IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.1097/ICO.0000000000003691

Rashmi Deshmukh, Harminder S Dua, Jodhbir S Mehta, Rasik B Vajpayee, Vishal Jhanji, Sayan Basu

引用次数: 0

Letter Regarding: Descemet Membrane Endothelial Keratoplasty as Treatment for Late-Onset Interface Fluid Syndrome After Laser In Situ Keratomileusis. 关于：角膜水肿是界面流体综合征病理生理学的关键因素。

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-08-01 DOI: 10.1097/ICO.0000000000003666

Alejandro Tello, Virgilio Galvis, Manuela Peralta-Olaya, Camila Estevez-Ramírez

引用次数: 0

Different Thicknesses of Acellular Porcine Corneal Stroma on Prognosis of Fungal Corneal Ulcers Treated by Lamellar Keratoplasty: A 5-Year Retrospective Study. 不同厚度的人工合成猪角膜基质对角膜板层移植术治疗真菌性角膜溃疡预后的影响：一项为期五年的回顾性研究。

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-07-05 DOI: 10.1097/ICO.0000000000003616

Yingxin Chen, Yifeng Chen, Cuiyu Wang, Ruiyao Gao, Kai Zhang

{"title":"Different Thicknesses of Acellular Porcine Corneal Stroma on Prognosis of Fungal Corneal Ulcers Treated by Lamellar Keratoplasty: A 5-Year Retrospective Study.","authors":"Yingxin Chen, Yifeng Chen, Cuiyu Wang, Ruiyao Gao, Kai Zhang","doi":"10.1097/ICO.0000000000003616","DOIUrl":"10.1097/ICO.0000000000003616","url":null,"abstract":"Purpose: To compare the prognosis and efficacy of acellular porcine corneal stroma (APCS) with different thicknesses for the treatment of fungal corneal ulcers by lamellar keratoplasty (LKP).Methods: A total of 52 patients who underwent LKP with APCS for the treatment of fungal corneal ulcers were included in this retrospective study. Patients were divided into 2 groups according to the different thicknesses of APCS (0.30 ± 0.05 mm, L2 group, n = 20; 0.40 ± 0.05 mm, L3 group, n = 32). Observation indicators included best corrected visual acuity, graft transparency, corneal neovascularization, ocular irritation symptoms, corneal epithelial healing time, graft survival, central corneal thickness at 1 year after surgery, and postoperative complications.Results: Compared with the L3 group, the L2 group had better postoperative best corrected visual acuity and graft transparency ( P < 0.001), less corneal neovascularization ( P < 0.001), and lower incidence of complications ( P < 0.05). There were significant differences in ocular irritation symptoms between the 2 groups ( P < 0.05) at 3 and 6 months postoperatively, which might be related to the higher recurrence rate and graft rejection rate in the L3 group. The comparison of postoperative epithelial healing time also showed significant differences in 2 groups ( P < 0.01). The 1-year survival rate was up to 63.5% in both groups, with no significant difference ( P < 0.05). However, the risk of transplantation was less in the L2 group. Both APCS thicknesses could provide adequate central corneal thickness at 1 year after surgery ( P > 0.05).Conclusions: APCS was safe and effective in the treatment of fungal corneal ulcers by LKP. Thinner grafts should be preferred for LKP for fungal corneal ulcers to reduce the risk of grafting.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"31-38"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suitability and Early Clinical Outcomes of Corneal Donor Tissue in the 76-80-Year-Old Age Group. 76 ~ 80岁人群角膜供体组织的适宜性及早期临床结果。

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-08-06 DOI: 10.1097/ICO.0000000000003644

Miles F Greenwald, Onkar B Sawant, Michael S Titus, Dena Ballouz, Christopher T Hood, Shahzad I Mian

