COPD: Journal of Chronic Obstructive Pulmonary Disease最新文献

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Physiological Assessment of ECCO2R on the Work of Breathing in Exacerbations of COPD. ECCO2R对COPD加重期呼吸功的生理评价。
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-12-05 DOI: 10.1080/15412555.2024.2436169
Nicholas A Barrett, Francesco Murgolo, Salvatore Grasso, Eirini Kostakou, Nicholas Hart, Patrick Murphy, Abdel Douiri, Luigi Camporota
{"title":"Physiological Assessment of ECCO<sub>2</sub>R on the Work of Breathing in Exacerbations of COPD.","authors":"Nicholas A Barrett, Francesco Murgolo, Salvatore Grasso, Eirini Kostakou, Nicholas Hart, Patrick Murphy, Abdel Douiri, Luigi Camporota","doi":"10.1080/15412555.2024.2436169","DOIUrl":"10.1080/15412555.2024.2436169","url":null,"abstract":"<p><strong>Rationale: </strong>The impact of extracorporeal carbon dioxide removal (ECCO<sub>2</sub>R) on work of breathing and aeration in exacerbations of chronic obstructive pulmonary disease (AECOPD) is poorly understood.</p><p><strong>Objectives: </strong>The study explores the impact of non-invasive ventilation (NIV) and ECCO<sub>2</sub>R on respiratory drive, effort and distribution of ventilation in AECOPD.</p><p><strong>Methods: </strong>Patients enrolled in a randomised controlled study of the addition of ECCO<sub>2</sub>R to NIV compared with NIV underwent oesophageal pressure measurement, electrical impedance tomography and parasternal electromyography.</p><p><strong>Measurements and main results: </strong>18 patients were enrolled, nine in each arm. Of these, eight in the NIV arm and seven in the ECCO<sub>2</sub>R arm underwent physiological assessment. Patients randomised to ECCO<sub>2</sub>R, had a period of NIV combined with ECCO<sub>2</sub>R and, after removal of NIV, a period of ECCO<sub>2</sub>R alone. The removal of NIV whilst remaining on ECCO<sub>2</sub>R resulted in a respiratory acidosis (pH 7.34 (7.31-7.34) vs. 7.31 (7.31-7.34), <i>p</i> < 0.0001), increased work of breathing (7.43 (6.08-10.19) vs. 11.1 (8.11-15.15) J/min, <i>p</i> < 0.0001) and increased neural drive (884.4 (684.7-967.3) vs. 1321.1 (903.3-1575.3) AU, <i>p</i> = 0.0005). On day 1, the work of breathing was lower in the NIV than the ECCO<sub>2</sub>R group (4.38 (2.76-7.27) vs. 8.03 (4.8-15.94) J/min, <i>p</i> < 0.0001), minute ventilation was higher (15.54 (13.14-18.48) vs. 12.24 (8.51-13.9) L/min, <i>p</i> < 0.0001) and neural drive was the same (1,163.8 (1,085.5-1,325.5) vs. 1,093.8 (885.7-1,258.7) AU, <i>p</i> = 0.5556).</p><p><strong>Conclusions: </strong>The combination of NIV and ECCO<sub>2</sub>R results in lower work of breathing and improved neuro-ventilatory coupling. NIV fully supports ventilation early whilst ECCO<sub>2</sub>R improves neuro-ventilatory coupling and work of breathing over time.</p><p><strong>Trial registration: </strong>Clinicaltrials.gov; NCT02086084; registered 1 December 2015; https://clinicaltrials.gov/study/NCT02086084?cond=copd&term=ecco2r&rank=4.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2436169"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD. Granzyme B 可作为一种效应分子控制慢性阻塞性肺病的炎症过程。
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-02-05 DOI: 10.1080/15412555.2023.2299104
Won-Dong Kim, Don D Sin
{"title":"Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD.","authors":"Won-Dong Kim, Don D Sin","doi":"10.1080/15412555.2023.2299104","DOIUrl":"10.1080/15412555.2023.2299104","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small proportion of smokers have disease severe enough to develop COPD. COPD is not always progressive. The question then arises as to what explains the different trajectories of COPD. The role of autoimmunity and regulatory T (Treg) cells in the pathogenesis of COPD is increasingly being recognized. Nine published studies on Treg cells in the lung tissue or bronchoalveolar lavage fluid have shown that smokers with COPD have fewer Treg cells than smokers without COPD or nonsmokers. Three studies showed a positive correlation between Treg cell count and FEV<sub>1</sub>%, suggesting an important role for Treg cells in COPD progression. Treg cells can regulate immunological responses <i>via</i> the granzyme B (GzmB) pathway. Immunohistochemical staining for GzmB in