Cornea最新文献

{"title":"Efficacy of the Rho-Kinase Inhibitor for Corneal Endothelial Protection in Fuchs Endothelial Corneal Dystrophy After Phacoemulsification.","authors":"Benjama Keeratidamkerngsakul, Vilavun Puangsricharern, Susama Chokesuwattanaskul, Krit Pongpirul, Thanachaporn Kittipibul","doi":"10.1097/ICO.0000000000003827","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003827","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of Rho-kinase (ROCK) inhibitors in corneal endothelial protection in Fuchs endothelial corneal dystrophy (FECD) after phacoemulsification.</p><p><strong>Methods: </strong>Forty-eight eyes from 31 patients with FECD and cataracts were randomly assigned to receive either the topical ROCK inhibitor (or ripasudil) or placebo 4 times a day, in addition to the standard antibiotic and antiinflammatory eye drops, for 1 month after phacoemulsification. Endothelial cell density (ECD), central corneal thickness (CCT), and corneal densitometry were measured. The primary outcome was the central ECD (C-ECD) loss percentage 3 months after phacoemulsification. Secondary outcomes included C-ECD loss and paracentral ECD loss percentages and the CCT change ratio at different time points after phacoemulsification. Adverse events were evaluated.</p><p><strong>Results: </strong>There was significantly less cell loss among those eyes treated with ripasudil. C-ECD significantly increased from a baseline of 2361 cells/mm2 (95% confidence interval, 2151-2571) to 2506 cells/mm2 (95% confidence interval, 2296-2716) 3 months after phacoemulsification. The paracentral ECD loss was 0.4% in the ripasudil group versus 7.3% in the control group. Corneal densitometry remained relatively unchanged in the ripasudil group but increased significantly over time in the control group. The mean CCT increased slightly in both groups from baseline to the final follow-up at 3 months, albeit without significant differences between the groups. In the ripasudil group, transient conjunctival erythema was the most common adverse event.</p><p><strong>Conclusions: </strong>The topical ROCK inhibitor, or ripasudil, demonstrated beneficial effects on preventing endothelial cell loss and improving endothelial function in patients with FECD undergoing phacoemulsification. Corneal densitometry showed reduced corneal light scattering in the ripasudil group after phacoemulsification, suggesting improved corneal endothelial function.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of a Tenon Patch Graft for Corneal Perforations in Resolving Infective Keratitis.","authors":"Aniruddh Heroor, Prajakta Dandekar, Somasheila I Murthy","doi":"10.1097/ICO.0000000000003834","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003834","url":null,"abstract":"<p><strong>Purpose: </strong>To report the outcomes of a Tenon patch graft (TPG) in sealing corneal perforations in cases with resolving infective keratitis.</p><p><strong>Methods: </strong>This retrospective interventional study was conducted at a tertiary eye care center. All patients who underwent a TPG for corneal perforations because of clinically or/and microbiologically diagnosed infective keratitis between 2021 and 2023 were included. The surgical technique was consistent with that used in noninfective etiology. Out of 100 cases undergoing a TPG during the same period, 15 eyes of 14 patients had corneal perforations secondary to infective keratitis.</p><p><strong>Results: </strong>The etiological profile included bacterial keratitis in 8, viral and fungal keratitis in 3, and Pythium keratitis in 1 eye of 15 eyes. One patient had bilateral infective keratitis after refractive surgery. The perforations were central in 7 and paracentral in 8 eyes. Successful restoration of tectonic integrity at 1 month was achieved in 14/15 eyes (93%). One patient had a repeat perforation at 3 weeks postoperatively, which was managed with a cyanoacrylate glue application. Infection control was achieved in all cases with adjunctive topical antimicrobial therapy.</p><p><strong>Conclusions: </strong>A TPG is a viable option for restoring globe integrity in corneal perforations encountered in resolving infective keratitis.