IF 1.9 3区医学

Cornea Pub Date : 2025-04-29 DOI: 10.1097/ICO.0000000000003884

Mohit Parekh, Ula V Jurkunas

{"title":"Cultivated Autologous Limbal Epithelial Cell Transplantation: A Comprehensive Review of Clinical Trials and Applications.","authors":"Mohit Parekh, Ula V Jurkunas","doi":"10.1097/ICO.0000000000003884","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003884","url":null,"abstract":"Purpose: Limbal stem cells (LSCs) are essential for corneal epithelial regeneration and ocular surface homeostasis. Dysfunction of LSCs results in LSC deficiency (LSCD), a leading cause of global blindness. Although ex vivo expansion and autologous transplantation of LSCs have demonstrated promising clinical outcomes, no Food and Drug Administration-approved therapies for LSCD are available in the United States. To address this gap, we developed a novel 2-step process for isolating and expanding LSCs on human amniotic membrane under good manufacturing practice conditions, using a xenobiotic-free, serum-free, and antibiotic-free environment.Methods: Autologous limbal biopsies were used to generate cultivated autologous limbal epithelial cell (CALEC) constructs, ensuring rigorous safety and efficacy measures. Furthermore, we compared the success rates of good manufacturing practice-manufactured cultivated limbal epithelial transplantation (CLET) products with those of CALEC.Results: Among 16 limbal biopsies harvested from 15 participants, 14 resulted in successful manufacturing of CALEC grafts. Phase I clinical trial demonstrated preliminary feasibility and no safety concerns. In the phase II trial, 92% of grafts showed partial or complete success at 18 months, with no safety issues. The success rate of CALEC grafts was comparable to currently available CLET products.Conclusions: The findings underscore the safety and efficacy of CALEC transplantation as a promising therapeutic strategy for LSCD. The current review focuses on the manufacturing, quality control, and clinical performance of CALEC constructs in phase I/II trials for unilateral LSCD, paving the way for future trials in advancing LSC-based regenerative therapies in the United States.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal Collagen Crosslinking for Progressive Post-Laser In Situ Keratomileusis Ectasia in Patients Older Than 50 years: A Case Series. 角膜胶原交联治疗50岁以上患者的进展性激光原位角膜磨除术后扩张：一个病例系列。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-22 DOI: 10.1097/ICO.0000000000003885

Margaret C Pollard, Alex Mammen, Gaurav Prakash, Vishal Jhanji

{"title":"Corneal Collagen Crosslinking for Progressive Post-Laser In Situ Keratomileusis Ectasia in Patients Older Than 50 years: A Case Series.","authors":"Margaret C Pollard, Alex Mammen, Gaurav Prakash, Vishal Jhanji","doi":"10.1097/ICO.0000000000003885","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003885","url":null,"abstract":"Purpose: Post-laser in situ keratomileusis (LASIK) ectasia has been rarely reported in older patients. We present the ectasia progression and treatment outcomes after corneal collagen crosslinking (CXL) in 5 patients with post-LASIK ectasia aged older than 50 years.Methods: This retrospective case series included patients with post-LASIK ectasia. Primary outcome parameters included preoperative and postoperative best corrected distance visual acuity (logMAR best corrected visual acuity). Corneal topography values included maximum keratometry (Kmax), flat keratometry (K1), and steep keratometry (K2). All patients underwent epithelium-off CXL using the Dresden protocol.Results: Five eyes of 5 patients were included. The mean patient age at CXL was 62.8 years (range 51-73 years). The average time since laser in situ keratomileusis surgery was 19 years (range 16-24 years). Patients were followed preoperatively for 343 days ± 150 and postoperatively for 3 to 5 years. Postoperatively, flattening of K2 and improvement in logMAR best corrected visual acuity were noted in all patients. There were no intraoperative or postoperative complications.Conclusions: Unlike primary corneal ectasia, post-LASIK corneal ectasia progresses in older patients. Our results support that CXL is effective in patients with post-LASIK ectasia aged older than 50 years.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Corneal Copper Deposition in Monoclonal Gammopathy of Undetermined Significance: Diagnostic Insights and Treatment With Descemet Membrane Endothelial Keratoplasty and Descemet Stripping Only. 双侧角膜铜沉积在单克隆性伽玛病中的意义尚不确定：仅用角膜内皮膜移植术和角膜剥离术诊断和治疗。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-16 DOI: 10.1097/ICO.0000000000003880