surgically resected lungs with centrilobular emphysema showed that the relationship between the amount of GzmB+ cells and FEV<sub>1</sub>% was comparable to that between Treg cell count and FEV<sub>1</sub>% in the COPD lung, suggesting that GzmB could be a functional marker for Treg cells. The volume fraction of GzmB+  cells in the small airways, the number of alveolar GzmB+ cells, and GzmB expression measured by enzyme-linked immunosorbent assay in the lung tissue of smokers were significantly correlated with FEV<sub>1</sub>%. These results suggest that the GzmB content in lung tissue may determine the progression of COPD by acting as an effector molecule to control inflammatory process. Interventions to augment GzmB-producing immunosuppressive cells in the early stages of COPD could help prevent or delay COPD progression.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Bioactive Small Molecules in COPD Pathogenesis. 生物活性小分子在慢性阻塞性肺病发病机制中的作用
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-02-08 DOI: 10.1080/15412555.2024.2307618
Sha Liao, Yahong Chen
{"title":"The Role of Bioactive Small Molecules in COPD Pathogenesis.","authors":"Sha Liao, Yahong Chen","doi":"10.1080/15412555.2024.2307618","DOIUrl":"10.1080/15412555.2024.2307618","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is recognized as a predominant contributor to mortality worldwide, which causes significant burdens to both society and individuals. Given the limited treatment options for COPD, there lies a critical realization: the imperative for expeditious development of novel therapeutic modalities that can effectively alleviate disease progression and enhance the quality of life experienced by COPD patients. Within the intricate field of COPD pathogenesis, an assortment of biologically active small molecules, encompassing small protein molecules and their derivatives, assumes crucial roles through diverse mechanisms. These mechanisms relate to the regulation of redox balance, the inhibition of the release of inflammatory mediators, and the modulation of cellular functions. Therefore, the present article aims to explore and elucidate the distinct roles played by different categories of biologically active small molecules in contributing to the pathogenesis of COPD.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2307618"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beclometasone Dipropionate/Formoterol Fumarate is Similarly Effective to Budesonide/Formoterol Fumarate in Chinese Patients with COPD: The FORSYYN Double-Blind, Randomised Study. 在中国慢性阻塞性肺病患者中,二丙酸倍氯米松/富马酸福莫特罗与布地奈德/富马酸福莫特罗疗效相似:FORSYYN 双盲随机研究。
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-11-11 DOI: 10.1080/15412555.2024.2425157
Fuqiang Wen, Yanmin Wu, Chunyan Xing, Yingqun Zhu, Yongxing Chen, Xiaodong Mei, Massimo Corradi, Glauco Cappellini, Emanuele Calabro, Sergio Amodio, Cissy Zhu, Dmitry Galkin
{"title":"Beclometasone Dipropionate/Formoterol Fumarate is Similarly Effective to Budesonide/Formoterol Fumarate in Chinese Patients with COPD: The FORSYYN Double-Blind, Randomised Study.","authors":"Fuqiang Wen, Yanmin Wu, Chunyan Xing, Yingqun Zhu, Yongxing Chen, Xiaodong Mei, Massimo Corradi, Glauco Cappellini, Emanuele Calabro, Sergio Amodio, Cissy Zhu, Dmitry Galkin","doi":"10.1080/15412555.2024.2425157","DOIUrl":"https://doi.org/10.1080/15412555.2024.2425157","url":null,"abstract":"<p><p>The fixed-dose combination of beclometasone dipropionate/formoterol fumarate (BDP/FF) delivered <i>via</i> pressurised metered-dose inhaler (pMDI) has demonstrated efficacy in chronic obstructive pulmonary disease (COPD), in studies predominantly conducted in Caucasian adults. The current study evaluated the efficacy and safety of BDP/FF pMDI in Chinese patients with COPD, as part of registration for COPD in China. This double-blind, double-dummy, randomised, parallel-group study was conducted in patients with COPD of Chinese ethnicity aged ≥40 years. After a 4-week open-label budesonide/formoterol fumarate (BUD/FF) run-in period, patients were randomised to BUD/FF or BDP/FF for 24 weeks. The primary objective was to demonstrate non-inferiority of BDP/FF to BUD/FF in terms of change from baseline in pre-dose morning forced expiratory volume in 1 sec (FEV<sub>1</sub>) at Week 24 (i.e. the lower 