Cornea最新文献 - Book学术

Keratoconus Profile in the Elderly: Prevalence and Clinical Indices. 老年人圆锥角膜的概况：患病率、圆锥角膜指数和圆锥角膜的类型。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2025-04-11 DOI: 10.1097/ICO.0000000000003878

Hassan Hashemi, Alireza Jamali, Fatemeh Pakbaz, Alireza Hashemi, Maryam Roshani, Mehdi Khabazkhoob

{"title":"Keratoconus Profile in the Elderly: Prevalence and Clinical Indices.","authors":"Hassan Hashemi, Alireza Jamali, Fatemeh Pakbaz, Alireza Hashemi, Maryam Roshani, Mehdi Khabazkhoob","doi":"10.1097/ICO.0000000000003878","DOIUrl":"10.1097/ICO.0000000000003878","url":null,"abstract":"Purpose: To assess the prevalence and associated characteristics of keratoconus (KCN) among individuals aged 60 years and older.Methods: In this study, total of 160 clusters and 20 strata were identified in Tehran, Iran through a multistage cluster sampling technique. Participants aged 60 years and older were included in the study. Corneal imaging used the Pentacam AXL. The diagnosis of KCN in this study was determined based on the measurements obtained from axial topography, pachymetry, and the elevation data from the Pentacam's refractive 4-maps.Results: The prevalence of KCN was determined to be 5.36% [95% confidence interval (CI), 4.52-6.2], with rates of 5.04% (95% CI, 3.88-6.2) in males and 5.68% (95% CI, 4.47-6.9) in females. The prevalence of KCN increased from 4.6% (95% CI, 3.29-5.92) among individuals aged 60 to 64 years to 6.92% (95% CI, 3.18-10.67) in those aged 80 years and older. A multiple regression analysis indicated that advancing age (odds ratio = 1.03; P < 0.001) and illiteracy (odds ratio = 1.65; P < 0.001) were significant factors associated with KCN in the elderly population. Besides, the predominant curvature pattern observed in KCN was the asymmetric bowtie with inferior steepening (18.91%), whereas the symmetric bowtie was the least common (0.29%).Conclusions: The prevalence of KCN is notably high among the elderly population and tends to rise with advancing age. Findings from the current study underscore the critical role of corneal topography and tomography in guiding clinical decisions for older patients, particularly in the context of intraocular lens power calculations.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"686-693"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Reframing the Risk in DMEK Regrafts: Host Environment Over Regraft Count. 对DMEK移植风险重构的回应：宿主环境对移植数量的影响。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2026-02-03 DOI: 10.1097/ICO.0000000000004123

Francis W Price, Marianne O Price

引用次数: 0

DescePrep Significantly Improves the Efficiency of High-Risk Diabetic Donor Descemet Membrane Endothelial Keratoplasty Processing. DescePrep可显著提高高风险糖尿病供体角膜内皮膜内皮移植术的治疗效率。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2026-03-17 DOI: 10.1097/ICO.0000000000004133

Katie Solley, Kendall Frank, Megan M W Straiko, Priyanka Ramulu, Noelle Nesbitt, Declan Chamberlain, Khoa D Tran, Kunal S Parikh

