IF 2.3 3区医学

Cornea Pub Date : 2026-10-15 DOI: 10.1097/ICO.0000000000004345

Howard Zhang, Lindsay Veach, Mario Davidson, Christine Shieh, Stephen Kim, Sapna Gangaputra

{"title":"Corneal Endothelial Outcomes in Diabetic Patients Following Repeated Anterior Chamber Paracentesis.","authors":"Howard Zhang, Lindsay Veach, Mario Davidson, Christine Shieh, Stephen Kim, Sapna Gangaputra","doi":"10.1097/ICO.0000000000004345","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004345","url":null,"abstract":"Purpose: The aim of this study was to evaluate longitudinal changes in corneal endothelial morphology following serial anterior chamber (AC) paracentesis in patients with type 2 diabetes mellitus.Methods: This is a prospective cohort study with both cross-sectional and longitudinal components. Participants with type 2 diabetes mellitus underwent bilateral AC paracentesis, specular microscopy analysis, and dilated fundus examination at baseline and at four-month intervals over 3 years. Endothelial parameters included cell density (CD), coefficient of variation, hexagonality, and central corneal thickness. Linear mixed-effects models were adjusted for age, sex, laterality, hemoglobin A1c, diabetes duration, diabetic retinopathy severity, and lens status.Results: One hundred twelve participants were included at baseline [median age 63 years, 50% female, median hemoglobin A1c 7.8% (interquartile range 1.93), median diabetes duration 20 years]. Most had mild-to-moderate nonproliferative DR (60%), and 30% were pseudophakic. At baseline, pseudophakic lens status (mean ± SD CD: 2566.7 ± 190.8 cells/mm2) predicts a lower CD of -161 cells/mm2 (95% confidence interval -243.1 to -83.1) compared with phakic eyes (2721.5 ± 184.1 cells/mm2). Pseudophakia also predicts a higher coefficient of variation of +3.7 (95% confidence interval, 0.2-7.0). These differences persisted longitudinally. Repeated AC paracentesis was not associated with any significant change in any parameters.Conclusions: To our knowledge, this is the largest and longest prospective evaluation of repeated AC paracentesis in humans with diabetes. Despite up to 10 AC paracenteses per eye over 3 years, no adverse effects on endothelial cell morphology were observed. These findings support the broader adoption of serial aqueous sampling as a precision-medicine tool in ophthalmology and research.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149191729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methodological Considerations Regarding Repeatability of Epithelial Thickness Mapping in Normal and Keratoconus Eyes Using a Novel Hybrid Scheimpflug-Optical Coherence Tomography Device. 使用一种新型混合scheimpflud -光学相干断层扫描设备对正常和圆锥角膜进行上皮厚度测量可重复性的方法学考虑。

IF 2.3 3区医学

Cornea Pub Date : 2026-10-15 DOI: 10.1097/ICO.0000000000004339

Armin Doostparast, Maryam Ghandhari, Alireza Eslampoor

引用次数: 0

The Effects of Age on the Presence of Atypical Corneal Nerve Formations. 年龄对非典型角膜神经形成的影响。

IF 2.3 3区医学

Cornea Pub Date : 2026-10-14 DOI: 10.1097/ICO.0000000000004341

Josef Štorm, Marcela Minaříková, Veronika Potočková, Matvei Slavenko, Marie Česká Burdová, Radim Mazanec, Jiří Uhlík, Gabriela Mahelková

