A Standardized Protocol of Simultaneous Transepithelial Phototherapeutic Keratectomy Followed by Corneal Collagen Crosslinking for Keratoconus.

Purpose: To report outcomes in patients with progressive keratoconus who underwent a standardized protocol of transepithelial phototherapeutic keratectomy (t-PTK) laser followed by accelerated corneal collagen crosslinking (CXL).

Methods: All patients with progressive keratoconus undergoing our protocol at a London clinic between 2019 and 2023 were included. The protocol involved t-PTK at 58-μm central ablation depth at a 9-mm treatment zone on the Schwind Amaris 1050RS platform. Preoperative K readings of 43.0D (both K1 and K2) were inputted for all cases. Patients then underwent CXL with a pulsed-light accelerated protocol (30 mW/cm 2 for 8 minutes of UVA exposure time with 1 second on/1 second off).

Results: Seventy-nine eyes from 55 patients were included with an average follow-up of 12 months (range 6-24 months). Both mean uncorrected distance visual acuity (UDVA) and best spectacle-corrected visual acuity improved significantly from 0.42 preoperatively to 0.29 postoperatively ( P < 0.01) and 0.11 to 0.06 postoperatively ( P < 0.01), respectively. The refractive cylinder reduced significantly from -3.07D to -2.63D ( P < 0.05). The mean Km improved from 46.15D to 45.44D ( P < 0.01) and mean Kmax from 54.03D to 52.52D ( P < 0.01). 77% of eyes (n = 61) exhibited Kmax improvement postoperatively, and 56% showed an improvement in UDVA (n = 44). 16% (n = 13) had worsening of vision, but of these, only 1 patient had visual loss of more than 2 lines. No eyes had corneal haze reported at the final follow-up, and none required additional treatment.

Conclusions: This standardized simultaneous t-PTK and CXL protocol is safe and effective for the treatment of progressive keratoconus, providing visual, refractive, and topographic improvements.