IF 1.9 3区医学

Cornea Pub Date : 2025-03-28 DOI: 10.1097/ICO.0000000000003856

Ahmet Kaan Gündüz, Ibadulla Mirzayev, Cevriye Cansiz Ersöz, Aylin Okçu Heper, Ömür Gündüz, Funda Seher Özalp Ateş

{"title":"Anterior Segment Swept-source Optical Coherence Tomography in Ocular Surface Tumors and Simulating Lesions and Correlation With Histopathologic Diagnosis.","authors":"Ahmet Kaan Gündüz, Ibadulla Mirzayev, Cevriye Cansiz Ersöz, Aylin Okçu Heper, Ömür Gündüz, Funda Seher Özalp Ateş","doi":"10.1097/ICO.0000000000003856","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003856","url":null,"abstract":"Purpose: To investigate anterior segment swept-source optical coherence tomography (AS SS-OCT) findings in ocular surface tumors and simulating conditions.Methods: AS SS-OCT imaging and histopathologic data pertaining to 92 eyes of 86 cases collected between September 2018 and April 2023 were evaluated.Results: The 3 most common lesions were conjunctival nevus (18 eyes), ocular surface squamous neoplasia (OSSN, 16 eyes), and pterygium/pinguecula (13 eyes). Excisional/incisional biopsy was performed in 58 of 86 (67.4%) cases. On AS SS-OCT, conjunctival nevi demonstrated mildly hyperreflective epithelium of normal thickness, internal hyperreflectivity, and intralesional cysts. OSSN showed epithelial hyperreflectivity, epithelial thickening, and an abrupt transition between normal and abnormal epithelium. Differences between median maximal epithelial thickness on AS SS-OCT for OSSN and pterygium (560 vs. 102 μm), OSSN and pseudopterygium (560 vs. 113 μm), OSSN and pinguecula (560 vs. 72.5 μm), and OSSN and conjunctival papilloma (560 vs. 965.5 μm) were statistically significant (P < 0.001, P < 0.001, P < 0.001, and P = 0.039, respectively). By receiver-operating characteristic curve, using 630.5 μm as a cutoff, the sensitivity and specificity of AS SS-OCT for differentiating between conjunctival papilloma and OSSN were 69% and 100%, respectively (P = 0.038). The presence of hyporeflective spaces/cysts was statistically significant in conjunctival papilloma compared to OSSN (P < 0.001) and in conjunctival nevus compared to conjunctival melanoma (P = 0.002).Conclusions: AS SS-OCT is a useful tool in differentiating OSSN from pterygium/papilloma and conjunctival nevus from melanoma. It provides important in vitro information on many other lesions including conjunctival lymphoma, primary acquired melanosis, and conjunctival amyloidosis.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of Corneal Ulcers Diagnosed in the Emergency Department in California. 加州急诊科诊断角膜溃疡的流行病学

IF 1.9 3区医学

Cornea Pub Date : 2025-03-28 DOI: 10.1097/ICO.0000000000003863

Albert Xu, John M Nesemann, Jeremy D Keenan

{"title":"Epidemiology of Corneal Ulcers Diagnosed in the Emergency Department in California.","authors":"Albert Xu, John M Nesemann, Jeremy D Keenan","doi":"10.1097/ICO.0000000000003863","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003863","url":null,"abstract":"Purpose: To determine the incidence, seasonality, geographic distribution, and risk factors for emergency department presentations with corneal ulcers and perforated corneal ulcers.Methods: Retrospective, population-based cohort study of corneal ulcers in California from 2012 to 2021. Overall and stratified yearly incidence rates, seasonality, individual-level and postal code-level risk factors for perforation, and geographic clustering were evaluated.Results: This study included 31,019 emergency department (ED) visits for corneal ulcers, with 263 cases coded as perforated corneal ulcers. The average yearly incidence was 7.94 (95% confidence interval, 7.85-8.03) per 100,000 people for ED-diagnosed corneal ulcers and 0.67 (95% confidence interval, 0.59-0.76) per 1,000,000 people for perforated corneal ulcers. Male patients, Black patients, and primary English-speaking patients had the highest incidences across sociodemographic groups. For ED-diagnosed corneal ulcers, the incidence was highest among individuals aged 20 to 60 and for perforated corneal ulcers the incidence was highest among individuals over age 75. Significant geographic clustering was observed, with hotspots in the Central Valley and inland Northern and Southern California. Visits were seasonal, with incidence peaking in July and lowest in February. Increasing age, Spanish as a preferred language, and having health insurance were significant risk factors for presenting with a perforated corneal ulcer. Indicators of low socioeconomic status were associated with higher rates of corneal ulcers.Conclusions: The incidence of ED-diagnosed corneal ulcers in California increased over the study period with a notable seasonal pattern. Higher rates were observed in Black individuals and in areas with lower socioeconomic status, providing evidence of health disparities and identifying potential targets for public health interventions.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Efficacy and Mechanisms of Mesenchymal Stem Cells and Their Exosomes in the Treatment of Ocular Graft-Versus-Host Disease. 间充质干细胞及其外泌体治疗眼部移植物抗宿主病的疗效及机制

