COPD: Journal of Chronic Obstructive Pulmonary Disease最新文献

{"title":"Response to \"Pulmonary Hypertension as a Determinant of In-Hospital Mortality in COPD: Insights and Methodological Considerations\".","authors":"Trishna Parikh, Saad Afzal Khan, Adishwar Rao, Bela Patel, Bindu Akkanti","doi":"10.1080/15412555.2026.2631253","DOIUrl":"https://doi.org/10.1080/15412555.2026.2631253","url":null,"abstract":"","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2631253"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smartphone-Enabled Cough Detection in Severely Exacerbated COPD: An Exploratory Pilot Study.","authors":"Maximilian Boesch, Julia Herrmann, Florent Baty, David Cleres, Jonathan Leathers, Elgar Fleisch, Martin H Brutsche, Filipe Barata, Frank Rassouli","doi":"10.1080/15412555.2026.2614152","DOIUrl":"10.1080/15412555.2026.2614152","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic obstructive pulmonary disease (COPD) shows rising incidence worldwide. Progressive decline in lung function is characteristic for the disease and results in various signature COPD symptoms. A significant part of COPD-associated morbidity and mortality is due to acute exacerbations, which often require hospital usage, thus disproportionately impacting healthcare expenses. Novel digital health technologies allowing remote patient monitoring are desirable to improve COPD management by tailoring treatment- and follow-up strategies.</p><p><strong>Methods: </strong>We here tested the feasibility and biomarker potential of smartphone-enabled cough monitoring during and after AECOPD in hospitalized patients. The study was designed as a single-center, prospective, longitudinal, observational cohort study and enrolled 23 subjects. A contact-free, near real-time, smartphone-enabled cough detection system was used for automated cough detection and quantification based on audio recordings. Cough counts were correlated to various clinical and biochemical markers.</p><p><strong>Results: </strong>Cough levels were highest at study enrollment (approx. 15 coughs per hour) and gradually declined over time toward recovery (to below 5 coughs per hour) (incidence rate ratio (IRR): 0.97 [0.95-0.98], <i>p</i> < 0.001). There was a high degree of intra- and inter-patient variation of cough frequency and evolution. In addition, cough counts underlay significant diurnal regulation, with higher counts during daytime. Cough counts were inversely associated with oxygen saturation (IRR: 0.9 [0.87-0.95], <i>p</i> < 0.001) and correlated positively with body temperature (IRR: 2.00 [1.47-2.73], <i>p</i> < 0.001).</p><p><strong>Discussion: </strong>Automated, contact-free, smartphone-enabled cough detection was feasible in COPD patients hospitalized for AECOPD. Cough counts declined over time and were associated with relevant clinical and biochemical markers. Our approach enables telemonitoring of AECOPD in near real-time and warrants further development to possibly establish cough count as an early digital biomarker for emerging AECOPD, allowing swift intervention and associated cost reductions.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2614152"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146008730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-hospital Mortality Patterns and Readmissions in Patients With Chronic Obstructive Pulmonary Disease: An Analysis of the Role of Pulmonary Hypertension.","authors":"Saad Afzal Khan, Trishna Parikh, Adishwar Rao, Akriti Agrawal, Aarohi Parikh, Farah Kazzaz, Sarah Shin, Harry Karmouty-Quintana, Maulin Patel, Kha Dinh, Bela Patel, Bindu Akkanti","doi":"10.1080/15412555.2025.2582902","DOIUrl":"10.1080/15412555.2025.2582902","url":null,"abstract":"<p><p>Chronic obstructive pulmonary disease (COPD) may be complicated by pulmonary hypertension (PH). We aimed to understand the impact of PH on in-hospital mortality and quantify the 30-day readmission rate among patients with COPD. For this cross-sectional study, we used the Nationwide Readmissions Database from 2017-2020 to identify adults ≥18 years with COPD. Patients were stratified according to PH diagnosis. Baseline characteristics between groups were compared using the Pearson chi-square test and two-sample t-test. Predictors of in-hospital mortality were determined using multivariate logistic regression analysis adjusted for demographics and confounders. The 30-day readmission rate and prevalence of PH subgroups by baseline COPD status were also obtained. There were 766,561 (7.43%) patients with concomitant PH and COPD among 10,312,543 patients with COPD. Patients with PH and COPD were older, female, and more often had a length of stay ≥7 days (all p < 0.001). Patients with PH suffered more from in-hospital mortality than those without PH (5.84% versus 3.94%, p < 0.001). PH predicted in-hospital mortality (adjusted odds ratio [aOR]: 1.22 [1.21-1.24], p < 0.001). COVID-19 (aOR: 6.20 [6.11-6.30]), metastatic cancer (aOR: 3.28 [3.23-3.32]), and moderate/severe liver disease (aOR: 3.09 [3.04-3.15]) were the strongest positive predictors of in-hospital mortality (all p < 0.001) in all patients with COPD. The 30-day readmission rate for the entire cohort was approximately 16%. Most patients had PH coded as unspecified/other.PH was associated with increased in-hospital mortality among patients with COPD, highlighting a high-risk group for targeted interventions to reduce morbidity and mortality.