Cornea最新文献

{"title":"Treatment Options for Alkali Burn-Induced Corneal Neovascularization: A Comparative Analysis of Two Tyrosine Kinase Inhibitors.","authors":"Titas Gladkauskas, Ida Marie Rundgren, Ileana Cristea, Tone Bukve, Eyvind Rødahl, Cecilie Bredrup","doi":"10.1097/ICO.0000000000003890","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003890","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of topical dasatinib and axitinib for treating experimentally induced corneal neovascularization (CNV) in a mouse alkali burn model, and to compare these treatments to established therapies like dexamethasone and bevacizumab.</p><p><strong>Methods: </strong>Thirty-six C57BL/6; 129 Sv mice underwent a standardized alkali burn to induce CNV in both eyes by applying a paper disc soaked in 1M NaOH to the cornea for 20 seconds. The mice were randomly assigned to one of 6 treatment groups: saline (0.9% sodium chloride), DMSO (5%), dexamethasone (0.1%), bevacizumab (0.5%), dasatinib (0.5%), or axitinib (0.5%). Treatments were applied topically 3 times daily. After 2 weeks of treatment, the mice were sacrificed. CNV assessments, including corneal neovascularization area (CNA), vessel length index (VLI), and limbus vasculature thickness, were conducted postmortem using corneal flat-mounts stained with a CD31 antibody for immunohistochemistry.</p><p><strong>Results: </strong>Dexamethasone proved the most effective in inhibiting alkali burn-induced CNA (P < 0.0001), with bevacizumab showing comparable efficacy (P < 0.001). Axitinib also effectively reduced CNA (P < 0.001) and VLI (P < 0.01). In contrast, dasatinib did not significantly reduce CNA (P = 0.74) or VLI (P = 0.98). All eyes in the dexamethasone group developed cataracts compared with 25%-41.7% in the other groups.</p><p><strong>Conclusions: </strong>Axitinib reduced CNA and VLI, although not as effectively as other established treatment modalities, whereas dasatinib did not demonstrate significant effects.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144156690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Assessment of FECD in the National Advanced Driving Simulator: Initial Study of Nighttime Glare and Scheimpflug Imaging.","authors":"Simran R Sarin, Matthew Kigin, Evan Balk, Ryan Diel, Jennifer Ling, Mark A Greiner, Elliott H Sohn, Mark E Wilkinson, Timothy Brown, Christopher S Sales","doi":"10.1097/ICO.0000000000003894","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003894","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to quantify nighttime driving differences in patients with Fuchs endothelial corneal dystrophy (FECD) using the FDA-validated National Advanced Driving Simulator MiniSim.</p><p><strong>Methods: </strong>We conducted a pilot study to calculate sample size, followed by a prospective study with 6 patients with FECD and 6 controls. Participants underwent Snellen visual acuity (VA) testing, Mars contrast sensitivity (CS) assessment, and Scheimpflug tomography. Participants completed 3 simulated driving scenarios, identifying hazards while detection distances were tracked. Driving scenarios simulated glare conditions from oncoming headlights at night: \"variable glare\" modulated glare intensity with passing traffic, \"constant glare\" kept glare intensity fixed, and \"no glare.\" The primary outcome was hazard recognition under \"variable glare.\"</p><p><strong>Results: </strong>Age, CS, and VA did not differ significantly between groups. Anterior and posterior densitometry were worse in the FECD group versus controls (anterior: 37.9 ± 6.0 vs. 28.9 ± 1.5, P = 0.01; posterior: 20.1 ± 3.1 vs. 16.5 ± 1.0, P = 0.02). Patients with FECD recognized 14% fewer hazards than controls (variable glare: 81.8 ± 12.1 vs. 95.8 ± 4.7%, P = 0.03). Patients with FECD required being nearly twice as close to hazards to recognize them versus controls (76.5 ± 38.8 vs. 137.7 ± 51.9 ft; P = 0.04). Tomographic markers of subclinical corneal edema (r = -0.61, P = 0.03) and higher anterior densitometry values (r = -0.61; P = 0.04) correlated with shorter hazard detection distance under \"constant glare.\" Thicker central corneal thickness (variable glare: r = -0.60, P = 0.04) and higher posterior densitometry values correlated with lower hazard recognition scores (variable glare: r = -0.67, P = 0.02; constant glare: r = -0.65, P = 0.02).