COPD: Journal of Chronic Obstructive Pulmonary Disease最新文献_第4页

The Application of Diaphragm Ultrasound in Chronic Obstructive Pulmonary Disease: A Narrative Review 膈肌超声在慢性阻塞性肺病中的应用：叙述性综述

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-18 DOI: 10.1080/15412555.2024.2331202

Heng Mu, Qunxia Zhang

引用次数: 0

Alleviatory Role of Panax Notoginseng Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications 三七皂苷在慢性阻塞性肺病中调节炎症和肺血管重塑的缓解作用：机制与意义

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-15 DOI: 10.1080/15412555.2024.2329282

Yanan Hu, Qiuyang Fan, Bo Qiao, Ou Xu, Bijun Lv, Niping Han, Xiaomei Zhang

引用次数: 0

Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression 失衡与失控：金属失衡在慢性阻塞性肺病发展过程中的作用

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-09 DOI: 10.1080/15412555.2024.2322605

Ye Cui, Xinqian Du, Yunqi Li, Dan Wang, Zhe Lv, Huihui Yuan, Yan Chen, Jie Liu, Ying Sun, Wei Wang

引用次数: 0

Comparative Efficacy of Budesonide/Formoterol Versus Fluticasone/Salmeterol in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis 布地奈德/福莫特罗与氟替卡松/沙美特罗对中重度慢性阻塞性肺病患者的疗效比较：系统回顾与元分析

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-04 DOI: 10.1080/15412555.2024.2328708

Nan Shang, Yang Liu, Yueping Jin

引用次数: 0

Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study 免疫细胞在慢性阻塞性肺病中的因果作用：双样本孟德尔随机研究

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-04 DOI: 10.1080/15412555.2024.2327352

Xinru Xiao, Ziqi Ding, Yujia Shi, Qian Zhang

引用次数: 0

The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease. IL5RA变体对慢性阻塞性肺疾病影响的研究。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2023-12-01 Epub Date: 2023-10-31 DOI: 10.1080/15412555.2023.2270729

Siguang Li, Lingsang Lin, Jie Zhao, Zehua Yang, Yi Zhong, Linhui Huang, Jie Chen, Lei Zhang, Yipeng Ding, Tian Xie

{"title":"The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease.","authors":"Siguang Li, Lingsang Lin, Jie Zhao, Zehua Yang, Yi Zhong, Linhui Huang, Jie Chen, Lei Zhang, Yipeng Ding, Tian Xie","doi":"10.1080/15412555.2023.2270729","DOIUrl":"10.1080/15412555.2023.2270729","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a complex disease, and its pathogenesis is influenced by genetic factors. This study aimed to evaluate the role of IL5RA genetic variation in the risk of COPD. In this study, 498 patients with COPD and 498 normal controls were recruited. Subsequently, five SNPs (rs3804795, rs2290610, rs13097407, rs334782, and rs3856850) in the IL5RA gene were genotyped. Logistic analysis examined the association of five single nucleotide polymorphisms (SNPs) in IL5RA with the risk of COPD under various genetic models. Furthermore, the association between IL5RA and susceptibility to COPD was comprehensively analyzed with stratification based on age, sex, smoking, and alcohol consumption. Our study showed that IL5RA rs13097407 reduced susceptibility to COPD (OR = 0.43, p < 0.001, p (FDR)< 0.001). On the other hand, rs3856850 was associated with an increased risk of COPD (OR = 1.71, p = 0.002, p (FDR) = 0.002). Interestingly, the effect of IL5RA SNPs on susceptibility to COPD was found to be influenced by factors such as sex and smoking. IL5RA gene variants were significantly associated with susceptibility to COPD.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"20 1","pages":"338-347"},"PeriodicalIF":2.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71411018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

It Is Smart to Set Treatment Goals, But Are Set Treatment Goals SMART? A Qualitative Assessment of Goals Described in the Assessment of the Burden of COPD Tool. 设定治疗目标是明智之举，但设定的治疗目标是否 SMART？对慢性阻塞性肺病负担评估工具中描述的目标进行定性评估。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2023-12-01 Epub Date: 2024-01-05 DOI: 10.1080/15412555.2023.2289908

