Current Analytical Chemistry最新文献

{"title":"Local Structure and Optical Studies of Mn2+ Doped L-histidine-4-nitrophenolate 4-nitrophenol Single Crystal","authors":"Maroj Bharati, Vikram Singh, Ram Kripal","doi":"10.2174/0115734110295420240314052821","DOIUrl":"https://doi.org/10.2174/0115734110295420240314052821","url":null,"abstract":"Background: The zero-field splitting parameters of Mn2+ doped L-histidine-4- nitrophenolate 4-nitrophenol single crystals are evaluated Methods: The superposition model and perturbation theory are used to obtain zero-field splitting parameters for Mn2+ ion-doped LHPP single crystals. The optical spectra of the system are computed using the crystal field parameters from the superposition model as input into the crystal field analysis program. Results: The evaluated zero field splitting parameters are in good match with the experimental values when local distortion is taken into account. The experimental finding that the Mn2+ ion enters the L-histidine-4-nitrophenolate 4-nitrophenol lattice at the interstitial position is supported by the theoretical result. Conclusion: It is found that the calculated and experimental band positions agree fairly well. Thus, the theoretical study supports the experimental observation.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"28 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Electrochemiluminescence (ECL) Immunoassay for the Quantitation of Monoclonal Antibody (mAb) PYX-106 in Human Serum","authors":"Feng Yin, Diana Adhikari, Xiaodong F. Liu, Jianxin Wang, Wensheng Yang, Gabriela A. Balogh, Teri Simon, Wenji Lei, Mariana Squicciarini, Lisa Bruce, Yan Ke, Mike Dyszel, Shawn Harriman, Jan Pinkas","doi":"10.2174/0115734110293837240320042928","DOIUrl":"https://doi.org/10.2174/0115734110293837240320042928","url":null,"abstract":"Background:: PYX-106 is a novel monoclonal antibody (mAb), targeting the sialic acidbinding immunoglobulin-like lectin 15 (Siglec-15) in the Tumor Microenvironment (TME). Precise measurement of PYX-106 is essential for the thorough assessment of PYX-106 pharmacokinetics in clinical investigations. Methods:: A novel Electrochemiluminescence (ECL) immunoassay for the quantitation of PYX- 106 in human serum was developed and validated. Biotinylated anti-PYX-106 antibody Bio-A1A1 was employed as the capture antibody, and ruthenylated anti-PYX-106 antibody Ru-A3G10 was utilized as the detection antibody in the ECL immunoassay on Meso Scale Discovery (MSD) platform. Results:: This assay was fully validated in terms of selectivity, accuracy, precision, hook effect, stability, etc., with a dynamic range from 50.0 to 2,500 ng/mL in human serum under the 2018 U.S. Food and Drug Administration (FDA) guidance and the 2022 U.S. FDA ICH M10 guidance. Conclusion:: PYX-106 bioanalytical assay validation was reported for the first time in a biological matrix, and this assay has been successfully applied to support a clinical trial PYX-106-101.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"23 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of UV Method for Simultaneous Estimation of Imipramine and Ferulic Acid in Bulk and Developed Freeze-Dried Mixed Micelles","authors":"Naman Deep Raj, Dilpreet Singh","doi":"10.2174/0115734110286586240222100116","DOIUrl":"https://doi.org/10.2174/0115734110286586240222100116","url":null,"abstract":"Introduction:: A simple, precise, and sensitive UV spectrophotometric method was developed to estimate Imipramine and Ferulic acid in bulk and polymeric micelles formulation. Moreover, imipramine and ferulic acid showed maximum absorbance at 237 nm and 216 nm. Method:: The method was validated for linearity, accuracy, precision, robustness, and ruggedness. The detector response for the imipramine and ferulic acid was linear over the selected range of 2 to 12 μg/ml with a correlation coefficient of 0.996 and 0.997. The accuracy was 99.4 and 101.02%. The precision (RSD) among six sample preparations was 0.68% and 0.85%. The method was validated as per the ICH guidelines. A polymeric micelle formulation was developed containing Vitamin E TPGS and F-127 as a surfactant and block co-polymer using different solvents. The optimized formulation containing 40 mg of F-127 and 30 mg of TPGS yielded the desired attributes of the optimized formulation. Result:: The optimized formulation was subjected to freeze-drying and yielded nanoparticulate size and excellent flowability. In vitro, the release of both drugs from the polymeric micelles was evaluated using dissolution, and multi-fold enhancement in release behavior was demonstrated compared to pure drugs. Both drugs were simultaneously detected successfully with accuracy and precision in bulk form and during in vitro analysis Conclusion:: The developed method can be adopted in routine analysis of imipramine and ferulic acid in bulk, and it involves relatively low-cost solvents with no complex extraction techniques.