Current Analytical Chemistry最新文献

{"title":"In vitro Antioxidant Activity of 5-caffeoylquinic Acid and Ester Analogues","authors":"Muamer Dizdar, Danijela Vidic, Sanja Ćavar Zeljković, Milka Maksimović","doi":"10.2174/0115734110299953240425035548","DOIUrl":"https://doi.org/10.2174/0115734110299953240425035548","url":null,"abstract":"Background: Chlorogenic acid, an ester of caffeic acid with quinic acid, also known as 5- O-caffeoylquinic acid (5-CQA), is a ubiquitous plant constituent that is an important intermediate in lignin biosynthesis. In some cases, it occurs at surprisingly high levels in the leaves and fruits of certain higher plants, such as coffee beans. Due to its catechol moiety and an extended side chain conjugation, it easily forms a resonance-stabilised phenoxy radical, accounting for its powerful antioxidant potential. Objective: The objective of this work was to determine if the esterification and methylation of 5- CQA would enhance its antioxidant activity. Methods: Two 5-CQA derivatives were prepared for this study. Chlorogenic acid was esterified with methanol over Amberlite IR120-H to obtain methyl chlorogenate, while methyl 3',4´-dimethyl chlorogenate was prepared from 5-CQA by treatment with diazomethane. Spectroscopic methods confirmed the structure of these derivatives. Their antioxidant properties were tested to establish a relationship between structure and antioxidant activity. Results: Antioxidant activity results were generated for 5-CQA and its ester analogues using eight different methods. Depending on the method applied, results were expressed as IC50/MCE50 values or as equivalents of the applied standard (ascorbic acid and Trolox). Conclusion: In most of these tests, 5-CQA showed the highest antioxidant activity compared to its derivatives. Nevertheless, due to their hydrophobic characteristics, their ester analogues remain promising antioxidant candidates in emulsifying systems.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"83 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advancement in the Development of Detection and Removal of Heavy Metal Ions by Deep Eutectic Solvents: A Review","authors":"Hamed M. Al-Saidia, Sikandar Khan","doi":"10.2174/0115734110294079240424103357","DOIUrl":"https://doi.org/10.2174/0115734110294079240424103357","url":null,"abstract":": Heavy metal pollution is one of the most serious environmental problems, because of the non-degradable nature of heavy metals and their accumulation in the food chain, which poses a severe threat to the environment and human health even at low concentrations. Most of these metal ions can coordinate with biological molecules and disturb their function. Exposure to heavy metals can cause different health threats such as endothelial dysfunction, allergy, infant mortality, cancer, neurological diseases, respiratory diseases, oxidative stress, cardiovascular disorders and kidney diseases. Therefore the detection and removal of these toxic species are very important. Deep eutectic solvents (DESs) are green solvents and have excellent applications in many fields. They contain nonsymmetrical ions that have low lattice energy, low vapor pressure, dipolar nature, nonflammability, low volatility, low melting points, excellent thermal and chemical stability and high solubility. DESs are also better in terms of the availability of raw materials, easy synthetic procedure, low cost of their starting materials and their easy storage. DESs have an excellent ability for the detection and removal of heavy metal ions. In this review, we discussed various DES-based spectrophotometric and fluorimetric chemosensors for the detection of heavy metal ions in different matrixes. Additionally, we have also explored the capabilities of different DESs in removing heavy metals.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"11 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Camptothecin and its Analogs: High-Yielding Ophiorrhiza Species from Sri Lanka for Sustainable Anticancer Compound Production","authors":"Hewagamage Dona Gihani Asmeer Ranasinghe, Peramune Arachchilage Amila Saman Prasad Kumara, Koonara Mudiyanselage Thilini Dinesha Weerasekara, Poruthotage Pradeep Rasika Perera, Nazeera Salim, Chandrika Udumalagala Gamage","doi":"10.2174/0115734110285332240424093539","DOIUrl":"https://doi.org/10.2174/0115734110285332240424093539","url":null,"abstract":"Introduction: Camptothecin (CPT) is pivotal in cancer treatment, derived from various CPT-producing plant species, and is a fundamental component in synthesizing valuable cancer drugs like Irnotican and Topotecan. Sourcing from nature poses conservation issues, fostering interest in the herbaceous Ophiorrhiza plant as a more sustainable alternative. Ophiorrhiza species in Sri Lanka lack comprehensive study, warranting exploration for echo-friendly anticancer compound production. Objectives: This study examines CPT and analog content in Ophiorrhiza mungos, O. pectinata, and O. rugosa across diverse Sri Lankan regions. Methods: The study employs Thin Layer Chromatography (TLC), High-Performance Liquid Chromatography-DAD (HPLC-DAD), and Liquid Chromatography-Mass Spectrometry (LC-MS) to quantify and confirm CPT and its analogs. Results: Significant variations in the content of CPT and its analogs were observed among plant parts and regions. O. mungos from Deraniyagala and Bibile regions notably exhibited elevated CPT levels in fruits and roots. O. rugosa var. Angustifolia and O. pectinata also exhibited a considerable content of CPT in their roots, though it was significantly lower (p < 0.005) than O. mungos. Conclusion: The study validates analytical methods for specificity, linearity, precision, accuracy, and sensitivity per ICH guidelines. The results indicate that Ophiorrhiza species, especially O. mungos and O. rugosa var. Angustifolia holds the potential to be a sustainable source of CPT. Optimizing cultivation practices offers an eco-friendly solution for anticancer compound production, alleviating species threats and conserving biodiversity.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"125 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Fluorescent Probe for Hydrazine Based on 4-hydroxycoumarin with High Selectivity and Sensitivity","authors":"Fang Fang, Wen-Di Han, Fang Ke, Shun Liu, Li-Peng Li, Mei Wu","doi":"10.2174/0115734110281725231218043256","DOIUrl":"https://doi.org/10.2174/0115734110281725231218043256","url":null,"abstract":"Background: Therefore, the development of reliable analytical techniques with high selectivity and sensitivity to detect hydrazine is required for the protection of human health and safety. Objectives: Traditional methods for detecting N2H4 are frequently time-consuming, less accurate, and unsuitable for the analysis of living systems. Numerous fluorescent probes for hydrazine have been produced and gained some valuable results recently. The creation of a simple fluorescent probe for hydrazine detection is the goal of this project Method: In this study, 300 µL of probe 3-methyl-2-oxo-2H-chromen-7-yl propionate (MOCP) was mixed with an equivalent amount of the solution of each analyte to obtain the measurement solution. Following a 10-minute room temperature incubation period, the fluorescence spectra of the resultant solution were recorded. Results: The fluorescence intensity of the probe was noticeably enhanced when N2H4 was added to the probe, but almost no fluorescence enhancement was observed when other competitive ions were added. Conclusion: A hydrazine fluorescent probe based on 4-hydroxycoumarin fluorophore was developed. The probe MOCP displayed high sensitivity and selectivity for hydrazine, with a color change from colourless to blue for detection by the naked eye. Moreover, it demonstrated a low detection limit of 20 nM and a fast reaction time of 30 s.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"60 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Time-of-flight Secondary Ion Mass Spectrometry in Lithium-ion Batteries","authors":"Pengwei Li, Xiaoning Xia","doi":"10.2174/0115734110299035240422114008","DOIUrl":"https://doi.org/10.2174/0115734110299035240422114008","url":null,"abstract":": Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is becoming a powerful tool in the Lithium-Ion Batteries (LIBs) field due to its excellent resolution and sensitivity, as well as its ability to provide spectrally and depth-resolved information. The perspective comprehensively delves into the application of ToF-SIMS in two major areas of LIBs research. Firstly, the article elucidates how ToF-SIMS has been instrumental in deciphering the Solid Electrolyte Interphase (SEI) composition and analyzing electrolyte aging. The insights gleaned from such studies have paved the way for enhancing the longevity and safety of LIBs. Secondly, we explore the role of ToF-SIMS in scrutinizing the distribution of interface reactions, which are critical for understanding charge and discharge mechanisms. The analysis aids in optimizing the interface properties, thereby improving battery performance. Such detections are paramount in ensuring the safety and operational stability of batteries. Overall, the integration of ToF-SIMS in LIBs research offers a promising avenue for the development of advanced and safer energy storage systems.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"99 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Revolutionary Green Technology for the Extraction of Essential Oil Using Microwave and Ultrasound-assisted Techniques","authors":"Pallavi Barik, komal Dagar, Rahul Makhija, Alamjot Singh, Vivek Asati","doi":"10.2174/0115734110296570240422063010","DOIUrl":"https://doi.org/10.2174/0115734110296570240422063010","url":null,"abstract":"Background: Essential oils are utilized in various food applications and are a rich source of naturally occurring volatile components. The extraction of essential oils has used conventional techniques for several years, but these methods require a long duration of time, more solvent, and high energy. However, recent advancements have led to novel and eco-friendly techniques that significantly enhance the essential oil yield while minimizing the use of resources. Method: This study describes the recent research on the extraction of essential oils and their components, focusing on microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE). Result: This review explores the instrumentation, mechanism, and applications behind MAE and UAE. It also describes the emerging technologies for the extraction of essential oils, along with their optimized conditions. Conclusion: These techniques represent a more sustainable and efficient approach for the extraction of essential oil from various plant sources, aligning with the principles of green chemistry.