IF 1.9 3区医学

Cornea Pub Date : 2025-04-01 Epub Date: 2024-08-27 DOI: 10.1097/ICO.0000000000003682

Thanachaporn Kittipibul, Rutuja Unhale, Clemence Bonnet, Chi-Hong Tseng, Sophie X Deng

{"title":"Comparison of Automated and Manual Measurement of Corneal Epithelial Thickness in Eyes With Limbal Stem Cell Deficiency.","authors":"Thanachaporn Kittipibul, Rutuja Unhale, Clemence Bonnet, Chi-Hong Tseng, Sophie X Deng","doi":"10.1097/ICO.0000000000003682","DOIUrl":"10.1097/ICO.0000000000003682","url":null,"abstract":"Purpose: The purpose of this study was to compare the outcomes of manual and automated corneal epithelial thickness (CET) assessments using anterior segment optical coherence tomography in eyes with limbal stem cell deficiency (LSCD).Methods: Eighty-seven eyes from 64 patients with LSCD and 65 eyes from 39 healthy subjects were included in this cross-sectional study. OCT images of corneas were acquired using a Fourier-domain anterior segment optical coherence tomography. The automated measurement of CET was obtained using the manufacturer's program and the manual measurements were obtained by 2 masked observers. The average CET was obtained from 3 consecutive epithelial profile maps. The average CET of manual measurement was obtained from 3 consecutive cross-line scans using 3-point measurement as previously described.Results: The central CET was thinner in patients with LSCD compared with healthy individuals by both manual and automated measurements. Automated CET measurements were similar to the manually obtained CET in the healthy controls (r = 0.911). However, there is a lower correlation between the automated and manually obtained CET in the LSCD group (r = 0.497). Manual measurements of CET (39.8 ± 11 μm) in eyes with LSCD were significantly lower than the automated measurements (48.8 ± 7.2 μm, P = 0.001, 95% CI -11.0 to -6.9). The correlations between the automated and manually obtained measurements in the mild, moderate, and severe stages of LSCD were 0.623, 0.632, and 0.378, respectively.Conclusions: There is a large discrepancy between the manual and automated measurements in eyes with LSCD but not in normal eyes. Automated measurements in LSCD exhibited a higher rate of errors and nonuniform measurements due to the presence of subepithelial scars. Automated CET measurements appear to be unreliable in eyes with corneal scars in LSCD.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"422-426"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142085933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Corneal Phenotypes in Japanese Patients With Myotonic Dystrophy Type 1. 日本 1 型肌营养不良症患者的角膜表型分析

IF 1.9 3区医学

Cornea Pub Date : 2025-04-01 Epub Date: 2024-08-21 DOI: 10.1097/ICO.0000000000003679

Kenya Kubo, Yoshinori Oie, Ryota Koto, Nozomi Nishida, Chifune Kai, Sayo Maeno, Tomoya Kubota, Masayuki Nakamori, Masanori P Takahashi, Motokazu Tsujikawa, Kohji Nishida

{"title":"Analysis of Corneal Phenotypes in Japanese Patients With Myotonic Dystrophy Type 1.","authors":"Kenya Kubo, Yoshinori Oie, Ryota Koto, Nozomi Nishida, Chifune Kai, Sayo Maeno, Tomoya Kubota, Masayuki Nakamori, Masanori P Takahashi, Motokazu Tsujikawa, Kohji Nishida","doi":"10.1097/ICO.0000000000003679","DOIUrl":"10.1097/ICO.0000000000003679","url":null,"abstract":"Purpose: To analyze the corneal phenotypes of Japanese patients with myotonic dystrophy type 1 (DM1).Methods: We included patients with DM1 who were diagnosed with clinical neuromuscular symptoms by neurologists and CTG trinucleotide repeat (TNR) expansion of the (myotonic dystrophy protein kinase) DMPK gene. We analyzed the corneal phenotype using slit-lamp examination, specular microscopy, and anterior segment optical coherence tomography. We evaluated TNR expansion in the TCF4 gene of leukocyte-derived genomic DNA by fragment analysis using polymerase chain reaction and triplet-repeat primed polymerase chain reaction.Results: Nineteen eyes from 10 patients with DM1 (DM1 group) and 72 eyes from 37 healthy participants (control group) were analyzed. The average age was 49.3 ± 11.9 and 51.8 ± 12.9 years in the DM1 and control groups, respectively ( P = 0.11). Slit-lamp examination demonstrated that 2 patients with DM1 had bilateral corneal guttae equivalent to modified Krachmer grade 1 of Fuchs endothelial corneal dystrophy. Dark areas on specular microscopy were observed in 4 of 19 eyes (21.1%) and 0 of 72 eyes (0%) in the DM1 and control groups, respectively, with statistically significant differences ( P = 0.002). The average endothelial cell density in the DM1 group (3536 ± 722 cells/mm 2 ) was significantly higher than that in the control group (3026 ± 412 cells/mm 2 ) ( P = 0.0006). TNR expansion in TCF4 was not detected in eyes with corneal guttae or in the dark areas in the DM1 group.Conclusions: Japanese patients with DM1 without TNR expansion in TCF4 have a mild phenotype equivalent to Fuchs endothelial corneal dystrophy. Endothelial cell density is higher in DM1 patients than in normal participants.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"412-417"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyanoacrylate Glue Patch for Corneal Melting in Keratoprosthesis. 氰基丙烯酸酯胶贴用于角膜修复术中角膜融化。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-01 DOI: 10.1097/ICO.0000000000003875