{"title":"Suitability and Early Clinical Outcomes of Corneal Donor Tissue in the 76-80-Year-Old Age Group.","authors":"Miles F Greenwald, Onkar B Sawant, Michael S Titus, Dena Ballouz, Christopher T Hood, Shahzad I Mian","doi":"10.1097/ICO.0000000000003644","DOIUrl":"10.1097/ICO.0000000000003644","url":null,"abstract":"Purpose: There is a significant global shortage of corneal donor tissue suitable for keratoplasty. One simple strategy for addressing this shortage is to increase the upper age limit for acceptable tissue over the current customary upper limit of age 75. We describe a pilot study completed at one eye bank procuring, processing, and distributing keratoplasty tissue from donors aged 76 to 80 years.Methods: This is a retrospective case series of donor tissues aged 76 to 80 years in comparison with donor tissues aged 71 to 75 years. Standard tissue parameters were evaluated for all tissues, including tissue suitability, mean endothelial cell density (ECD), death-to-procurement time, and cause of death. For the older tissues, clinical outcomes through 3 months were obtained from each surgeon, including intraoperative and postoperative complications.Results: Corneal tissues from donors aged 76 to 80 years had a similar suitability rate (57%) when compared with donors aged 71 to 75 years (59%) ( P = 0.635). Both groups had comparable ECDs ( P = 0.097). Early clinical outcomes of corneal grafts from donors older than 76 years were favorable, with no early graft failure or significant concerns for clinical safety or efficacy.Conclusions: Our findings suggest that corneal tissues aged 76 to 80 years can be safely and efficiently transplanted in the United States. While additional study is needed, our results strengthen the case that expanding the upper age limit for donor age has the potential to help meet the global shortage for suitable keratoplasty tissue.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":"44 1","pages":"26-30"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply. 答复

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-09-20 DOI: 10.1097/ICO.0000000000003702

Marcela Huertas-Bello, Karen Sem, Kendall E Donaldson, Ellen H Koo

引用次数: 0

Decellularized Descemet Membrane Anterior Keratoplasty With Allogeneic Simple Limbal Epithelial Transplantation for Partial Limbal Stem Cell Deficiency Following Partial Keratolimbal Allograft Failure. 角膜移植失败后的部分角膜缘干细胞缺乏症的脱细胞化角膜前角膜移植术与同种异体单纯角膜缘上皮移植。

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-05-03 DOI: 10.1097/ICO.0000000000003565

Albert Y Cheung, Cameron B Reinisch, Joshua H Hou

{"title":"Decellularized Descemet Membrane Anterior Keratoplasty With Allogeneic Simple Limbal Epithelial Transplantation for Partial Limbal Stem Cell Deficiency Following Partial Keratolimbal Allograft Failure.","authors":"Albert Y Cheung, Cameron B Reinisch, Joshua H Hou","doi":"10.1097/ICO.0000000000003565","DOIUrl":"10.1097/ICO.0000000000003565","url":null,"abstract":"Purpose: The purpose of this study was to describe the use of Descemet membrane anterior keratoplasty (DMAK) with modified allogeneic simple limbal epithelial transplantation to treat a case of partial limbal stem cell deficiency (LSCD) following keratolimbal allograft failure.Methods: Case report.Results: A 21-year-old woman with autoimmune polyglandular syndrome-related LSCD presented with pain and decreased vision. There was partial failure and recurrence of LSCD after a severe/acute keratolimbal allograft rejection that led to persistent epithelial defects refractory to conservative therapy. This was treated with a superficial keratectomy and placement of a DMAK. A modified allogeneic simple limbal epithelial transplantation was performed with an overlying amniotic membrane and temporary tarsorrhaphy. There was epithelialization of the corneal surface by 3 to 4 weeks with an improved ocular surface. Despite partial recurrence of late staining, the cornea has remained epithelized, vision has improved, and the patient has remained pain-free more than 1.5 years following the procedure.Conclusions: DMAK may be a long-term substrate to help improve and maintain epithelization of the cornea up to 1.5 years. DMAK may be a viable alternative to using amniotic membrane as a scaffold in allogeneic simple limbal epithelial transplantation for treatment of partial LSCD. While late epithelial staining recurred in our patient, DMAK appears to prevent recurrent epithelial defects and reduce ocular surface pain, conveying an improvement in quality of life in patients at high risk of rejection/failure.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"108-112"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter Regarding: Descemet Stripping Only: Long-Term Outcomes. 致编辑的信 - 仅关于 Descemet 剥脱术。

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-09-18 DOI: 10.1097/ICO.0000000000003705

Maria Rizk, Mathieu Dubois, Sina Elahi, Wassim Ghazal, Roxane Flamant, Ilan Tordjmane, Romain Courtin, Christophe Panthier, Damien Gatinel, Alain Saad

引用次数: 0

Comprehensive Assessment of the Meibomian Glands by Meibography: Why the Upper Eyelids Matter. 通过 Meibography 全面评估睑板腺：为什么上眼睑很重要？

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-11-27 DOI: 10.1097/ICO.0000000000003729

