COPD: Journal of Chronic Obstructive Pulmonary Disease最新文献_第5页

Guidelines for the Pharmacologic Treatment of COPD 2023: Canada versus GOLD. 慢性阻塞性肺疾病药物治疗指南 2023》：加拿大与 GOLD。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-02-08 DOI: 10.1080/15412555.2023.2292613

Samy Suissa

引用次数: 0

Knockdown of RTEL1 Alleviates Chronic Obstructive Pulmonary Disease by Modulating M1, M2 Macrophage Polarization and Inflammation. 敲除 RTEL1 可通过调节 M1、M2 巨噬细胞极化和炎症缓解慢性阻塞性肺病

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-02-29 DOI: 10.1080/15412555.2024.2316607

He-Ping Xu, Huan Niu, Hong Wang, Jie Lin, Jin-Jian Yao

{"title":"Knockdown of RTEL1 Alleviates Chronic Obstructive Pulmonary Disease by Modulating M1, M2 Macrophage Polarization and Inflammation.","authors":"He-Ping Xu, Huan Niu, Hong Wang, Jie Lin, Jin-Jian Yao","doi":"10.1080/15412555.2024.2316607","DOIUrl":"10.1080/15412555.2024.2316607","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a common chronic disease characterized by airflow obstruction, which seriously threatens people's health. The COPD mouse model was established with cigarette smoke induction. Hematoxylin-eosin staining and Masson staining were carried out to observe the pathological changes of lung tissues in COPD mice. RTEL1 was silenced in COPD mice, and immunohistochemistry was used to detect RTEL1, ki67 and Caspase-3 expression. The role of RTEL1 in inflammation were evaluated by ELISA, and the impacts of RTEL1 on M1 and M2 macrophage markers (iNOS and CD206) were evaluated by qPCR and western blotting. In COPD model, there was an increase in the number of inflammatory cells, with slightly disorganized cell arrangement, unclear hierarchy, condensed and solidified nuclei, while knockdown of RTEL1 improved the inflammatory infiltration. Moreover, knockdown of RTEL1 reduced ki67-positive cells and increased Caspase-3 positive cells in COPD group. The increased inflammatory factors (IL-1β, MMP-9, TNF-α, IL-4, IL-6, and IL-23) in COPD were suppressed by knockdown of RTEL1, while iNOS was raised and CD206 was inhibited. In conclusion, knockdown of RTEL1 promoted M1 and inhibited M2 macrophage polarization and inflammation to alleviate COPD.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2316607"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139989560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in Hospital Admissions of Patients with COPD in Poland: A 14-Year Nationwide Analysis (2006-2019). 波兰慢性阻塞性肺病患者入院情况的变化：14 年全国范围分析（2006-2019 年）》。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-08-11 DOI: 10.1080/15412555.2024.2387114

Bogdan Bochenek, Mateusz Jankowski, Joanna Wieczorek, Marta Gruszczynska, Adam Jaczewski, Paweł Goryński, Mariusz Figurski, Jarosław Pinkas

{"title":"Changes in Hospital Admissions of Patients with COPD in Poland: A 14-Year Nationwide Analysis (2006-2019).","authors":"Bogdan Bochenek, Mateusz Jankowski, Joanna Wieczorek, Marta Gruszczynska, Adam Jaczewski, Paweł Goryński, Mariusz Figurski, Jarosław Pinkas","doi":"10.1080/15412555.2024.2387114","DOIUrl":"https://doi.org/10.1080/15412555.2024.2387114","url":null,"abstract":"Poland is a country with a high burden of COPD and its risk factors. This population-wide and geospatial study on COPD in Poland, aimed to analyze changes in hospitalizations of patients with a diagnosis of COPD between 2006 and 2019 as well as to identify changes in the demographic characteristics of patients hospitalized with COPD. This is a retrospective analysis of hospital discharge records of patients with a diagnosis of COPD (ICD-10 code J44 and age 40 and over), hospitalized in Poland between 2006 and 2019. Data were analyzed separately for all patients hospitalized with COPD (primary and secondary diagnosis), for patients admitted due to COPD (primary diagnosis) and patients hospitalized with COPD as a comorbidity (secondary diagnosis). Between 2006 and 2019, a total of 1,663,420 hospital admissions of patients with COPD were reported. Between 2006 and 2019, the annual number of patients hospitalized due to COPD decreased by 53.8%, including 57.3% among men and 46.6% among women. The number of patients hospitalized with COPD as comorbidity increased by 35.8%. The lowest hospital admissions rate was in north-western Poland and the highest in north-eastern Poland. Among patients admitted due to COPD, the percentage of women increased from 32.6% to 37.7%. The percentage of patients admitted due to COPD and living in rural areas decreased from 51.2% in 2006 to 40.8%in 2019. This study provided data on changes in sociodemographic characteristics of hospitalizations of patients with a diagnosis of COPD, including overall reduction in COPD admissions but an increase in COPD burden among women.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"21 1","pages":"2387114"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and Severity Assessment of COPD Using a Novel Fast-Response Capnometer and Interpretable Machine Learning 利用新型快速反应血压计和可解释的机器学习诊断慢性阻塞性肺病并评估其严重程度

