Current Directions in Biomedical Engineering最新文献_第8页

Surgical Phase Recognition for different hospitals 不同医院的手术阶段识别

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1079

Eric L. Wisotzky, Sophie Beckmann, Peter Eisert, Lasse Renz-Kiefel, Anna Hilsmann, Sebastian Lünse, René Mantke

{"title":"Surgical Phase Recognition for different hospitals","authors":"Eric L. Wisotzky, Sophie Beckmann, Peter Eisert, Lasse Renz-Kiefel, Anna Hilsmann, Sebastian Lünse, René Mantke","doi":"10.1515/cdbme-2023-1079","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1079","url":null,"abstract":"Abstract Surgical phase recognition is an important aspect of surgical workflow analysis, as it allows an automatic analysis of the performance and efficiency of surgical procedures. A big challenge for training a neural network for surgical phase recognition is the availability of training data and the large (visual) variability in procedures of different surgeons. Hence, a network must be able to generalize to new data. In this paper, we present an adaptation of a Temporal Convolutional Network for surgical phase recognition in order to ensure the generalization of the network to new scenes with different conditions on the example of cholecystectomy. We used publicly available datasets of 104 surgeries from four different centers for training. The results showed that the network was able to generalize to new scenes and we obtained recognition results with accuracy up to 82% on our own six captured surgeries, performed in a different hospital. This performance is similar for test data from the hospitals of the training data, suggesting that the network can well generalize to new surgical rooms and surgeons. The findings have important implications for the development of automated surgical decision support systems that can be applied in a variety of real-world surgical settings.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a current controlled stimulation setup for investigating the effect of electrical currents on implant infections caused by biofilms 开发一种电流控制刺激装置，用于研究电流对由生物膜引起的植入物感染的影响

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1028

Maxim Fenko, Constantin Wiesener, Rima Fanaei Pirlar, Andrej Trampuz, Markus Valtin, Thomas Schauer

{"title":"Development of a current controlled stimulation setup for investigating the effect of electrical currents on implant infections caused by biofilms","authors":"Maxim Fenko, Constantin Wiesener, Rima Fanaei Pirlar, Andrej Trampuz, Markus Valtin, Thomas Schauer","doi":"10.1515/cdbme-2023-1028","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1028","url":null,"abstract":"Abstract Introduction: Biofilms are bacterial communities that transform into a state enclosed in an extracellular polymeric substance, which makes them less susceptible to antibiotics. Those bacterial formations often develop on metal implants and cause chronic infections. Due to the severely reduced impact of antibiotics against biofilms, the effect of electric stimulation (on its own and in combination with antimicrobials) needs to be further observed, as available studies indicate a positive effect. Methods: Therefore, this work examined the development of a six-channel current-controlled stimulation setup, which enables further in vitro research on the effects of electric stimulation on biofilms. The setup controls the desired stimulation current through the load to counteract electrochemical processes, which constantly change its resistive and capacitive properties. Results: Each channel of the stimulator is able to operate within an amplitude range of 50 A to 1 mA, a frequency range of 0 Hz to 1 kHz, and a pulse width range of 50 s to 1 ms. The current control provides a sufficient rise time of 3.3 s for three different stimulation modes: constant direct current (DC), pulsed DC, and biphasic-pulsed alternating current (AC). Furthermore, a graphical user interface enables the user to regulate and observe the stimulation on a computer to which the stimulator device is connected. Conclusion: The achieved variety of stimulation parameters in one device makes it possible to analyze the effect of different stimulation paradigms on biofilms and therefore enables more in vitro research which is inevitable to develop a sufficient treatment for patients with biofilm-infected implants.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative ECG based emotion state recognition using Detrended Fluctuation Analysis 基于非趋势波动分析的定量心电情绪状态识别