M Voorhaar, O C P van Schayck, B Winkens, J W M Muris, A H M Slok

{"title":"It Is Smart to Set Treatment Goals, But Are Set Treatment Goals SMART? A Qualitative Assessment of Goals Described in the Assessment of the Burden of COPD Tool.","authors":"M Voorhaar, O C P van Schayck, B Winkens, J W M Muris, A H M Slok","doi":"10.1080/15412555.2023.2289908","DOIUrl":"10.1080/15412555.2023.2289908","url":null,"abstract":"The Assessment of the Burden of COPD (ABC) tool facilitates shared decision-making and goal setting to develop a personalized care plan. In a previous trial (RCT), the ABC tool was found to have a significant effect on patients' Health-related Quality of Life (HRQoL). In this exploratory study we used data from the intervention group of the RCT to investigate if patients with health-related goals had an improved HRQoL compared to those without goals, and if the quality and types of goals differed for those who have a clinically meaningful improvement in HRQoL. We hypothesized that the quality and the type of the goal described in the ABC tool, relates to an improved HRQoL. We assessed the quality of the goals according to the Specificity, Measurability, Achievability, Relevance and Timeliness (SMART) criteria, and coded and counted each type of goal. We found that having a goal or not, did not differ significantly for those who had a clinically meaningful improved HRQoL versus those who had not, nor was the quality or type of goal significantly different. The most common types of goals were exercise more, smoke less, and improve weight. Based on the results, we speculate that when a clinically meaningful improvement in HRQoL is achieved, it is not related to a single component (i.e. goal setting as part of shared decision-making) but that the different components of the ABC tool (visualization of burden, shared decision making, utilization of tailored evidence based interventions, and regular monitoring of progress) may have a synergistic effect on disease cognition and/or behavior change. Noteworthy, the sample size was small while the calculated effect size was moderate, making it unlikely to find a significant effect.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"20 1","pages":"357-362"},"PeriodicalIF":2.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimal-Resource Home Exercise Program Improves Activities of Daily Living, Perceived Health Status, and Shortness of Breath in Individuals with COPD Stages GOLD II to IV. 最小资源家庭锻炼计划改善COPD GOLD II至IV期患者的日常生活活动、感知健康状况和呼吸急促。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2023-12-01 Epub Date: 2023-10-18 DOI: 10.1080/15412555.2023.2253907

Vanessa Joaquim Ribeiro Moço, Aline Almeida Gulart, Agnaldo José Lopes, Arthur de Sá Ferreira, Luis Felipe da Fonseca Reis

{"title":"Minimal-Resource Home Exercise Program Improves Activities of Daily Living, Perceived Health Status, and Shortness of Breath in Individuals with COPD Stages GOLD II to IV.","authors":"Vanessa Joaquim Ribeiro Moço, Aline Almeida Gulart, Agnaldo José Lopes, Arthur de Sá Ferreira, Luis Felipe da Fonseca Reis","doi":"10.1080/15412555.2023.2253907","DOIUrl":"10.1080/15412555.2023.2253907","url":null,"abstract":"Home exercises (HE) with minimal resources seem to be useful in individuals with COPD. The objective was to evaluate the effects of HE, on activities of daily living (ADL), dyspnea, on the health status(CAT) and quality of life (HRQoL) of individuals with COPD GOLD II to IV. Quasi-experimental study of the effects of HE, for 2 months, 3 times a week. Individuals with COPD(n = 45) were recruited, 37 started the protocol(9 did not complete it). 28 individuals (mean age 62.04 ± 5.8 years, FEV1: 44.7 ± 2.25%, FEV1/FVC 59.8 ± 6.9%) were evaluated before and after training. We observed improvements in the ADL-Glittre (4.9 ± 1.4 vs 3.9 ± 1.1 min; mean difference: -0.9 ± 0.2 min [95%CI: -1.3 to -0.2]; p = 0.008), as well as the mMRC score(2.8 ± 1.1 vs 2.07 ± 0.81; mean difference: 0.7 ± 0.3 [95%CI: -1.20.18 to -0.2]; p = 0.009), and in the CAT (25.6 ± 4.8 vs 18.9 ± 3.1; mean difference: -6.6 ± 3.4 [95%CI: -10.6 to -1.6]; p = 0.042). Analyzing the mean change before and after the intervention, a weak correlation was observed between ADL-Glittre and mMRC (r = 0.35; [95% CI 0.09; 0.56]; p = 0.009); moderate between ADL-Glittre and CAT (r = 0.52; [95% CI 0.30; 0.69]; p < 0.001) and between ADL-Glittre and SGRQ (r = 0.50; [95% CI 0 .27; 0.67]; p < 0.001). Individuals with COPD can benefit from HE performed autonomously and with minimal resources, as this proposal improves functional capacity for ADL, health perception and dyspnea.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"20 1","pages":"298-306"},"PeriodicalIF":2.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41233046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sevoflurane with Low Concentration Decrease DNA Methylation on Chronic Obstructive Pulmonary Disease (COPD)-Related Gene Promoter in COPD Rat. 低浓度七氟醚降低慢性阻塞性肺疾病(COPD)相关基因启动子DNA甲基化。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2023-12-01 Epub Date: 2023-11-27 DOI: 10.1080/15412555.2023.2278282

