IF 2.1 3区医学

Cornea Pub Date : 2025-09-08 DOI: 10.1097/ICO.0000000000003983

Onyinye Onyia, Elise L Ma, Kishan Gupta, Omai B Garner, Sophie X Deng, Simon S M Fung

{"title":"Predictors of Post-treatment Visual Improvement After Bacterial Keratitis Infection at a Referral Center in Southern California.","authors":"Onyinye Onyia, Elise L Ma, Kishan Gupta, Omai B Garner, Sophie X Deng, Simon S M Fung","doi":"10.1097/ICO.0000000000003983","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003983","url":null,"abstract":"Purpose: To evaluate visual outcomes after bacterial keratitis (BK) and identify predictive factors for poor prognosis at a tertiary referral center in Southern California.Methods: This is a cross-sectional retrospective review of patients' medical records with culture-positive BK at University of California Los Angeles from January 1, 2014, to December 31, 2019. Main outcome measure was change in best-corrected visual acuity (BCVA) at 12 weeks posttreatment. Statistical analyses included ANOVA for independent populations, Pearson correlation, and binary logistic regression. P-value <0.05 was considered significant.Results: A total of 317 patients with 374 culture-positive cases were identified. Mean age was 62.1 ± 19.9 years, 52% were female, and 68.1% of isolates were Gram-positive. A total of 114 cases occurred during the summer months (June-August), and 29.8% had a history of contact lens wear, trauma, or systemic disease. Median symptom-to-presentation time was 3.5 days (range 1-60). Mean BCVA improved from 1.84 ± 0.91 at presentation to 1.40 ± 0.96 log of the minimum angle of resolution at 12 weeks (mean difference = 0.44, 95% confidence interval, 0.34-0.53; P < 0.001). Increasing age correlated negatively with change in BCVA (Pearson β = -0.167, P < 0.008). Multivariate analysis identified age >60 years, presence of systemic comorbidities, and presenting BCVA >1.00 log of the minimum angle of resolution as predictors of poor visual outcome.Conclusions: This study provides the largest contemporary analysis of BK in Southern California and establishes a clinically applicable risk stratification model. Older age, systemic comorbidities, and poor presenting vision were independently associated with worse visual outcomes. These findings support earlier identification of high-risk patients, tailored treatment strategies to improve visual prognosis and optimize care delivery in BK.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Outcomes of Deep Anterior Lamellar Keratoplasty in Pediatric Keratoconus: A 15-Year Retrospective Analysis. 儿童圆锥角膜深前板层角膜移植术的远期疗效：15年回顾性分析。

IF 2.1 3区医学

Cornea Pub Date : 2025-09-05 DOI: 10.1097/ICO.0000000000003993

Revathi Rajaraman, Venugopal Anitha, Arjun Velayudhan, Pinkal Shiroya, Anita Raghavan, Iswarya Mani, Mohammed Uduman Siddique

{"title":"Long-Term Outcomes of Deep Anterior Lamellar Keratoplasty in Pediatric Keratoconus: A 15-Year Retrospective Analysis.","authors":"Revathi Rajaraman, Venugopal Anitha, Arjun Velayudhan, Pinkal Shiroya, Anita Raghavan, Iswarya Mani, Mohammed Uduman Siddique","doi":"10.1097/ICO.0000000000003993","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003993","url":null,"abstract":"Purpose: To evaluate the long-term visual, functional outcomes, and complications associated with Deep Anterior Lamellar Keratoplasty (DALK) in pediatric keratoconus (KC).Methods: A retrospective analysis of children aged ≤18 years who underwent DALK for KC between February 2006 and April 2021. Data on preoperative uncorrected visual acuity (UCVA), best-corrected visual acuity (BCVA), corneal topography, surgical technique, and complications. The big bubble technique was preferred, with manual or hydrodissection used when necessary. Outcome measures included postoperative UCVA, BCVA, manifest refraction, epithelial healing time, and complications.Results: A total of 348 eyes from 303 children (mean age of 14.62 ± 2.59 years) were analyzed. Preoperative corneal scarring was observed in 24.4%, and 27.9% had vernal keratoconjunctivitis. Big bubble technique was successful in 69.8% of eyes. Descemet membrane microperforation occurred in 38 cases (10.9%), and intracameral air tamponade was required in 29 eyes (48.3%). The mean epithelial healing time was 5.00 ± 6.09 days. Postoperatively, mean spherical correction improved from -8.43 ± 5.52D to -2.42 ± 2.60D, and mean refractive astigmatism from -4.65 ± 1.62D to -2.60 ± 1.87D. The UCVA improved from 1.26 ± 0.27 to 0.76 ± 0.32 Log MAR and BCVA from 0.64 ± 0.31 to 0.18 ± 0.17 Log MAR. Complications included graft vascularization in 14.7%, graft infections 6.9%, and glaucoma in 26.7.Conclusions: DALK is a safe and effective procedure for managing pediatric KC, offering significant improvements in visual outcomes and refractive parameters with excellent graft survival rates over the long term.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Dry Eye and Corneal Ulcers With Collagen Vascular Diseases in a Medicare Population. 在医疗保险人群中干眼和角膜溃疡与胶原血管疾病的关系。