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2582902"},"PeriodicalIF":2.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Anion Inhalation in a Mouse Model of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease.","authors":"Yuanyuan Li, Jianing Lu, Yuqin Chen, Zhixiong Li, Zili Zhang, Haichun Zheng, Yuhan Jiang, Qinghui Huang, Wenju Lu","doi":"10.1080/15412555.2025.2603725","DOIUrl":"10.1080/15412555.2025.2603725","url":null,"abstract":"<p><strong>Background: </strong>Oxidative/anti-oxidative stress unbalance is one of the mechanisms of chronic obstructive pulmonary disease (COPD). Anion has been shown to be effective to eliminate reactive oxygen species, yet it is unknown if inhalation of anion (IA) can be beneficial for COPD intervention.</p><p><strong>Methods: </strong>COPD model mice were established by cigarette smoke (CS) exposure in combination with tracheal instillation of LPS, and treated with various dosages of IA for 120 days. Pulmonary function, inflammatory mediators, anti-oxidatives and collagen deposition level were measured to evaluate the therapeutic effects of IA in COPD model mice. The pathological morphology and structure of lung, liver, renal, spleen, heart, and brain were analyzed to assess the safety of IA.</p><p><strong>Results: </strong>IA improved COPD mice pulmonary function, reversed the decrease in SOD in blood serum and lung tissue, and increased the anti-oxidative stress protein NQO1 expression. IA could also decrease the collagen deposition and Smad2/3 phosphorylation in COPD mice lung. Additionally, IA did not affect the pathological structure and the index of major body organs.</p><p><strong>Conclusions: </strong>This preclinical study demonstrated that IA is beneficial for COPD treatment, likely by increasing the anti-oxidative capacity and inhibiting Smad2/3 activation in lung tissue.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2603725"},"PeriodicalIF":2.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing Patterns of Gabapentinoids in Patients with Chronic Obstructive Pulmonary Disorder.","authors":"Mollie Vergara, Mate Michael Soric, Olivia King, Reece Bullock, Brandon Skory, Kelly Bole, Anika Englehart, Nita Mara, Amgad Moqbl, Manysha Patel, Alexandra Dimit","doi":"10.1080/15412555.2025.2596683","DOIUrl":"10.1080/15412555.2025.2596683","url":null,"abstract":"<p><p>In 2019, the U.S. Food and Drug Administration (FDA) issued a warning regarding the risk of serious respiratory depression in patients using gabapentin or pregabalin who have respiratory risk factors, including those with chronic obstructive pulmonary disorder (COPD). With the overall prescribing of gabapentinoids continuing to grow, there is the potential for inappropriate prescribing in this patient population. Data from the National Ambulatory Medical Care Survey (NAMCS) from 2013 to 2018, with the exception of 2017, was used to assess prevalence and predictors of gabapentinoid prescribing in patients with COPD. The data consists of 1,131 unweighted visits, representing approximately 53.6 million ambulatory care visits nationally. Of these visits, 146 patients (10.8%) with a COPD diagnosis were also prescribed a gabapentinoid, which represents more than a million office visits annually when weighted. Patients with an increased risk of receiving gabapentinoids were those with concomitant diabetes mellitus, concurrent opioid use, and those currently using tobacco. Due to increased risk of serious respiratory depression caused by gabapentinoids, prescribers should take caution when prescribing to individuals with COPD and other respiratory risk factors. Based on the reviewed prescribing patterns, more education is needed to inform providers about the risks associated with concomitant COPD and gabapentinoid use.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2596683"},"PeriodicalIF":2.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Rehabilitation on Readmission Rates in Older Patients with COPD with Disability After Hospital Discharge.","authors":"Chigusa Shirakawa, Akihiro Shiroshita, Chisato Miyakoshi, Kazuaki Uda, Kazuma Nagata, Ryo Tachikawa, Keisuke Tomii, Yuki Kataoka","doi":"10.1080/15412555.2025.2593282","DOIUrl":"10.1080/15412555.2025.2593282","url":null,"abstract":"<p><p>This study aimed to evaluate the impact of rehabilitation on readmission rates among older patients requiring nursing care following with COPD following hospitalization for lower respiratory tract infection, focusing on whether initiating rehabilitation within two months post-discharge reduces readmissions. We conducted a retrospective observational study using insurance claim data in Kobe City, Japan, with a population of approximately 1.5 million. We included Patients with COPD aged 65 or older with certified care-need levels under Long-term Care Insurance system in Japan, hospitalized for lower respiratory tract infections and survived alive. Patients were classified based on their functional capacity in Activities of Daily Living (ADL). We used the extended Cox model to consider rehabilitation as time-varying exposure