Cornea最新文献

{"title":"Topical Cenegermin for Pediatric Neurotrophic Keratopathy: A Review of the Literature and Systematic Review.","authors":"Mohammad Bakr, Taher K Eleiwa, Hajirah N Saeed, Abdelrahman M Elhusseiny","doi":"10.1097/ICO.0000000000003960","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003960","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate current available evidence supporting the use of topical cenegermin (Oxervate, Dompe Farmaceutici, Milan, Italy) in pediatric neurotrophic keratopathy (pNK).</p><p><strong>Methods: </strong>A literature search was conducted in PubMed CENTRAL, Google Scholar, EMBASE, the Register of Controlled Trials, and Ovid MEDLINE electronic databases of literature published up until May 2024 using the following terms singularly or in combination: \"Oxervate,\" \"cenegermin,\" \"pediatric,\" \"neurotrophic keratopathy,\" and \"neurotrophic keratitis.\"</p><p><strong>Results: </strong>Twelve studies (10 case reports, 2 case series) evaluating the outcomes of topical cenegermin in pNK were identified: 6 studies were conducted in the United States and 6 were conducted in Europe. In total, 26 eyes of 22 pediatric patients with a mean age of 6.75 ± 4.75 years (range: 0.3-18 years) were treated with topical cenegermin for pNK. A total of 20 of 26 eyes (76.9%) achieved an improvement of NK (19 eyes with complete resolution and 1 eye with partial improvement) that remained stable over 13.88 ± 8.2 months (range: 5-31 months) of follow-up. Of the remaining 6 eyes (23.1%), 3 eyes had no improvement, 1 eye had progressive melt and perforation during treatment, requiring a penetrating keratoplasty, and 2 eyes had recurrences with one eye requiring corneal neurotization and the other requiring amniotic membrane transplantation during treatment.</p><p><strong>Conclusions: </strong>Topical cenegermin seems to be an effective option for treating pNK. However, the current literature is limited, and prospective controlled studies are needed to study its effects further.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Observations of the First Human Implantation of an Artificial Endothelial Layer for Endothelial Dysfunction: A Pilot Study.","authors":"Hyeck-Soo Son, Victor A Augustin, Charles G Eberhart, Maximilian Friedrich, Emanuel Reitemeyer, Nikola Henningsen, Oliver Hassel, Louise Blöck, Gerd U Auffarth","doi":"10.1097/ICO.0000000000003972","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003972","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the long-term observations of the first human implantation of EndoArt, a synthetic endothelial implant, in a small cohort of patients with corneal edema secondary to endothelial dysfunction.</p><p><strong>Methods: </strong>This retrospective case series analyzed 5 eyes from 5 patients who underwent EndoArt implantation, with a minimum follow-up of 12 months. Clinical outcomes, including corrected distance visual acuity and central corneal thickness, were evaluated pre- and postoperatively. Rebubbling procedures and any complications were recorded. Histological analysis was performed on 1 explanted corneal button.</p><p><strong>Results: </strong>The mean follow-up was 38.4 ± 20 months (range: 19-72 months). A reduction in mean central corneal thickness was observed, from 741.2 ± 88.3 μm preoperatively to 558.4 ± 72.7 μm postoperatively (P < 0.001). Corrected distance visual acuity improved in 4 of 5 eyes, although not significantly overall (P = 0.19). The mean number of rebubbling procedures was 2.8 ± 1.3 per eye. No serious implant-related complications were observed during the follow-up period. Histological findings showed fibrocellular tissue partially integrating the implant, which may contribute to graft adherence. Two patients with Fuchs dystrophy received the device as a primary procedure because of ethical or religious constraints regarding donor tissue.</p><p><strong>Conclusions: </strong>This small pilot series of the first human EndoArt implantation observed a significant reduction of corneal edema over time and a favorable safety profile in select patients. Although these findings are encouraging, they should be interpreted with caution given the limited sample size. Larger, controlled studies are needed to better understand the safety, efficacy, and long-term outcomes of this synthetic implant.