IF 2.1 3区医学

Cornea Pub Date : 2025-09-05 DOI: 10.1097/ICO.0000000000003986

Arvind Sommi, Gavin Li, Jihwan Hwang, Janek Klawe, Beverly Johnson, Sumayya Ahmad

{"title":"Association of Dry Eye and Corneal Ulcers With Collagen Vascular Diseases in a Medicare Population.","authors":"Arvind Sommi, Gavin Li, Jihwan Hwang, Janek Klawe, Beverly Johnson, Sumayya Ahmad","doi":"10.1097/ICO.0000000000003986","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003986","url":null,"abstract":"Purpose: There is a lack of research on the extent to which non-Sjögren collagen vascular diseases affect the ocular surface. This study aims to understand the associations between collagen vascular diseases and dry eye and corneal ulcers.Methods: This study analyzed a random 5% sample of national Medicare beneficiaries from 2011 to 2015 and included claims for those with collagen vascular diseases and either dry eye or corneal ulcers (n = 2,688,114). Two multivariable logistic regression models assessed the outcomes of dry eye and corneal ulceration, considering age, sex, race, and collagen vascular diseases as exposure variables.Results: A total of 219,352 patients with dry eye and 4366 patients with corneal ulcer were identified. Various collagen vascular diseases exhibited distinct associations with dry eye (primary Sjögren's: [odds ratio (OR) 9.67], [95% confidence interval (CI) = 9.06 to 10.31]; secondary Sjögren's: OR 3.92, 95% CI = 3.64 to 4.21; rheumatoid arthritis: OR 2.43, 95% CI = 2.37 to 2.48; systemic sclerosis: OR 2.12, 95% CI = 1.91 to 2.36). Corneal ulcers also had an association with rheumatologic diseases (primary Sjögren's: OR 6.26, 95% CI = 4.48-8.47; secondary Sjögren's: OR 3.59, 95% CI = 2.63-4.81; rheumatoid arthritis: OR 3.34, 95% CI = 2.95-3.76; psoriatic arthritis: OR 1.64, 95% CI = 1.01-2.49).Conclusions: The strong association between collagen vascular disease and dry eye and corneal ulcers necessitates an interdisciplinary approach with close collaboration between rheumatologists and ophthalmologists in the diagnosis and management of systemic inflammatory diseases.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Preoperative Aqueous Cytokine Levels and Mid-term Reduction of Corneal Endothelial Cells After Descemet Stripping Automated Endothelial Keratoplasty. 术前水细胞因子水平与角膜剥离自动内皮角膜移植术后中期角膜内皮细胞减少的相关性

IF 2.1 3区医学

Cornea Pub Date : 2025-09-04 DOI: 10.1097/ICO.0000000000003989

Hiroshi Matsumae, Yukari Yagi-Yaguchi, Osama Ma Ibrahim, Kaon Kataoka, Kazunari Higa, Mariko Shirane, Hirotsugu Kasamatsu, Daisuke Tomida, Jun Shimazaki, Takefumi Yamaguchi

