Cornea最新文献

{"title":"Severe Dupilumab-Associated Ocular Surface Disease: Multicenter Experience and Management Considerations.","authors":"Allison Kufta, Syeda Zainab Kazmi, Seyyedehfatemeh Ghalibafan, Jeonghyun Kwon, Rishi Sharma, Josh Sun, Lisa M Nijm, Elmer Y Tu, Maria S Cortina, Asim V Farooq, Mohammad Soleimani, Kyle T Amber, Mohammadali Ashraf, Hajirah N Saeed, Ali R Djalilian","doi":"10.1097/ICO.0000000000004336","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004336","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate severe dupilumab-associated ocular surface disease (DAOSD) and identify clinical features, risk factors, and outcomes associated with delayed ophthalmologic referral.</p><p><strong>Methods: </strong>A multicenter retrospective case series of 13 patients (26 eyes) with severe DAOSD presenting to tertiary centers between January 2014 and April 2026 was conducted. Clinical findings were analyzed alongside a focused review of current evidence on pathophysiology, diagnosis, and management.</p><p><strong>Results: </strong>Initial ocular symptoms were frequently mild and nonspecific, most commonly redness and pruritus (13/13, 100%), followed by blurred vision with tearing (3/13, 23.1%), eye pain (2/13, 15.4%), and mucoid discharge (2/13, 15.4%), contributing to delayed referral. Symptom onset ranged from 0 to 37 months after dupilumab initiation (mean 11.7 months). At presentation, advanced disease manifestations included limbitis (3/13, 23.1%), conjunctivalization with corneal neovascularization (3/13, 23.1%), limbal stem cell deficiency (2/13, 15.4%), and cicatricial conjunctivitis (1/13, 7.7%). Preexisting atopic ocular disease was present in 6/13 patients (46.2%). Management included lubrication, topical corticosteroids, calcineurin inhibitors, and scleral lenses. Dupilumab was discontinued in 7/13 patients (53.8%). Clinical stabilization was achieved in 12/13 patients (92.3%) over a mean follow-up of 21.4 ± 20.3 months.</p><p><strong>Conclusions: </strong>Severe DAOSD may be underrecognized, as mild early symptoms can delay referral and allow progression to advanced, vision-threatening complications. Preexisting ocular surface disease identifies a high-risk subgroup. Early ophthalmologic evaluation and timely referral are essential to prevent irreversible ocular surface damage and vision loss.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of Transforming Growth Factor Beta-Induced Gene Dystrophy Associated With the p.Met619Lys Mutation in the Posterior Stroma After Deep Anterior Lamellar Keratoplasty.","authors":"Jhuwala Venkatakrishnan, Reza Ghaffari, Ben J Glasgow, Anthony J Aldave","doi":"10.1097/ICO.0000000000004333","DOIUrl":"10.1097/ICO.0000000000004333","url":null,"abstract":"<p><strong>Purpose: </strong>To report the visually significant recurrence of the transforming growth factor beta-induced gene ( TGFBI ) dystrophy associated with p.Met619Lys mutation in the posterior stroma after deep anterior lamellar keratoplasty (DALK), necessitating penetrating keratoplasty (PK).</p><p><strong>Methods: </strong>Slit-lamp and anterior segment optical coherence tomography imaging were performed for 2 individuals with a variant TGFBI corneal dystrophy associated with the p.Met619Lys mutation. Histopathologic examination of the corneal buttons excised at the time of PK from each individual was performed.</p><p><strong>Results: </strong>An unrelated 58-year-old woman (case 1) and a 61-year-old man (case 2) with a variant TGFBI corneal dystrophy associated with p.Met619Lys mutation underwent manual (case 1) and big-bubble (case 2) DALK for visually significant dystrophic stromal deposits. Both individuals developed decreased vision approximately 5 years after DALK, attributed to recurrence of dystrophic deposits in the posterior stroma, necessitating PK in both individuals. Histopathologic examination of the excised residual posterior host stroma (case 1) and the excised posterior donor stroma (case 2) revealed dystrophic deposits that demonstrated staining with Masson trichrome and red-green dichroism with Congo red stain.