IF 1.9 3区医学

Cornea Pub Date : 2025-03-27 DOI: 10.1097/ICO.0000000000003868

Chenxi Ye, Shuwan Liu, Jing Hong

{"title":"Therapeutic Efficacy and Mechanisms of Mesenchymal Stem Cells and Their Exosomes in the Treatment of Ocular Graft-Versus-Host Disease.","authors":"Chenxi Ye, Shuwan Liu, Jing Hong","doi":"10.1097/ICO.0000000000003868","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003868","url":null,"abstract":"Purpose: To provide a comprehensive overview of the clinical manifestations, pathophysiology, and current treatments of ocular graft-versus-host disease (oGVHD), and to explore the therapeutic potential of mesenchymal stem cells (MSCs) and their exosomes (MSC-Exos) as novel treatments.Methods: A literature review was conducted using major databases (PubMed, Web of Science, Scopus) to identify studies published between 2000 and 2024. The focus was on clinical trials, case series, and experimental studies related to oGVHD. Data were synthesized to summarize current knowledge.Results: oGVHD affects 40% to 60% of Hematopoietic Stem Cell Transplantation recipients, causing symptoms such as dryness, irritation, and vision impairment. Current treatments often fail to provide long-term relief and may cause significant side effects. MSCs and MSC-Exos offer a promising alternative because of their immunosuppressive and regenerative properties. Preclinical and clinical studies have demonstrated their safety and efficacy in improving oGVHD symptoms and promoting corneal health.Conclusions: MSCs and MSC-Exos show promise in treating oGVHD, with potential to improve symptoms and promote tissue repair. Further research is needed to establish their long-term safety and efficacy.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Recovery After Descemet Membrane Endothelial Keratoplasty in Eyes With Preexisting Multifocal Intraocular Lens. 已有多焦人工晶状体的眼视网膜内皮角膜移植术后视力恢复。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-26 DOI: 10.1097/ICO.0000000000003864

Pratima Vishwakarma, Björn Bachmann, Mert Mestanoglu, Silvia Schrittenlocher, Johanna Wiedemann, Simona L Schlereth, Claus Cursiefen

{"title":"Visual Recovery After Descemet Membrane Endothelial Keratoplasty in Eyes With Preexisting Multifocal Intraocular Lens.","authors":"Pratima Vishwakarma, Björn Bachmann, Mert Mestanoglu, Silvia Schrittenlocher, Johanna Wiedemann, Simona L Schlereth, Claus Cursiefen","doi":"10.1097/ICO.0000000000003864","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003864","url":null,"abstract":"Purpose: To assess visual acuity outcomes in pseudophakic eyes with a multifocal (MF)-IOL (intraocular lens) and endothelial failure receiving Descemet membrane endothelial keratoplasty (DMEK).Method: This is a retrospective case-series analyzing patients from the prospective Cologne DMEK database where visual acuity outcome in 14 eyes of 9 patients requiring DMEK after MF-IOL implantation was compared with 14 eyes of 14 age-matched controls for DMEK after monofocal IOL implantation. All patients suffered from Fuchs endothelial corneal dystrophy.Results: The average age at presentation was 69 ± 8.9 and 68 ± 7.6 years for cases and control group, respectively. Average pretransplant best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution was 0.45 ± 0.32 and 0.39 ± 0.19 among cases and control groups, respectively. After exclusion of 4 eyes with other visual acuity limitations and their age-matched control eyes, final average BCVA at follow-up among cases was 0.1 ± 0.07 at 3 months and 0.15 ± 0.10 at 6 months, whereas it was 0.14 ± 0.10 at 3 months (P = 0.435) and 0.05 ± 0.05 at 6 months (P = 0.054) of follow-up among the control group. When including eyes with IOL calcification, BCVA at 1 and 2 years in cases was significantly worse compared with controls. IOL calcification was more common in eyes with preexisting MF-IOL (3/14).Conclusions: Good visual outcomes can be achieved in eyes where DMEK is done after MF-IOL implantation. Visual acuity recovery may be slower and slightly lesser compared with eyes with preexisting monofocal IOL in situ. The risk of IOL calcification seems higher in MF-IOLs.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter Regarding: Post-penetrating Keratoplasty Acute Corneal Hydrops as an Additional Indication for Compression Sutures. 关于：穿透性角膜移植术后急性角膜积液作为加压缝合的附加指征。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003871