{"title":"The Effects of Age on the Presence of Atypical Corneal Nerve Formations.","authors":"Josef Štorm, Marcela Minaříková, Veronika Potočková, Matvei Slavenko, Marie Česká Burdová, Radim Mazanec, Jiří Uhlík, Gabriela Mahelková","doi":"10.1097/ICO.0000000000004341","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004341","url":null,"abstract":"Purpose: The aim of this study was to describe the presence of atypical nerve formations (ANFs, previously termed microneuromas) and their relation to standardized ocular surface parameters and changes in the sub-basal nerve plexus in a group of patients with suspected small fiber neuropathy or type 1 diabetes referred for in vivo confocal microscopy (IVCM).Methods: This retrospective single-center study enrolled 143 patients (286 eyes) referred for corneal nerve morphology evaluation between 2019 and 2024. Patients with severe dry eye disease, a history of ocular surgery, or recent eye drop use were excluded. All participants underwent comprehensive ocular surface assessment, including OSDI, Cochet-Bonnet esthesiometry, tear break-up time (TBUT), Oxford grading, tear osmolarity, and tear metalloproteinase-9 (MMP-9) concentration. IVCM was performed to obtain corneal nerve fiber metrics (corneal nerve fiber length, corneal nerve fiber density, corneal nerve branch density) and to manually identify ANFs. Generalized estimating equations were used to account for intereye correlation.Results: Corneal ANFs were identified in 25.5% of the 286 eyes. Age demonstrated a statistically significant association with ANF presence, with the odds increasing by approximately 5% for each additional year of age (odds ratio 1.05; P < 0.001). A statistically significant inverse association was observed with corneal sensitivity (P = 0.040). No statistically significant correlations were found between ANFs and TBUT, tear osmolarity, MMP-9 concentrations, OSDI scores, or standard IVCM metrics.Conclusions: Corneal ANFs seem to be strongly associated with aging, suggesting that they may represent age-related degenerative remodeling rather than specific biomarkers for ocular neuropathic pain or inflammation in this population and, as such, should be interpreted with caution and within the broader clinical context.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Culture-Proven Endophthalmitis Associated With Penetrating Keratoplasty: Clinical Features, Microbiologic Aspects, and Outcomes. 培养证实与穿透性角膜移植术相关的眼内炎：临床特征、微生物学方面和结果。

IF 2.3 3区医学

Cornea Pub Date : 2026-10-13 DOI: 10.1097/ICO.0000000000004337

Charles Zhang, Mariam Tadross, Baltaj S Sandhur, Guillermo Amescua, Harry W Flynn

{"title":"Culture-Proven Endophthalmitis Associated With Penetrating Keratoplasty: Clinical Features, Microbiologic Aspects, and Outcomes.","authors":"Charles Zhang, Mariam Tadross, Baltaj S Sandhur, Guillermo Amescua, Harry W Flynn","doi":"10.1097/ICO.0000000000004337","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004337","url":null,"abstract":"Purpose: The objective of this study was to report the clinical features, microbiologic profile, treatments, and outcomes of culture-proven endophthalmitis following penetrating keratoplasty (PKP) in a contemporary cohort.Methods: A retrospective chart review of all patients with culture-proven endophthalmitis following PKP between January 2017 and July 2025 was conducted. Patients with endophthalmitis from endothelial keratoplasty, trauma, or other surgery were excluded.Results: Ten eyes of 10 patients met inclusion criteria. The mean age was 74 ± 3 years, and 70% were female. Indications for PKP were diverse, including 5 optical grafts for Fuchs dystrophy, keratoconus, and corneal edema and 4 therapeutic grafts. Initial visual acuity was hand motion on average. Hypopyon was present in 60%, vitritis in 80%, and suture abscesses in 30%. Initial management was intravitreal aspiration, with intravitreal injection of antimicrobials in 90% and primary pars plana vitrectomy in 10% of eyes. A pars plana vitrectomy for endophthalmitis was performed 1 to 5 days later in an additional 5 of 10 eyes (50%): 3 of 5 for debulking of the vitreous and 2 of 5 because of retinal detachments. Vitreous cultures were positive in all cases, with Candida in 40% isolates, Streptococcus sp. in 20%, Staphylococcus aureus in 10%, Staphylococcus epidermidis in 10%, Enterococcus in 10%, and Pseudomonas in 10%. Despite prompt treatment, visual acuity at the last follow-up was poor at <5/200; however, no eyes were eviscerated or enucleated.Conclusions: Endophthalmitis after PKP is an uncommon but devastating complication. In this series, fungal pathogens accounted for a substantial proportion of cases. Management was individualized, but outcomes were generally poor.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter Regarding: Color at What Cost? The Case Against Cosmetic Keratopigmentation in Sighted Eyes. 关于：颜色的代价是什么？视力正常眼美容性角膜色素沉着的病例分析。

IF 2.3 3区医学

Cornea Pub Date : 2026-10-13 DOI: 10.1097/ICO.0000000000004347

Alexander Movshovich

引用次数: 0

Topical Insulin in the Treatment of Ocular Surface Disease: A Retrospective Cohort Study. 局部胰岛素治疗眼表疾病：一项回顾性队列研究