</p><p><strong>Conclusions: </strong>The TGFBI dystrophy secondary to the p.Met619Lys mutation is associated with recurrence of visually significant dystrophic deposits in the posterior stroma after DALK. Given the need for PK only 5 years after DALK in the cases that we report, we recommend genetic testing in individuals in whom a variant TGFBI corneal dystrophy is suspected, and the conversion to PK instead of DALK for such individuals if intraoperative baring of Descemet membrane cannot be achieved.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Management Patterns and Outcomes in Recurrent Corneal Erosion: An IRIS Registry Study.","authors":"Nicholas Whitcomb, Joshua B Gilbert, Connor J Ross, William Kearney, Alice Lorch, Hyunjoo J Lee","doi":"10.1097/ICO.0000000000004338","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004338","url":null,"abstract":"<p><strong>Purpose: </strong>Surgical management of recurrent corneal erosion (RCE) lacks large-scale evidence, and national patterns of care and procedural outcomes remain incompletely defined. We characterized national practice patterns, repeat surgery rates, and risk factors for surgical failure using the American Academy of Ophthalmology IRIS Registry.</p><p><strong>Methods: </strong>Retrospective cohort study of patients with RCE between 2016 and 2025. Multilevel logistic regression and Cox proportional hazards modeling were used to evaluate odds of surgical intervention and hazard of repeat surgery after phototherapeutic keratectomy (PTK), epithelial debridement, and anterior stromal puncture (ASP).</p><p><strong>Results: </strong>Among 187,112 eyes with RCE, 12,956 (6.9%) underwent surgery: 5590 (43.0%) PTK, 5038 (39.0%) epithelial debridement, and 2328 (18.0%) ASP. Mean follow-up was 2.23 years. Two-year cumulative incidence of repeat surgery was 12% for PTK, 17% for epithelial debridement, and 29% for ASP. ASP carried a 2.5-fold higher hazard of repeat surgery versus PTK (HR 2.50, 95% CI 2.22-2.78, P < 0.001) and 64% higher versus epithelial debridement (HR 1.64, 95% CI 1.47-1.85, P < 0.001). Among eyes with RCE, concomitant epithelial basement membrane dystrophy was the ocular comorbidity most strongly associated with undergoing surgery (OR 2.57, 95% CI 2.35-2.81, P < 0.001). RCE etiology, including epithelial basement membrane dystrophy (HR 0.90), other dystrophies (HR 1.02), and prior trauma (HR 1.07), was not associated with surgical failure.</p><p><strong>Conclusions: </strong>Despite continued use as a first-line therapy, ASP carries substantially higher repeat intervention risk compared with laser and manual corneal surface procedures. Initial procedure choice, rather than underlying indication or comorbidity, was the primary predictor of surgical failure, underscoring the importance of surgical selection for recurrent corneal erosion.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple Oral Mucosal Epithelial Transplantation for Bilateral Limbal Stem Cell Deficiency in Congenital Aniridia.","authors":"Jai Paris, Fady K Sammouh, Walid Dandan, Mark Chehade","doi":"10.1097/ICO.0000000000004343","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004343","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the surgical approach and postoperative outcome of simple oral mucosal epithelial transplantation (SOMET) combined with penetrating keratoplasty for congenital aniridia-associated limbal stem cell deficiency (LSCD).</p><p><strong>Methods: </strong>A 61-year-old woman with congenital aniridia, severe bilateral keratopathy, and longstanding visual impairment underwent right-sided combined penetrating keratoplasty, lensectomy with intraocular lens implantation, and modified SOMET using autologous oral buccal mucosal epithelial graft segments. Ocular history included bilateral foveal and optic nerve hypoplasia, nystagmus, and a previously failed right limbal stem cell transplant. Examination demonstrated dense fibrovascular membranes covering both corneas, consistent with advanced LSCD. A review of the literature was also performed to identify prior reports of SOMET or SOMET-like techniques for LSCD.