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"34 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging Technologies for Sensitive Detection of Organophosphate Pesticides: A Review","authors":"A. Kumaravel, S. Aishwarya, S. Sathiyamoorthi","doi":"10.2174/0115734110294187240315082239","DOIUrl":"https://doi.org/10.2174/0115734110294187240315082239","url":null,"abstract":": The use of organophosphate pesticides (OPPs) in agricultural practices improves crop yield and controls pests, but their indiscriminate use and persistence in the environment pose significant health risks. Therefore, it has become increasingly important to develop reliable and efficient detection methods for OPPs to ensure food safety and monitor their presence. In recent years, OPP detection methods have undergone significant advancements. Sensors such as colorimetric, fluorescence, electrochemical, and impedometric offer several advantages over traditional methods, such as high sensitivity, selectivity, and portability. The purpose of this review paper is to provide an overview of recent developments in OPP detection methods. The paper discusses the different types of sensors that are available for the detection of OPPs, as well as their advantages and disadvantages. Many electrochemical methods have been employed to investigate OPP detection, including voltammetry, impedance spectroscopy, and amperometry. The integration of nanomaterials, such as carbon nanotubes, graphene, and metal nanoparticles, has significantly enhanced the performance of electrochemical sensors by providing high surface area, enhanced electron transfer, and specific analyte interactions. Furthermore, the review discusses the utilization of biomolecules, such as enzymes and aptamers, as recognition elements in sensor platforms for selective and sensitive OPP detection. The incorporation of these biomolecules offers high specificity and enables real-time monitoring of OPP residues in food samples and environmental matrices. It emphasizes the importance of continued research and development to optimize detection methods, improve sensor performance, and make these technologies more widely accessible for effective monitoring and control of OPP contamination in various domains.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"235 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advancements in Biochar and its Composite for the Remediation of Hazardous Pollutants","authors":"Akshay Verma, Gaurav Sharma, Amit Kumar, Pooja Dhiman, F. J. Stadler","doi":"10.2174/0115734110286724240318051113","DOIUrl":"https://doi.org/10.2174/0115734110286724240318051113","url":null,"abstract":": Biochar has garnered considerable attention in recent times due to its potential uses in the environmental field. In this study, we comprehensively examine and condense information on biochar production, characteristics, and adsorption mechanisms, with a focus on its economic applications for remediating hazardous contaminants. Our assessment is based on over 200 publications from the past decade. Biochar, a carbon-rich material, can be derived from various organic waste sources, such as food waste and urban sewage sludge. Researchers are particularly interested in biochar due to its high carbon content, cation exchange capacity, substantial specific surface area, and stable structure. We investigate how the physical and chemical properties of biochar may vary based on the feedstock used, providing a comprehensive overview of biochar and its composition for pollution remediation. The review also discusses common techniques such as gasification, hydrothermal carbonization, and pyrolysis used to produce biochar. We analyze current research on the mechanisms involved in pollutant treatment using biochar and its composites while also addressing future directions in biochar research.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"39 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140314219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ag-TiO2 Photovoltaic Synergistic Field-catalyzed Degradation Performance of Tetracycline","authors":"Qirui Wang, Xian Liu, Ziqi Qin, Xiang Ge, Chengcheng Li, Lei Zhu, Xun Wang","doi":"10.2174/0115734110300566240314051129","DOIUrl":"https://doi.org/10.2174/0115734110300566240314051129","url":null,"abstract":"Background: Tetracycline (TC), a commonly used antibiotic, is extensively utilized in the medical sector, leading to a significant annual discharge of tetracycline effluent into the water system, which harms both human health and the environment. background: Tetracycline (TC), a commonly used antibiotic, is extensively utilized in the medical sector, leading to a significant annual discharge of tetracycline effluent into the water system. This harms both human health and the environment. Objective: A novel technique was developed to address the issues of photogenerated carrier complexation and photocatalyst immobilization. Compared to traditional photocatalytic photoelectrodes, the suspended catalyst used in the photovoltaic synergy field is more stable and increases the solidliquid contact area between the catalyst and the pollutant. objective: This paper uses sol-gel-prepared Ag-doped-TiO2 materials for the photoelectrocatalytic degradation of TC. Methods: This paper uses sol-gel-prepared Ag-doped-TiO2 materials for the photoelectric synergistic field-catalyzed degradation of TC. The study examined how the Ag