Sofía Del-Pozo-Lérida, Antonio Sabala Llopart, Júlia Widmer-Pintos, Consuelo Arnaldos-López, Maria Julia Martínez, Maria Teresa Salcedo Allende, Ariadna Quer Pi-Sunyer

{"title":"Bilateral Corneal Copper Deposition in Monoclonal Gammopathy of Undetermined Significance: Diagnostic Insights and Treatment With Descemet Membrane Endothelial Keratoplasty and Descemet Stripping Only.","authors":"Sofía Del-Pozo-Lérida, Antonio Sabala Llopart, Júlia Widmer-Pintos, Consuelo Arnaldos-López, Maria Julia Martínez, Maria Teresa Salcedo Allende, Ariadna Quer Pi-Sunyer","doi":"10.1097/ICO.0000000000003880","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003880","url":null,"abstract":"Purpose: To present a case of bilateral corneal copper deposition as the initial sign of monoclonal gammopathy of undetermined significance (MGUS), detailing diagnostic insights and outcomes of treatment with Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Only (DSO).Methods: Comprehensive ophthalmological evaluation and laboratory testing (including serum copper, protein electrophoresis, immunofixation) were performed. Surgical interventions were DMEK (right eye) and subsequently DSO (left eye), with postoperative monitoring. Anatomic pathology of the surgical specimen was also analyzed.Results: Ophthalmological evaluation revealed bilateral central corneal deposits at Descemetx{2019}s membrane. Elevated serum copper and high levels of gamma globulin with absence of malignancy in bone marrow biopsy confirmed MGUS by the hematologist. As to ocular treatment,DMEK initially improved visual acuity but deposits recurred within a year, decreasing vision by 18 months. DSO achieved corneal clearing and improved vision at 3 months, showing promising early results.Conclusions: Bilateral corneal copper deposition can be a presenting sign of MGUS, mandating systemic investigation. While DMEK offered temporary improvement although recurrence occurred. DSO shows potential as a therapeutic alternative. Recognizing these ocular findings is critical for timely MGUS diagnosis and monitoring, though optimal corneal treatment requires further research.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of Corneal Collagen Crosslinking Under General Anesthesia in Down Syndrome. 唐氏综合征全身麻醉下角膜胶原交联的结果。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-15 DOI: 10.1097/ICO.0000000000003881

Luis C Barrientos, Ryan Frisbie, Jennifer L Jung, Lauren Mehner, Casey Smith, Rebecca G Edwards Mayhew, Ronald Wise, Emily A McCourt, Michael A Puente

{"title":"Outcomes of Corneal Collagen Crosslinking Under General Anesthesia in Down Syndrome.","authors":"Luis C Barrientos, Ryan Frisbie, Jennifer L Jung, Lauren Mehner, Casey Smith, Rebecca G Edwards Mayhew, Ronald Wise, Emily A McCourt, Michael A Puente","doi":"10.1097/ICO.0000000000003881","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003881","url":null,"abstract":"Purpose: Down syndrome is one of the strongest risk factors of keratoconus. Corneal collagen crosslinking (CXL) is the standard-of-care treatment to reduce progression, but there is limited published literature about CXL in patients with Down syndrome. We sought to describe outcomes of epithelium-off CXL under general anesthesia in patients with Down syndrome and keratoconus.Methods: We conducted a retrospective descriptive case series at a single tertiary pediatric hospital. Standard epithelium-off Dresden protocol CXL under general anesthesia was performed in all cases. Preoperative and postoperative corneal characteristics were obtained. All perioperative and postoperative complications were reported.Results: Between August 2020 and February 2024, CXL was performed on 34 eyes of 20 patients with Down syndrome. The mean age was 20.2 years at the time of crosslinking. The mean preoperative Kmax was 62.3 diopters (range 45.5-95.4), with a mean preoperative central corneal thickness of 466 μm (range 306-538). Visual acuity post procedure in patients seen 1 week postoperatively was stable to improved. One eye developed corneal edema that resolved within 3 weeks postoperatively, and another was found to have new apical scarring a year after the procedure. No other complications were noted.Conclusions: Keratoconus was diagnosed at an advanced stage in most of the patients with Down syndrome in our cohort. Epithelium-off CXL under general anesthesia was well tolerated. Though follow-up was limited, our results suggest that CXL is feasible and effective in keratoconus associated with Down syndrome.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratoconus Profile in the Elderly Population: Prevalence, Keratoconus Indices, and Patterns of Keratoconus. 老年人圆锥角膜的概况：患病率、圆锥角膜指数和圆锥角膜的类型。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-11 DOI: 10.1097/ICO.0000000000003878