{"title":"Correlation Between Preoperative Aqueous Cytokine Levels and Mid-term Reduction of Corneal Endothelial Cells After Descemet Stripping Automated Endothelial Keratoplasty.","authors":"Hiroshi Matsumae, Yukari Yagi-Yaguchi, Osama Ma Ibrahim, Kaon Kataoka, Kazunari Higa, Mariko Shirane, Hirotsugu Kasamatsu, Daisuke Tomida, Jun Shimazaki, Takefumi Yamaguchi","doi":"10.1097/ICO.0000000000003989","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003989","url":null,"abstract":"Purpose: To investigate the association between preoperative aqueous humor (AqH) cytokines and mid-term endothelial cell density (ECD) after Descemet stripping automated endothelial keratoplasty (DSAEK).Methods: This prospective study included 80 eyes: 47 eyes undergoing DSAEK and 33 cataract surgery eyes as controls. AqH samples were collected at the beginning of surgery. The levels of cytokines [interleukins (ILs)-1α, -1β, -4, -6, -8, -10, -12p70, -17A, monocyte chemotactic protein-1, interferon-α, IFN-γ, E-selectin, P-selectin, and soluble intercellular adhesion molecule-1 (sICAM-1)] in the AqH were measured using a multiplex beads immunoassay. Total protein levels in the AqH were measured independently using the detergent compatible (DC) Protein Assay. DSAEK subjects were divided into 2 groups by 36 months ECD: group 1 (ECD <1200 cells/mm2 or graft failure, n = 29 eyes) and group 2 (ECD ≥1200, n = 18 eyes).Results: The ECD reduction per year was significantly correlated with preoperative levels of total protein (r = 0.44; P = 0.002) and sICAM-1 (r = 0.46; P = 0.002). Group 1 exhibited significantly higher levels of sICAM-1 compared with group 2 (P = 0.001). Although not statistically significant, trends were observed between graft failure and levels of total protein (P = 0.003), IL-17A (P = 0.04), and sICAM-1 (P = 0.003).Conclusions: Elevated AqH levels of total protein and sICAM-1 are associated with mid-term ECD reduction and graft failure after DSAEK. Pathological alterations of the AqH microenvironment may critically affect corneal endothelial cells and graft survival after DSAEK.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cataract Surgery Outcomes in Patients With Axenfeld-Rieger Syndrome. Axenfeld-Rieger综合征患者白内障手术的结果。

IF 2.1 3区医学

Cornea Pub Date : 2025-09-03 DOI: 10.1097/ICO.0000000000003991

Priyanka Sudanaboina, Somasheila I Murthy

{"title":"Cataract Surgery Outcomes in Patients With Axenfeld-Rieger Syndrome.","authors":"Priyanka Sudanaboina, Somasheila I Murthy","doi":"10.1097/ICO.0000000000003991","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003991","url":null,"abstract":"Purpose: To analyze the outcomes of phacoemulsification with intraocular lens (IOL) implantation in patients with Axenfeld-Rieger syndrome (ARS).Methods: This was a retrospective observational study. Patients with ARS who underwent cataract surgery and had a minimum postoperative follow-up of 6 weeks were included. Visual outcomes after cataract surgery and complications were evaluated in these patients.Results: All patients underwent uneventful cataract surgery. A total of 12 eyes of 11 patients were included, 6 males and 5 females. The mean age was 45.3 ± 10.5 years, and the mean follow-up period was 21.6 months. The mean best-corrected visual acuity (BCVA) preoperatively was 0.9 ± 0.3 Log MAR and postoperatively was 0.4 ± 0.3 LogMAR (P = 0.0043). Eleven patients had secondary glaucoma requiring surgical intervention in 6/12 eyes (50%). Two patients required Descemet stripping automated endothelial keratoplasty (DSAEK) postcataract surgery for corneal decompensation. No significant intraoperative complications occurred in these patients.Conclusions: Cataract surgery and intraocular lens implantation in patients with ARS is safe, but visual improvement depends on comorbid conditions.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Clinical Outcomes of Cultured Human Corneal Endothelial Cell Injection (Vyznova) for Bullous Keratopathy: Initial Clinical Experience. 培养人角膜内皮细胞注射（Vyznova）治疗大疱性角膜病变的早期临床结果：初步临床经验。

