Current Directions in Biomedical Engineering最新文献

Comparative Analysis of Mechanical Water Level Tank and Human Fluid Flow 机械水位槽与人体流体流动的对比分析

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1206

Jasmina V Lozanovic, M. Polz, T. Rienmüller, S. Langthaler, D. Ziesel, J. Schröttner, Christian Baumgartner

引用次数: 0

Consideration of Kv ion channels as firstorder systems 将 Kv 离子通道视为一阶系统

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1209

Jasmina V Lozanovic, S. Langthaler, T. Rienmüller, M. Polz, D. Ziesel, J. Schröttner, Christian Baumgartner

引用次数: 0

Stability of cell adhesion noise analysis for the detection of cancer cell lines 用于检测癌细胞系的细胞粘附噪音分析的稳定性

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1205

Maximilian Ell, Günther Zeck

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ECG Beat classification: Impact of linear dependent samples 心电图搏动分类：线性依赖样本的影响

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1207

Christoph Hintermüller, Michael Hirnschrodt, Hermann Blessberger, Clemens Steinwender

{"title":"ECG Beat classification: Impact of linear dependent samples","authors":"Christoph Hintermüller, Michael Hirnschrodt, Hermann Blessberger, Clemens Steinwender","doi":"10.1515/cdbme-2023-1207","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1207","url":null,"abstract":"Abstract The Electro Cardio Gram (ECG) is a very valuable clinical tool to access the electric function of the heart. It provides insight into the different phases of the heart beat and various kinds of disorders which may affect them. In literature the impact of linear dependency between feature signals upon the classification outcome and how to reduce it have been largely investigated and discussed. This study puts a focus upon linear dependency between samples of imbalanced data sets, its relation to the observed over fitting with respect to majority classes and hot to reduce it. A set of 58 feature signals is used to train a several LDA classifier either discriminating 3 classes (Normal, Artefact, Arrhythmic) or 5 Classes (Normal, Artefact, Atrial and ventricular premature contractions and bundle branch blocks). The training data set is preprocessed using four sample reduction approaches and a nearest neighbour clustering method. In the case of 5 classes accuracies of 96.82% in the imbalanced case and 97.44% for the data preprocessed with the QR or SVD methods were obtained. For 3 classes curacies of 97.68% and 98.12% were achieved. With the nearest neighbour clustering method only accuracies of 96.00% for 5 classes and 97.37% for 3 classes could be achieved. The results clearly show that imbalanced ECG data does contain linear dependent samples. These cause a bias towards majority class which will be over fitted by the classifier. Sample reduction methods and algorithms which are not aware of the presence linear dependent samples like the nearest neighbour clustering approach even further increase this bias ore even worse destroy relevant information by merging samples which encode distinct aspects of the beat class, destroying relevant information.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":" 17","pages":"23 - 26"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138614406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CloveBiotech: Complex structural variant calling for engineered microbial strains 丁香生物技术公司：工程微生物菌株的复杂结构变异调用

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1210

Veronika Schusterbauer, Pierre Reinprecht, G. Thallinger

引用次数: 0

Photovoltaic Stimulation Induces Overdrive Suppression in Embryonic Chicken Cardiomyocytes 光电刺激诱导胚胎鸡心肌细胞过速抑制

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1204

M. Polz, D. Ziesel, Niroj Shrestha, B. Pelzmann, Petra Lang, S. Scherübel, M. Üçal, Karin Kornmüller, J. Schröttner, Vedran Đerek, Aleksandar Opančar, Eric Daniel Głowacki, Christian Baumgartner, T. Rienmüller

{"title":"Photovoltaic Stimulation Induces Overdrive Suppression in Embryonic Chicken Cardiomyocytes","authors":"M. Polz, D. Ziesel, Niroj Shrestha, B. Pelzmann, Petra Lang, S. Scherübel, M. Üçal, Karin Kornmüller, J. Schröttner, Vedran Đerek, Aleksandar Opančar, Eric Daniel Głowacki, Christian Baumgartner, T. Rienmüller","doi":"10.1515/cdbme-2023-1204","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1204","url":null,"abstract":"Abstract In this study, we employed calcium imaging to investigate the dynamics of intracellular calcium levels in embryonic chicken cardiomyocytes upon extracellular, optoelectronic stimulation. A photovoltaic layer of donoracceptor pigments on a flexible PET substrate was used as a wireless stimulation electrode. Our findings revealed a distinct change in their spontaneous activity pattern in cardiac cells following asynchronous light stimulation. A short pause in cellular activity, indicative of overdrive suppression, was observed in recordings from several different cells. The pause in activity signifies a transient refractory period induced by stimulation of the photovoltaic device with red light. These findings suggest that photovoltaic electrodes can be used to effectively modulate the electrical activity of cardiac cells in a wireless, non-pharmacological manner. This opens new avenues for non-invasive and precise light-modulated control of cellular electrophysiology as well as potential therapeutic applications for cardiac rhythm disorders.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":" 10","pages":"12 - 15"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138612979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simulating auditory nerve fiber response following micro-electrode stimulation 模拟微电极刺激后的听觉神经纤维反应