Hassan Hashemi, Alireza Jamali, Fatemeh Pakbaz, Alireza Hashemi, Maryam Roshani, Mehdi Khabazkhoob

{"title":"Keratoconus Profile in the Elderly Population: Prevalence, Keratoconus Indices, and Patterns of Keratoconus.","authors":"Hassan Hashemi, Alireza Jamali, Fatemeh Pakbaz, Alireza Hashemi, Maryam Roshani, Mehdi Khabazkhoob","doi":"10.1097/ICO.0000000000003878","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003878","url":null,"abstract":"Purpose: To assess the prevalence and associated characteristics of keratoconus (KCN) among individuals aged 60 years and older.Methods: In this study, total of 160 clusters and 20 strata were identified in Tehran, Iran through a multistage cluster sampling technique. Participants aged 60 years and older were included in the study. Corneal imaging used the Pentacam AXL. The diagnosis of KCN in this study was determined based on the measurements obtained from axial topography, pachymetry, and the elevation data from the Pentacam's refractive 4-maps.Results: The prevalence of KCN was determined to be 5.36% [95% confidence interval (CI), 4.52-6.2], with rates of 5.04% (95% CI, 3.88-6.2) in males and 5.68% (95% CI, 4.47-6.9) in females. The prevalence of KCN increased from 4.6% (95% CI, 3.29-5.92) among individuals aged 60 to 64 years to 6.92% (95% CI, 3.18-10.67) in those aged 80 years and older. A multiple regression analysis indicated that advancing age (odds ratio = 1.03; P < 0.001) and illiteracy (odds ratio = 1.65; P < 0.001) were significant factors associated with KCN in the elderly population. Besides, the predominant curvature pattern observed in KCN was the asymmetric bowtie with inferior steepening (18.91%), whereas the symmetric bowtie was the least common (0.29%).Conclusions: The prevalence of KCN is notably high among the elderly population and tends to rise with advancing age. Findings from the current study underscore the critical role of corneal topography and tomography in guiding clinical decisions for older patients, particularly in the context of intraocular lens power calculations.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Clinical Outcomes After Femtosecond Laser-Assisted Pterygium Excision. 飞秒激光辅助翼状胬肉切除术后的长期临床疗效。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-09 DOI: 10.1097/ICO.0000000000003873

Kenric Rui-Pin Fan, Yu-Chi Liu, Matthias Fuest, Hon Shing Ong, Hla Myint Htoon, Marcus Ang, Jodhbir S Mehta

{"title":"Long-Term Clinical Outcomes After Femtosecond Laser-Assisted Pterygium Excision.","authors":"Kenric Rui-Pin Fan, Yu-Chi Liu, Matthias Fuest, Hon Shing Ong, Hla Myint Htoon, Marcus Ang, Jodhbir S Mehta","doi":"10.1097/ICO.0000000000003873","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003873","url":null,"abstract":"Purpose: To report the long-term recurrence and complication rates after femtosecond laser-assisted pterygium excision surgery (FLAPS) with conjunctival autograft surgery.Methods: Single-center retrospective study of consecutive cases of primary nasal and/or temporal pterygia who underwent primary pterygium excision surgery with femtosecond laser-assisted conjunctival autograft. All subjects underwent manual pterygium excision, followed by femtosecond laser (Femto LDV Z8)-assisted conjunctival autograft surgery and with follow-up duration up to 5 years. Recurrence was defined as appearance of secondary pterygium at the same location. All complications intra- and postoperative were recorded. Primary outcome measure was postoperative pterygia recurrence, and secondary outcomes assessed were the intra- and postoperative complication rates associated with FLAPS.Results: We included 277 sequential FLAPS performed from September 2016 to September 2024. At baseline, mean (SD) age was 62.8 years (13.9); 183 males (66.1%); mean best-corrected visual acuity (BCVA) logMAR 0.23 [0.29]. A total of 200 (72.2%) were of Chinese ethnicity, with 3 (1.2%), 14 (4.9%), and 60 (21.6%) being Indian, Malay, or others. Recurrence was seen in 2/277 patients (0.72%) at 12 and 21 months, respectively, both of which were nasal pterygia, because of glue failure, but declined repeat excision surgery. There were no differences in postoperative BCVA, applanation duration, graft depth, or graft area between the groups. Cox regression analysis showed no significant association between pterygia grade or side with recurrence. Overall 5 years probability to be recurrence free was 99.20%. Five patients (1.8%) experienced dry eyes postoperatively. No intraoperative complications were seen.Conclusions: Primary pterygium excision with femtosecond laser-assisted conjunctival autograft results in low rates of recurrence and complications.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preoperative Risk Factors of Keratometry, Myopia, Astigmatism, Age, and Sex for Myopic Regression After Laser-Assisted In Situ Keratomileusis, Photorefractive Keratectomy, and Keratorefractive Lenticule Extraction. 术前角膜测量、近视、散光、年龄和性别对激光辅助原位角膜磨除术、光屈光性角膜切除术和角膜屈光性晶状体摘除术后近视消退的危险因素。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-08 DOI: 10.1097/ICO.0000000000003874