{"title":"DescePrep Significantly Improves the Efficiency of High-Risk Diabetic Donor Descemet Membrane Endothelial Keratoplasty Processing.","authors":"Katie Solley, Kendall Frank, Megan M W Straiko, Priyanka Ramulu, Noelle Nesbitt, Declan Chamberlain, Khoa D Tran, Kunal S Parikh","doi":"10.1097/ICO.0000000000004133","DOIUrl":"10.1097/ICO.0000000000004133","url":null,"abstract":"Purpose: To evaluate Descemet membrane endothelial keratoplasty (DMEK) graft preparation efficiency, success rate, and graft viability after clinically relevant processing of diabetic human donor corneas using DescePrep or submerged cornea using backwards away (SCUBA).Methods: Fifteen pairs of diabetic donor corneas with an average diabetic risk score of 4.0 ± 1.3 and mild-moderate cell loss were processed for DMEK by an experienced certified eye bank technician. Corneas within each pair were randomly assigned to DescePrep or SCUBA and trephined with the number 7 trephine for orientation marking. Donor cornea characteristics, preparation duration, number of graft touches, and success rate were recorded. To simulate clinical graft preparation, DMEK grafts were loaded into a Straiko Modified Jones Tube, shipped, and unscrolled on a glass slide before masked cell viability analysis.Results: We found that 93.3% (14/15) of corneas per group were prepared successfully by DescePrep and by SCUBA. DescePrep significantly reduced overall preparation time from 19.2 ± 0.5 to 15.1 ± 1.1 minutes ( P < 0.005) and significantly reduced stripping time from 10.9 ± 0.5 to 6.97 ± 1.1 minutes ( P < 0.005). Grafts processed by DescePrep and SCUBA demonstrated comparable cell loss of 15.8% ± 1.2% and 16.1% ± 1.4%, respectively, after loading, shipping, and unscrolling.Conclusions: DescePrep offers safe and reliable DMEK graft preparation with high success rates in diabetic tissue. DescePrep reduced preparation time by 21.3% and the number of endothelium contacts by 85.7% in comparison to SCUBA.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"799-805"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Femtosecond Descemet Membrane Endothelial Keratoplasty for Failed Deep Anterior Lamellar Keratoplasty: A Case Series. 飞秒网膜内皮角膜移植术治疗失败的深前板层角膜移植术：一个病例系列。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2025-05-22 DOI: 10.1097/ICO.0000000000003902

Dana Barequet, Mor Bareket, Mobin Abdi, Adi Einan-Lifshitz, Nir Sorkin, Manokamna Agarwal, Marcela Huertas-Bello, Ae Ra Kee, Clara C Chan, David S Rootman

{"title":"Femtosecond Descemet Membrane Endothelial Keratoplasty for Failed Deep Anterior Lamellar Keratoplasty: A Case Series.","authors":"Dana Barequet, Mor Bareket, Mobin Abdi, Adi Einan-Lifshitz, Nir Sorkin, Manokamna Agarwal, Marcela Huertas-Bello, Ae Ra Kee, Clara C Chan, David S Rootman","doi":"10.1097/ICO.0000000000003902","DOIUrl":"10.1097/ICO.0000000000003902","url":null,"abstract":"Purpose: To suggest a new surgical approach for the treatment of failed deep anterior lamellar keratoplasty (DALK) because of posterior opacities or persistent Descemet membrane (DM) detachment and to report the outcome of femtosecond intralase-enabled Descemet membrane endothelial keratoplasty (FE-DMEK) in a series of patients with DALK graft failure.Methods: A retrospective case series of eight patients who underwent FE-DMEK for failed DALK at Toronto Western Hospital.Results: Eight eyes of eight patients (four female and four male) aged 63.91 ± 9.66 years were included. Average follow-up time after DMEK surgery was 30.0 months (range 3.8-93.1). Indications for DALK surgery were corneal dystrophy in four patients, corneal scars in two patients, and keratoconus in two patients. DALK failure was because of endothelial/stromal scarring in three patients, recurrence of corneal dystrophy in the stromal interface in three patients, endothelial decompensation in one patient, and persistent DM detachment that created a double chamber in one patient. All DMEK procedures were uneventful. Rebubbling was indicated in 5/8 (62.5%) patients, performed at a mean time of 15.6 days (range 3-26 days). Mean best-corrected distance visual acuity at 12 months and final visit was 0.37 ± 0.10 logMAR (Snellen equivalent ∼20/45) and 0.25 ± 0.16 logMAR (Snellen equivalent ∼20/35), respectively. Endothelial cell-loss rates were 39% at 1 year.Conclusions: FE-DMEK is effective in managing DALK graft failure in selected cases. Postoperative outcomes are favorable, with detachment and rebubbling rates comparable with those reported for DMEK after failed PK.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"714-720"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wide-Field Contact Specular Microscopy Can Reliably and Repeatedly Image the Same Corneal Endothelial Location. 宽视场接触镜面显微镜可以可靠地重复成像相同的角膜内皮位置。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2025-06-02 DOI: 10.1097/ICO.0000000000003904