</p><p><strong>Results: </strong>Oral mucosal grafts harvested from the inner cheek were divided into 6 3-mm grafts and sutured around the limbus, followed by placement of a double-layer amniotic membrane. Postoperatively, the oral mucosal grafts remained adherent with stable epithelialization. Visual acuity improved from hand movements preoperatively to 6/120 unaided at 4 weeks, with maintained ocular surface integrity. Corneal impression cytology at 6 months demonstrated mixed epithelial populations with morphologic features favouring oral mucosal origin. Five prior studies describing SOMET or SOMET-like techniques for LSCD were identified, all reporting favourable anatomical and visual outcomes.</p><p><strong>Conclusions: </strong>Modified SOMET using direct oral mucosal transplantation is a simplified alternative to cultivated oral mucosal transplantation. To our knowledge, this is the first report describing its use in congenital aniridia with bilateral LSCD.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Morphometrics in Congenital Primary Aphakia: A Multimodal Imaging Perspective.","authors":"Sai Sivani Koonapa Reddy, Diya Sree Ramya Achanta, Sunita Chaurasia, Deepak P Edward, Muralidhar Ramappa","doi":"10.1097/ICO.0000000000004316","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004316","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize in vivo corneal architectural changes in congenital primary aphakia (CPA) using depth-resolved, layer-specific AS-OCT findings with those of age-matched controls.</p><p><strong>Methods: </strong>This observational study includes 31 eyes of 16 children with clinically diagnosed CPA. High-resolution AS-OCT was used to obtain meridional and lamellar corneal thickness measurements: anterior, central stromal, and posterior layers were quantified across 5 standard locations (central, nasal, temporal, superior, and inferior). Quadrant-wise and layer-wise values were compared within the CPA cohort and against 13 eyes of 7 age-matched controls. Statistical comparisons between groups and within the CPA group were performed using linear mixed-effects models with Bonferroni-adjusted pairwise comparisons.</p><p><strong>Results: </strong>CPA corneas demonstrated significant layer-wise thickness variations in both horizontal and vertical meridians (all P <0.001), driven predominantly by regional lamellar abnormalities. Central stromal layer thickness was markedly reduced in CPA group compared with controls (355 ± 22.7 vs.501 ± 33.6 μm; P = 0.001). In contrast, the anterior layer thickness paradoxically increased in several quadrants (central: 57.6 ± 6.6 vs. 32.9 ± 9.3 μm; P = 0.040), whereas the posterior layer was consistently and profoundly thick across all quadrants (central: 56.4 ± 9.1 vs. 15.5 ± 10.6 µm; P = 0.007). The total central corneal thickness was significantly lower in the CPA group than in the control group (433 ± 25.3 vs. 543 ± 38.3 µm; P = 0.023).</p><p><strong>Conclusions: </strong>CPA is associated with a unique, depth-specific corneal morphometric phenotype characterized by central stromal hypoplasia and thickening of anterior and posterior layers. These findings are likely because of the absence of embryonic lens impairing normal corneal morphogenesis. Layer-specific AS-OCT analysis refines CPA phenotype and supports clinical decision making.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Burden of Herpes Zoster Ophthalmicus in New Zealand: A Retrospective Cohort Cost Analysis.","authors":"Priya Darshni Samalia, Chen Lian Ji, Jay Meyer, Rachael Louise Niederer","doi":"10.1097/ICO.0000000000004342","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004342","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to estimate the direct health care cost burden of herpes zoster ophthalmicus (HZO) in New Zealand and to evaluate potential implications for shingles vaccination policy.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 869 participants with HZO treated at Greenlane Eye Clinic, Auckland, using data from the Auckland Zoster Study. Clinical and demographic data were reviewed and cross-referenced with hospital electronic databases. The total number of hospital visits, medications, and procedures associated with HZO and its complications were recorded. Unit costs were derived from New Zealand pricing data, and cumulative hospital-based direct health care costs were calculated. Factors associated with health care costs were evaluated using a generalized linear model (GLM) with a gamma distribution and log link, with multivariable linear regression performed as a sensitivity analysis.