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deformable Biomechanics of DMEK Tissue Scrolls Traveling Through Narrow Lumens II: Double Scrolls Do Not Behave Like Single Scrolls.","authors":"Matthew Kigin, Evan Balk, Benjamin Revis, Sarah Vigmostad, Christopher Sales","doi":"10.1097/ICO.0000000000003830","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003830","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate and compare the dimensional characteristics of Descemet membrane endothelial keratoplasty (DMEK) scrolls in single-scroll and double-scroll conformations at various ages and velocities.</p><p><strong>Methods: </strong>DMEK tissues from three donor pairs (ages 47, 62, and 69) were used to compare single-scroll and double-scroll widths under different velocities. Tissues were randomized and manipulated into single-scroll or double-scroll conformation using a syringe pump connected to an hourglass-shaped glass tube. All scrolls were passed through the tube at three different velocities set by syringe pump settings, and high-speed videography at 2000 frames per second captured scroll dimensions. Scroll dimensions were measured using IDT Motion Studio software.</p><p><strong>Results: </strong>Single-scrolled DMEK tissue was narrower than double-scrolled tissue across all donor ages. Double-scrolled tissue width remained relatively unchanged regardless of age or velocity. Significant differences in scroll width between single and double scrolls were observed in the 47-year-old donor tissue at all velocities (P <0.001). Significant scroll width differences between single and double scrolls were observed in the 62-year-old donor tissue at medium and high velocities (P = 0.03 and P = 0.01, respectively). In the 69-year-old donor tissue, significant differences in scroll width between single and double scrolls were observed only at high velocities (P = 0.003). Single-scroll width decreased with increasing velocity for 47-year-old and 62-year-old donor tissues (P <0.001, P = 0.03), but not for the 69-year-old donor tissue (P = 1.0).</p><p><strong>Conclusions: </strong>There is a significant difference in scroll width between single-scrolled and double-scrolled tissues at high speeds. These differences become less significant as scrolls increase in age and velocity decreases.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Study of Biomechanics and Associated Factors of Lenticule Intrastromal Keratoplasty for the Correction of Hyperopia.","authors":"Xiaosong Han, Meiyan Li, Fei Xia, Ling Sun, Yang Shen, Haipeng Xu, Feng Lin, Xingtao Zhou","doi":"10.1097/ICO.0000000000003816","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003816","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate long-term corneal biomechanical changes and influencing factors of lenticule intrastromal keratoplasty (LIKE) in the treatment of hyperopia.</p><p><strong>Methods: </strong>9 eyes of 9 patients with a mean age of 34.00 ± 9.34 years were included. Full-scale examinations were conducted on all patients preoperatively and during 2 years of follow-ups. Topographical and biomechanical parameters were evaluated with Pentacam and Corvis ST preoperatively and during all follow-up visits.</p><p><strong>Results: </strong>All surgeries were uneventful without complications. The safety index was 1.27 ± 0.64 and the efficacy index was 0.96 ± 0.62 at the last follow-up. The central corneal thickness (CCT) (P < 0.05*) and the thinnest corneal thickness (TCT) (P < 0.05*) significantly increased 2 years postoperatively while the Ambrosio relational thickness horizontal (ARTh) (P < 0.05*) and the Corvis biomechanical index (CBI) (P < 0.05*) decreased. The deformation amplitude ratio (DA ratio), the stiffness parameter at the first applanation (SP-A1), the stress-strain index, and the posterior elevation (PE) remained stable 2 years after LIKE. The DA ratio was negatively correlated with the CCT and the TCT (r = -0.54, P = 0.019*; r = -0.59, P = 0.009*) while the SP-A1 was positively correlated with the CCT and the TCT (r = 0.84, P < 0.001*; r = 0.87, P < 0.001*). The ARTh was positively correlated with the TCT (r = 0.47, P = 0.049*), and the CBI was positively correlated with the PE (r = 0.63, P = 0.005*).