Elias H Kahan, Maria de Los Angeles Ramos Cadena, Ting-Fang Lee, Kathryn Colby

{"title":"Wide-Field Contact Specular Microscopy Can Reliably and Repeatedly Image the Same Corneal Endothelial Location.","authors":"Elias H Kahan, Maria de Los Angeles Ramos Cadena, Ting-Fang Lee, Kathryn Colby","doi":"10.1097/ICO.0000000000003904","DOIUrl":"10.1097/ICO.0000000000003904","url":null,"abstract":"Purpose: To assess whether slit-scanning specular microscopy (CellChek C; Konan Medical) can repeatedly image the same corneal location using anatomic landmarks (posterior corneal rings and corneal undulations) and unique cells identified during imaging.Methods: A total of 203 eyes (113 patients) with and without corneal pathology were imaged to assess the prevalence of anatomic landmarks. A subcohort of 20 healthy eyes was used to identify unique cells adjacent to anatomic landmarks. Landmarks were then used to locate the same cells on repeat imaging approximately 1 week later. Endothelial cell density (ECD), coefficient of variation, and percent hexagonality were calculated. Intraclass correlation coefficient and 95% limits of agreement were used to measure variability and reproducibility of imaging.Results: Approximately 91% of eyes had either posterior corneal rings or undulations present. Undulations were more common than posterior corneal rings in both healthy and diseased corneas. Among subcohort eyes, unique cells were found adjacent to anatomic landmarks in 100% of eyes. Landmarks were used to reimage the same cells in 75% of eyes. There was minimal variation in ECD, coefficient of variation, and hexagonality; intraclass correlation coefficient and 95% confidence intervals were 0.891 [0.715-0.962], 0.612 [0.179-0.849], and 0.793 [0.499-0.925], respectively. The 95% limits of agreement for ECD was -359.9-260.98.Conclusions: Landmarks identified with slit-scanning specular microscopy allowed reliable reimaging of the same endothelial location, providing a powerful tool to better understand the role of the peripheral endothelium in health and disease.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"721-726"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Clinical Outcomes of Cultured Human Corneal Endothelial Cell Injection (Vyznova) for Bullous Keratopathy: Initial Clinical Experience. 培养人角膜内皮细胞注射（Vyznova）治疗大疱性角膜病变的早期临床结果：初步临床经验。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2025-09-03 DOI: 10.1097/ICO.0000000000003984

Akira Kobayashi, Natsuko Mori, Hideaki Yokogawa, Seiichiro Sugita, Yukari Yagi-Yaguchi, Takefumi Yamaguchi, Tomomi Higashide