95% CI limit of the difference was above the pre-defined non-inferiority margin of -0.07 L). Of 750 patients randomised (377 BDP/FF; 373 BUD/FF), 87.6% completed the study. The primary endpoint was met in both the per-protocol (adjusted mean difference -0.001 L [95% CI: -0.025, 0.022], non-inferiority <i>p</i> < 0.001) and intention-to-treat populations (-0.001 L [-0.024, 0.022]; non-inferiority <i>p</i> < 0.001). There were no statistically significant BDP/FF-BUD/FF differences for the secondary endpoints, and a similar proportion of patients had adverse events (BDP/FF, 51.7%; BUD/FF, 51.2%), with most mild/moderate in severity. In conclusion, BDP/FF pMDI was non-inferior to BUD/FF in terms of pre-dose morning FEV<sub>1</sub>, supported by a range of secondary endpoints. Both treatments were similarly tolerated. The study supports the use of BDP/FF pMDI in Chinese patients with COPD.</p><p><strong>Study registration: </strong>China Centre for Drug Evaluation (CTR20180475).</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2425157"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Significance of Long Non-Coding RNA SNHG5 in the Diagnosis and Prognosis of Chronic Obstructive Pulmonary Disease. 长非编码 RNA SNHG5 在慢性阻塞性肺病诊断和预后中的临床意义
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-07-08 DOI: 10.1080/15412555.2024.2363630
Xue-Ting Yao, Wen-Ping Feng, Zhi-Peng Gong, Xin-Peng Li
{"title":"Clinical Significance of Long Non-Coding RNA SNHG5 in the Diagnosis and Prognosis of Chronic Obstructive Pulmonary Disease.","authors":"Xue-Ting Yao, Wen-Ping Feng, Zhi-Peng Gong, Xin-Peng Li","doi":"10.1080/15412555.2024.2363630","DOIUrl":"https://doi.org/10.1080/15412555.2024.2363630","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) is preventable and requires early screening. The study aimed to examine the clinical values of long non-coding RNA (lncRNA) SNHG5 in COPD diagnosis and prognosis. Out of 160 COPD patients, 80 were in the stable stage and 80 were in the acute exacerbation of COPD stage (AECOPD). SNHG5 expression was detected <i>via</i> qRT-PCR. The survival analysis was conducted using Cox regression analysis and K-M curve. SNHG5 levels significantly reduced in both stable COPD and AECOPD groups compared with the control group, with AECOPD group recording the lowest values. SNHG5 levels were negatively correlated with GOLD stage. Serum SNHG5 can differentiate stable COPD patients from healthy individuals (AUC = 0.805), and can screen AECOPD from stable ones (AUC = 0.910). SNHG5 negatively influenced the release of inflammatory cytokines. For AECOPD patients, those with severe cough and wheezing dyspnea symptoms exhibited the lowest values of SNUG5. Among the 80 AECOPD patients, 16 cases died in the one-year follow-up, all of whom had low levels of SNHG5. SNHG5 levels independently influenced survival outcomes, patients with low SNHG5 levels had a poor prognosis. Thus, lncRNA SNHG5, which is downregulated in patients with COPD (especially AECOPD), can potentially protect against AECOPD and serve as a novel prognostic biomarker for AECOPD.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2363630"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Study on the Association between Cough Sensitivity and Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease. 慢性阻塞性肺病患者咳嗽敏感性与急性加重之间的关系研究
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-11-19 DOI: 10.1080/15412555.2024.2425153
Haodong Bai, Shuangxi Wang, Bingxian Sha, Xianghuai Xu, Li Yu
{"title":"A Study on the Association between Cough Sensitivity and Acute Exacerbations in Patients with Chronic Obstructive Pulmonary Disease.","authors":"Haodong Bai, Shuangxi Wang, Bingxian Sha, Xianghuai Xu, Li Yu","doi":"10.1080/15412555.2024.2425153","DOIUrl":"10.1080/15412555.2024.2425153","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between cough sensitivity and acute exacerbation in stable chronic obstructive pulmonary disease (COPD) patients.