</p><p><strong>Conclusions: </strong>Despite normal VA and CS, patients with FECD performed significantly worse in driving simulations than controls. Driving disability was associated with tomographic measures of subclinical corneal edema and abnormal corneal densitometry.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femtosecond Descemet Membrane Endothelial Keratoplasty for Failed Deep Anterior Lamellar Keratoplasty: A Case Series.","authors":"Dana Barequet, Mor Bareket, Mobin Abdi, Adi Einan-Lifshitz, Nir Sorkin, Manokamna Agarwal, Marcela Huertas-Bello, Ae Ra Kee, Clara C Chan, David S Rootman","doi":"10.1097/ICO.0000000000003902","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003902","url":null,"abstract":"<p><strong>Purpose: </strong>To suggest a new surgical approach for the treatment of failed deep anterior lamellar keratoplasty (DALK) because of posterior opacities or persistent Descemet membrane (DM) detachment and to report the outcome of femtosecond intralase-enabled Descemet membrane endothelial keratoplasty (FE-DMEK) in a series of patients with DALK graft failure.</p><p><strong>Methods: </strong>A retrospective case series of eight patients who underwent FE-DMEK for failed DALK at Toronto Western Hospital.</p><p><strong>Results: </strong>Eight eyes of eight patients (four female and four male) aged 63.91 ± 9.66 years were included. Average follow-up time after DMEK surgery was 30.0 months (range 3.8-93.1). Indications for DALK surgery were corneal dystrophy in four patients, corneal scars in two patients, and keratoconus in two patients. DALK failure was because of endothelial/stromal scarring in three patients, recurrence of corneal dystrophy in the stromal interface in three patients, endothelial decompensation in one patient, and persistent DM detachment that created a double chamber in one patient. All DMEK procedures were uneventful. Rebubbling was indicated in 5/8 (62.5%) patients, performed at a mean time of 15.6 days (range 3-26 days). Mean best-corrected distance visual acuity at 12 months and final visit was 0.37 ± 0.10 logMAR (Snellen equivalent ∼20/45) and 0.25 ± 0.16 logMAR (Snellen equivalent ∼20/35), respectively. Endothelial cell-loss rates were 39% at 1 year.</p><p><strong>Conclusions: </strong>FE-DMEK is effective in managing DALK graft failure in selected cases. Postoperative outcomes are favorable, with detachment and rebubbling rates comparable with those reported for DMEK after failed PK.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Keratolimbal Allograft Outcomes: Optical Coherence Tomography Analysis of Donor Graft Phenotypes in Limbal Stem Cell Deficiency.","authors":"Wenyu Wu, Szy Yann Chan, Haozhe Yu, Qiaoyu Li, Yun Feng","doi":"10.1097/ICO.0000000000003899","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003899","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the morphology of donor grafts and limbal microstructure after keratolimbal allograft (KLAL) surgery using anterior segment optical coherence tomography (AS-OCT) and to explore the relationship between graft shape and clinical outcomes.</p><p><strong>Methods: </strong>This retrospective study included patients with limbal stem cell deficiency from severe ocular surface burns who underwent KLAL with or without concurrent keratoplasty. AS-OCT was used to assess graft morphology and the graft-recipient interface. Grafts were classified into 3 types-wedge-shaped, trapezoidal, and irregular-shaped-based on AS-OCT imaging. Postoperative clinical outcomes, including neovascularization, conjunctivalization, and corneal opacity, were recorded and compared across graft types.</p><p><strong>Results: </strong>Among 26 eyes from 23 patients, wedge-shaped grafts showed significantly higher success rates, with fewer complications of neovascularization, conjunctivalization, and corneal opacity, compared with trapezoidal and irregular-shaped grafts. Specifically, wedge-shaped grafts had superior outcomes in neovascularization (vs. trapezoidal: χ2 = 5.658, P = 0.017; vs. irregular: χ2 = 6.062, P = 0.014), conjunctivalization (vs. trapezoidal: χ2 = 5.855, P = 0.016; vs. irregular: χ2 = 6.814, P = 0.009), and corneal opacity (vs. trapezoidal: χ2 = 7.088, P = 0.008). AS-OCT imaging showed closer adherence of wedge-shaped grafts to the recipient bed, potentially enhancing stability, whereas trapezoidal and irregular-shaped grafts exhibited gaps that may hinder attachment.