IF 2.1 3区医学

Cornea Pub Date : 2025-09-03 DOI: 10.1097/ICO.0000000000003984

Akira Kobayashi, Natsuko Mori, Hideaki Yokogawa, Seiichiro Sugita, Yukari Yagi-Yaguchi, Takefumi Yamaguchi, Tomomi Higashide

{"title":"Early Clinical Outcomes of Cultured Human Corneal Endothelial Cell Injection (Vyznova) for Bullous Keratopathy: Initial Clinical Experience.","authors":"Akira Kobayashi, Natsuko Mori, Hideaki Yokogawa, Seiichiro Sugita, Yukari Yagi-Yaguchi, Takefumi Yamaguchi, Tomomi Higashide","doi":"10.1097/ICO.0000000000003984","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003984","url":null,"abstract":"Purpose: To report early clinical outcomes of cultured human corneal endothelial cell (cHCEC) injection therapy (Vyznova) for bullous keratopathy (BK). To our knowledge, this is the first study reporting use of an initial commercial lot of Vyznova implemented at 3 independent institutions specializing in corneal transplantation in Japan.Methods: This retrospective case series included 4 eyes of 4 patients (mean age, 76.8 years, 1 man, 3 women) with BK owing to Fuchs endothelial corneal dystrophy (n = 2), pseudophakic bullous keratopathy (n = 1), or primary angle-closure disease (n = 1), treated between August 2024 and October 2024. All patients received an intracameral injection of 1.0 × 106 cHCECs (Vyznova). Best-corrected visual acuity (BCVA), central corneal thickness (CCT), and endothelial cell density (ECD) were assessed preoperatively and 6 months postoperatively. Complications were also recorded.Results: In the 3 uncomplicated cases, corneal clarity was restored by 6 months, and BCVA improved from a mean of 0.20 to 0.55. Mean CCT reduced from 729 μm to 586 μm, and ECD reached 2483 cells/mm2 mean (unmeasurable preoperatively). Corneal clarity was also achieved in 1 case with intraoperative and postoperative Descemet membrane detachment. However, BCVA remained unchanged at 0.5, CCT increased from 646 μm to 689 μm, and ECD was 660 cells/mm2.Conclusions: Vyznova therapy seems to be effective in restoring corneal clarity in patients with BK. This real-world experience underscores the feasibility of implementing cHCEC injections in institutions beyond the developer sites. Careful intraoperative management is necessary to avoid complications, such as detachment of Descemet membrane.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Diabetic Donor Grafts in Descemet Membrane Endothelial Keratoplasty. 糖尿病供体移植物对角膜内皮成形术的影响。

IF 2.1 3区医学

Cornea Pub Date : 2025-09-03 DOI: 10.1097/ICO.0000000000003977

Luisa Matterne, André M Trouvain, Marie Della Volpe-Waizel, Alexander Wolf, Warda Darwisch, Silke Wahl, Peter Szurman, Berthold Seitz, Fabian Fries, Annekatrin Rickmann