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Outcomes in Patients Diagnosed With Corneal Opacity: An IRIS (Intelligent Research in Sight) Registry Study.","authors":"Rohan Bir Singh, Thomas H Dohlman, Alexander Ivanov, Nathan Hall, Connor Ross, Tobias Elze, Joan W Miller, Alice Lorch, Erdem Yuksel, Jia Yin, Reza Dana","doi":"10.1097/ICO.0000000000003943","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003943","url":null,"abstract":"<p><strong>Purpose: </strong>Corneal opacity is a leading cause of vision loss in the United States. This study examines the demographics, underlying causes, and vision outcomes of patients undergoing surgical interventions for corneal opacity.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using data from the American Academy of Ophthalmology's Intelligent Research Insight (IRIS) Registry, which includes clinical data from 79,887,324 patients who presented to participating eye clinics between January 1, 2013, and November 30, 2020. Patients diagnosed with corneal opacity who underwent surgical procedures were identified using current procedural terminology codes. Demographic variables (age, sex, race, ethnicity), underlying causes of corneal opacity, and best-corrected visual acuity (BCVA) at diagnosis and 12 months postsurgery were analyzed. Linear regression assessed risk factors associated with worse visual outcomes.</p><p><strong>Results: </strong>A total of 44,073 patients underwent surgery, with a mean age of 67.24 ± 14.40 years; 55% were female. The leading indications for surgery were corneal dystrophy (39%), corneal edema (21%), noninfectious ulcers (6.4%), infectious keratitis (6.1%), and trauma (1.7%); 15% had multiple etiologies. The most common procedures included endothelial keratoplasty (62.81%), penetrating keratoplasty (31.32%), and lamellar keratoplasty (2.1%). In addition, ocular surface reconstruction procedures were performed in a few cases. BCVA improved significantly postsurgery (0.72 ± 0.68 vs. 0.56 ± 0.74 logarithm of the minimum angle of resolution; P < 0.0001). Worse outcomes correlated with poorer baseline BCVA (P < 0.0001).</p><p><strong>Conclusions: </strong>Surgical interventions significantly improve vision outcomes in patients with corneal opacity. However, poorer preoperative BCVA predicts worse postoperative outcomes, emphasizing the importance of early intervention.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Onset Infectious Crystalline Keratopathy After Corneal Cross-linking.","authors":"Angela C Chen, Sophie X Deng, Anthony J Aldave","doi":"10.1097/ICO.0000000000003954","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003954","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of delayed onset infectious crystalline keratopathy after corneal cross-linking (CXL).</p><p><strong>Methods: </strong>Slit-lamp examination, confocal microscopy, anterior segment optical coherence tomography imaging, and corneal culture were performed to characterize the corneal opacification.</p><p><strong>Results: </strong>A 49-year-old man presented with progressively worsening vision in the left eye 8 months after uncomplicated epithelium-off CXL for keratoconus. Examination demonstrated focal central corneal stromal thinning with surrounding stromal opacification. Confocal microscopy did not demonstrate evidence of parasitic or fungal infection. Two months later, gray-white crystalline stromal opacities were observed surrounding the area of central stromal thinning, consistent with infectious crystalline keratopathy. Corneal scrapings of the left eye were obtained, which were positive for Enterococcus faecalis. After cessation of topical loteprednol and initiation of topical vancomycin and linezolid, the stromal infiltrate increased in size and a hypopyon developed but had resolved before the discontinuation of 7 weeks of topical antibiotic therapy. A deep anterior lamellar keratoplasty was performed 6 weeks later, with no recurrence of infection 10 months after surgery.