Garrett N Manion, Kayvon A Moin, Alex H Brown, Tyler V Olson, Guy M Kezirian, Phillip C Hoopes, Majid Moshirfar

{"title":"Preoperative Risk Factors of Keratometry, Myopia, Astigmatism, Age, and Sex for Myopic Regression After Laser-Assisted In Situ Keratomileusis, Photorefractive Keratectomy, and Keratorefractive Lenticule Extraction.","authors":"Garrett N Manion, Kayvon A Moin, Alex H Brown, Tyler V Olson, Guy M Kezirian, Phillip C Hoopes, Majid Moshirfar","doi":"10.1097/ICO.0000000000003874","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003874","url":null,"abstract":"Purpose: The purpose of this study was to identify preoperative and demographic risk factors of myopic regression 1 year after corneal refractive surgery.Methods: A retrospective study of 2093 patients (2781 eyes) who underwent laser-assisted in situ keratomileusis (LASIK), photorefractive keratectomy (PRK), or small incision lenticule extraction (SMILE) and experienced myopic regression of ≥0.5 D 1 year after surgery was conducted.Results: The incidence of regression at 1 year was higher in the overall SMILE group (10.1%) and steep keratometry group (9.6%) (P < 0.05). SMILE eyes with normal (9.0%) and steep corneas (18.2%) had a higher incidence of regression than those of LASIK and PRK eyes (P < 0.05). The mean magnitude of spherical equivalent (SEQ) regression for all regressed eyes was -0.63 ± 0.15 D. The overall SMILE group had a greater mean magnitude of spherical regression than the overall LASIK and PRK groups (-0.66 D vs. -0.48 D vs. -0.46 D, P < 0.05). There were no differences in cylindrical regression between any analyzed groups (P > 0.05). Female status and SEQ predicted -0.034 D [(-0.051, -0.017), P < 0.001] and -0.012 D [(-0.018, -0.006), P < 0.001] of regression, respectively. Age and preoperative Km had an odds ratio for regression of 1.033 [(1.017, 1.049), P < 0.001] and 1.109 [(1.006, 1.221), P < 0.001], respectively.Conclusions: Risk factors of myopic regression at 1 year included older age, female sex, steep corneas, and higher preoperative SEQ. SMILE had a higher incidence and greater magnitude of regression compared with LASIK and PRK.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter Regarding: Intereye Asymmetry as a Predictor of Progression in Patients With Untreated Keratoconus: Findings from a Longitudinal Study. 关于：眼间不对称作为未经治疗的圆锥角膜患者进展的预测因子：来自一项纵向研究的发现。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-08 DOI: 10.1097/ICO.0000000000003879

Alejandro Tello, Laura María Duarte-Bueno, Paula Alejandra Navarro, Angelica Pedraza-Concha, Virgilio Galvis

引用次数: 0

Assessment of Corneal Crosslinking for the Treatment of Corneal Neovascularization With and Without Associated Infection. 角膜交联治疗伴或不伴感染角膜新生血管的疗效评价。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-02 DOI: 10.1097/ICO.0000000000003869

