IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003867

Yongwoo Lee

引用次数: 0

Impact of Simultaneous TG-PRK on Corneal Haze After Cross-Linking for Keratoconus: A Quantitative Densitometry Analysis. 同时TG-PRK对圆锥角膜交联后角膜雾度的影响：定量密度分析。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003862

João Q Gil, Pedro Gil, Sara Geada, Esmeralda Costa, Cristina Tavares, Andreia Rosa, Maria J Quadrado, Joaquim N Murta

{"title":"Impact of Simultaneous TG-PRK on Corneal Haze After Cross-Linking for Keratoconus: A Quantitative Densitometry Analysis.","authors":"João Q Gil, Pedro Gil, Sara Geada, Esmeralda Costa, Cristina Tavares, Andreia Rosa, Maria J Quadrado, Joaquim N Murta","doi":"10.1097/ICO.0000000000003862","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003862","url":null,"abstract":"Purpose: To compare the impact of simultaneous topography-guided photorefractive keratectomy (TG-PRK) on corneal haze in patients undergoing accelerated corneal cross-linking (CXL) for keratoconus, using corneal densitometry.Methods: Retrospective, case-control study comparing patients undergoing accelerated CXL alone (CXL group) or combined CXL and TG-PRK (TG-PRK group). All patients performed PTK-assisted 50-μm deepithelization, followed by 10-minute ultraviolet-A exposure at 10 mW/cm2 (6 J/cm2 total dose). In the TG-PRK group, patients had simultaneous TG-PRK ablation for topographic regularization. Corneal densitometry was measured preoperatively, at 3 months, and at 1 year postoperatively using a Scheimpflug device. Changes in densitometry values across different corneal regions were analyzed to assess haze evolution.Results: A total of 106 eyes were included, with 50 eyes in the CXL group and 56 eyes in the TG-PRK group. At 3 months and 1 year postoperatively, patients in the TG-PRK group exhibited significantly higher corneal densitometry values across all areas of the anterior and central middle stroma (P < 0.001). By 1 year, densitometry values in both groups had largely returned to baseline, except for the central 2 mm of the anterior cornea in the TG-PRK group. Patients with greater flattening had significantly more haze after CXL with TG-PRK, but no correlation was found between haze formation and changes in visual acuity in both groups.Conclusions: Simultaneous TG-PRK and CXL result in more significant and prolonged corneal haze compared with CXL alone. Haze improves over time but persists longer in the combined procedure. Corneal densitometry is valuable for assessing haze and optimizing patient management.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjunctival Silicone Granuloma From Breast Implants. 乳房植入物引起的结膜硅胶肉芽肿。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003866

Anna J Sun, Anna M Stagner, Han-Ying P Chang

引用次数: 0

Long-term Tomographic, Refractive, and Visual Analysis of Keratoconus Eyes With Extreme Corneal Flattening After Corneal Cross-linking. 角膜交联后角膜极度扁平化圆锥角膜的长期断层、屈光和视觉分析。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003861

Maria A Henriquez, Luis Izquierdo, Ignacia Zenteno, Rolando Rojas, Jose Chauca, Mark Mannis