</p><p><strong>Results: </strong>The median follow-up was 6.3 years [IQR 3.7-8.9]. The average hospital-based health care cost captured in this study was New Zealand dollars $3185.95 ± 6791.22 (range $30.49-$85,967.59). Mean inpatient, outpatient, drug, and procedure costs were $278.82 ± 1628.79, $2231.16 ± 3762.62, $113.51 ± 1288.57, and $562.45 ± 2582.89, respectively. In multivariable GLM analysis, higher health care costs were independently associated with older age (P < 0.001), immunosuppression (P = 0.047), uveitis (P < 0.001), optic neuropathy (P < 0.001), and recurrent disease (P < 0.001).</p><p><strong>Conclusions: </strong>HZO imposes a significant direct health care cost burden on the New Zealand health care system. These findings provide important local cost data for future economic evaluations, including cost-effectiveness analyses of HZ prevention strategies.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Standardized Protocol for Murine Endothelial Keratoplasty: From Donor Preparation to Outcome Assessment.","authors":"Akitomo Narimatsu, Yeganeh Farsi, Seokjoo Lee, Shima Dehghani, Mark Krauthammer, Reza Dana","doi":"10.1097/ICO.0000000000004304","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004304","url":null,"abstract":"<p><strong>Purpose: </strong>While the first murine endothelial keratoplasty (EK) model established surgical feasibility, manual lamellar dissection and endothelial scraping introduce significant procedural variability. This study aims to develop a standardized murine EK model implementing a controlled stromal peeling technique and quadrant-based host bed preparation to minimize inconsistency.</p><p><strong>Methods: </strong>We introduced 2 critical methodological refinements. First, donor corneas were prepared using a controlled stromal peeling approach to ensure uniform graft thickness. Second, traditional circular scraping of the recipient endothelium was replaced with quadrant-based mechanical removal to standardize the denuded area. Postoperative outcomes were quantified using AS-OCT and a novel time-resolved opacity scoring system designed to distinguish early technical failure from immunologic rejection.</p><p><strong>Results: </strong>Controlled stromal peeling produced posterior lamellar grafts with significantly higher thickness consistency compared with traditional needle dissection. The quadrant-based removal resulted in highly reproducible postoperative corneal edema, reflecting standardized disruption of host endothelial function. Furthermore, the time-resolved grading system allowed more granular, objective differentiation between early graft failure and delayed rejection compared with traditional binary survival assessments.</p><p><strong>Conclusions: </strong>These refinements overcome the inherent variability of the initial murine EK model. By standardizing both the surgical procedure and the interpretive framework, this optimized model provides a robust, reproducible platform for investigating cellular mechanisms of graft outcomes in experimental keratoplasty.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149243516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter Regarding: Global Consensus on Keratoconus and Ectatic Diseases-Edition 2.","authors":"Alejandro Tello, Luis David Rodríguez-Valdivieso, Letizia Prada, Virgilio Galvis","doi":"10.1097/ICO.0000000000004346","DOIUrl":"10.1097/ICO.0000000000004346","url":null,"abstract":"","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149243556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eyelid Calcinosis Cutis in a Child With Chronic Vernal Keratoconjunctivitis: A Case Report and Review of the Literature.","authors":"Rohan Madan, Sikha Misra, Ananya Joshi, Dilip Kumar Misra, Geeta K Vemuganti, Deepak Paul Edward, Muralidhar Ramappa","doi":"10.1097/ICO.0000000000004340","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004340","url":null,"abstract":"<p><strong>Purpose: </strong>To describe multifocal eyelid margin and canthal calcinosis cutis in a child with chronic recalcitrant vernal keratoconjunctivitis (VKC), and to review the reported ophthalmic cases of periocular calcinosis cutis.