{"title":"Impact of Diabetic Donor Grafts in Descemet Membrane Endothelial Keratoplasty.","authors":"Luisa Matterne, André M Trouvain, Marie Della Volpe-Waizel, Alexander Wolf, Warda Darwisch, Silke Wahl, Peter Szurman, Berthold Seitz, Fabian Fries, Annekatrin Rickmann","doi":"10.1097/ICO.0000000000003977","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003977","url":null,"abstract":"Purpose: To investigate the impact of donor diabetes mellitus on donor corneal tissue in organ culture on graft preparation, surgical outcomes, and graft survival.Methods: Retrospective comparison of 273 eyes (218 patients) undergoing DMEK, divided into 2 subgroups [0: donor without diabetes (n = 210); D: donor with diabetes (n = 63)]. The data of visual acuity (VA), central corneal thickness (CCT) and endothelial cell count (ECC), and intra- and postoperative complications were collected.Results: Donor ECC was comparable in both groups (group 0: 2618 ± 183 cells/mm2 vs. group D 2556 ± 218 cells/mm2; P = 1.0). Preparation was slightly more difficult in group D (25% vs. 20%; P = 0.45), as peripheral tears occurred more frequently (25% vs. 16%; P = 0.08), however, these donors were also significantly more frequently already pseudophakic (59% vs. 35%; P = 0.001). The scrolling behavior of the graft and the intraoperative difficulties in the anterior chamber were comparable in both groups. Preparation time and difficulties during preparation or implantation had no significant influence on postoperative rate of rebubbling or repeat DMEK in either group (all P > 0.05). The postoperative outcome was comparable regarding VA, CCT and ECC, rebubbling rate (40% both groups; P = 0.99) and repeat DMEK (group 0: 6% vs. group D: 9%; P = 0.57) during 12-month follow-up.Conclusions: We could not demonstrate any significant differences in graft preparation using the liquid-bubble technique in organ culture conditions, nor in postoperative outcomes after DMEK, between corneas from diabetic and nondiabetic donors. However, further prospective research is needed to fully understand the impact of diabetes on corneal transplantation.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Biomechanical Alterations in Granular Corneal Dystrophy Type 2 From p.Ala546Asp Mutation Carriers. p.Ala546Asp突变携带者2型颗粒性角膜营养不良的早期生物力学改变。

IF 2.1 3区医学

Cornea Pub Date : 2025-09-03 DOI: 10.1097/ICO.0000000000003981

Jorge L Domene-Hickman, Luis Haro-Morlett, Guillermo Raul Vera-Duarte, Leire Irusteta, Alejandro Navas, Enrique O Graue-Hernandez, Arturo Ramirez-Miranda

{"title":"Early Biomechanical Alterations in Granular Corneal Dystrophy Type 2 From p.Ala546Asp Mutation Carriers.","authors":"Jorge L Domene-Hickman, Luis Haro-Morlett, Guillermo Raul Vera-Duarte, Leire Irusteta, Alejandro Navas, Enrique O Graue-Hernandez, Arturo Ramirez-Miranda","doi":"10.1097/ICO.0000000000003981","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003981","url":null,"abstract":"Purpose: The aim of this study was to describe corneal biomechanical changes in individuals carrying the p.Ala546Asp mutation, compare those with and without visible corneal deposits, and explore their potential relevance for early biomechanical characterization.Methods: A case series was conducted in a Mexican mestizo family with confirmed molecular diagnosis of granular corneal dystrophy type 2 (GCD2). Participants were classified into 3 groups: mutation carriers with clinically visible corneal deposits (n = 8), mutation carriers without visible deposits (n = 3), and healthy controls without the mutation (n = 20). Corneal biomechanics were evaluated using the Corvis ST system, focusing on the corneal biomechanical index (CBI), stiffness parameter at first applanation (SP-A1), Corvis biomechanical factor (CBiF), and deformation amplitude ratio (DA ratio).Results: CBI was significantly higher in mutation carriers, regardless of deposit presence (mutation with deposits: 0.63 ± 0.23; mutation without deposits: 0.57 ± 0.25 vs. controls: 0.11 ± 0.11, P < 0.0001). SP-A1 was significantly lower in mutation carriers, suggesting early corneal stiffness alterations. No significant differences were found between mutation carriers with and without visible deposits, indicating that biomechanical changes occur before clinical deposits form.Conclusions: The p.Ala546Asp mutation may be associated with early corneal biomechanical instability, regardless of visible deposits. These findings suggest that biomechanical assessment may aid in the description of subclinical corneal changes in GCD2 and contribute to a better understanding of biomechanical variability among mutation carriers.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in Corneal Transplantation at a Mexican Ophthalmological Center: 12 Years of Experience. 墨西哥眼科中心角膜移植的趋势：12年的经验。

IF 2.1 3区医学

Cornea Pub Date : 2025-09-03 DOI: 10.1097/ICO.0000000000003975

Nicole Macriz-Romero, David Jimenez-Collado, Guillermo Raul Vera-Duarte, Nicole Lara-Cortes, Fernanda Granillo-Blancas, Nicolás Kahuam-López, Arturo Ramirez-Miranda, Alejandro Navas, Denise Loya-Garcia, Lucero Pedro-Aguilar, Enrique O Graue-Hernandez