</p><p><strong>Conclusions: </strong>Infectious crystalline keratopathy can present more than 6 months after CXL. Progressive corneal stromal thinning associated with stromal opacification should raise suspicion of this rare late onset complication of CXL and prompt corneal scraping for stains and cultures to rule out an indolent infectious process.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Clinic-Based Loop-Mediated Isothermal Amplification and Quantitative PCR for Fungal and Acanthamoeba Keratitis.","authors":"Binh Cao, Chi Hoang Viet Vu, Cung Xuan Le, Tuan Hoang Anh, Dong Pham Ngoc, Hiep Nguyen Xuan, Thu Anh Tran, Dionna M Wittberg, Krisianne M Aromin, Cindi Chen, Thuy Doan, Jeremy D Keenan","doi":"10.1097/ICO.0000000000003944","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003944","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the diagnostic accuracy of loop-mediated isothermal amplification (LAMP) and quantitative polymerase chain reaction (qPCR) for fungal and acanthamoeba keratitis when performed on simple clinic-based platforms.</p><p><strong>Methods: </strong>A total of 177 corneal scrapings were collected from 174 patients ≥18 years old diagnosed with presumed infectious keratitis at Vietnam National Eye Hospital. Smear was performed per routine by the microbiology laboratory. Clinic-based LAMP and qPCR testing for acanthamoeba and fungal targets was performed by a trained technician. The diagnostic accuracy of acanthamoeba LAMP, acanthamoeba qPCR, and panfungal qPCR was assessed relative to smear.</p><p><strong>Results: </strong>Of 177 cornea swabs tested with LAMP and qPCR for acanthamoeba, 5 were smear-positive for acanthamoeba. Sensitivity was 40% (95% CI, 12%-77%) for acanthamoeba LAMP and 100% (95% CI, 57%-100%) for acanthamoeba qPCR, and specificities were 100% (95% CI, 98%-100%) and 99% (95% CI, 96%-100%), respectively. Of 177 swabs tested with panfungal qPCR, 61 had a smear positive for fungus. Panfungal qPCR had a sensitivity of 84% (95% CI, 73%-91%) and specificity of 72% (95% CI, 64%-80%).</p><p><strong>Conclusions: </strong>A clinic-based qPCR was highly sensitive and specific for diagnosis of acanthamoeba keratitis but had poorer diagnostic performance for fungal keratitis. The LAMP protocol used in this study requires optimizations to improve sensitivity and reliability.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Donor and Recipient Smoking, Diabetes, and Age With Graft Failure and Rejection After Penetrating Keratoplasty.","authors":"Hasan Alsetri, Ahmed Saeed Saad, Eric J Shiuey, Christopher J Rapuano, Zeba A Syed","doi":"10.1097/ICO.0000000000003961","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003961","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether the combined donor and recipient factors of smoking, diabetes, and age have an association with graft failure and rejection after penetrating keratoplasty (PK).</p><p><strong>Methods: </strong>Data from 597 eyes of 516 patients who underwent PK at a single tertiary center between May 2007 and September 2018 were included. Donor and recipient smoking, diabetes, and age were extracted from electronic medical records. The primary outcomes were graft failure and graft rejection. Cox proportional hazards models for graft failure and rejection were generated to assess significant risk factors.</p><p><strong>Results: </strong>The smoker donor-recipient pairing had a higher proportion of graft failures (57.6% vs. 31.5%), a higher hazard ratio (HR) for failure (1.69, 95% confidence interval [CI], 1.00-2.84), and a lower graft survival (2.85 years, 95% CI, 1.87-3.83 years vs. 4.81 years, 95% CI, 4.40-5.21 years) compared with the nonsmoker donor-recipient pairing (P < 0.05 for all). In addition, the low age donor-recipient pairing had a higher proportion of graft rejection (43.5% vs. 28.7%), a higher HR for rejection (2.11, 95% CI, 1.45-3.06), and a lower graft rejection-free survival (3.72 years, 95% CI, 3.20-4.20 years vs. 5.55 years, 95% CI, 4.97-6.13 years) compared with the high age donor-recipient pairing (P < 0.05 for all). Donor-recipient smoking was not associated with graft rejection, donor-recipient age was not associated with graft failure, and diabetic donor-recipient pairs did not yield significant associations with graft failure or rejection.