Preeya K Gupta, Paul Karpecki

引用次数: 0

Multimodal Imaging in Mucolipidosis Type IV: Siblings With Novel Genetic Variant. 粘脂病 IV 型的多模态成像：伴有新型基因变异的兄弟姐妹

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-06-24 DOI: 10.1097/ICO.0000000000003612

Sonam Yangzes, Anjali Verma, Anupriya Kaur, Stanzin Spalkit, Nandita Kakkar, Amit Gupta

{"title":"Multimodal Imaging in Mucolipidosis Type IV: Siblings With Novel Genetic Variant.","authors":"Sonam Yangzes, Anjali Verma, Anupriya Kaur, Stanzin Spalkit, Nandita Kakkar, Amit Gupta","doi":"10.1097/ICO.0000000000003612","DOIUrl":"10.1097/ICO.0000000000003612","url":null,"abstract":"Purpose: Utilization of multimodal imaging techniques to diagnose cases of mucolipidosis type IV (ML-IV) and report a new genetic variant.Methods: This study is a case report.Results: Case 1 involves a 4-year-old boy with corneal haziness and global developmental delay who showed an increased reflectivity of the corneal epithelium on anterior segment optical coherence tomography (AS-OCT). In addition, neurologic evaluation was suggestive of ML-IV. Further genetics evaluation confirmed ML-IV. Histology of the button revealed a thickened epithelial basement membrane. Case 2, the younger sibling, showed a milder corneal haze with similar changes on AS-OCT prompting us to further evaluate for ML-IV by genetics (positive MCOLN1 gene mutation). Both instances highlighted varied ML-IV presentations, but a persistent feature was hyperreflective epithelium.Conclusions: Our study emphasizes AS-OCT's role in screening ML-IV and advocates the role of genetic counseling of affected parents. We present 2 South-Asian siblings with ML-IV with a new genetic variant, emphasizing the utility of detailed ophthalmic and neurologic assessments using multimodal imaging.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"104-107"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Tomographic Indicators Forecasting Decompensation in Fuchs Endothelial Corneal Dystrophy. 预测福克斯内皮性角膜营养不良症患者角膜脱落的断层扫描指标比较分析。

IF 1.9 3区医学

Cornea Pub Date : 2025-01-01 Epub Date: 2024-11-27 DOI: 10.1097/ICO.0000000000003521

Maria Laura Passaro, Matteo Airaldi, Chiara Ancona, Rosangela Cucco, Ciro Costagliola, Francesco Semeraro, Vito Romano

{"title":"Comparative Analysis of Tomographic Indicators Forecasting Decompensation in Fuchs Endothelial Corneal Dystrophy.","authors":"Maria Laura Passaro, Matteo Airaldi, Chiara Ancona, Rosangela Cucco, Ciro Costagliola, Francesco Semeraro, Vito Romano","doi":"10.1097/ICO.0000000000003521","DOIUrl":"10.1097/ICO.0000000000003521","url":null,"abstract":"Purpose: To compare the performance of 3 commercially available tomographers (the Pentacam Scheimpflug camera, the swept-source optical coherence tomography Casia, and the blue light slit-scanning tomographer Precisio) in the identification of patterns associated with Fuchs endothelial corneal dystrophy (FECD) decompensation.Methods: This was a clinic-based cross-sectional imaging study. Pachymetry maps and posterior surface elevation maps were acquired with the 3 devices from 61 eyes affected by FECD. The maps were graded according to the evidence of tomographic patterns predictive of FECD decompensation (loss of parallel isopachs, displacement of the thinnest point, and focal posterior depression) by 2 blind cornea specialists.Results: The loss of parallel isopachs was significantly less frequently evident in Pentacam pachymetry maps [8%, 95% confidence interval (CI) (3%, 18%)] compared with both the Casia [31%, 95% CI (20%, 44%), P = 0.01] and Precisio devices [24%, 95% CI (15%, 37%), P = 0.05]. The displacement of the thinnest point was graded as most evident in a significantly higher proportion of Precisio pachymetry maps [43%, 95% CI (31%, 55%)] compared with both the Pentacam [13%, 95% CI (6%, 24%), P = 0.001] and Casia devices [21%, 95% CI (12%, 33%), P = 0.03]. There were no significant differences in the identification of focal posterior depression on posterior elevation maps across the 3 devices.Conclusions: Identification of patterns predictive of FECD prognosis on pachymetry and posterior elevation maps is possible with different devices. However, their evidence varies across tomographers, and the results from different devices are not interchangeable.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"39-47"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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