Gustavo Ortiz-Morales, Guillermo Raul Vera-Duarte, Thelma Cortés-Moreno, Mariana Navarrete-Azuara, Panotsom Ngowyutagon, Alejandro Navas, Arturo Ramirez-Miranda, M Soledad Cortina, Enrique O Graue-Hernandez

{"title":"Cyanoacrylate Glue Patch for Corneal Melting in Keratoprosthesis.","authors":"Gustavo Ortiz-Morales, Guillermo Raul Vera-Duarte, Thelma Cortés-Moreno, Mariana Navarrete-Azuara, Panotsom Ngowyutagon, Alejandro Navas, Arturo Ramirez-Miranda, M Soledad Cortina, Enrique O Graue-Hernandez","doi":"10.1097/ICO.0000000000003875","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003875","url":null,"abstract":"Purpose: To report clinical outcomes of cyanoacrylate glue patches in managing corneal melting in keratoprosthesis (KPro).Methods: Multicenter, retrospective, noncontrolled, interventional case series. Subjects underwent cyanoacrylate glue patches for corneal melt after KPro implantation, regardless of the underlying cause, KPro design, or melt severity. Clinical success was defined as resolving aqueous leak, halting further corneal melting, and avoiding KPro or carrier corneal graft exchange for at least 12 months after cyanoacrylate glue patch application.Results: Sixteen eyes of 15 patients with KPro underwent a cyanoacrylate glue patch for corneal melting. The mean time from KPro implantation to the development of corneal melt was 49.2 months. Implanted KPro models included Lucia (37.5%) and Boston type 1 with titanium (31.2%) or polymethylacrylate backplate (31.2%). Underlying etiologies for KPro implantation included recurrent graft rejection (56.2%), autoimmune disease (31.2%), and chemical injury (12.5%). A combined procedure with a cyanoacrylate glue patch and amniotic membrane transplantation was performed in 2 cases. The criteria for clinical success were met in 87.5% of patients, with only 2 eyes (12.5%) exhibiting clinical failure. Glue patches were retained successfully for a mean time of 25.50 ± 23.87 months (range: 0-84 months).Conclusions: Cyanoacrylate glue patches provide a simple, safe, cost-effective, and effective treatment for corneal melts in patients with KPro.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of the Direct Anterior Chamber Air Replacement Method During Descemet Stripping Automated Endothelial Keratoplasty. 直接前房空气置换法在角膜内皮剥离自动角膜移植术中的疗效。

IF 1.9 3区医学

Cornea Pub Date : 2025-04-01 Epub Date: 2025-01-17 DOI: 10.1097/ICO.0000000000003784