</p><p><strong>Conclusions: </strong>AS-OCT imaging effectively visualizes donor graft morphology and graft-recipient microstructure, providing insights into KLAL outcomes. Wedge-shaped grafts, which align more closely with natural limbal anatomy, show greater ocular surface stability.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Graft-Versus-Host Disease in Allogeneic Stem Cell Transplant Recipients: A Longitudinal Cohort Study Evaluating Ocular Surface Parameters Before and After Transplantation.","authors":"Dimitri Roels, Anke Delie, Dominiek Mazure, Katrien De Grove, Ineke van Gremberghe, Joke Deprez, Isabelle Peene, Dirk Elewaut, Bart Leroy, Ilse Claerhout, Tessa Kerre","doi":"10.1097/ICO.0000000000003897","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003897","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this longitudinal cohort study was to identify predictors of progression to ocular graft-versus-host disease in allogeneic hematopoietic stem cell transplant recipients.</p><p><strong>Methods: </strong>Patients (n = 49) were examined before hematopoietic stem cell transplantation (HSCT) and 3, 6, 12, 24, and 36 months after HSCT. Outcome measures included ocular surface disease index questionnaire, Schirmer I test, corneal fluorescein staining, tear break-up time, and tear cytokine concentration. Diagnosis of ocular GVHD (oGVHD) was made in accordance with the International Consensus Criteria for chronic oGVHD. A group of healthy controls (n = 20) without dry eye disease was recruited for comparison.</p><p><strong>Results: </strong>At baseline, the intended HSCT group had a lower Schirmer test value, a higher corneal fluorescein staining score, and a lower tear film break-up time compared with the control group. There was no significant difference in ocular surface disease index score. The intended HSCT group had significantly higher tear interleukin (IL)-1, IL-6, IL-8, IL-10, interferon gamma-induced protein (IP)-10, and TNF-α concentrations at baseline. When considering an increase of at least 2 points of the International Consensus Criteria for chronic oGVHD score after HSCT to exclude preexisting dry eye disease, only 19% (n = 7) developed either probable (11%, n = 4) or definite (8%, n = 3) oGVHD. In a longitudinal analysis, a significant association between progression to oGVHD and tear IL-6, IL-8, IL-17A, and IP-10 concentration was detected.</p><p><strong>Conclusions: </strong>This study highlights the added value of performing a baseline ophthalmological examination in intended HSCT recipients. Posttransplant oGVHD rates may be overestimated if pretransplant ocular surface disease is not considered. Longitudinal tear cytokine analysis in our cohort suggests that IL-6, IL-8, IL-17A, and IP-10 may be useful as biomarkers for oGVHD.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Corneal Ulceration After Cosmetic Keratopigmentation.","authors":"Olivia Uddin, Yesha Shah, Shahriyar Majidi, Frank Mei, Allen O Eghrari, Esen Akpek","doi":"10.1097/ICO.0000000000003895","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003895","url":null,"abstract":"<p><strong>Purpose: </strong>Keratopigmentation is a well-described procedure often used to address corneal opacities. Purely cosmetic keratopigmentation, in the absence of underlying corneal pathology has increased in popularity recently, with the intention of changing eye color appearance. In the context of this increased popularity, public knowledge and data regarding the risks of this procedure are lacking.</p><p><strong>Methods: </strong>This study is a case report conducted at a single academic institution.</p><p><strong>Results: </strong>Here we present a case of a patient who underwent purely cosmetic keratopigmentation and who developed severe corneal ulceration as a sequela. We outline the clinical course and management of this ulceration, which ultimately resolved with amniotic membrane grafting as well as oral and topical steroids.</p><p><strong>Conclusions: </strong>This case serves as an important illustration of the risks that may be associated with purely cosmetic keratopigmentation.