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1176

Meena Anandan, Pandiyarasan Veluswamy, Rohini Palanisamy

{"title":"Quantitative ECG based emotion state recognition using Detrended Fluctuation Analysis","authors":"Meena Anandan, Pandiyarasan Veluswamy, Rohini Palanisamy","doi":"10.1515/cdbme-2023-1176","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1176","url":null,"abstract":"Abstract Wearable emotion recogniton system is essential in identifying mental health disorders by early detection and continuous monitoring of human emotions to provide proper treatment care. Electrocardiogram (ECG) signals can be used for emotion recognition for its noninvasiveness and easy usability. In this study, Detrended Fluctuation Analysis (DFA) and Extreme Gradient Boost (XG Boost) classifier is used to classify the scary and boring emotion from the ECG signals. For this, ECG signal corresponding to these emotions are obtained from public database. The preprocessing is performed by adding the video IDs to the signal and annotating it. This preprocessed signal is subjected to DFA to understand the power-law correlations and similarity property. Further, from the power law correlations, features namely Hurst exponent and DFA intercept are extracted. These features are subjected to XG Boost classifier to differentiate the two emotions. Results shows that the log-log plot of power law correlation is linear in nature which indicates that ECG signals of both the emotions have long range correlations and self-similarity property. The extracted scaling exponent indicates variations between scary and boring with a mean and standard deviation of 0.81±0.13 and 0.68±0.07 respectively. Similarly, DFA intercept provides mean and standard deviation for scary and boring 0.15±0.06 and 0.17±0.07 respectively, showing less variability in the ECG signal. XG Boost classifier gives accuracy of 80.5% for classifying scary and boring emotion. Thus, the proposed approach can be used for wearable emotion recognition system to differentiate scary and boring emotion.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PCB Coil Enables In Situ Calibration of Magnetoelectric Sensor Systems PCB线圈实现磁电传感器系统的原位校准

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1142

Henrik Wolframm, Johannes Hoffmann, Ralf Burgardt, Eric Elzenheimer, Gerhard Schmidt, Michael Höft

引用次数: 0

Decoupling the effects of varying amplitude and frequency in the electrical stimulation of optic nerve fibers 视神经纤维电刺激中不同振幅和频率的解耦效应

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1049

Simone Romeni, Gabriele Marino, Luca Pierantoni, Silvestro Micera

{"title":"Decoupling the effects of varying amplitude and frequency in the electrical stimulation of optic nerve fibers","authors":"Simone Romeni, Gabriele Marino, Luca Pierantoni, Silvestro Micera","doi":"10.1515/cdbme-2023-1049","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1049","url":null,"abstract":"Abstract Introduction. Computational models of optic nerve stimulation can allow to estimate the neural response of optic nerve fibers electrical stimulation and thus can be exploited to tune stimulation parameters to obtain a specific target perception. In principle, such tuning should be performed in an automatic way, so that the chosen stimulation parameters minimize some given cost function related to the quality of resulting the visual perception, but the use of such automatic methods is still under study and no satisfactory solution is available yet. In the absence of automatic methods, stimulation parameters are customarily set via manual tuning, which can be extremely time-consuming if performed in a non-principled way. Methods. We build biophysically-accurate hybrid models of monopolar and bipolar electrical stimulation of optic nerve fibers to study how the fibers firing rates depend upon the stimulation parameters. Results. In the case of monopolar sinusoidal stimulation of optic nerve fibers, we show that the amplitude of stimulation controls the size of the recruited cluster of fibers, and that the frequency controls their firing rate, independently. Instead, for bipolar stimulation, we show that when cross-talk is non negligible it is very difficult to obtain rules of thumb linking the firing rate of target fibers to stimulation parameters. Conclusion. We show that, if the stimulation amplitude is kept such that neighboring stimulating sites do not produce cross-talk, it is possible to reconstruct visual scenes “pixel-by-pixel” without needing any optimization process. If on the contrary current steering is required and cross-talk is non negligible, then it is very difficult to obtain rules of thumb and the development and use of automatic optimization techniques should be preferable.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Concept for Myocardial Current Density Estimation with Magnetoelectric Sensors 磁电传感器估算心肌电流密度的概念