Sho Ishikawa, Takafumi Maruyama, Kei Shinoda

{"title":"Efficacy of the Direct Anterior Chamber Air Replacement Method During Descemet Stripping Automated Endothelial Keratoplasty.","authors":"Sho Ishikawa, Takafumi Maruyama, Kei Shinoda","doi":"10.1097/ICO.0000000000003784","DOIUrl":"10.1097/ICO.0000000000003784","url":null,"abstract":"Purpose: This study aimed to describe a novel technique of direct anterior chamber (AC) air replacement (DACAR) for the management of Descemet stripping automated endothelial keratoplasty (DSAEK) in postvitrectomized eyes and eyes with previous glaucoma surgery.Methods: DACAR was performed after a corneal donor graft was transplanted through a wound using the pull-through technique. DACAR involves stabilizing the graft with forceps while introducing air into the AC via an infusion cannula to ensure complete air exchange. The air was maintained in the AC at all times using a vitrectomy machine. The air pressure was maintained at 30 mm Hg for 15 minutes.Results: The DACAR technique was performed in 34 patients, and conventional pull-through technique DSAEK was performed in 32 high-risk patients. The DACAR group had shorter DSAEK surgical procedures ( P = 0.009) and a lower incidence of corneal graft detachment in the early postoperative period ( P < 0.001) than the conventional DSAEK group.Conclusions: DACAR is performed in patients having previously undergone vitrectomy or glaucoma surgery to prevent corneal graft detachment during the early postoperative period and to reduce the length of surgery.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"517-521"},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central Cornea Changes on Anterior Segment OCT and In Vivo Confocal Microscopy After Autologous Limbal Epithelial Cell Transplantation. 自体角膜缘上皮细胞移植后中央角膜前段OCT和体内共聚焦显微镜的变化。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-28 DOI: 10.1097/ICO.0000000000003865

Leyla Yavuz Saricay, Aaron R Kaufman, Lynette K Johns, Jia Yin, Lassana Samarakoon, Allison R Ayala, Maureen Maguire, Mohit Parekh, Diego E Hernandez Rodriguez, Heather Daley, Reza Dana, Myriam Armant, Jerome Ritz, Ula V Jurkunas

{"title":"Central Cornea Changes on Anterior Segment OCT and In Vivo Confocal Microscopy After Autologous Limbal Epithelial Cell Transplantation.","authors":"Leyla Yavuz Saricay, Aaron R Kaufman, Lynette K Johns, Jia Yin, Lassana Samarakoon, Allison R Ayala, Maureen Maguire, Mohit Parekh, Diego E Hernandez Rodriguez, Heather Daley, Reza Dana, Myriam Armant, Jerome Ritz, Ula V Jurkunas","doi":"10.1097/ICO.0000000000003865","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003865","url":null,"abstract":"Purpose: To describe 1-year changes in the cornea as assessed by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) for participants receiving a tissue graft generated from a new manufacturing process using cultivated autologous limbal epithelial cells.Methods: Cultivated autologous limbal epithelial cell grafts were produced in a 2-stage manufacturing process following a good manufacturing process-compliant protocol. AS-OCT and IVCM were completed at baseline and 12 months after the treatment in subsets of these participants. Secondary efficacy outcomes were determined based on improvement of central corneal epithelial morphology and thickness [corneal epithelial thickness (CET)] and presence of conjunctival or corneal cells in central cornea.Results: Among 14 participants, 13 (93%) were male, 12 (86%) were white, the mean age was 46 ± 16 years. At baseline, CET was 53 (range: 34, 64) microns, and epithelial basal cell density was 3964 (range: 822-5788) cells/mm2; the ratio of the cells at central cornea was 20% corneal and 90% conjunctival epithelial cells. At 12 months, the mean changes were 3 μm in CET (P = 0.67), and 1967 cells/mm2 in epithelial basal cell density (P = 0.02); the proportion of the central cells improved to 75% corneal and 38% conjunctival epithelial cells.Conclusions: The AS-OCT and IVCM findings are consistent with the clinical improvement, indicating the reconstitution of the corneal phenotype and clearing of the optical axis. Nevertheless, IVCM is notably more effective for in-depth analysis of the epithelial phenotype and thickness than AS-OCT.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anterior Segment Swept-Source Optical Coherence Tomography in Ocular Surface Tumors and Simulating Lesions and Correlation With Histopathologic Diagnosis. 前段扫描源光学相干断层扫描在眼表肿瘤和模拟病变中的应用及其与组织病理学诊断的相关性。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-28 DOI: 10.1097/ICO.0000000000003856

Ahmet Kaan Gündüz, Ibadulla Mirzayev, Cevriye Cansiz Ersöz, Aylin Okçu Heper, Ömür Gündüz, Funda Seher Özalp Ateş