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-24 DOI: 10.1080/15412555.2024.2321379

Leeran Talker, Cihan Dogan, Daniel Neville, Rui Hen Lim, Henry Broomfield, Gabriel Lambert, Ahmed Selim, Thomas Brown, Laura Wiffen, Julian Carter, Helen F. Ashdown, Gail Hayward, Elango Vijaykumar, Scott T. Weiss, Anoop Chauhan, Ameera X. Patel

引用次数: 0

The Application of Diaphragm Ultrasound in Chronic Obstructive Pulmonary Disease: A Narrative Review 膈肌超声在慢性阻塞性肺病中的应用：叙述性综述

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-18 DOI: 10.1080/15412555.2024.2331202

Heng Mu, Qunxia Zhang

引用次数: 0

Alleviatory Role of Panax Notoginseng Saponins in Modulating Inflammation and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease: mechanisms and Implications 三七皂苷在慢性阻塞性肺病中调节炎症和肺血管重塑的缓解作用：机制与意义

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-15 DOI: 10.1080/15412555.2024.2329282

Yanan Hu, Qiuyang Fan, Bo Qiao, Ou Xu, Bijun Lv, Niping Han, Xiaomei Zhang

引用次数: 0

Imbalanced and Unchecked: The Role of Metal Dyshomeostasis in Driving COPD Progression 失衡与失控：金属失衡在慢性阻塞性肺病发展过程中的作用

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-09 DOI: 10.1080/15412555.2024.2322605

Ye Cui, Xinqian Du, Yunqi Li, Dan Wang, Zhe Lv, Huihui Yuan, Yan Chen, Jie Liu, Ying Sun, Wei Wang

引用次数: 0

Comparative Efficacy of Budesonide/Formoterol Versus Fluticasone/Salmeterol in Patients With Moderate-to-Severe Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis 布地奈德/福莫特罗与氟替卡松/沙美特罗对中重度慢性阻塞性肺病患者的疗效比较：系统回顾与元分析

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-04 DOI: 10.1080/15412555.2024.2328708

Nan Shang, Yang Liu, Yueping Jin

引用次数: 0

Causal Role of Immune Cells in Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study 免疫细胞在慢性阻塞性肺病中的因果作用：双样本孟德尔随机研究

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-04-04 DOI: 10.1080/15412555.2024.2327352

Xinru Xiao, Ziqi Ding, Yujia Shi, Qian Zhang

引用次数: 0

The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease. IL5RA变体对慢性阻塞性肺疾病影响的研究。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2023-12-01 Epub Date: 2023-10-31 DOI: 10.1080/15412555.2023.2270729

Siguang Li, Lingsang Lin, Jie Zhao, Zehua Yang, Yi Zhong, Linhui Huang, Jie Chen, Lei Zhang, Yipeng Ding, Tian Xie

{"title":"The Study of the Influence of IL5RA Variants on Chronic Obstructive Pulmonary Disease.","authors":"Siguang Li, Lingsang Lin, Jie Zhao, Zehua Yang, Yi Zhong, Linhui Huang, Jie Chen, Lei Zhang, Yipeng Ding, Tian Xie","doi":"10.1080/15412555.2023.2270729","DOIUrl":"10.1080/15412555.2023.2270729","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a complex disease, and its pathogenesis is influenced by genetic factors. This study aimed to evaluate the role of IL5RA genetic variation in the risk of COPD. In this study, 498 patients with COPD and 498 normal controls were recruited. Subsequently, five SNPs (rs3804795, rs2290610, rs13097407, rs334782, and rs3856850) in the IL5RA gene were genotyped. Logistic analysis examined the association of five single nucleotide polymorphisms (SNPs) in IL5RA with the risk of COPD under various genetic models. Furthermore, the association between IL5RA and susceptibility to COPD was comprehensively analyzed with stratification based on age, sex, smoking, and alcohol consumption. Our study showed that IL5RA rs13097407 reduced susceptibility to COPD (OR = 0.43, p < 0.001, p (FDR)< 0.001). On the other hand, rs3856850 was associated with an increased risk of COPD (OR = 1.71, p = 0.002, p (FDR) = 0.002). Interestingly, the effect of IL5RA SNPs on susceptibility to COPD was found to be influenced by factors such as sex and smoking. IL5RA gene variants were significantly associated with susceptibility to COPD.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"20 1","pages":"338-347"},"PeriodicalIF":2.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71411018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0