Radhika Natarajan, Ankita Kumari

引用次数: 0

Reply to Letter Regarding: Clinical Outcomes and Indications of In-Office Sutureless Dried Gamma Ray-Sterilized Human Amniotic Membrane Transplantation With Bandage Contact Lenses in Various Ocular Surface Disorders. 给编辑的信。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003867

Yongwoo Lee

引用次数: 0

Impact of Simultaneous TG-PRK on Corneal Haze After Cross-Linking for Keratoconus: A Quantitative Densitometry Analysis. 同时TG-PRK对圆锥角膜交联后角膜雾度的影响：定量密度分析。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003862

João Q Gil, Pedro Gil, Sara Geada, Esmeralda Costa, Cristina Tavares, Andreia Rosa, Maria J Quadrado, Joaquim N Murta

{"title":"Impact of Simultaneous TG-PRK on Corneal Haze After Cross-Linking for Keratoconus: A Quantitative Densitometry Analysis.","authors":"João Q Gil, Pedro Gil, Sara Geada, Esmeralda Costa, Cristina Tavares, Andreia Rosa, Maria J Quadrado, Joaquim N Murta","doi":"10.1097/ICO.0000000000003862","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003862","url":null,"abstract":"Purpose: To compare the impact of simultaneous topography-guided photorefractive keratectomy (TG-PRK) on corneal haze in patients undergoing accelerated corneal cross-linking (CXL) for keratoconus, using corneal densitometry.Methods: Retrospective, case-control study comparing patients undergoing accelerated CXL alone (CXL group) or combined CXL and TG-PRK (TG-PRK group). All patients performed PTK-assisted 50-μm deepithelization, followed by 10-minute ultraviolet-A exposure at 10 mW/cm2 (6 J/cm2 total dose). In the TG-PRK group, patients had simultaneous TG-PRK ablation for topographic regularization. Corneal densitometry was measured preoperatively, at 3 months, and at 1 year postoperatively using a Scheimpflug device. Changes in densitometry values across different corneal regions were analyzed to assess haze evolution.Results: A total of 106 eyes were included, with 50 eyes in the CXL group and 56 eyes in the TG-PRK group. At 3 months and 1 year postoperatively, patients in the TG-PRK group exhibited significantly higher corneal densitometry values across all areas of the anterior and central middle stroma (P < 0.001). By 1 year, densitometry values in both groups had largely returned to baseline, except for the central 2 mm of the anterior cornea in the TG-PRK group. Patients with greater flattening had significantly more haze after CXL with TG-PRK, but no correlation was found between haze formation and changes in visual acuity in both groups.Conclusions: Simultaneous TG-PRK and CXL result in more significant and prolonged corneal haze compared with CXL alone. Haze improves over time but persists longer in the combined procedure. Corneal densitometry is valuable for assessing haze and optimizing patient management.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjunctival Silicone Granuloma From Breast Implants. 乳房植入物引起的结膜硅胶肉芽肿。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003866

Anna J Sun, Anna M Stagner, Han-Ying P Chang

引用次数: 0

Long-term Tomographic, Refractive, and Visual Analysis of Keratoconus Eyes With Extreme Corneal Flattening After Corneal Cross-linking. 角膜交联后角膜极度扁平化圆锥角膜的长期断层、屈光和视觉分析。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003861

Maria A Henriquez, Luis Izquierdo, Ignacia Zenteno, Rolando Rojas, Jose Chauca, Mark Mannis