</p><p><strong>Conclusions: </strong>Donor and recipient smoking and age could be jointly considered when counseling patients on graft outcomes.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Endothelial Cell Damage in Corneal Grafts Used for Endothelial Keratoplasty and Correlation to Donor Tissue Characteristics and Postoperative Parameters.","authors":"Nicolas C D Scherer, Stefan Kassumeh, Martin Dirisamer, Nikolaus Luft, Siegfried G Priglinger, Wolfgang J Mayer","doi":"10.1097/ICO.0000000000003971","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003971","url":null,"abstract":"<p><strong>Purpose: </strong>To provide quantitative analysis of endothelial cell damage in corneal grafts before preparation for Descemet membrane endothelial keratoplasty (DMEK) in patients with Fuchs endothelial dystrophy by studying thecorrelation between the amount of cell damage, donor tissue-associated aspects, and postoperative parameters, and by comparing postoperative parameters between patients with and without endothelial cell damage.</p><p><strong>Methods: </strong>Corneal graft preparation in DMEK or triple DMEK cases was recorded on video. Graft staining and preparation were performed by the surgeon immediately before transplantation using trypan blue and a no-touch liquid bubble dissection technique. Endothelial cell damage unmasked by staining before preparation was classified using a target grid with 8.25- and 4-mm zones. The amount of cell damage was quantified based on pixels.</p><p><strong>Results: </strong>Endothelial cell damage was visible in 20 of 36 corneal grafts (55.6%). The mean percentage of cell damage in the complete endothelium was 2.53% (SD 1.67%). Nine cases (45%) showed cell damage inside the 8.25-mm zone and none inside the 4-mm zone. There was no significant correlation between the extent of endothelial cell damage and donor tissue preservation time or postoperative endothelial cell density (ECD). Patients with and without endothelial cell damage showed no significant differences in postoperative ECD or central pachymetry.</p><p><strong>Conclusions: </strong>Although over 50% of the grafts showed endothelial cell damage before preparation, the extent of cell damage was rather small. Although the 8.25-mm zone was affected in half of all cases, the presence and amount of cell damage did not seem to exert a negative influence on postoperative factors such as ECD and central pachymetry.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cataract Surgery in Patients With Scleritis in the United States: An IRIS Registry (Intelligent Research in Sight) Analysis.","authors":"Karen R Armbrust, Laura J Kopplin","doi":"10.1097/ICO.0000000000003949","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003949","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate outcomes of and risk factors for cataract surgery in patients with scleritis.</p><p><strong>Methods: </strong>This retrospective cohort study evaluated demographic and ocular features of a surgical cohort of IRIS Registry (Intelligent Research in Sight) patients with scleritis undergoing cataract surgery between 2013 and 2019. Multiple logistic regression was used to identify factors associated with poor postoperative best visual acuity (BVA) in the surgical cohort and to identify risk factors for undergoing cataract surgery by comparing the surgical cohort with a nonsurgical scleritis cohort.</p><p><strong>Results: </strong>A total of 6716 eyes of 5618 patients with a preexisting scleritis diagnosis underwent cataract surgery. Average BVA improved by approximately 3 Snellen lines: mean ± SD BVA was 0.39 ± 0.43 logMAR preoperatively versus 0.12 ± 0.27 logMAR postoperatively (P < 0.001). Postoperative complication rates were 5% for cystoid macular edema (CME), 2% for retinal detachment, and 2% for corneal edema. Preoperative CME [adjusted odds ratio (aOR) = 2.78, 95% confidence interval (CI) = 1.56-4.86] and poorer preoperative BVA (aOR = 9.10, 95% CI = 5.99-14.30) were associated with postoperative BVA >0.3 logMAR. After adjusting for age and bilaterality, female sex (aOR = 1.15, 95% CI = 1.08-1.22) and smoking (aOR = 1.63, 95% CI = 1.49-1.77) were risk factors for cataract surgery.