that are economically marginal or technically challenging due to low permeability, elevated water content and bearing heavy oil, particularly under current economic constraints in the petroleum industry. Over the last few decades, intensive efforts have been invested and extensive studies have been conducted regarding MEOR in both laboratory studies and field applications, with positive responses in oil reservoirs under different conditions. This study reviews recent advances in microbial enhanced oil recovery in oilfields in China, focusing on the latest knowledge regarding dominant microbial communities in oil reservoirs, microbes and their interactions in oil reservoirs and the key roles of microbial products in oil recovery. Strategies for microbial enhanced oil recovery and microbial enhanced energy recovery, including the novel concept of \"Microbial plus\" which refers to the microbial combined chemical method to enhance synergistic efficiency for enhanced oil recovery, are investigated. At last, recent field trials in Chinese oilfields were systematized based on the corresponding technologies utilized.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"1-19"},"PeriodicalIF":7.7,"publicationDate":"2026-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The thermal cycling methods for rapid PCR. 快速PCR的热循环方法。

IF 7.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-02-01 Epub Date: 2025-09-14 DOI: 10.1080/07388551.2025.2540368

Ruihua Ding, Jiali Zhang, Chang Chen

{"title":"The thermal cycling methods for rapid PCR.","authors":"Ruihua Ding, Jiali Zhang, Chang Chen","doi":"10.1080/07388551.2025.2540368","DOIUrl":"10.1080/07388551.2025.2540368","url":null,"abstract":"Polymerase chain reaction (PCR) is a critical technology in nucleic acid detection and quantification. The PCR reaction requires thermal cycling the reaction mixture between two or more temperature stages for ∼30 cycles to achieve exponential amplification of the target DNA. Typically, the thermal cycling takes roughly an hour to finish and the large time consumption is a drawback for PCR. We review the various methods developed to reduce the thermal cycling time and build a rapid PCR. We group the methods to two approaches. The first approach is to increase the local heating/cooling power. The methods in this approach include contact heating, such as: heating resistors and Peltier pumps, and non-contact heating using air-blow, radiation on water and plasmonics. The other approach is to rapidly move the reaction mixture to a different temperature zone. Methods in this approach include: relocating the reaction vessel, continuous flow PCR using microfluidic chips, long tubes or oscillatory PCR scheme, and convective PCR. We analyze the advantages and challenges for each method used and the critical parameters to consider when evaluating the technologies. We review the technological advances and commercialization for each method. We also discuss the current challenges and future directions in building an effective and commercial rapid PCR, with the emphasis on sensitivity, portability and cost.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"80-99"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on experimental to large-scale production of bacteriophages against superbugs: a review. 从实验到大规模生产抗超级细菌噬菌体的进展综述。

IF 7.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-02-01 Epub Date: 2025-08-04 DOI: 10.1080/07388551.2025.2531446

Mohammadreza Rahimian, Elham Mohammadi, Mohammad Aghazadeh-Soltan-Ahmadi, Alireza Samari, Nosratollah Zarghami

{"title":"An update on experimental to large-scale production of bacteriophages against superbugs: a review.","authors":"Mohammadreza Rahimian, Elham Mohammadi, Mohammad Aghazadeh-Soltan-Ahmadi, Alireza Samari, Nosratollah Zarghami","doi":"10.1080/07388551.2025.2531446","DOIUrl":"10.1080/07388551.2025.2531446","url":null,"abstract":"The escalating problem of antibiotic resistance has sparked renewed interest in bacteriophages (phages) as potential substitutes for conventional antibiotics in treating infectious diseases, improving food safety, and advancing sustainable agriculture. The key phage research processes, such as host range, burst size, and environmental stability tests, strongly influence phage production processes. Hence, the standardization of the mentioned techniques must be prioritized. The introduction of high-throughput sequencing technologies with high accuracy and the emergence of novel bioinformatic tools to analyze the resulting raw molecular data provide comprehensive identification of phages and phage-verse (the universe of phage). While encapsulation of phages was studied comprehensively before, the production of encapsulated phages is still unclear. Moreover, recent advances in artificial intelligence (AI) contribute to phage research by increasing the accuracy of bioinformatic tools, improving resistance profiling, and facilitating phage host prediction. Incorporating AI promises a future of automated, precisely tailored phage applications. This review covers efficient techniques appropriate for industrial and agricultural applications as well as large-scale phage production methods, covering upstream and downstream processing. Also, encapsulated phage production and AI-based automated systems in various applications are proposed in this review. By covering both present issues and potential future uses of phages in the fight against antibiotic resistance, this review seeks to give academics and industry experts the fundamental information they need to advance phage-based solutions.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"25-44"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilization of arbuscular mycorrhizal fungi symbiosis-related genes from host plants in biotechnology for sustainable agriculture. 寄主植物丛枝菌根真菌共生相关基因在可持续农业生物技术中的应用。