IF 2.3 3区医学

Cornea Pub Date : 2026-10-13 DOI: 10.1097/ICO.0000000000004331

Marie Lammens, Dimitri Roels, Silke Oellerich, Sorcha Ní Dhubhghaill, Iva Krolo

{"title":"Topical Insulin in the Treatment of Ocular Surface Disease: A Retrospective Cohort Study.","authors":"Marie Lammens, Dimitri Roels, Silke Oellerich, Sorcha Ní Dhubhghaill, Iva Krolo","doi":"10.1097/ICO.0000000000004331","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004331","url":null,"abstract":"Purpose: To assess the efficacy of topical insulin for the treatment of various ocular surface diseases.Methods: A retrospective, multicenter cohort study was conducted at the university hospitals of Brussels and Ghent and included 57 eyes (45 patients) treated with topical insulin (1 IU/mL 4 times daily) for neurotrophic keratopathy (NK) (n = 31), dry eye disease (DED) (n = 9), graft-versus-host disease (GVHD) (n = 7), and various other ocular surface diseases (n = 10) between October 2023 and March 2025. Data from medical records and anterior segment photographs were analyzed. Primary outcome was treatment success; secondary outcomes included clinical evolution, symptoms, data on persistent epithelial defects (PED), vision, and adverse events.Results: Treatment success was highest in NK eyes (83.9%) as compared to DED and GVHD eyes (44.4% and 14.3%, respectively), with a statistically significant difference between NK and GVHD (P = 0.028). Treatment success did not differ significantly between eyes with NK grade 1, 2, and 3 (83.3%, 72.7%, and 92.9%, respectively) (all P > 0.05). Twenty out of 28 (71.4%) PED eyes of various etiologies achieved complete closure after 5.2 weeks, whereas 6 eyes (21.4%) showed partial closure, and 2 eyes (7.1%) showed no improvement. One eye showed a significant transient IOP increase; no other adverse events were noted.Conclusions: These results suggest that topical insulin drops are a safe and affordable treatment option for ocular surface diseases, particularly for NK eyes with and without PED. Further prospective clinical trials, however, are needed to confirm the efficacy and define the place of topical insulin in standardized treatment protocols.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Dupilumab-Associated Ocular Surface Disease: Multicenter Experience and Management Considerations. 严重dupilumab相关眼表疾病：多中心经验和管理考虑。

IF 2.3 3区医学

Cornea Pub Date : 2026-10-13 DOI: 10.1097/ICO.0000000000004336

Allison Kufta, Syeda Zainab Kazmi, Seyyedehfatemeh Ghalibafan, Jeonghyun Kwon, Rishi Sharma, Josh Sun, Lisa M Nijm, Elmer Y Tu, Maria S Cortina, Asim V Farooq, Mohammad Soleimani, Kyle T Amber, Mohammadali Ashraf, Hajirah N Saeed, Ali R Djalilian

{"title":"Severe Dupilumab-Associated Ocular Surface Disease: Multicenter Experience and Management Considerations.","authors":"Allison Kufta, Syeda Zainab Kazmi, Seyyedehfatemeh Ghalibafan, Jeonghyun Kwon, Rishi Sharma, Josh Sun, Lisa M Nijm, Elmer Y Tu, Maria S Cortina, Asim V Farooq, Mohammad Soleimani, Kyle T Amber, Mohammadali Ashraf, Hajirah N Saeed, Ali R Djalilian","doi":"10.1097/ICO.0000000000004336","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004336","url":null,"abstract":"Purpose: To evaluate severe dupilumab-associated ocular surface disease (DAOSD) and identify clinical features, risk factors, and outcomes associated with delayed ophthalmologic referral.Methods: A multicenter retrospective case series of 13 patients (26 eyes) with severe DAOSD presenting to tertiary centers between January 2014 and April 2026 was conducted. Clinical findings were analyzed alongside a focused review of current evidence on pathophysiology, diagnosis, and management.Results: Initial ocular symptoms were frequently mild and nonspecific, most commonly redness and pruritus (13/13, 100%), followed by blurred vision with tearing (3/13, 23.1%), eye pain (2/13, 15.4%), and mucoid discharge (2/13, 15.4%), contributing to delayed referral. Symptom onset ranged from 0 to 37 months after dupilumab initiation (mean 11.7 months). At presentation, advanced disease manifestations included limbitis (3/13, 23.1%), conjunctivalization with corneal neovascularization (3/13, 23.1%), limbal stem cell deficiency (2/13, 15.4%), and cicatricial conjunctivitis (1/13, 7.7%). Preexisting atopic ocular disease was present in 6/13 patients (46.2%). Management included lubrication, topical corticosteroids, calcineurin inhibitors, and scleral lenses. Dupilumab was discontinued in 7/13 patients (53.8%). Clinical stabilization was achieved in 12/13 patients (92.3%) over a mean follow-up of 21.4 ± 20.3 months.Conclusions: Severe DAOSD may be underrecognized, as mild early symptoms can delay referral and allow progression to advanced, vision-threatening complications. Preexisting ocular surface disease identifies a high-risk subgroup. Early ophthalmologic evaluation and timely referral are essential to prevent irreversible ocular surface damage and vision loss.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrence of Transforming Growth Factor Beta-Induced Gene Dystrophy Associated With the p.Met619Lys Mutation in the Posterior Stroma After Deep Anterior Lamellar Keratoplasty. 深层前板层角膜移植术后基质中与p.Met619Lys突变相关的转化生长因子β诱导基因营养不良的复发