doping ratio, calcination conditions, catalyst injection, pH, electrolytes, and electrolyte injection affected photoelectric synergistic field-catalyzed degradation. The experiments were performed in a photocomposite field with a constant 50 mA current and a 357 nm UV lamp for 60 minutes. The composites underwent characterization using XRD, TEM, and XPS techniques. method: The study examined how the Ag doping ratio, calcination conditions, catalyst injection, pH, electrolytes, and electrolyte injection affected photoelectrocatalytic activity. The experiments were done in a photocomposite field with a constant 50 mA current and a 357 nm UV lamp for 60 minutes. The composites underwent characterization using XRD, TEM, and XPS techniques. Results: Ag-TiO2 photoelectric synergistic field-catalyzed reaction with 357 nm ultraviolet lamp irradiation for 60 min and a constant current of 50 mA degraded 5 mg/LTC under preparation conditions of molar doping ratio of Ti: Ag=100:0.5, roasting temperature of 500 °C, and roasting time of 2 h. The photoelectric synergistic field-catalyzed degradation process achieved a degradation rate of 90.49% for 5 mg/L TC, surpassing the combined degradation rates of electrocatalysis and photocatalysis. The quenching experiments demonstrated that the degradation rate of TC decreased from 90.49% in the absence of a quencher to 53.23%, 42.58%, and 74.52%. The presence of •OH had a more significant impact than h+ and •O2-. Conclusion: The findings suggest that Ag-TiO2 significantly enhanced the efficacy of photoelectric synergistic field-catalyzed degradation and can be employed to treat high-saline and lowconcentration TC. This establishes a benchmark for using photoelectrocatalytic materials based on titanium in treating organic wastewater. result: Ag-TiO2 photoelectrocatalytic reaction with 357 nm ultraviolet lamp irr","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"367 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone-Based Colourimetric Detection of Methyl Red, Co(II), Uric Acid, and Topotecan after Pre-concentration onto a Hectorite Clay-Hydroxyethylcellulose Hybrid","authors":"Anastasios Phoebus Mazarakis, Georgia Eleni Tsotsou","doi":"10.2174/0115734110290080240314043658","DOIUrl":"https://doi.org/10.2174/0115734110290080240314043658","url":null,"abstract":"Objective: This paper describes a new, digital image colourimetry-based format for the quantification of analytes in an aqueous solution. Method: The proposed method is based on analyte pre-concentration by adsorption onto Bentone LT. Bentone LT pellet isolation comes after adsorption, followed by in-situ application of an analyteselective chromogenic reaction. The resulting pellet colouration is captured by the phone’s integrated camera and assessed using the free open-source image processing software, ImageJ. Responses are calibrated and quantified. Results: We tested the applicability of the proposed methodology for the quantification of specific model analytes which are of concern in environmental matrices (methyl red, Co(II), uric acid, topotecan). The smartphone-based assay was proven reliable in quantifying the model analytes (standard recovery of 82-116%), alone or in mixture, from dilute aqueous solutions and was found to depict accurately the adsorption behaviour followed photometrically in solution. Lower limit of linearity was calculated at 0.05, 0.11, 0.85 and 0.20 μg/mL for methyl red, Co(II), uric acid, and topotecan, respectively. The proposed format was found superior when compared to alternative published photometric/ colourimetric assays in terms of the lower limit of linearity. In the presence of possible adsorption interferents, the lower limit of linear response was shifted to slightly higher concentrations for topotecan i.e. from 0.2 μg/mL to 0.5 μg/mL. Conclusion: We here demonstrate the extended applicability of the proposed methodology for the smartphone-based quantification of the specific model analytes. The applicability of this analysis format likely extends to other analytes, where analyte-specific colour formation is feasible.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"8 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paper-based Microfluidic Devices for the Analysis of Various Pathogens from Diverse Samples","authors":"Namita Ashish Singh, Nitish Rai, Ashish Kumar Singh, Vidhi Jain, Jagriti Narang","doi":"10.2174/0115734110292458240306055653","DOIUrl":"https://doi.org/10.2174/0115734110292458240306055653","url":null,"abstract":": In today’s era, detection of disease is utmost important for the management of disease. Early detection leads to early management of disease. Paper-based microfluidic devices are promising technologies that are cost-effective, portable and easy to use over conventional methods. In addition, paper-based microfluidics offers low reagent/sample volume, less response time and can be used in resource-limited settings. Researchers are highly fascinated by this technology as it has a lot of potential to convert into commercial monitoring devices. The present article covers the uses of paper-based microfluidic technology for the swift and sensitive detection of pathogens from diverse samples, viz. food, water and blood. In this comprehensive review, paper-based microfluidic devices are introduced, including the basic concepts, current status and applications, along with the discussion of the limitations of microfluidics for the detection of pathogens. Although paper-based microfluidic devices are being developed, their commercialization requires simplification of manufacturing processes, reduction in production costs as well as an increase in production efficiency. Nonetheless, the integration of artificial intelligence (AI) and the Internet of Things (IoT) like smartphones, digital cameras, webcam etc. with paper-associated diagnosis has transformed the point-of-care (POC) diagnostics.