{"title":"Long-term Tomographic, Refractive, and Visual Analysis of Keratoconus Eyes With Extreme Corneal Flattening After Corneal Cross-linking.","authors":"Maria A Henriquez, Luis Izquierdo, Ignacia Zenteno, Rolando Rojas, Jose Chauca, Mark Mannis","doi":"10.1097/ICO.0000000000003861","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003861","url":null,"abstract":"Purpose: To evaluate the long-term tomographic, refractive, and visual characteristics of eyes with extreme corneal flattening after corneal cross-linking (CXL) for progressive keratoconus.Methods: A retrospective observational study included eyes that underwent corneal CXL with epithelial removal between June 2006 and March 2017 and had extreme keratometric flattening [greater than 5 diopters (D)] and a minimum follow-up of 5 years. Visual, tomographic, pachymetric, and refractive characteristics were evaluated.Results: Mean follow-up time was 7.6 ± 2.6 years (range 5-13 years). Fifteen eyes were included in the study. Mean maximum keratometric (Kmax) flattening was -7.58 ± 2.63 D [range 5.0-12.2 D, (P <0.001)]. Approximately 56.25% (9/15) of the eyes experienced progressive flattening over the years. And 40% (6/15) presented an improvement of one or more lines of corrected distance visual acuity (CDVA), and 26.6% (5/16) of the eyes showed a worsening of CDVA. Logistic regression analysis revealed that postoperative Kmax flattening greater than 2 D at the first year postop (odds ratio 17.7, 95% confidence interval, 4.4-71.2) and preoperative Kmax greater than 55 D (odds ratio 8.8, 95% confidence interval, 2.7-28.3) were significant risk factors for extreme postop keratometric flattening.Conclusions: Progressive extreme corneal flattening when accompanied with a decrease of CDVA was a late complication of CXL that may have required corneal transplantation for visual rehabilitation. Preoperative steeper corneas and keratometric flattening greater than 2 D at the first year postoperative period were risk factors associated with long-term extreme postoperative corneal flattening.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Manual Technique for Corneal Allogeneic Intrastromal Ring Segments Without a Femtosecond Laser. 无飞秒激光人工角膜异体角膜间环段技术研究。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-19 DOI: 10.1097/ICO.0000000000003853

Takahiko Hayashi, Yusuke Hara, Chihiro Sunouchi, Kentaro Yuda, Takashi Kojima, Naoko Kato, Brendan Cronin, Satoru Yamagami

{"title":"A Manual Technique for Corneal Allogeneic Intrastromal Ring Segments Without a Femtosecond Laser.","authors":"Takahiko Hayashi, Yusuke Hara, Chihiro Sunouchi, Kentaro Yuda, Takashi Kojima, Naoko Kato, Brendan Cronin, Satoru Yamagami","doi":"10.1097/ICO.0000000000003853","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003853","url":null,"abstract":"Purpose: To evaluate the outcomes of corneal allogeneic intrastromal ring segments (CAIRS) using a simplified manual technique for treating keratoconus.Methods: This prospective case series included 5 eyes from 5 patients with keratoconus (4 males, 1 female, mean age 32.5 ± 10.6 years) treated with manual CAIRS. Surgeries were performed under local anesthesia by a single surgeon. An intrastromal pocket for donor tissue implantation was manually created using a spatula, and donor corneas were prepared using a Jacobs CAIRS trephine. Corneal parameters, including higher-order aberrations, coma, and spherical aberrations at a 6 mm diameter, were measured using optical coherence tomography (CASIA SS-1000, Tomey, Japan). Anterior and posterior corneal indices, subjective refractive power, cylinder, spherical equivalent, best-corrected visual acuity (BCVA; logarithm of the minimum angle of resolution [logMAR]), and central corneal thickness. Intra- and postoperative complications were also analyzed.Results: Over a mean follow-up of 6.4 ± 2.9 months, no complications occurred. BCVA improved from 0.74 ± 0.44 logMAR preoperatively to 0.19 ± 0.66 logMAR (P = 0.043). The maximum keratometry (Kmax) value decreased from 63.6 ± 8.3D preoperatively to 59.6 ± 6.8D postoperatively (P = 0.043). Spherical equivalent improved from -11.2 ± 5.8D to -5.3 ± 3.1D (P = 0.043), and astigmatism reduced from -5.0 ± 3.4D to -3.3 ± 2.9D. Total corneal higher-order aberrations decreased from 5.6 ± 1.6D to 4.2 ± 1.6D postoperatively (P = 0.043).Conclusions: Manual CAIRS is an effective treatment when a femtosecond laser is not available.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cornea Classic: Nichols, Nichols, and Mitchell, "The Lack of Association Between Signs and Symptoms in Patients With Dry Eye Disease" (2004). 角膜经典：尼科尔斯、尼科尔斯和米切尔，“干眼症患者的体征和症状之间缺乏联系”（2004年）。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-19 DOI: 10.1097/ICO.0000000000003857

Karla Zadnik

引用次数: 0

Processing Methods Affect Biological Properties of Amniotic Membrane Sheet Products. 加工方法对羊膜片制品生物学特性的影响。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-18 DOI: 10.1097/ICO.0000000000003849

Yuan Zhang, Allison Helman, Olivia G Mead, Sean Tighe, Yingting Zhu, Scheffer C G Tseng