</p><p><strong>Conclusions: </strong>LIKE for the correction of hyperopia is safe and effective in the long term. The PE remained stable and the CBI improved 2 years postoperatively.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of a 360-Degree Intracorneal Ring Implantation for Keratoconus: A 10-Year Follow-Up.","authors":"Masoud Khorrami-Nejad, Khosrow Jadidi, Zeinab Fadhil Hasan, Hossein Aghamolaei, Qaysser Sattar Abed, Ali Majdi","doi":"10.1097/ICO.0000000000003832","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003832","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term visual, refractive, and tomographic outcomes of a 360-degree intracorneal ring implant for treating keratoconus (KC).</p><p><strong>Methods: </strong>This historical cohort study included 29 eyes of 29 patients with KC who underwent MyoRing implantation. Uncorrected and best-corrected distance visual acuity, refraction, keratometry, and corneal thickness were evaluated preoperatively and at 5 and 10 years postoperatively.</p><p><strong>Results: </strong>Significant improvements were observed in all outcome measures at 5 and 10 years postoperatively compared with the preoperative values (P < 0.001). Uncorrected distance visual acuity improved from 1.25 ± 0.34 logarithm of the minimum angle of resolution (logMAR) preoperatively to 0.36 ± 0.24 logMAR at 5 years but showed regression to 0.48 ± 0.35 logMAR at 10 years. Corrected distance visual acuity similarly showed improvement from 0.50 ± 0.24 logMAR preoperatively to 0.18 ± 0.12 logMAR at 5 years, with some regression to 0.25 ± 0.22 logMAR at 10 years. Spherical equivalent improved from -9.38 ± 4.09 diopters (D) preoperatively to -2.70 ± 1.54 D at 5 years but regressed to -3.29 ± 2.22 D at 10 years. Although corneal flattening was observed at 5 years, a slight steepening trend was noted at 10 years. Corneal thickness exhibited an increase after 5 years (P < 0.001), but this trend reversed by the 10-year mark.</p><p><strong>Conclusions: </strong>MyoRing implantation demonstrated significant initial improvements in visual, refractive, and tomographic outcomes in patients with KC; however, some regression toward preoperative values was observed by the 10-year follow-up. This highlights the importance of continued monitoring to assess the long-term impact of the implant and to manage any potential late effects.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary CD4+ T-Cell Lymphoproliferative Disorder of Conjunctiva.","authors":"Curtis E Margo, Kendra D DeAngelis","doi":"10.1097/ICO.0000000000003824","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003824","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to describe a patient with a primary CD4+ T-cell lymphoproliferative disorder of conjunctiva.</p><p><strong>Methods: </strong>Case report and review of the literature.</p><p><strong>Results: </strong>An 81-year-old man was referred for asymptomatic bilateral conjunctival masses that on biopsy revealed a proliferation of mature CD4+ lymphocytes associated with T-cell receptor γ gene rearrangement. The histopathology and immunophenotypic profile in the absence of disease elsewhere bore resemblance to primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder.</p><p><strong>Conclusions: </strong>In 2016, the World Health Organization reclassified primary cutaneous CD4+ small/medium T-cell lymphoma to a lymphoproliferative disorder because neither dissemination nor death had been documented. This case displays similarities with the latter but has nonconforming features. Multicentric clonal expansion of T cells do not inevitably indicate lymphoma. Lymphoproliferative disorders that display features of reactive hyperplasia and lymphoma and are not easily classified need to be carefully monitored.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Survey on Corneal Transplantation in Japan.","authors":"Jun Shimazaki, Takeshi Soma, Keiko Yamada, Akira Kobayashi, Tomohiko Usui, Tsutomu Inatomi","doi":"10.1097/ICO.0000000000003807","DOIUrl":"10.1097/ICO.0000000000003807","url":null,"abstract":"<p><strong>Purpose: </strong>To report the results of a national survey on corneal transplantation in Japan.