IF 2.3 3区医学

Cornea Pub Date : 2026-10-13 DOI: 10.1097/ICO.0000000000004333

Jhuwala Venkatakrishnan, Reza Ghaffari, Ben J Glasgow, Anthony J Aldave

{"title":"Recurrence of Transforming Growth Factor Beta-Induced Gene Dystrophy Associated With the p.Met619Lys Mutation in the Posterior Stroma After Deep Anterior Lamellar Keratoplasty.","authors":"Jhuwala Venkatakrishnan, Reza Ghaffari, Ben J Glasgow, Anthony J Aldave","doi":"10.1097/ICO.0000000000004333","DOIUrl":"10.1097/ICO.0000000000004333","url":null,"abstract":"Purpose: To report the visually significant recurrence of the transforming growth factor beta-induced gene ( TGFBI ) dystrophy associated with p.Met619Lys mutation in the posterior stroma after deep anterior lamellar keratoplasty (DALK), necessitating penetrating keratoplasty (PK).Methods: Slit-lamp and anterior segment optical coherence tomography imaging were performed for 2 individuals with a variant TGFBI corneal dystrophy associated with the p.Met619Lys mutation. Histopathologic examination of the corneal buttons excised at the time of PK from each individual was performed.Results: An unrelated 58-year-old woman (case 1) and a 61-year-old man (case 2) with a variant TGFBI corneal dystrophy associated with p.Met619Lys mutation underwent manual (case 1) and big-bubble (case 2) DALK for visually significant dystrophic stromal deposits. Both individuals developed decreased vision approximately 5 years after DALK, attributed to recurrence of dystrophic deposits in the posterior stroma, necessitating PK in both individuals. Histopathologic examination of the excised residual posterior host stroma (case 1) and the excised posterior donor stroma (case 2) revealed dystrophic deposits that demonstrated staining with Masson trichrome and red-green dichroism with Congo red stain.Conclusions: The TGFBI dystrophy secondary to the p.Met619Lys mutation is associated with recurrence of visually significant dystrophic deposits in the posterior stroma after DALK. Given the need for PK only 5 years after DALK in the cases that we report, we recommend genetic testing in individuals in whom a variant TGFBI corneal dystrophy is suspected, and the conversion to PK instead of DALK for such individuals if intraoperative baring of Descemet membrane cannot be achieved.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical Management Patterns and Outcomes in Recurrent Corneal Erosion: An IRIS Registry Study. 复发性角膜糜烂的手术治疗模式和结果：IRIS注册研究。

IF 2.3 3区医学

Cornea Pub Date : 2026-10-09 DOI: 10.1097/ICO.0000000000004338

Nicholas Whitcomb, Joshua B Gilbert, Connor J Ross, William Kearney, Alice Lorch, Hyunjoo J Lee