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1023

Gerhard Schmidt, Erik Engelhardt, Eric Elzenheimer, Johannes Hoffman, Tobias Schmidt, Adrian Zaman, Norbert Frey

引用次数: 0

Investigation of manufacturing deviations of CPC scaffolds for improving the design process CPC支架制造偏差调查，改进设计工艺

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1138

Alexander Seidler, Martin Pendzik, Arthur Hilbig, Philipp Sembdner, Stefan Holtzhausen, Kristin Paetzold-Byhain

{"title":"Investigation of manufacturing deviations of CPC scaffolds for improving the design process","authors":"Alexander Seidler, Martin Pendzik, Arthur Hilbig, Philipp Sembdner, Stefan Holtzhausen, Kristin Paetzold-Byhain","doi":"10.1515/cdbme-2023-1138","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1138","url":null,"abstract":"Abstract In current implantology, calcium phosphate cement (CPC) is increasingly used. A special focus is given to CPC scaffolds, as they are suitable for cell settlement and growth due to their positive osteoconductive properties. The design of the scaffolds is of decisive importance for this. The value ranges of the geometric parameters of these scaffolds (e.g. path distance, path diameter), which are positive for both cell settlement and cell growth, are very small. Manufacturing deviations therefore have a significant impact on cell settlement and growth. The pasty manufacturing consistency can cause sagging at the path interstices of a layer immediately below, resulting in significant manufacturing deviations. A larger path distance and thus a larger path interstitial space promotes cell settlement, but at the same time increases the risk of CPC path shape inconsistency. This in turn can have a negative effect on cell settlement. Therefore, the aim of this paper is to investigate the discrepancies between the nominal and actual state at a path distance favourable to cell settlement on the basis of manufactured CPC scaffolds. In this context, geometric and manufacturing parameters of the shape deviation are to be identified and constructive design adaptations are to be derived on the basis of these. In addition, the effects of the shape and position deviations on the flow behaviour will be investigated.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-printed scaffolds with perfusable channels for low-cost large construct 3D cell culture 具有可灌注通道的3D打印支架，用于低成本的大型3D细胞培养

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1166

Klaus Kreuels, Carina Schemmer, Arnold Gillner, Maximilian Frederick Flesch, Arnold Gillner

{"title":"3D-printed scaffolds with perfusable channels for low-cost large construct 3D cell culture","authors":"Klaus Kreuels, Carina Schemmer, Arnold Gillner, Maximilian Frederick Flesch, Arnold Gillner","doi":"10.1515/cdbme-2023-1166","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1166","url":null,"abstract":"Abstract This study presents a novel approach for threedimensional (3D) cell culture using a two-component system consisting of a 3D-printed scaffold structure combined with a perfusion channel. A polymeric scaffold structure with an overall size of 9 mm x 9 mm x 1 mm composed of a cubic lattice with a web thickness of 200 μm and pore size of 600 μm was 3D-printed using a hot UV-stereolithography (SLA) system. The perfusion channel with an inner diameter of 800 μm and channel wall pores of 300 μm for cell culture medium supply was 3D-printed with the same system and material. Scaffolds were investigated with respect to the printing accuracy by digital microscopy. Cytotoxicity of the materials was assessed using MTT-assay and Live/Dead staining. Scaffold were subsequently seeded with 3T3- fibroblasts within a fibrin-based hydrogel and then conditioned either statically or under passive perfusion using a hydrostatic pressure driven flow system. The results show that the scaffold structure and perfusion channel can be produced with high accuracy and stability allowing a supply of nutrient and oxygen via perfusion channel to the cells within the scaffold. This approach has potential for nutrient supply within larger constructs for tissue engineering and regenerative medicine applications.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radial compliance of porcine Fallopian tubes ex vivo – perspectives for the development of a gynecological microstent 猪输卵管体外的径向顺应性——妇科微支架的发展前景