{"title":"Anterior Segment Swept-Source Optical Coherence Tomography in Ocular Surface Tumors and Simulating Lesions and Correlation With Histopathologic Diagnosis.","authors":"Ahmet Kaan Gündüz, Ibadulla Mirzayev, Cevriye Cansiz Ersöz, Aylin Okçu Heper, Ömür Gündüz, Funda Seher Özalp Ateş","doi":"10.1097/ICO.0000000000003856","DOIUrl":"10.1097/ICO.0000000000003856","url":null,"abstract":"Purpose: To investigate anterior segment swept-source optical coherence tomography (AS SS-OCT) findings in ocular surface tumors and simulating conditions.Methods: AS SS-OCT imaging and histopathologic data pertaining to 92 eyes of 86 cases collected between September 2018 and April 2023 were evaluated.Results: The 3 most common lesions were conjunctival nevus (18 eyes), ocular surface squamous neoplasia (OSSN, 16 eyes), and pterygium/pinguecula (13 eyes). Excisional/incisional biopsy was performed in 58 of 86 (67.4%) cases. On AS SS-OCT, conjunctival nevi demonstrated mildly hyperreflective epithelium of normal thickness, internal hyperreflectivity, and intralesional cysts. OSSN showed epithelial hyperreflectivity, epithelial thickening, and an abrupt transition between normal and abnormal epithelium. Differences between median maximal epithelial thickness on AS SS-OCT for OSSN and pterygium (560 vs. 102 μm), OSSN and pseudopterygium (560 vs. 113 μm), OSSN and pinguecula (560 vs. 72.5 μm), and OSSN and conjunctival papilloma (560 vs. 965.5 μm) were statistically significant ( P < 0.001, P < 0.001, P < 0.001, and P = 0.039, respectively). By receiver-operating characteristic curve, using 630.5 μm as a cutoff, the sensitivity and specificity of AS SS-OCT for differentiating between conjunctival papilloma and OSSN were 69% and 100%, respectively ( P = 0.038). The presence of hyporeflective spaces/cysts was statistically significant in conjunctival papilloma compared to OSSN ( P < 0.001) and in conjunctival nevus compared to conjunctival melanoma ( P = 0.002).Conclusions: AS SS-OCT is a useful tool in differentiating OSSN from pterygium/papilloma and conjunctival nevus from melanoma. It provides important in vitro information on many other lesions including conjunctival lymphoma, primary acquired melanosis, and conjunctival amyloidosis.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"806-818"},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of Corneal Ulcers Diagnosed in the Emergency Department in California. 加州急诊科诊断角膜溃疡的流行病学

IF 1.9 3区医学

Cornea Pub Date : 2025-03-28 DOI: 10.1097/ICO.0000000000003863

Albert Xu, John M Nesemann, Jeremy D Keenan

{"title":"Epidemiology of Corneal Ulcers Diagnosed in the Emergency Department in California.","authors":"Albert Xu, John M Nesemann, Jeremy D Keenan","doi":"10.1097/ICO.0000000000003863","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003863","url":null,"abstract":"Purpose: To determine the incidence, seasonality, geographic distribution, and risk factors for emergency department presentations with corneal ulcers and perforated corneal ulcers.Methods: Retrospective, population-based cohort study of corneal ulcers in California from 2012 to 2021. Overall and stratified yearly incidence rates, seasonality, individual-level and postal code-level risk factors for perforation, and geographic clustering were evaluated.Results: This study included 31,019 emergency department (ED) visits for corneal ulcers, with 263 cases coded as perforated corneal ulcers. The average yearly incidence was 7.94 (95% confidence interval, 7.85-8.03) per 100,000 people for ED-diagnosed corneal ulcers and 0.67 (95% confidence interval, 0.59-0.76) per 1,000,000 people for perforated corneal ulcers. Male patients, Black patients, and primary English-speaking patients had the highest incidences across sociodemographic groups. For ED-diagnosed corneal ulcers, the incidence was highest among individuals aged 20 to 60 and for perforated corneal ulcers the incidence was highest among individuals over age 75. Significant geographic clustering was observed, with hotspots in the Central Valley and inland Northern and Southern California. Visits were seasonal, with incidence peaking in July and lowest in February. Increasing age, Spanish as a preferred language, and having health insurance were significant risk factors for presenting with a perforated corneal ulcer. Indicators of low socioeconomic status were associated with higher rates of corneal ulcers.Conclusions: The incidence of ED-diagnosed corneal ulcers in California increased over the study period with a notable seasonal pattern. Higher rates were observed in Black individuals and in areas with lower socioeconomic status, providing evidence of health disparities and identifying potential targets for public health interventions.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Efficacy and Mechanisms of Mesenchymal Stem Cells and Their Exosomes in the Treatment of Ocular Graft-Versus-Host Disease. 间充质干细胞及其外泌体治疗眼部移植物抗宿主病的疗效及机制