</p><p><strong>Methods: </strong>The clinicopathological data of a 14-year-old immunocompetent boy with a 9-year history of chronic VKC and inconsistent treatment adherence were reviewed retrospectively. Eyelid-margin papules and a gelatinous canthal mass were excised and examined by light microscopy with hematoxylin and eosin and with calcium-specific staining. A PubMed/MEDLINE review of periocular calcinosis cutis and subepidermal calcified nodules was additionally conducted, and individual patient data were synthesized.</p><p><strong>Results: </strong>Histopathology showed keratinized stratified squamous epithelium with epithelial atrophy; the stroma contained calcific lobules, focal metaplastic ossification, and hyaline-fibrinoid degeneration, with calcium confirmed on Von Kossa and Alizarin red staining. Immunosuppression and dysmetabolic states were excluded (HIV, HBsAg, HCV negative; serum calcium and phosphate normal). After tacrolimus withdrawal, the right canthal mass enlarged over 6 months and produced mechanical ptosis, prompting definitive excision with cryotherapy. Best-corrected visual acuity improved from 20/200 to 20/80 and from 20/50 to 20/30, with resolution of ptosis, remission of VKC, and no recurrence. Across the 12 reported cases and the present one, all were painless upper lid nodules in healthy young patients, cured by excision; none occurred in VKC.</p><p><strong>Conclusions: </strong>Eyelid dystrophic calcification, or calcinosis cutis, is diagnosed histopathologically and cured by excision and can arise in chronic poorly controlled VKC. Sustained Th2-driven inflammation with repeated low-grade injury to the lid margin and tarsus is the most plausible mechanism; calcinosis cutis warrants consideration when a child with long-standing VKC develops firm lid margin papules or a canthal mass.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149243500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial Differences in Corneal Endothelial Cells in Adult Patients.","authors":"Stephen Ellsworth, Rohini Chahal, Viana Phan, Travis Williams, Alice Chuang, Ahmad Kheirkhah","doi":"10.1097/ICO.0000000000004326","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004326","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the racial differences in corneal endothelial cell parameters in adult patients undergoing cataract surgery.</p><p><strong>Methods: </strong>This retrospective study included 218 eyes of 218 patients 50 years or older who underwent surgery for senile cataract. Patients with cornea/anterior segment abnormalities, trauma, or surgery were excluded. Preoperatively, all patients had specular microscopy to evaluate endothelial cell density (ECD), hexagonal cell percentage (HEX%), coefficient of variation (CV), and pachymetry. Corneal endothelial cell and ocular biometric parameters were then compared between White and Black participants. Correlations between endothelial cell parameters and ocular biometric parameters from IOLMaster were also examined.</p><p><strong>Results: </strong>There were 154 White and 64 Black individuals. There were no significant differences between the races in age, sex, anterior chamber depth, axial length, or steep keratometry. However, Black patients had significantly lower pachymetry (544.22 ± 35.49 vs. 558.59 ± 38.39 µm, P = 0.01), lower lens thickness (4.28 ± 0.51 vs. 4.50 ± 0.51 mm, P = 0.004), and greater flat keratometry (43.61 ± 1.42 vs. 43.01 ± 1.86 degrees, P = 0.02) compared with White patients. For corneal endothelial parameters, HEX% was significantly lower in Black patients (56.4 ± 5.8%) than in White patients (58.7 ± 5.9%, P = 0.01). However, no significant differences were noted in ECD (P = 0.75) or CV (P = 0.22) between White and Black patients. ECD had a significant positive correlation with pachymetry, whereas CV had a significant negative correlation with axial length.</p><p><strong>Conclusions: </strong>In addition to some anatomical differences in anterior segment anatomy, HEX% was significantly lower in Black patients than in White patients.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}