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1147

Stefan Siewert, Ariane Dierke, Thomas Stahnke, Swen Großmann, Christoph Brandt-Wunderlich, Laura Supp, Michael Stiehm, Andrea Bock, Klaus-Peter Schmitz, Paula Rosam, Marek Zygmunt

{"title":"Radial compliance of porcine Fallopian tubes ex vivo – perspectives for the development of a gynecological microstent","authors":"Stefan Siewert, Ariane Dierke, Thomas Stahnke, Swen Großmann, Christoph Brandt-Wunderlich, Laura Supp, Michael Stiehm, Andrea Bock, Klaus-Peter Schmitz, Paula Rosam, Marek Zygmunt","doi":"10.1515/cdbme-2023-1147","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1147","url":null,"abstract":"Abstract Fallopian tube occlusions represent one of the most common causes of female sterility. As an innovative treatment approach for affected persons, we previously presented the concept of a novel polymeric, self-expanding, and bioresorbable microstent. As a basis for microstent development, knowledge of the mechanical properties of the anatomical target structure represents a crucial requirement. The current work describes a methodological approach for the experimental determination of radial Fallopian tube compliance using optical coherence tomography. It could be shown that a quantitative assessment of the mechanical properties of porcine Fallopian tube samples - as a whole anatomical structure including the Tunica mucosa, the Tunica muscularis, and the Tunica serosa - is possible, using the described test setup. Future investigations on human samples will allow for valuable information regarding the structural-mechanical properties of the Fallopian tube. Therefore, the current work offers perspectives for the development of a novel gynecological microstent for the treatment of Fallopian tube occlusions.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel airflow ring for the reduction of germ load in a surgical field 一种新型的气流环，用于减少手术现场的细菌负荷

Current Directions in Biomedical Engineering Pub Date : 2023-09-01 DOI: 10.1515/cdbme-2023-1098

Andreas Scherrieble, Elena Haab, Evi Held-Föhn, Carsten Linti, Michael Doser, Götz T. Gresser, Tobias Baumgartner, Claus G. Wandres

{"title":"Novel airflow ring for the reduction of germ load in a surgical field","authors":"Andreas Scherrieble, Elena Haab, Evi Held-Föhn, Carsten Linti, Michael Doser, Götz T. Gresser, Tobias Baumgartner, Claus G. Wandres","doi":"10.1515/cdbme-2023-1098","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1098","url":null,"abstract":"Abstract Hospital-acquired infections occur through microbial contamination of the surgical wound and can lead to severe complications. A significant transmission path is the aerogenic transmission, where pathogens stick to floating particles like skin scales or to air moisture. A novel porous airflow ring which is placed around the surgical field aims to overcome this by applying sterile air directly at the operation wound. The ring is provided with an air tight coating at the outer side and allows for fixation on the skin by an adhesive coating at the lower side. To evaluate its performance the airflow ring was placed in an atmosphere with nebulized suspension of Staphylococcus arlettae of a concentration of 5.0 x 10^5 CFU/ml resp. 5.0 x 10^6 CFU/ml within a box. The formation of bacterial colonies (CFU) on contact plates placed within the airflow ring was subsequently determined by visual counting after incubating at 37 °C for one day. CFU counts of the ventilated and the unventilated situation were compared. With the smaller inoculum, the introduction of bacteria into the inner site of the ring was completely prevented, whereas the contact plate of the unventilated ring resulted in 77 to 427 colonies in different trials. With the higher inoculum, the bacteria ingress was very strongly reduced by 99.7% respectively 99.9%. In conclusion the airflow ring shows a strong shielding effect for germs adhered to fog-sized water droplets. To clearly demonstrate the effect, the number of bacteria was greatly increased compared to reality in this setup. It was shown that it can withstand even conditions significantly worse than those encountered in an operating theatre. In order to demonstrate the effect in vivo, clinical trials have to be conducted to confirm the laboratory results.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135394565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0