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"64 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Recent Analytical Techniques for Air Quality Monitoring and Assessment","authors":"Sa’adatu Eri Mohammed, Hamza Badamasi, Augustine A. Unimke, Naseer Inuwa Durumin Iya, Aderibigbe Deborah Olubunmi, Chinyere Okoro, Onyemaechi Okezie, Abdul Ademola Olaleye","doi":"10.2174/0115734110302106240404105903","DOIUrl":"https://doi.org/10.2174/0115734110302106240404105903","url":null,"abstract":": Access to clean air, a vital necessity for life, faces severe constraints globally due to industrialization and urbanization, leading to widespread air quality deterioration. To safeguard human health and the environment from detrimental effects, the essential components of proper monitoring, assessment, and management of air quality are paramount. Conventional air quality analytical techniques such as gas chromatography/ mass spectrometry, selected ion flow tube mass spectrometry, thermal desorption/ gas chromatography, and mass spectrometry are widely used for air quality analysis. These methods, however, are laborious, necessitate sample preparation, require expansive and hazardous reagents, and have a high cost of equipment and maintenance. As such, more rapid, sensitive, specific, cost-effective, portable, user-friendly, and environmentally friendly analytical tools are required for efficient air quality monitoring and control. Over the years, various techniques have emerged to address these challenges, including mobile sensors, microbial monitoring, the Internet of Things (IoT), biomonitoring, and bio- and nanosensors in both indoor and outdoor settings. This paper offers an overview of recent advancements in air quality monitoring and assessment methods. The review encompasses sample preparations for air pollutants, data analysis methodologies, and monitoring strategies. It also delves into the crucial role of microorganisms in air quality analysis. Additionally, the paper explores the applications of the Internet of Things (IoT) and biosensors in air quality monitoring and assessment, elucidating their roles in advancing these endeavors. The paper concludes by presenting insightful perspectives on the current state of air quality monitoring techniques and outlining future directions for research and development in this critical field.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"240 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applicability of QbD-assisted Analytical Method for Simultaneous Detection of Tetrahydrocurcumin and Folic Acid in Developed Nanostructured","authors":"Parina Kumari, Sarwar Beg, Kamalinder K Singh, Vandita Kakkar","doi":"10.2174/0115734110297757240317065850","DOIUrl":"https://doi.org/10.2174/0115734110297757240317065850","url":null,"abstract":"Aims:: Applicability of QbD-assisted analytical method for simultaneous detection of tetrahydrocurcumin and folic acid in developed nanostructured. background: Background: Diabetic foot ulcer (DFU), a multifactorial disorder involves chronic inflammation, oxidative stress and neuropathy. Current treatment therapies, involving the use of growth factors and skin substitutes being costly, are out of reach for the majority of patients. The present research explored the usefulness of (5929IN008, application number 202211045937) a combination of tetrahydrocurcumin and folic acid loaded nanostructured lipidic carriers. Background:: Diabetic foot ulcer (DFU) is a multifactorial disorder that involves chronic inflammation, oxidative stress and neuropathy. Current treatment therapies involving the use of growth factors and skin substitutes being costly, are out of reach for the majority of patients. The present research explored the usefulness of (5929IN008, application number 202211045937), a combination of tetrahydrocurcumin and folic acid-loaded nanostructured lipidic carriers. Objectives:: To develop and validate a QbD-assisted method for simultaneous analysis of tetrahydrocurcumin (THC) and folic acid (FA). Applicability of the above method to determine total drug content (TDC) and entrapment efficiency (EE) of nanostructured lipid carriers (NLCs) loaded THC and FA. Methods:: A high-performance liquid chromatographic (HPLC) method was developed, optimized and validated using Box-Behnken design for improved method performance. Chromatographic separation was conducted on a Supelco 250 x 4.6 mm (5 μm) column with optimized mobile phase composition containing tetrahydrofuran: citric acid buffer pH 3.5 (50:50) at a flow rate of 0.4 mL.min-1 and diode array detection between 210 and 360 nm. Results:: The method developed in a concentration range of 1 to 100 μg.mL-1 was found to be linear (R2 0.999, p≤0.001), accurate (99.10-101.70%) and precise with high recovery values in intra and inter-day results. The system adaptability and robustness evaluation revealed that the percent recovery ranged from 96.90 to 102.80%, and the percent relative standard deviation (%RSD) values were less than 2%. Moreover, the method was further applied for the determination of TDC (86±6% and 96±8%) and drug EE (81±21% and 73±13%) for THC and FA, respectively. Conclusion:: The investigation indicated the applicability of the developed and validated method for the estimation of THC and FA in the developed nanostructured lipidic carriers.