</p><p><strong>Methods: </strong>Stable COPD patients who visited our department from July 2022 to June 2023 were included. They were subjected to cough sensitivity test, spirometry, induced sputum cytology examination, questionnaire assessment such as cough symptom score, etc. They were followed up for 12 months, and were divided into the acute exacerbation (AE) group and the stable group according to whether acute exacerbation occurred during the follow-up period. We compared the differences in cough sensitivity, pulmonary function, and questionnaires between the two groups, analyzed the relationship between cough sensitivity and acute exacerbation, and screened the risk factors for AECOPD.</p><p><strong>Results: </strong>A total of 145 patients with stable COPD were included. AE group (<i>n</i> = 94) had lower FEV<sub>1</sub>/FVC (50.08 ± 11.11 <i>versus</i> 54.28 ± 11.58, <i>p</i> = 0.03) and cough sensitivity lgC<sub>5</sub> [-0.01(0.90) <i>versus</i> 0.59(0.90), <i>p</i> < 0.01] than those in the stable group (<i>n</i> = 51) patients, the daytime cough symptom score [2(2) <i>versus</i> 1(2), <i>p</i> = 0.02] and VAS score [50(40) <i>versus</i> 30(50), <i>p</i> < 0.01] were higher than stable group. Multivariate logistic regression analysis showed lgC<sub>5</sub> (<i>OR</i> = 0.34, 95% <i>CI</i> = 0.16-0.71, <i>p</i> < 0.01) was an independent risk factor for AECOPD. When lgC<sub>5</sub> was used to predict acute exacerbation in stable COPD patients, the AUC was 0.69, the sensitivity was 59.57%, and the specificity was 72.55%.</p><p><strong>Conclusion: </strong>Although causality is not necessarily demonstrated, baseline cough sensitivity lgC<sub>5</sub> in stable COPD patients is an independent risk factor for AECOPD, and it has some predictive value for future acute exacerbations.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2425153"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Causal Role of Walking Pace and Hand Grip Strength with Chronic Obstructive Pulmonary Disease Hospital: A Mendelian Randomization Study. 在慢性阻塞性肺疾病医院评估步行速度和握力的因果作用:孟德尔随机研究。
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-12-02 DOI: 10.1080/15412555.2024.2427737
Lu Wang, Xiaomin Wang, Dong Chen
{"title":"Assessing the Causal Role of Walking Pace and Hand Grip Strength with Chronic Obstructive Pulmonary Disease Hospital: A Mendelian Randomization Study.","authors":"Lu Wang, Xiaomin Wang, Dong Chen","doi":"10.1080/15412555.2024.2427737","DOIUrl":"https://doi.org/10.1080/15412555.2024.2427737","url":null,"abstract":"<p><strong>Background: </strong>Chronic obstructive pulmonary disease(COPD) hospitalization heightens risks for patients, including mortality, reduced quality of life, and financial strain. Walking pace (WP) and hand grip strength (HGS) are key indicators, their direct connection to COPD hospitalization is uncertain.</p><p><strong>Objective: </strong>To investigate the relationship between genetic determinants of walking pace, hand grip strength, and the risk of COPD hospitalization as well as lung function.</p><p><strong>Methods: </strong>The data pertaining to WP (<i>n</i> = 459,915), HGS (<i>n</i> = 922,115), COPD hospitalizations (<i>n</i> = 309,154), and lung function (<i>n</i> = 79,055) were procured from comprehensive large-scale genome-wide association studies. In carrying out the causal inference analysis, robust statistical methods were utilized, encompassing inverse variance weighted (IVW), MR-Egger, weighted median, simple median and Weighted mode. To address issues of heterogeneity, pleiotropy, and outliers, we incorporated sensitivity analyses and Mendelian randomization (MR) techniques.</p><p><strong>Results: </strong>The IVW analysis suggests that a faster WP reduces the risk of COPD hospitalization (OR = 0.3559, 95% CI: 0.22-0.52; <i>p</i> = 5.197 × 10<sup>-5</sup>). It also reveals a potential association between gait speed and the likelihood of developing early-onset COPD (OR = 0.189, 95% CI 0.09 to 0.39; <i>p</i> = 8.89 × 10-6) as well as late-onset COPD (OR = 0.44, 95% CI 0.25 to 0.76; <i>p</i> = 0.0036). The IVW analysis further indicates a potential correlation between an increased WP and enhanced peak expiratory flow (PEF) (OR = 1.699, 95% CI: 1.23 to 2.35; <i>p</i> = 0.0014), forced expiratory volume in 1 s(FEV1, OR = 1.557, 95% CI 1.24 to 1.95; <i>p</i> = 0.0001), and forced vital capacity(FVC, OR = 1.584, 95% CI 1.26 to 1.99; <i>p</i> = 8.89 × 10-5). The IVW analysis suggests a possible causal link between stronger left-hand grip strength and elevated levels of FVC (OR = 1.29, 95% CI: 1.15 to 1.46; <i>p</i> = 1.68 × 10-5), FEV1 (OR = 1.24, 95% CI: 1.11 to 1.39; <i>p</i> = 1.63 × 10-4), and PEF (OR = 1.2, 95% CI: 1.07 to 1.36; <i>p</i> = 2.67 × 10-3). Similarly, right-hand grip strength exhibits a comparable causal relationship with FVC and PEF as left-hand grip strength.