Chuanxin Yang, Libing Deng, Fang Bao, Hui Jiang, Long Zhang

{"title":"Sevoflurane with Low Concentration Decrease DNA Methylation on Chronic Obstructive Pulmonary Disease (COPD)-Related Gene Promoter in COPD Rat.","authors":"Chuanxin Yang, Libing Deng, Fang Bao, Hui Jiang, Long Zhang","doi":"10.1080/15412555.2023.2278282","DOIUrl":"10.1080/15412555.2023.2278282","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a difficult-to-cure disease that mainly affects the respiratory system. Inhaled anesthetic drug such as sevoflurane plays a controversial role in COPD by different concentration, but the underlying epigenetic mechanism remains unclear. Here, we prepared lipopolysaccharide (LPS)-induced COPD rat model, and isolated Alveolar type II (ATII) cells. We mainly focused DNA methylation on the promoter of COPD-related genes including Sftpa1, Napsa, Ca2, Sfta2, Lamp3, Wif1, Pgc, and Etv5. We observed COPD rat treated by sevoflurane with low (0.5%) and high (2%) concentrations displayed an opposite DNA methylation pattern. These six genes' promoter were all hypomethylated by 0.5% sevoflurane whereas hypermethylated by 2% sevoflurane, accompanied with the opposite transcriptional activity. We further verified that the DNMT1 binding ability contributed to DNA methylation these six genes' promoter. Moreover, we also captured DNMT1 and identified REC8 meiotic recombination protein (REC8) as the specific binding protein only existed in ATII cells treated with 0.5% sevoflurane rather than 2% and control. The binding ability of REC8 on these target genes' promoter showed highly positive correlation with DNMT1. In summary, we uncovered a potential epigenetic role of sevoflurane with low concentration in ATII cells of COPD that may help us deeply understand the pathogenesis and treatment mechanism of inhaled anesthesia drugs in COPD via a dose-dependent manner.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"20 1","pages":"348-356"},"PeriodicalIF":2.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138444202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FOXO3 Activation Prevents Cellular Senescence in Emphysema Induced by Cigarette Smoke. FOXO3 激活可防止吸烟诱发肺气肿的细胞衰老

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2023-12-01 Epub Date: 2023-01-19 DOI: 10.1080/15412555.2022.2164262

Hui Jiang, Yuanrui Xu, Yaona Jiang, Yaqing Li

{"title":"FOXO3 Activation Prevents Cellular Senescence in Emphysema Induced by Cigarette Smoke.","authors":"Hui Jiang, Yuanrui Xu, Yaona Jiang, Yaqing Li","doi":"10.1080/15412555.2022.2164262","DOIUrl":"10.1080/15412555.2022.2164262","url":null,"abstract":"Because cigarette smoke can induce COPD/emphysema through accelerating senescence with or without an incomplete repair system. However, the pathogenesis of COPD following lung senescence induced by CS is not fully understood. Airspace enlargement and airway epithelial cell senescence are common finding during the COPD development. We investigated the lung tress response to CS and demonstrated that a stress-responsive transcription factor, FOXO3, was regulated by deacetylase. SIRT1 inhibited FOXO3 acetylation and FOXO3 degradation, leading to FOXO3 accumulation and activation in airway epithelial cells. CS exposure activated SIRT1 contributed to FOXO3 activation and functioned to protect lungs, as deletion of SIRT1 decreased CS-induced FOXO3 activation and resulted in more severe airway epithelial cells senescence airspace enlargement. Strikingly, deletion of FOXO3 during the development of COPD aggravated lung structural and functional damage, leading to a much more profound COPD phenotype. We show that deletion of FOXO3 resulted in decreased autophagic response and increased senescence, which may explain lung protection by FOXO3. Our study indicates that in the COPD, stress-responsive transcription factors can be activated for adaptions to counteract senescence insults, thus attenuating COPD development.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":" ","pages":"80-91"},"PeriodicalIF":2.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10543394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0