</p><p><strong>Conclusions: </strong>Substantial visual improvement occurs after cataract surgery in eyes with scleritis, although close observation for CME, retinal detachment, and corneal edema is warranted. Female sex and smoking are risk factors for cataract surgery in the setting of scleritis.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Rotational Tenon Flaps for Corneal and Scleral Sterile Stromalysis After Pterygium Surgery: A Case Report.","authors":"Paula González-Palomo, Erick Navarro, Erik Navas-Villar, Dean Ouano, Ivonne Curiel-Arce, Arturo Chayet","doi":"10.1097/ICO.0000000000003958","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003958","url":null,"abstract":"<p><strong>Purpose: </strong>To report the management of progressive corneal and scleral stromalysis in a monocular patient after pterygium surgery with beta irradiation and highlight the effectiveness of posterior rotational Tenon flaps in restoring ocular integrity.</p><p><strong>Methods: </strong>Single-case report conducted in Mexico.</p><p><strong>Results: </strong>A 55-year-old man with a history of pterygium surgery and beta irradiation developed corneal and scleral stromalysis that was unresponsive to initial treatment, including oral steroids and intravenous rituximab. After confirming the avascular etiology, the patient underwent a corneal lamellar patch and posterior rotational Tenon flaps combined with conjunctival autografts. The follow-up evaluations included best-corrected visual acuity, intraocular pressure, and posterior segment optical coherence tomography.</p><p><strong>Conclusions: </strong>Posterior rotational Tenon flaps successfully managed sterile scleral and corneal stromalysis associated with prior beta irradiation by reestablishing the vascular supply and restoring functional vision. Early recognition of the avascular etiology and avoidance of inappropriate immunosuppression are crucial for preventing further ocular damage.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen-dependent Cancers in Female Patients With Fuchs Endothelial Corneal Dystrophy.","authors":"Sarah Pajek, Robert O'Brien, Ruiyang Huang, Anam Ahmed, Constance Chen, Karen Sem, Ellen H Koo","doi":"10.1097/ICO.0000000000003952","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003952","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of our study is to elucidate the odds of estrogen-dependent cancers in patients with Fuchs endothelial corneal dystrophy (FECD).</p><p><strong>Methods: </strong>This was a retrospective chart review. Charts from 400 patients over the age of 40 were reviewed. Using data from the records of Bascom Palmer Eye Institute, 297 patients with FECD who had a routine gynecological screening were identified. A 2:1 match control was performed. A total of 670 controls without FECD, who had undergone ophthalmic examination and had routine gynecological screening, were identified. Data were analyzed in SPSS using an unadjusted odds ratio and a multivariable logistic regression model adjusting for age, race, and ethnicity.</p><p><strong>Results: </strong>Among 297 patients with FECD (mean age 72 years), 35 (12%) were diagnosed with estrogen-dependent cancers, compared with 119 (18%) of 670 controls. Patients with FECD had significantly lower odds of estrogen-dependent cancer (OR 0.62, 95% CI, 0.41-0.93, P < 0.05). After adjusting for age, race, and ethnicity, the odds remained significantly lower (OR 0.55, 95% CI, 0.36-0.84). The mean age of cancer diagnosis was 64 ± 12 years in the FECD group and 64 ± 11 years in the control group. Subgroup analysis revealed significantly lower odds in White patients with FECD (OR 0.503, 95% CI, 0.319-0.792) and Non-Hispanic patients with FECD (OR 0.570, 95% CI, 0.357-0.912).</p><p><strong>Conclusions and relevance: </strong>Patients with FECD exhibited significantly lower odds of estrogen-dependent cancers, suggesting a potential protective association. Further research is needed to elucidate the underlying mechanisms.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}