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1202

Cornelia Wenger, Andreas Fellner, Fred Bucek, Paul Werginz, Frank Rattay

{"title":"Simulating auditory nerve fiber response following micro-electrode stimulation","authors":"Cornelia Wenger, Andreas Fellner, Fred Bucek, Paul Werginz, Frank Rattay","doi":"10.1515/cdbme-2023-1202","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1202","url":null,"abstract":"Abstract The cochlear implant was the first effective and is still the most common neuroprosthetic device which is employed for people with severe to profound hearing loss. To restore auditory perception, an array of micro-electrodes that deliver electrical pulses to the auditory nerve is surgically implanted into the lower cochlea duct, the scala tympani (ST). However, implantation into the upper cavity, the scala vestibuli (SV) has been tested due to severe anatomical obstruction or ossification of the ST. Clinical results revealed similar performance and thresholds for SV and ST cochlear implant users. We present a simulation study of auditory nerve fibre response to monophasic stimulation of both polarities. Excitation profiles are compared for microelectrodes placed in the SV and equivalent positions in the ST. In total, 7 different electrode positions for 4 different fibres have been investigated in a homogenous 2D model. Results for the intact fibres predict generally higher anodic thresholds in comparison to cathodic stimulation at the same electrode position and mostly lower thresholds for the SV electrodes in comparison to their ST counterparts. In contrast, anodic thresholds are mostly lower than cathodic thresholds for the degenerated fibres. Furthermore, due to the increased electrode-fibre distance for degenerate fibres which have completely lost the dendrite, SV stimulation is less beneficial. However, for basal fibres and the clinically relevant mid scala placement of the electrode the typically high thresholds remain similar for ST and SV positions.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":" 4","pages":"5 - 8"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138615879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Universal design for learning as a basis for curriculum development 将通用学习设计作为课程开发的基础

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1203

Iris Nemec, Sarah Langer, Andrea Balz

引用次数: 0

Advancements in Adult and Neonatal Breathing Simulation Using the xPULTM Electro-mechanical Lung Simulator 使用 xPULTM 电子机械肺模拟器进行成人和新生儿呼吸模拟的进展

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1208

Vasil Vodenicharov, R. Pastêka

引用次数: 0

Towards Implantable Brain-Computer Interface for Communication in Locked-In Syndrome patients 为闭锁综合征患者的交流开发植入式脑机接口

Current Directions in Biomedical Engineering Pub Date : 2023-12-01 DOI: 10.1515/cdbme-2023-1201

Gernot R. Müller-Putz, Markus Crell, Johanna Egger, Patrick Suwandjieff, Kyriaki Kostoglou

{"title":"Towards Implantable Brain-Computer Interface for Communication in Locked-In Syndrome patients","authors":"Gernot R. Müller-Putz, Markus Crell, Johanna Egger, Patrick Suwandjieff, Kyriaki Kostoglou","doi":"10.1515/cdbme-2023-1201","DOIUrl":"https://doi.org/10.1515/cdbme-2023-1201","url":null,"abstract":"Abstract Locked-in Syndrome (LIS) severely restricts the communication abilities of individuals due to extensive paralysis. The Intracranial Neuro Telemetry to Restore communication (INTRECOM) project aims to aid patients in overcoming these limitations by developing a fully implantable brain computer interface (BCI) system based on state-of-the-art technology holding great promise in revolutionizing the lives of LIS patients. In this project, the Graz BCI group, with its expertise in understanding brain dynamics associated with movement, focuses on the algorithmic development of advanced decoders that enable the user to execute specific commands by simply attempting corresponding movements. Our preliminary findings using electrocorticography (ECoG) data obtained from one individual with LIS that underwent implantation of a BCI communication system demonstrate the applicability of a ‘brain switch’ function that detects brain signals associated with attempted movements. This switch can then be used to translate the intention of the user into a click/select function on a screen.","PeriodicalId":10739,"journal":{"name":"Current Directions in Biomedical Engineering","volume":"60 4","pages":"1 - 4"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138626530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0