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of Descemet-Sparing Technique for Boston Type I Keratoprosthesis With Clinical Follow-Up.","authors":"Mayan M Elammary, Pratima Vishwakarma, Roberto Pineda","doi":"10.1097/ICO.0000000000003896","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003896","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to describe the long-term outcome following a modified technique of the Boston type I keratoprosthesis (KPro) placement over a period of 7 years.</p><p><strong>Method: </strong>Deep anterior lamellar keratoplasty combined with Boston type I KPro Click-On implantation was performed in a patient with history of uveitic glaucoma, glaucoma drainage device placement, and multiple graft failures including four Descemet stripping automated endothelial keratoplasty procedures for pseudophakic bullous keratopathy followed by penetrating keratoplasty.</p><p><strong>Result: </strong>Using this modified surgical approach, the patient's right eye vision improved from hand motion preoperatively to 20/150 on postoperative day 1. Six months later, he underwent Nd:YAG laser of an opacified central Descemet membrane, after which vision improved to 20/80 and was maintained over 7 years. No other postoperative common KPro complications occurred. A recent contact lens trial with a correction of -9D improved vision further to 20/30.</p><p><strong>Conclusions: </strong>This modified surgical technique for placement of Boston type I KPro is less invasive compared with conventional methods and may prevent complications associated with an open-sky surgery, making it a safer alternative. Furthermore, when combined with Nd:YAG laser membranectomy of the Descemet membrane, vision can be further improved.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latin American Consensus on Ocular Lubricants and Dry Eye Disease (LUBOS): A Report on Severity Classification, Diagnosis, and Therapy.","authors":"Alejandro Rodriguez-Garcia, Maria Ximena Nuñez, José Alvaro Pereira-Gomes, Maria A Henriquez, Manuel Garza-Leon, Alejandro Aguilar","doi":"10.1097/ICO.0000000000003886","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003886","url":null,"abstract":"<p><strong>Purpose: </strong>This consensus aims to establish a practical severity classification for applying a tailored stepladder treatment algorithm helpful to any clinician.</p><p><strong>Methods: </strong>A modified Delphi methodology was used to establish a consensus on the definition, diagnosis, severity classification, and treatment algorithms for dry eye disease (DED) adapted to the needs of Latin America. The consensus focused on promoting the effective use of lubricants and providing straightforward, practical guidance for ophthalmologists treating dry eyes. Twenty-eight corneal specialists from representative Latin American countries reviewed the scientific evidence and drew on their expertise to answer specifically designed open-ended questions.</p><p><strong>Results: </strong>A simple diagnostic algorithm (clinical history, DED questionnaire, and dry eye clinical tests) identified patients with the disease. A practical severity classification system of four grades: mild, moderate, severe, and LUBOS plus DED was based on four criteria: OSDI, film break-up time, Sjögren International Collaborative Clinical Alliance ocular surface staining score, and international workshop on meibomian gland dysfunction meibomian gland functionality test. For classification, ≥2 criteria of the highest severity grade from the worse eye were considered. A stepladder therapeutic algorithm aligned with disease severity consisted of 5 steps, each with proposed and recommended treatment alternatives. Patient education, lifestyle recommendations, adverse environment avoidance, lubricants, and eyelid therapy were reinforced during the therapy period.</p><p><strong>Conclusions: </strong>The LUBOS expert panel consensus considered the diverse geoenvironmental, socioeconomic, cultural, and ethnic factors pertinent to Latin America. This consensus offers an accessible and cost-effective tool, enabling professionals to detect, evaluate, and grade the severity of dry eye disease effectively for planning adequate therapeutic strategies that can be monitored with confidence.