IF 7.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-02-01 Epub Date: 2025-11-23 DOI: 10.1080/07388551.2025.2581883

Lei Tian, Aarti Gupta, Weiqiang Li, Guanghua Wang, Dongxue Jiang, Yuxin Yan, Zhongjun Jia, Lam-Son Phan Tran, Chunjie Tian

{"title":"Utilization of arbuscular mycorrhizal fungi symbiosis-related genes from host plants in biotechnology for sustainable agriculture.","authors":"Lei Tian, Aarti Gupta, Weiqiang Li, Guanghua Wang, Dongxue Jiang, Yuxin Yan, Zhongjun Jia, Lam-Son Phan Tran, Chunjie Tian","doi":"10.1080/07388551.2025.2581883","DOIUrl":"10.1080/07388551.2025.2581883","url":null,"abstract":"In recent years, interest in the role of nutrient cycling in sustainable agriculture has significantly increased. The potential of arbuscular mycorrhizal (AM) fungi (AMFs) in nutrient cycling and plant growth improvement has long been recognized. However, there have been only a few studies on the identification and exploration of AM symbiosis-related plant genes for sustainable agriculture. We have developed a new constructive model for using host plant-derived AM symbiosis-related genes to improve breeding and AMF utilization for sustainable agriculture, particularly in the context of climate change. This model include: 1) the discovery of AM symbiosis-related genes in crop wild-relatives for molecular breeding and 2) the screening and propagation of AMFs that can help improve water-use efficiency and nutrient-use efficiency by crops, thereby reducing chemical fertilizer use in agricultural production. The first approach uniquely facilitates the identification of host plant-derived AM symbiosis-related genes, such as CHITIN ELICITOR RECEPTOR KINASE 1 (OsCERK1) from Dongxiang (DY) wild rice (Oryza rufipogon) (OsCERK1DY), MILDEW RESISTANCE LOCUS 1 (MLO1) from wild barley (Hordeum spontaneum), and WRKY60 from wild soybean (Glycine soja), for breeding purposes. The second one involves identifying soil-borne AMF species, such as Rhizophagus intraradices and Glomus mosseae for practical applications in the field. This suggestive model presents an emerging biotechnological potential for engineering climate-resilient crops.","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"120-131"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astaxanthin: nature's multifunctional molecule, natural sources, health benefits, and process advancements. 虾青素：自然界的多功能分子，天然来源，健康益处和工艺进步。

IF 7.7 2区工程技术

Critical Reviews in Biotechnology Pub Date : 2026-02-01 Epub Date: 2025-08-04 DOI: 10.1080/07388551.2025.2537816

Vaibhav Sunil Tambat, Reeta Rani Singhania, Yamini Sumathi, Chiu-Wen Chen, Cheng-Di Dong, Philippe Michaud, Anil Kumar Patel

{"title":"Astaxanthin: nature's multifunctional molecule, natural sources, health benefits, and process advancements.","authors":"Vaibhav Sunil Tambat, Reeta Rani Singhania, Yamini Sumathi, Chiu-Wen Chen, Cheng-Di Dong, Philippe Michaud, Anil Kumar Patel","doi":"10.1080/07388551.2025.2537816","DOIUrl":"10.1080/07388551.2025.2537816","url":null,"abstract":"Astaxanthin, a natural di-keto carotenoid xanthophyll, is a highly valued nutraceutical and food ingredient due to its potent health benefits, including: anti-inflammatory, antioxidant, anti-cancer, cardiovascular, and anti-diabetic effects. This review examines the primary natural sources of: astaxanthin microalgae, yeast, bacteria, and plants, with a focus on microalgae due to their superior accumulation potential and bioactivity. It explores the growing prospects for large-scale astaxanthin production, highlighting advancements in both upstream and downstream processes. Upstream innovations include enhanced bioprocess designs that improve biomass yield, light and stress tolerance. Downstream, sustainable extraction methods such as aqueous two-phase systems with deep eutectic solvents (99.64% recovery) and high-pressure supercritical CO2 extraction have improved efficiency and scalability. Additionally, eco-friendly techniques, such as bead milling and pulsed electric field permeabilization offer cost-effective solutions, among other cell disruption techniques, and ensure higher yields. This study provides a comprehensive overview of recent advances in astaxanthin production and extraction, aligned with the Sustainable Development Goals (SDGs) linked to health and well-being (SDG 3) and responsible consumption and production (SDG 12).","PeriodicalId":10752,"journal":{"name":"Critical Reviews in Biotechnology","volume":" ","pages":"61-79"},"PeriodicalIF":7.7,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0