</p><p><strong>Methods: </strong>The Japan Cornea Society and the Keratoplasty Society of Japan conducted a national survey on corneal transplantation performed from 2017 to 2019. Data from various institutions were collected through an online database and subsequently analyzed.</p><p><strong>Results: </strong>In total, 4951 cases from 44 facilities were documented. The leading cause of corneal transplantation was corneal edema (CE), which accounted for 39.3% of cases, followed by repeat keratoplasty at 27.7%. Among CE cases, postcataract surgery was the most prevalent (25.1%), followed by postglaucoma surgery (20.8%) and laser iridotomy-induced CE (18.2%). Fuchs endothelial corneal dystrophy was the fourth most common cause (10.9%). Regarding surgical methods, Descemet stripping automated endothelial keratoplasty was the most common, used in 41.3% of procedures, followed by penetrating keratoplasty at 37.1%. Deep anterior lamellar keratoplasty and Descemet membrane endothelial keratoplasty were used in 8.1% and 2.6% of cases, respectively. One year after transplantation, graft clarity was maintained in 80.5% of cases, and regrafting was necessary in 15.2% of instances.</p><p><strong>Conclusions: </strong>The national survey reveals that CE is the most frequent indication for corneal transplantation in Japan. Increases in cases from glaucoma surgery and Fuchs endothelial corneal dystrophy were noted among patients with CE. Endothelial keratoplasty, especially Descemet stripping automated endothelial keratoplasty, is now the preferred surgical technique for these transplants.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Utility of CRISPR-Based RID-MyC Assay in Smear and Culture-Negative Fungal Keratitis: A Case Series.","authors":"Hanith Raj Deivarajan, Dharani Chelliah, Prabhakara Sethupathy Ramkumar, Dharsini Nandhakumar, Bennet Mathew Chacko, Anita Raghavan, Jaishree Pandian, Lalitha Prajna, Venkatesh N Prajna, Siddharth Narendran","doi":"10.1097/ICO.0000000000003808","DOIUrl":"https://doi.org/10.1097/ICO.0000000000003808","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the clinical utility of the clustered regularly interspaced short palindromic repeats/Cas12a-based RID-MyC assay in diagnosing Fungal Keratitis (FK) in cases where conventional smear and culture methods fail to identify the causative pathogen.</p><p><strong>Methods: </strong>This retrospective case series included 5 patients with clinically suspected FK and negative smear and culture results who were evaluated in the Cornea Department at Aravind Eye Hospital, Coimbatore, India, between January 1, 2024, and March 31, 2024. The primary outcome was the diagnostic performance of the RID-MyC assay in detecting fungal nucleic acids in cases of suspected FK with negative smear and culture results. In vivo confocal microscopy served as a reference standard to validate the RID-MyC assay findings.</p><p><strong>Results: </strong>The RID-MyC assay successfully detected fungal nucleic acids in 3 cases, corroborated by in vivo confocal microscopy findings suggestive of fungal filaments, leading to targeted antifungal therapy and resolution of the infections. In addition, 2 cases tested negative for fungal nucleic acids, aligning with clinical and confocal evidence of nonfungal etiology, thus guiding appropriate alternative treatments that led to clinical improvement.</p><p><strong>Conclusions: </strong>The RID-MyC assay demonstrates clinical utility in diagnosing FK in scenarios where conventional smear and culture methods prove inadequate, such as in cases with prior antifungal therapy or polymicrobial infections. This assay facilitates accurate diagnosis and timely initiation of appropriate antifungal treatment without the need for sophisticated equipment or expertise, making it particularly valuable in resource-limited settings.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intereye Agreement in Dry-Eye Signs in the DREAM Study: Implications for Future Dry-Eye Trials.","authors":"Anny Zhong, Patrick Augello, Penny Asbell, Gui-Shuang Ying","doi":"10.1097/ICO.0000000000003605","DOIUrl":"10.1097/ICO.0000000000003605","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate intereye agreement in dry-eye disease (DED) signs in the Dry Eye Assessment and Management study.