{"title":"Early Clinical Outcomes of Cultured Human Corneal Endothelial Cell Injection (Vyznova) for Bullous Keratopathy: Initial Clinical Experience.","authors":"Akira Kobayashi, Natsuko Mori, Hideaki Yokogawa, Seiichiro Sugita, Yukari Yagi-Yaguchi, Takefumi Yamaguchi, Tomomi Higashide","doi":"10.1097/ICO.0000000000003984","DOIUrl":"10.1097/ICO.0000000000003984","url":null,"abstract":"Purpose: To report early clinical outcomes of cultured human corneal endothelial cell (cHCEC) injection therapy (Vyznova) for bullous keratopathy (BK). To our knowledge, this is the first study reporting use of an initial commercial lot of Vyznova implemented at 3 independent institutions specializing in corneal transplantation in Japan.Methods: This retrospective case series included 4 eyes of 4 patients (mean age, 76.8 years, 1 man, 3 women) with BK owing to Fuchs endothelial corneal dystrophy (n = 2), pseudophakic bullous keratopathy (n = 1), or primary angle-closure disease (n = 1), treated between August 2024 and October 2024. All patients received an intracameral injection of 1.0 × 10 6 cHCECs (Vyznova). Best-corrected visual acuity (BCVA), central corneal thickness (CCT), and endothelial cell density (ECD) were assessed preoperatively and 6 months postoperatively. Complications were also recorded.Results: In the 3 uncomplicated cases, corneal clarity was restored by 6 months, and BCVA improved from a mean of 0.20 to 0.55. Mean CCT reduced from 729 μm to 586 μm, and ECD reached 2483 cells/mm 2 mean (unmeasurable preoperatively). Corneal clarity was also achieved in 1 case with intraoperative and postoperative Descemet membrane detachment. However, BCVA remained unchanged at 0.5, CCT increased from 646 μm to 689 μm, and ECD was 660 cells/mm 2 .Conclusions: Vyznova therapy seems to be effective in restoring corneal clarity in patients with BK. This real-world experience underscores the feasibility of implementing cHCEC injections in institutions beyond the developer sites. Careful intraoperative management is necessary to avoid complications, such as detachment of Descemet membrane.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"775-784"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter Regarding: Temporary Conjunctival Flap Plus Medical Treatment Versus Medical Treatment Only for High-Risk Fungal Keratitis: A Randomized Controlled Trial. 关于：临时结膜瓣加药物治疗与仅药物治疗高风险真菌性角膜炎：一项随机对照试验。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2026-02-06 DOI: 10.1097/ICO.0000000000004126

Mridul Trisal, Manisha Acharya, Shailja Tibrewal

引用次数: 0

Letter Regarding Host Factors Drive Outcomes After DMEK Regrafts: In Response To: "Characteristics and outcomes of Descemet membrane endothelial keratoplasty for treatment of failed endothelial keratoplasty". 关于DMEK移植后宿主因素驱动结果的信函：回应：“内皮角膜移植术治疗失败的内皮角膜移植术的特点和结果”。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2026-02-18 DOI: 10.1097/ICO.0000000000004097

Henry Bair, Zeba A Syed

引用次数: 0

Barriers and Facilitators to Cornea Subspecialty for Ophthalmology Residents. 辅导计划对角膜的影响：来自参与者的定性研究结果。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2025-06-06 DOI: 10.1097/ICO.0000000000003901

Parma E Montufar Wright, Patrice M Hicks, Elise V Mike, Mikhayla L Armstrong, Osama Ahmed, Bennie Jeng, Stephanie Marioneaux, Fasika Woreta, Maria A Woodward