</p><p><strong>Conclusions: </strong>Our research shows a link between slower walking pace and higher COPD hospitalization risk, as well as decreased lung function (PEF, FEV1, FVC). We also found a significant correlation between weaker hand grip and reduced lung function, especially FVC. These findings have the potential to improve risk assessment approaches, intervention strategies, and management methods for COPD patients, while simultaneously enhancing their overall quality of life and health status.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2427737"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Application of Self-Made Disseminating and Descending Breathing Exercises in Home Rehabilitation of Stable COPD. 自制发散式和下降式呼吸练习在稳定型慢性阻塞性肺疾病家庭康复中的应用。
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-08-01 DOI: 10.1080/15412555.2024.2369541
Ling-Xiu Chen, Shu-Lei Peng, Liang-Ping Mao, Xin-Wei Luo, Qian He, Jian-Hua Xiang, Fu-Juan Long, Yan Jiao
{"title":"The Application of Self-Made Disseminating and Descending Breathing Exercises in Home Rehabilitation of Stable COPD.","authors":"Ling-Xiu Chen, Shu-Lei Peng, Liang-Ping Mao, Xin-Wei Luo, Qian He, Jian-Hua Xiang, Fu-Juan Long, Yan Jiao","doi":"10.1080/15412555.2024.2369541","DOIUrl":"10.1080/15412555.2024.2369541","url":null,"abstract":"<p><p>To investigate the clinical effects and application value of self-made disseminating and descending breathing exercises on home rehabilitation of patients with stable chronic obstructive pulmonary disease (COPD). Seeking to generate concepts for creating novel, convenient, and efficient COPD prognosis rehabilitation exercises aimed at enhancing the well-being and rehabilitation confidence of both COPD patients and their families. A total of 70 COPD patients admitted to our outpatient department from July 2019 to September 2021 were randomly divided into the exercise group (<i>n</i> = 35) and the control group (<i>n</i> = 35). The control group received routine breathing training, while the exercise group was treated with self-made disseminating and descending breathing exercises. The respiratory function, including pulmonary function (FVC, FEV1, FEV1/FVC) and respiratory muscle strength (MIP, MEP), exercise tolerance (6-min walking distance, 6MWT), Modified Medical Research Council Dyspnea Scale (mMRC, Borg), COPD quality of life score (CAT, SGRQ), anxiety and depression scores (HAMA, HAMD) were compared between the two groups after 12-week exercise. After 12-week training, the FEV1, MIP, and MEP in the exercise group were significantly higher than those in the control group (<i>p</i> < 0.001), and the 6MWT was significantly increased in the exercise group compared to the control group (<i>p</i> < 0.001); while the mMRC, Borg score, the scores of CAT, SGRQ, HAMA, and HAMD were found significantly lower than those in the control group (<i>p</i> < 0.001). The self-made disseminating and descending breathing exercises can improve respiratory function and reduce symptoms of dyspnea in COPD patients, while enhancing exercise tolerance and relieving anxiety and depression, and are worthy of clinical application.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2369541"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Adults with Chronic Obstructive Pulmonary Disease in the United States, Utilizing State-Based Surveillance. 美国成人慢性阻塞性肺病患者的风险因素,利用基于州的监测。
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-10-11 DOI: 10.1080/15412555.2024.2413712
Brandon Workman, Laura Nabors
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引用次数: 0
Proposal for a 4-Level Classification System of Severe COPD Exacerbation According to Healthcare Resource Utilization. 根据医疗资源使用情况建立严重慢性阻塞性肺疾病恶化四级分类系统的建议。
IF 2.2 4区 医学
COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-05-28 DOI: 10.1080/15412555.2024.2358097
Georgios Hillas, Stelios Loukides, Athena Gogali, Konstantinos Kostikas
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引用次数: 0
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