引用次数: 0

Implantation of Opposing Dual Corneal Allogeneic Intrastromal Ring Segments With Topography-Guidance: A Novel Method for Improved Corneal Reshaping. 在地形引导下植入对对双角膜异体真皮内环段：一种改善角膜重塑的新方法。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-18 DOI: 10.1097/ICO.0000000000003833

Dilan Colak, Burcu Yakut, Ugur Tunc, Aylin Kilic

{"title":"Implantation of Opposing Dual Corneal Allogeneic Intrastromal Ring Segments With Topography-Guidance: A Novel Method for Improved Corneal Reshaping.","authors":"Dilan Colak, Burcu Yakut, Ugur Tunc, Aylin Kilic","doi":"10.1097/ICO.0000000000003833","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003833","url":null,"abstract":"Purpose: To present the outcomes of topography-guided opposing dual-segment KeraNatural implantation in patients with keratoconus with symmetrical corneal cones.Methods: This study evaluated 6 eyes from 5 patients who had undergone dual allogeneic intrastromal ring segment (corneal allogeneic intrastromal ring segment) opposite horizontal implantation surgery based on topographic cone location with a follow-up period ranging from 6 months to 3 years. Preoperative and postoperative measurements, including visual acuity, refractive, topographic keratometric values, and central corneal thickness, were analyzed.Results: Corrected distance visual acuity increased from 0.93 ± 0.58 preoperatively to 0.33 ± 0.14 postoperatively and Kmax decreased from 57.87 ± 1.87 to 55.47 ± 1.62 diopters. No significant complications were reported during the follow-up period.Conclusions: This study investigates the outcomes of dual KeraNatural implantation in patients with keratoconus with symmetrical cones. The findings from this study may yield enhanced outcomes, necessitating additional exploration and possible implementation as a new standard in keratoconus surgery.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timeframe to Keratoplasty After Ocular Surface Stem Cell Transplantation. 眼表干细胞移植后角膜移植的时间框架。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-18 DOI: 10.1097/ICO.0000000000003860

Daniel Peretz, Kian M Madjedi, Edward J Holland

{"title":"Timeframe to Keratoplasty After Ocular Surface Stem Cell Transplantation.","authors":"Daniel Peretz, Kian M Madjedi, Edward J Holland","doi":"10.1097/ICO.0000000000003860","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003860","url":null,"abstract":"Purpose: The aim of this study is to report the actual time delay between ocular surface stem cell transplantation (OSST) and keratoplasty at a high-volume center for limbal stem cell deficiency (LSCD). Understanding expected timelines and reasons for any delays or deferrals can allow for more accurate expectation-setting discussions with prospective patients.Methods: A retrospective chart review was performed on all patients having undergone OSST between January 2013 and December 2022. Charts were reviewed to determine whether the need for keratoplasty was specified at the time of OSST planning. Parameters for these cases were then collected including underlying diagnoses, type of OSST performed, and time delay between OSST and keratoplasty (if performed). Results were then aggregated, and subgroup analysis was conducted.Results: A total of 219 eyes were included, of which, 128 eyes had initial intent for keratoplasty. Of these, 48% had keratoplasty within 6 months of OSST, 17% between 6 and 24 months, 5% beyond 2 years, and, interestingly, 30% had no subsequent keratoplasty. Most eyes with no eventual keratoplasty experienced unanticipated stromal clearing after OSST obviating the need for keratoplasty.Conclusions: This is the first study to report realized time delay between OSST and keratoplasty at a large LSCD practice. Prospective patients can be counselled that 76% of compliant cases with initial intent for keratoplasty either had keratoplasty within 6 months or exhibited unanticipated stromal clearing after OSST alone. Patients with congenital aniridia or contact lens-related LSCD are more likely to have unanticipated stromal clearing.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter Regarding: Optical Coherence Tomography Angiography in Patients With the Boston Keratoprosthesis Type 1. 关于：波士顿1型角膜假体患者的光学相干断层血管造影。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-18 DOI: 10.1097/ICO.0000000000003872

David Mikhail, Daniel Milad, Mona Harissi-Dagher

引用次数: 0

Cornea最新文献