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"148 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140153133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Diagnostics: Evaluating the Potential of Nanoparticle-Based Immunoassays as PCR Alternatives for Disease Confirmation","authors":"Aditya Kurdekar, Venkataramaniah Kamisetti","doi":"10.2174/0115734110287852240228064645","DOIUrl":"https://doi.org/10.2174/0115734110287852240228064645","url":null,"abstract":": In diagnostic technologies, searching for quick, accurate, and cost-efficient ways to confirm diseases has prompted the investigation of alternative methodologies to classic PCR-based tests. This article delves into the growing field of nanoparticle-based immunoassays, offering a comprehensive evaluation of their potential as viable alternatives to PCR for disease diagnostics. We discuss the basic principles of nanoparticle-based immunoassays, highlighting their distinctive capacity to combine the specialized binding characteristics of antibodies with the improved detection capacities of nanoparticles. The article compares the performance attributes of nanoparticle-based immunoassays compared to PCR, focusing on sensitivity, specificity, and detection speed. We further delve into a novel diagnostic technology, immuno-PCR, which integrates the strengths of immunoassays and PCR techniques. Healthcare systems and stakeholders must comprehend and implement novel diagnostic procedures emphasizing accuracy and sensitivity as the diagnostic landscape advances globally. This review contributes to the advancement of diagnostics by synthesizing current research and suggesting future directions for development. It highlights the transformative potential of current and emerging methods in shaping the future of disease diagnostics.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"291 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140116384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sorption Efficacy of Weathered Basalt Rock for Metal Ions of Nuclear Importance","authors":"Harshala Parab, Rahul Sirvi, Shrutika Kadam, Pranesh Sengupta, Sangita D. Kumar, Uttam K. Bhui","doi":"10.2174/0115734110295747240305061230","DOIUrl":"https://doi.org/10.2174/0115734110295747240305061230","url":null,"abstract":"Background:: A safe and long-term isolation of radionuclides is crucial for efficient waste management in the nuclear fuel cycle. Clay minerals of geological origin are considered candidate barrier materials for the sequestration of nuclear waste for geological disposal applications. Objective:: The present study encompasses a systematic characterization of weathered basalt rock and the influence of its constituent clay minerals (formed mainly due to the weathering process) in the uptake of metal ions of nuclear importance, such as cesium (Cs+) and strontium (Sr2+). Method:: The structural profile of the weathered basalt has been investigated using different analytical techniques, including polarizing microscope, XRD, FTIR and EDXRF. The sorption behaviour of the rock sample for Cs+ and Sr2+ has been investigated in a comprehensive batch mode by varying the experimental conditions. The analytical findings for structure and batch sorption performance of the material have been further correlated to understand the influence of different parameters on the uptake of metal ions and the underlying mechanism. Results:: Structural analyses confirmed the presence of clay minerals viz., kaolinite, illite and montmorillonite in the sample. A comprehensive sorption performance assessment carried out in batch mode at different experimental conditions revealed that the uptake of both the metal ions was rapid and dependent on initial metal ion concentration and solution pH. The uptake of Cs+ ions was found to be higher as compared to the Sr2+ ions. EDXRF analysis confirmed the loading of Cs+ and Sr2+ on the weathered basalt. Experimental batch sorption data presented a better agreement with the theoretical Freundlich isotherm pertaining to the heterogeneous nature of the sorbent. Conclusion:: The studies highlight that the clay minerals formed by structural alteration of basalt rock upon intense weathering could be very useful in fixing the nuclear fission waste components such as Cs+ and Sr2+.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"75 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140107987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}