IF 1.9 3区医学

Cornea Pub Date : 2025-03-27 DOI: 10.1097/ICO.0000000000003868

Chenxi Ye, Shuwan Liu, Jing Hong

{"title":"Therapeutic Efficacy and Mechanisms of Mesenchymal Stem Cells and Their Exosomes in the Treatment of Ocular Graft-Versus-Host Disease.","authors":"Chenxi Ye, Shuwan Liu, Jing Hong","doi":"10.1097/ICO.0000000000003868","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003868","url":null,"abstract":"Purpose: To provide a comprehensive overview of the clinical manifestations, pathophysiology, and current treatments of ocular graft-versus-host disease (oGVHD), and to explore the therapeutic potential of mesenchymal stem cells (MSCs) and their exosomes (MSC-Exos) as novel treatments.Methods: A literature review was conducted using major databases (PubMed, Web of Science, Scopus) to identify studies published between 2000 and 2024. The focus was on clinical trials, case series, and experimental studies related to oGVHD. Data were synthesized to summarize current knowledge.Results: oGVHD affects 40% to 60% of Hematopoietic Stem Cell Transplantation recipients, causing symptoms such as dryness, irritation, and vision impairment. Current treatments often fail to provide long-term relief and may cause significant side effects. MSCs and MSC-Exos offer a promising alternative because of their immunosuppressive and regenerative properties. Preclinical and clinical studies have demonstrated their safety and efficacy in improving oGVHD symptoms and promoting corneal health.Conclusions: MSCs and MSC-Exos show promise in treating oGVHD, with potential to improve symptoms and promote tissue repair. Further research is needed to establish their long-term safety and efficacy.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Recovery After Descemet Membrane Endothelial Keratoplasty in Eyes With Preexisting Multifocal Intraocular Lens. 已有多焦人工晶状体的眼视网膜内皮角膜移植术后视力恢复。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-26 DOI: 10.1097/ICO.0000000000003864

Pratima Vishwakarma, Björn Bachmann, Mert Mestanoglu, Silvia Schrittenlocher, Johanna Wiedemann, Simona L Schlereth, Claus Cursiefen

{"title":"Visual Recovery After Descemet Membrane Endothelial Keratoplasty in Eyes With Preexisting Multifocal Intraocular Lens.","authors":"Pratima Vishwakarma, Björn Bachmann, Mert Mestanoglu, Silvia Schrittenlocher, Johanna Wiedemann, Simona L Schlereth, Claus Cursiefen","doi":"10.1097/ICO.0000000000003864","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003864","url":null,"abstract":"Purpose: To assess visual acuity outcomes in pseudophakic eyes with a multifocal (MF)-IOL (intraocular lens) and endothelial failure receiving Descemet membrane endothelial keratoplasty (DMEK).Method: This is a retrospective case-series analyzing patients from the prospective Cologne DMEK database where visual acuity outcome in 14 eyes of 9 patients requiring DMEK after MF-IOL implantation was compared with 14 eyes of 14 age-matched controls for DMEK after monofocal IOL implantation. All patients suffered from Fuchs endothelial corneal dystrophy.Results: The average age at presentation was 69 ± 8.9 and 68 ± 7.6 years for cases and control group, respectively. Average pretransplant best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution was 0.45 ± 0.32 and 0.39 ± 0.19 among cases and control groups, respectively. After exclusion of 4 eyes with other visual acuity limitations and their age-matched control eyes, final average BCVA at follow-up among cases was 0.1 ± 0.07 at 3 months and 0.15 ± 0.10 at 6 months, whereas it was 0.14 ± 0.10 at 3 months (P = 0.435) and 0.05 ± 0.05 at 6 months (P = 0.054) of follow-up among the control group. When including eyes with IOL calcification, BCVA at 1 and 2 years in cases was significantly worse compared with controls. IOL calcification was more common in eyes with preexisting MF-IOL (3/14).Conclusions: Good visual outcomes can be achieved in eyes where DMEK is done after MF-IOL implantation. Visual acuity recovery may be slower and slightly lesser compared with eyes with preexisting monofocal IOL in situ. The risk of IOL calcification seems higher in MF-IOLs.","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter Regarding: Strategies and Application of Compression Sutures With a Modified Technique for Rapid Resolution of Large (Grade III) Hydrops: A Prospective Interventional Study. 关于：穿透性角膜移植术后急性角膜积液作为加压缝合的附加指征。

IF 1.9 3区医学

Cornea Pub Date : 2025-03-25 DOI: 10.1097/ICO.0000000000003871

Radhika Natarajan, Ankita Kumari

引用次数: 0

Cornea最新文献