{"title":"Surgical Management Patterns and Outcomes in Recurrent Corneal Erosion: An IRIS Registry Study.","authors":"Nicholas Whitcomb, Joshua B Gilbert, Connor J Ross, William Kearney, Alice Lorch, Hyunjoo J Lee","doi":"10.1097/ICO.0000000000004338","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004338","url":null,"abstract":"Purpose: Surgical management of recurrent corneal erosion (RCE) lacks large-scale evidence, and national patterns of care and procedural outcomes remain incompletely defined. We characterized national practice patterns, repeat surgery rates, and risk factors for surgical failure using the American Academy of Ophthalmology IRIS Registry.Methods: Retrospective cohort study of patients with RCE between 2016 and 2025. Multilevel logistic regression and Cox proportional hazards modeling were used to evaluate odds of surgical intervention and hazard of repeat surgery after phototherapeutic keratectomy (PTK), epithelial debridement, and anterior stromal puncture (ASP).Results: Among 187,112 eyes with RCE, 12,956 (6.9%) underwent surgery: 5590 (43.0%) PTK, 5038 (39.0%) epithelial debridement, and 2328 (18.0%) ASP. Mean follow-up was 2.23 years. Two-year cumulative incidence of repeat surgery was 12% for PTK, 17% for epithelial debridement, and 29% for ASP. ASP carried a 2.5-fold higher hazard of repeat surgery versus PTK (HR 2.50, 95% CI 2.22-2.78, P < 0.001) and 64% higher versus epithelial debridement (HR 1.64, 95% CI 1.47-1.85, P < 0.001). Among eyes with RCE, concomitant epithelial basement membrane dystrophy was the ocular comorbidity most strongly associated with undergoing surgery (OR 2.57, 95% CI 2.35-2.81, P < 0.001). RCE etiology, including epithelial basement membrane dystrophy (HR 0.90), other dystrophies (HR 1.02), and prior trauma (HR 1.07), was not associated with surgical failure.Conclusions: Despite continued use as a first-line therapy, ASP carries substantially higher repeat intervention risk compared with laser and manual corneal surface procedures. Initial procedure choice, rather than underlying indication or comorbidity, was the primary predictor of surgical failure, underscoring the importance of surgical selection for recurrent corneal erosion.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple Oral Mucosal Epithelial Transplantation for Bilateral Limbal Stem Cell Deficiency in Congenital Aniridia. 单纯口腔黏膜上皮移植治疗先天性无虹膜双侧角膜缘干细胞缺乏症。

IF 2.3 3区医学

Cornea Pub Date : 2026-10-08 DOI: 10.1097/ICO.0000000000004343

Jai Paris, Fady K Sammouh, Walid Dandan, Mark Chehade

{"title":"Simple Oral Mucosal Epithelial Transplantation for Bilateral Limbal Stem Cell Deficiency in Congenital Aniridia.","authors":"Jai Paris, Fady K Sammouh, Walid Dandan, Mark Chehade","doi":"10.1097/ICO.0000000000004343","DOIUrl":"https://doi.org/10.1097/ICO.0000000000004343","url":null,"abstract":"Purpose: To describe the surgical approach and postoperative outcome of simple oral mucosal epithelial transplantation (SOMET) combined with penetrating keratoplasty for congenital aniridia-associated limbal stem cell deficiency (LSCD).Methods: A 61-year-old woman with congenital aniridia, severe bilateral keratopathy, and longstanding visual impairment underwent right-sided combined penetrating keratoplasty, lensectomy with intraocular lens implantation, and modified SOMET using autologous oral buccal mucosal epithelial graft segments. Ocular history included bilateral foveal and optic nerve hypoplasia, nystagmus, and a previously failed right limbal stem cell transplant. Examination demonstrated dense fibrovascular membranes covering both corneas, consistent with advanced LSCD. A review of the literature was also performed to identify prior reports of SOMET or SOMET-like techniques for LSCD.Results: Oral mucosal grafts harvested from the inner cheek were divided into 6 3-mm grafts and sutured around the limbus, followed by placement of a double-layer amniotic membrane. Postoperatively, the oral mucosal grafts remained adherent with stable epithelialization. Visual acuity improved from hand movements preoperatively to 6/120 unaided at 4 weeks, with maintained ocular surface integrity. Corneal impression cytology at 6 months demonstrated mixed epithelial populations with morphologic features favouring oral mucosal origin. Five prior studies describing SOMET or SOMET-like techniques for LSCD were identified, all reporting favourable anatomical and visual outcomes.Conclusions: Modified SOMET using direct oral mucosal transplantation is a simplified alternative to cultivated oral mucosal transplantation. To our knowledge, this is the first report describing its use in congenital aniridia with bilateral LSCD.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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