</p><p><strong>Methods: </strong>Tear break-up time (TBUT), Schirmer test, conjunctival staining, corneal staining, meibomian gland dysfunction (MGD), and tear osmolarity were measured at baseline, 3, 6, and 12 months. Intereye agreement was assessed by intraclass correlation coefficient, weighted kappa, and percentage of participants with absolute intereye difference (AID) exceeding a clinically significant threshold (2 points for conjunctival staining and MGD, 2 seconds for TBUT, 3 points for corneal staining, 5 mm/5 minutes for Schirmer test, and 8 mOsms/L for osmolarity). The worse eye at each visit for each DED sign was determined as the eye with a sign worse than the contralateral eye by at least the clinically significant threshold.</p><p><strong>Results: </strong>DED signs had moderate-to-good intereye agreement with intraclass correlation coefficient ranging from 0.45 (tear osmolarity) to 0.81 (corneal staining and Schirmer test) and weighted kappa from 0.58 (plugging) to 0.69 (lid secretion). Percentage of participants exceeding threshold AID was 15% to 20% for conjunctival staining, 11% to 15% for TBUT, 17% to 21% for MGD, 13% to 18% for corneal staining, 21% to 23% for Schirmer test, and 44% to 47% for osmolarity. The eye with a worse DED sign ranged between 36% (TBUT) and 80% (osmolarity) of participants.</p><p><strong>Conclusions: </strong>Participants demonstrated moderate-to-good intereye agreement, yet a substantial portion showed clinically significant intereye differences in each sign. The worse eye was not the same eye in the majority during follow-up. These findings suggest considering signs from both eyes in future DED trials.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"149-156"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Detachment Rates After Uncomplicated DMEK Versus Cataract Surgery Combined (Triple-)DMEK.","authors":"Verena Schöneberger, Volkan Tahmaz, Leonie Menghesha, Jan Niklas Lüke, Claus Cursiefen, Friederike Schaub, Björn O Bachmann","doi":"10.1097/ICO.0000000000003554","DOIUrl":"10.1097/ICO.0000000000003554","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the rate of and risk factors for rhegmatogenous retinal detachment (RRD) after Descemet membrane endothelial keratoplasty (DMEK) either alone or in combination with cataract surgery.</p><p><strong>Design: </strong>Retrospective analysis of prospective database.</p><p><strong>Methods: </strong>Consecutive eyes with Fuchs endothelial corneal dystrophy that received DMEK surgery with a minimum follow-up of 1 year between July 2011 and January 2021 at the Department of Ophthalmology at the University of Cologne were analyzed. Exclusion criteria were complicated history including repeat DMEK within 1-year, previous retinal or glaucoma surgery, complicated phacoemulsification, congenital cataract, history of trauma.</p><p><strong>Results: </strong>From 3858 consecutive DMEKs, 1961 patients were identified suitable for analysis. 846 (43.1%) were pseudophakic DMEK, 91 (4.6%) phakic DMEK and 1,024 (52.2%) combined with cataract surgery. RRD occurred in 13 eyes (12 patients). Within two years after DMEK RRD occurred in 0.49% and 0.47% after DMEK and DMEK with cataract surgery, respectively. Mean age of 59.24 ± 8.42 years with subsequent RRD was significantly lower than overall 68.81 ± 9.89 years (t-test two-tailed; p < 0.001). The spherical equivalent was -4.69 ± 3.98 D (range -9.00 to 0.5) in RRD after pseudophakic DMEK compared to -2.79 ± 3.54 D (range -7.5 to 0.75) in combined procedures. Re-bubbling had no influence on RRD rate.</p><p><strong>Conclusions: </strong>DMEK alone or in combination with cataract surgery showed similar postoperative RRD rates in the first two years, generally in the range of pseudophakic RRDs. Risk factors such as myopia and younger age could be identified. Re-bubbling has no influence on RRD rates.</p>","PeriodicalId":10710,"journal":{"name":"Cornea","volume":" ","pages":"203-208"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}