{"title":"Trends in Corneal Transplantation at a Mexican Ophthalmological Center: 12 Years of Experience.","authors":"Nicole Macriz-Romero, David Jimenez-Collado, Guillermo Raul Vera-Duarte, Nicole Lara-Cortes, Fernanda Granillo-Blancas, Nicolás Kahuam-López, Arturo Ramirez-Miranda, Alejandro Navas, Denise Loya-Garcia, Lucero Pedro-Aguilar, Enrique O Graue-Hernandez","doi":"10.1097/ICO.0000000000003975","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003975","url":null,"abstract":"Purpose: To analyze the trends and characteristics of eye banking and corneal transplantation over a 12-year period at an ophthalmological center in Mexico City.Methods: We performed a retrospective, descriptive study including all patients who underwent corneal transplantation at a Mexican ophthalmology reference center between January 2011 and December 2022. Statistical analyses were conducted with data reported as complete counts or mean with standard deviations. Comparisons were made using independent t-tests. P-values less than 0.05 were considered statistically significant.Results: A total of 1251 corneal transplants were performed during the study period. The most common indications for transplantation were bullous keratopathy (23.4%), keratoconus (22.9%), and previous graft failure (12.8%). The mean recipient age was 52.8 years, with a slight male predominance (51.9%). Systemic comorbidities included hypertension (21.7%) and diabetes mellitus (13.7%). Donor characteristics revealed a mean death-to-procurement time of 7.98 hours and a mean procurement-to-transplantation time of 16.3 days-14.2 days for optical corneas and 38.8 days for tectonic tissue. The average endothelial cell count was 2884 cells/mm2. Penetrating keratoplasty was the most frequently performed surgical technique.Conclusions: This 12-year analysis provides valuable insight into corneal transplant trends in Mexico. The findings highlight the ongoing reliance on imported tissue and the predominance of penetrating keratoplasty. Strengthening national eye banking systems and donation culture is essential to improve access and outcomes in corneal transplantation.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four Unique Cases of Keratopathy From Vitamin A Deficiency in a Tertiary Care Center in the United States: A Case Series. 美国三级保健中心维生素A缺乏引起的角膜病变的四个独特病例：一个病例系列。

IF 2.1 3区医学

Cornea Pub Date : 2025-09-03 DOI: 10.1097/ICO.0000000000003992

Joshua Van Swol, Catherine Reppa

{"title":"Four Unique Cases of Keratopathy From Vitamin A Deficiency in a Tertiary Care Center in the United States: A Case Series.","authors":"Joshua Van Swol, Catherine Reppa","doi":"10.1097/ICO.0000000000003992","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003992","url":null,"abstract":"Purpose: To identify ocular manifestations of vitamin A deficiency in a case series of patients presenting with keratopathy at a tertiary care center of a high-income country, and to highlight clinical features and treatment outcomes.Methods: A retrospective chart review was conducted of patients diagnosed with xerophthalmia at as single institution between January 1, 2025, and May 31, 2025. Patients were identified using diagnostic codes for xerophthalmia and related ocular surface disease. Inclusion criteria were a clinical diagnosis of xerophthalmia during the study period with documented ocular findings. Data collected included ocular findings, serum vitamin A levels, nutritional history, medical history, treatment, and outcomes. Data were deidentified and analyzed descriptively.Results: Four patients were found to fit the inclusion criteria. Cases were complicated by malignancy, alcoholism, severe autism, and end-stage renal disease requiring dialysis. Most cases were late presentations and severe being complicated by corneal perforations caused by sterile stromalysis or superimposed infections. One case was more minor in nature and involved a Bitot spot.Conclusions: Vitamin A deficiency remains a notable cause of preventable vision loss and keratopathy in high-income countries, especially in certain at-risk populations. Prompt recognition of ocular signs and timely vitamin A repletion can lead to reversal or stabilization of keratopathy; however, at the institution in this study, patients more frequently presented after significant corneal damage had occurred.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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