Francis W Price, Zelalem Tefasse, Kathleen Dudasko Frances, Matthew T Feng, Anjulie Gang, Marianne O Price

{"title":"Assessment of Corneal Crosslinking for the Treatment of Corneal Neovascularization With and Without Associated Infection.","authors":"Francis W Price, Zelalem Tefasse, Kathleen Dudasko Frances, Matthew T Feng, Anjulie Gang, Marianne O Price","doi":"10.1097/ICO.0000000000003869","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003869","url":null,"abstract":"Purpose: To evaluate investigational use of corneal crosslinking (CXL) to treat corneal neovascularization (CNV) with or without concomitant infection.Methods: This prospective, single-center study assessed investigational use of epithelium-off CXL with 0.1% riboflavin/20% dextran ophthalmic solution to treat various scenarios of CNV with standard 30-minute or accelerated 10-minute irradiation.Results: The CXL treatment was investigated for 38 CNV scenarios in 37 eyes of 35 participants (2 bilateral) and was repeated once in 2 eyes and twice in 1 eye. Treatment was considered successful in 24 cases, partially successful in 1 case, and unsuccessful in 8 cases; 2 cases were lost to follow up and 3 developed complications unrelated to the CXL that precluded efficacy evaluation. The CXL was considered successful in all 4 cases treated for CNV with melting and/or cheese wiring of the recipient cornea postkeratoplasty, in 7 of 9 cases with active infection, in 5 of 10 cases treated in conjunction with penetrating keratoplasty, in 3 of 4 cases treated in conjunction with lamellar keratoplasty or wound revision, and in 6 of 11 cases without associated infection or surgery.Conclusions: Investigational use of CXL can contribute to CNV regression in the following scenarios: postkeratoplasty corneal melting and suture cheese wiring, infectious keratitis, and combined with keratoplasty. However, it has limited, if any, benefit in treating CNV in situations where the stimulus for CNV is not eliminated, such as ongoing infection or chronic conditions such as limbal stem cell dysfunction.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Donor History of Sleep Apnea on Corneal Tissue Evaluation Parameters. 供体睡眠呼吸暂停史对角膜组织评估参数的影响

IF 1.9 3区医学

Cornea Pub Date : 2025-04-01 Epub Date: 2024-06-18 DOI: 10.1097/ICO.0000000000003588

Abhishek Ramini, Nancy Zhang, Megan Lee, Indu Vadakkepattath, Onkar B Sawant, Charles S Bouchard

{"title":"The Impact of Donor History of Sleep Apnea on Corneal Tissue Evaluation Parameters.","authors":"Abhishek Ramini, Nancy Zhang, Megan Lee, Indu Vadakkepattath, Onkar B Sawant, Charles S Bouchard","doi":"10.1097/ICO.0000000000003588","DOIUrl":"10.1097/ICO.0000000000003588","url":null,"abstract":"Purpose: The goal of this study was to explore whether the donor history of sleep apnea affects corneal tissue evaluation parameters.Methods: This was a retrospective study assessing the impact of donor history of sleep apnea in a dataset obtained from the Eversight Eye Bank. Comparative analysis and multivariate regression were used to assess differences in key parameters including endothelial cell density (ECD) and central corneal thickness.Results: Data analyzed consisted of 50,170 tissues from 25,399 donors with no history of sleep apnea and 5473 tissues from 2774 donors with a history of sleep apnea. Tissue from donors with a history of sleep apnea showed lower ECD than those from donors with no history of sleep apnea (-51 cells/mm 2 , P < 0.001). Multivariate linear regression demonstrated that history of sleep apnea was a predictor of lower ECD by 13.72 cells/mm 2 ( P = 0.0264). Secondary analysis demonstrated that underweight and obese body mass indexes were significant predictors of increased ECD in donors with no history of sleep apnea ( P < 0.0001, P = 0.025, respectively). Body mass index category was not a significant predictor of ECD in donors with a history of sleep apnea. In a smaller subset of 10,756 tissues, sleep apnea was not a significant predictor of central corneal thickness.Conclusions: This is the first study to demonstrate that a donor's history of sleep apnea is associated with a lower ECD in a large eye bank dataset. Future studies are needed to investigate whether history of sleep apnea affects posttransplantation outcomes.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"463-467"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12032443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141418264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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