{"title":"Long-term Tomographic, Refractive, and Visual Analysis of Keratoconus Eyes With Extreme Corneal Flattening After Corneal Cross-linking.","authors":"Maria A Henriquez, Luis Izquierdo, Ignacia Zenteno, Rolando Rojas, Jose Chauca, Mark Mannis","doi":"10.1097/ICO.0000000000003861","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003861","url":null,"abstract":"Purpose: To evaluate the long-term tomographic, refractive, and visual characteristics of eyes with extreme corneal flattening after corneal cross-linking (CXL) for progressive keratoconus.Methods: A retrospective observational study included eyes that underwent corneal CXL with epithelial removal between June 2006 and March 2017 and had extreme keratometric flattening [greater than 5 diopters (D)] and a minimum follow-up of 5 years. Visual, tomographic, pachymetric, and refractive characteristics were evaluated.Results: Mean follow-up time was 7.6 ± 2.6 years (range 5-13 years). Fifteen eyes were included in the study. Mean maximum keratometric (Kmax) flattening was -7.58 ± 2.63 D [range 5.0-12.2 D, (P <0.001)]. Approximately 56.25% (9/15) of the eyes experienced progressive flattening over the years. And 40% (6/15) presented an improvement of one or more lines of corrected distance visual acuity (CDVA), and 26.6% (5/16) of the eyes showed a worsening of CDVA. Logistic regression analysis revealed that postoperative Kmax flattening greater than 2 D at the first year postop (odds ratio 17.7, 95% confidence interval, 4.4-71.2) and preoperative Kmax greater than 55 D (odds ratio 8.8, 95% confidence interval, 2.7-28.3) were significant risk factors for extreme postop keratometric flattening.Conclusions: Progressive extreme corneal flattening when accompanied with a decrease of CDVA was a late complication of CXL that may have required corneal transplantation for visual rehabilitation. Preoperative steeper corneas and keratometric flattening greater than 2 D at the first year postoperative period were risk factors associated with long-term extreme postoperative corneal flattening.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Manual Technique for Corneal Allogeneic Intrastromal Ring Segments Without a Femtosecond Laser. 无飞秒激光人工角膜异体角膜间环段技术研究。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-19 DOI: 10.1097/ICO.0000000000003853

Takahiko Hayashi, Yusuke Hara, Chihiro Sunouchi, Kentaro Yuda, Takashi Kojima, Naoko Kato, Brendan Cronin, Satoru Yamagami

{"title":"A Manual Technique for Corneal Allogeneic Intrastromal Ring Segments Without a Femtosecond Laser.","authors":"Takahiko Hayashi, Yusuke Hara, Chihiro Sunouchi, Kentaro Yuda, Takashi Kojima, Naoko Kato, Brendan Cronin, Satoru Yamagami","doi":"10.1097/ICO.0000000000003853","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003853","url":null,"abstract":"Purpose: To evaluate the outcomes of corneal allogeneic intrastromal ring segments (CAIRS) using a simplified manual technique for treating keratoconus.Methods: This prospective case series included 5 eyes from 5 patients with keratoconus (4 males, 1 female, mean age 32.5 ± 10.6 years) treated with manual CAIRS. Surgeries were performed under local anesthesia by a single surgeon. An intrastromal pocket for donor tissue implantation was manually created using a spatula, and donor corneas were prepared using a Jacobs CAIRS trephine. Corneal parameters, including higher-order aberrations, coma, and spherical aberrations at a 6 mm diameter, were measured using optical coherence tomography (CASIA SS-1000, Tomey, Japan). Anterior and posterior corneal indices, subjective refractive power, cylinder, spherical equivalent, best-corrected visual acuity (BCVA; logarithm of the minimum angle of resolution [logMAR]), and central corneal thickness. Intra- and postoperative complications were also analyzed.Results: Over a mean follow-up of 6.4 ± 2.9 months, no complications occurred. BCVA improved from 0.74 ± 0.44 logMAR preoperatively to 0.19 ± 0.66 logMAR (P = 0.043). The maximum keratometry (Kmax) value decreased from 63.6 ± 8.3D preoperatively to 59.6 ± 6.8D postoperatively (P = 0.043). Spherical equivalent improved from -11.2 ± 5.8D to -5.3 ± 3.1D (P = 0.043), and astigmatism reduced from -5.0 ± 3.4D to -3.3 ± 2.9D. Total corneal higher-order aberrations decreased from 5.6 ± 1.6D to 4.2 ± 1.6D postoperatively (P = 0.043).Conclusions: Manual CAIRS is an effective treatment when a femtosecond laser is not available.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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