{"title":"Barriers and Facilitators to Cornea Subspecialty for Ophthalmology Residents.","authors":"Parma E Montufar Wright, Patrice M Hicks, Elise V Mike, Mikhayla L Armstrong, Osama Ahmed, Bennie Jeng, Stephanie Marioneaux, Fasika Woreta, Maria A Woodward","doi":"10.1097/ICO.0000000000003901","DOIUrl":"10.1097/ICO.0000000000003901","url":null,"abstract":"Purpose: A cornea mentorship program aims to increase the number of underrepresented in medicine physicians pursuing cornea fellowships in ophthalmology. This study evaluates participant demographics, career facilitators and barriers, and the program's impact.Methods: Participants from the 2022 and 2023 cornea mentorship program cohorts completed an anonymous survey assessing demographics, motivations for participation, and mentorship in ophthalmology. They were also invited to participate in semistructured interviews exploring barriers and facilitators to a career in ophthalmology. Survey responses were analyzed using descriptive statistics, whereas interview transcripts were examined for thematic content, classifying sentiments as facilitators or barriers.Results: Of 12 participants, 10 completed the survey and 7 were interviewed. Four main themes emerged: 1) institution-home institution/residency program; 2) mentoring-aspects of mentorship; 3) personal-traits, support systems, and identities; 4) programs-extracurricular ophthalmology programs. Among 133 quotes, personal life was the most frequently cited barrier (35 citations, 26%) hindering participants' pathways to medical school and an ophthalmology career, whereas mentoring was the leading facilitator (29 citations, 22%) supporting their progress. Programs were solely cited as facilitators (16 citations, 12%). Notably, 100% of participants who graduated from residency are cornea fellows.Conclusions: Participants reported personal life as the most frequent barrier and mentoring as the most frequent facilitator to a career in medicine. Mentorship and pathway programs were crucial to success. The cornea mentorship program effectively encouraged underrepresented in medicine residents to pursue cornea fellowships, underscoring the need for continued diversity initiatives in ophthalmology.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"706-713"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myeloid-Derived Suppressor Cells Enhance Wound Healing in a Murine Model of Corneal Injury. 髓源性抑制细胞促进小鼠角膜损伤模型的创面愈合。

IF 2.1 3区医学

Cornea Pub Date : 2026-06-01 Epub Date: 2025-12-02 DOI: 10.1097/ICO.0000000000004056

Seokjoo Lee, Neda Heydarian, Vinay K Pulimamidi, Asmaa A Zidan, Shweta Sandhu, Lei Xi, Yihe Chen, Jia Yin, Thomas H Dohlman, Sunil K Chauhan, Reza Dana

{"title":"Myeloid-Derived Suppressor Cells Enhance Wound Healing in a Murine Model of Corneal Injury.","authors":"Seokjoo Lee, Neda Heydarian, Vinay K Pulimamidi, Asmaa A Zidan, Shweta Sandhu, Lei Xi, Yihe Chen, Jia Yin, Thomas H Dohlman, Sunil K Chauhan, Reza Dana","doi":"10.1097/ICO.0000000000004056","DOIUrl":"10.1097/ICO.0000000000004056","url":null,"abstract":"Purpose: Corneal injury is a leading cause of vision loss and demands rapid, coordinated regeneration. Myeloid-derived suppressor cells (MDSC), innate immunoregulatory cells that aid repair in peripheral tissues, have not been evaluated in corneal healing. We tested whether MDSC promote epithelial closure and temper postinjury inflammation.Methods: For scratch assays, 1.0 × 10 5 human corneal epithelial cells were cocultured with 1.5 × 10 6 MDSC or CD11b + Gr-1 - control cells, and wound areas at 18 and 24 hours were quantified in ImageJ. In vivo, corneal epithelial debridement was induced in BALB/c mice using an Algerbrush-II, followed by subconjunctival injection of MDSC or control cells (5 × 10 4 cells in 50 μL saline). Epithelial healing was assessed by fluorescein staining and slitlamp imaging at 6, 22, and 28 hours, with ImageJ analysis. At 28 hours, corneas were collected for real-time polymerase chain reaction and flow cytometry to assess inflammatory markers. On day 3, corneas were harvested for hematoxylin and eosin staining and histological analysis.Results: MDSC significantly enhanced human corneal epithelial cells migration in vitro versus controls. In vivo, MDSC delivery accelerated epithelial wound closure, reduced CD11b + Ly6G + neutrophil infiltration, and lowered corneal tumor necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) expression compared with saline or CD11b + Gr-1 - control cells. Histology confirmed restoration of epithelial integrity in MDSC-treated eyes.Conclusions: MDSC expedite corneal epithelial repair and attenuate acute inflammation after injury. These findings identify a previously unrecognized reparative function for MDSC in the cornea and support their development as a cell-based therapy for ocular surface injury.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"763-771"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0