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"6 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silica-Based 1,3-Diphenyl-1,3-Propanedione Composites: Efficient Uranium Capture for Environmental Remediation","authors":"Mohammed A. Al-Anber, Wala Al-Qaisi, Idrees F. Al-Momani, Ahmed K. Hijazi, Dinara Sobola, Wasim Alhalasah, Zaid A. Al-Anber","doi":"10.2174/0115734110300973240325131908","DOIUrl":"https://doi.org/10.2174/0115734110300973240325131908","url":null,"abstract":"Introduction:: This study synthesizes and characterizes a novel hybrid composite, SGdpm, to capture UO2 2+ ions from water. The composite has successfully formed by hosting covalently diphenylmethane-1,3-dione (dpm) within an inorganic silica gel matrix, showing promising potential for environmental remediation and nuclear waste management. Methods:: The preparation involved the reaction of tetraethylorthosilicate (TEOS) with diphenylmethane- 1,3-dione (dpm) under acidic conditions, resulting in white solids. The doped composite was characterized by Fourier Transform Infrared Spectroscopy (FTIR), revealing the presence of siloxane and Si-O-C bonds. The application of SG-dpm for capturing UO2 2+ ions from water was investigated, showing a shift in FTIR peaks and confirming the formation of SG-dpm-UO2 2+ as inner-sphere complexes. Scanning Electron Microscopy (SEM) revealed a non-uniform distribution of particles, essential for consistent behavior in applications such as adsorption. Results and Discussion:: Batch sorption experiments demonstrated temperature-dependent sorption behavior with increased efficiency at higher temperatures (T = 55 °C). The study also explored the influence of pH and initial concentration on UO2 2+ sorption, revealing optimal conditions at pH 5 and lower initial concentrations (1.0 mg L-1). Kinetic studies using pseudo-second-order models indicated a high efficiency of UO2 2+ ion removal (99 %) as a chemisorption process. Intraparticle diffusion models highlighted three distinct sorption stages. Sorption isotherm studies favored the Langmuir model, emphasizing monolayer adsorption. The thermodynamic analysis suggested an endothermic (ΔH = + 16.120 kJ mol-1) and spontaneous (ΔG = −25.113 to − 29.2449 kJ mol-1) sorption process. Selectivity studies demonstrated high efficiency in capturing Cu2+, Co2+, and Cr3+ ions, high degree selectivity of UO2 2+ ions (74 %), moderate efficiency for Fe3+ and Zn2+, and lower efficiency for Pb2+, Ni2+, and Cd2+, and poor efficiency for Mn2+ ions. In Conclusion,: SG-dpm exhibits promising potential for selective UO2 2+ ion removal, demonstrating favorable characteristics for various applications, including environmental remediation and nuclear waste management.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"35 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical Perspectives and Roles of XRD in Drug Discovery: A Review","authors":"Ashish Mehta, Rahul Makhija, Pallavi Barik, Shubham Dhiman, Ghanshyam Das Gupta, Vivek Asati","doi":"10.2174/0115734110296435240323113938","DOIUrl":"https://doi.org/10.2174/0115734110296435240323113938","url":null,"abstract":": Biophysical techniques include various methodologies applied in studying biological systems at the molecular and cellular level for the drug discovery process. Various methods like isothermal calorimetry, electron microscopy, XRD (X-ray diffraction), electron microscopy, mass spectrometry, atomic force microscopy, differential scanning calorimetry, surface plasmon resonance, and nuclear magnetic resonance are important techniques for drug discovery. Out of these techniques, XRD is widely employed in structure-based drug discovery, whereas FBDD (fragment-based drug discovery) is widely used in the different phases of drug discovery. XRD was considered one of the most important tools for structure determination of biomolecules and peptides. Consistent development and advancement in XRD improved the various aspects of data processing, collection, sample loading, and increased throughput. This advancement is crucial in obtaining highly resolved protein and other biomolecule crystal structures. The structure obtained from XRD forms the core of structure-based drug discovery and FBDD. This review article focuses on the different roles of biophysical techniques with special emphasis on advancement, data collection, and XRD's role in different drug discovery phases.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":"48 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}