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Differences in the Expression of p63α and Proliferation of Limbal Epithelial Stem Cells From Donor Corneas.","authors":"Jessica E Ludwig, Sudhir Verma, Alexa Thibodeau, Kirsten S Evonuk, Nambi Nallasamy, Shahzad I Mian, Vivien J Coulson-Thomas, Onkar B Sawant","doi":"10.1097/ICO.0000000000003888","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003888","url":null,"abstract":"<p><strong>Purpose: </strong>Limbal stem cell deficiency is a blinding corneal disease that requires transplantation to replenish the limbal epithelial stem cells (LESCs) and restore vision. Keratolimbal allografts from cadaveric donors are commonly used as a source for LESCs. The goal of this study was to verify the efficacy of Food and Drug Administration-approved hypothermic corneal storage solutions in preserving LESCs within human donor corneas over time.</p><p><strong>Methods: </strong>Limbal segments from deceased donor corneas were stored in Food and Drug Administration-approved corneal storage solutions for 0, 4, or 7 days. Tissues were then processed for immunohistochemistry, and number of p63α+ cells within the limbus were calculated. LESC density was calculated as the number of p63α+ cells per total number of cells. LESCs were isolated from donor corneas after 7 days of hypothermic storage and subjected to a colony formation assay, and the numbers of holoclones were calculated.</p><p><strong>Results: </strong>The average density of p63α+ cells was 37.4% on day 0, 27.3% on day 4, and 10.9% on day 7 (P < 0.05) in limbal segments. Holoclones (15.33 ± 3.5) were formed by cells isolated from the limbal region of donor corneas after 7 days in the hypothermic storage conditions, indicating that viable LESCs are still present in human donor corneas after 7 days in storage.</p><p><strong>Conclusions: </strong>Although the density of p63α+ LESCs significantly decreases over time, viable LESCs are present in the donor corneas after 7 days in hypothermic storage conditions. Thus, failure of detection or absence of expression of standard marker(s) does not necessarily indicate the loss of functional LESCs.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Eye Drops and Pain Sensitivity: A Marker for Dry Eye Syndrome?","authors":"Oded Rock, Margarita Safir, Michael Mimouni, Roie Holzman, Irit Bahar, Avihu Pereg, Dan Gaton","doi":"10.1097/ICO.0000000000003893","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003893","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this prospective study was to evaluate whether the duration and intensity of pain induced by commonly used diagnostic eye drops correlate with the presence and severity of dry eye syndrome.</p><p><strong>Methods: </strong>This study included 33 patients (66 eyes) undergoing routine evaluations at tertiary ophthalmology clinics from 2016 to 2017. Each eye received one drop of either oxybuprocaine or tropicamide. Pain intensity and duration were assessed using a visual analog scale and a stopwatch. Dry eye syndrome was diagnosed and graded according to international guidelines, incorporating clinical signs and standardized tests. Statistical analyses included Kruskal-Wallis tests for discrete variables and Pearson correlations for continuous variables, with significance set at P <0.05.</p><p><strong>Results: </strong>Patients with dry eye syndrome experienced significantly longer pain duration compared with those with healthy eyes (P = 0.035). Pain intensity was notably higher in patients with severe dry eye (P = 0.048). Duration of pain correlated with corneal fluorescein staining (P = 0.027). In eyes treated with oxybuprocaine, shorter tear break-up time and lower Schirmer test results were significantly associated with pain response (P = 0.021 and P = 0.037, respectively). In eyes treated with tropicamide, pain intensity was significantly associated with functional limitations (P = 0.042).</p><p><strong>Conclusions: </strong>This study highlights that pain sensitivity to commonly used diagnostic eye drops is a potential marker for the presence and severity of dry eye syndrome. Clinicians should consider evaluating pain responses during routine examinations as a simple, supplementary tool for identifying patients who may benefit from further diagnostic investigations and tailored management.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}