and assess the hazard ratios for readmission, adjusting for ADL. The ADL level was adjusted as a confounder. The survival probabilities were estimated among patients who experienced rehabilitation within two months and those who did not experience rehabilitation. Among 745 patients, 479 received rehabilitation within two months post-discharge, 105 received it later, and 161 did not receive rehabilitation. Participation in rehabilitation was associated with an increased hazard ratio for readmission (HR: 1.63, 95% CI: 1.19, 2.24), compared to those without it. The estimated survival curve of patients receiving rehabilitation within two months overlapped with that of those who did not receive rehabilitation. Rehabilitation following exacerbation in older patients with COPD who have disability may increase the risk of readmission after discharge. Healthcare providers should consider that patients with COPD with severe disability and complex needs may require staged, individualized rehabilitation.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2593282"},"PeriodicalIF":2.1,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemocytometric Parameters Associated with Bacterial and Viral Etiology in COPD Exacerbations: An Exploratory Analysis.","authors":"Sandra J van Krimpen, Hans J P M Koenen, Bram van Cranenbroek, Esther van Rijssen, Lisa H van Smoorenburg, Alice Staats-Niemeijer, Norbert C J de Wit, Jaco J Verweij, Frits M E Franssen, Harry R Gosker, Ramon C J Langen, Annemie M W J Schols, Huib A M Kerstjens, Maarten van den Berge, Marien I de Jonge, Sami O Simons","doi":"10.1080/15412555.2026.2733469","DOIUrl":"10.1080/15412555.2026.2733469","url":null,"abstract":"<p><strong>Clinical trial registration: </strong>NCT04961060.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2733469"},"PeriodicalIF":2.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Number Needed to Treat with Biologics in Type-2 Inflammation COPD: A Systematic Review and Meta-Analysis.","authors":"Qinqin Wang, Qianli Ma","doi":"10.1080/15412555.2026.2689394","DOIUrl":"10.1080/15412555.2026.2689394","url":null,"abstract":"<p><p>In moderate‑to‑severe chronic obstructive pulmonary disease (COPD), the number needed to treat (NNT) quantifies therapeutic benefit but remains underused for type-2-targeted biologics. This meta-analysis quantified the NNT for type-2-targeted biologics in moderate-to-severe COPD and incorporated the recent evidence on exacerbations, lung function, symptoms, health status, and responder outcomes. We searched PubMed, Embase and Web of Science through July 2025 for phase 2 or 3 RCTs of type-2targeted biologics in adults with COPD. The primary outcome was NNT for moderate-to-severe exacerbations; secondary outcomes included pre-bronchodilator forced expiratory volume in 1 s (FEV₁), St. George's Respiratory Questionnaire (SGRQ), Evaluating Respiratory Symptoms in COPD (E-RS-COPD), and responder proportions. Pooled ratios and mean differences were synthesized using fixed‑ or random‑effects models. Patient-based NNT was derived from cumulative incidence, event‑based NNT was derived from annualized exacerbation rates. Pooled NNTs were estimated under selected baseline‑risk scenarios. Under three baseline‑risk scenarios, pooled patient‑based NNTs for reducing moderate‑to‑severe COPD exacerbations were 12-17 for dupilumab and 11-16 for mepolizumab, benralizumab showed no clear reduction. Event-based NNTs at a baseline annual exacerbation rate of 1.055 per year were 3 for dupilumab and 5 for mepolizumab. Dupilumab was associated with improvements in pre-bronchodilator FEV₁, SGRQ, and E-RS-COPD. For mepolizumab, evidence across these non‑exacerbation outcomes was not consistently observed. In conclusion, pooled patient-based and event-based analyses suggest that both dupilumab and mepolizumab consistently reduce moderate-to-severe exacerbations in eosinophilic or type 2 inflammatory COPD, while improvements in lung function and patient-reported outcomes remain less consistent across biologics and warrant further validation. These findings derive from separate placebo‑controlled trials and should not be interpreted as establishing a comparative efficacy hierarchy among biologics.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2689394"},"PeriodicalIF":2.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-slice Functional Lung MRI During Metronome-Paced Tachypnea Detects Changes in Regional Ventilation Dynamics After a Single Dose of Dual Bronchodilator Treatment in COPD.","authors":"Robin A Müller, Andreas Voskrebenzev, Filip Klimeš, Marius M Klein, Frank Wacker, Jens Vogel-Claussen, Jens M Hohlfeld","doi":"10.1080/15412555.2026.2706659","DOIUrl":"10.1080/15412555.2026.2706659","url":null,"abstract":"<p><p>Dual long-acting bronchodilators are a standard treatment in chronic obstructive pulmonary disease (COPD), aimed at alleviating dyspnea, improving exercise tolerance, and preventing exacerbations. Metronome-paced tachypnea (MPT) offers a feasible alternative to exercise testing for the evaluation of dynamic hyperinflation (DH) in COPD. Because MPT can be performed during MRI, its combination with single-slice phase-resolved functional lung (PREFUL) MRI provides a promising approach to investigate changes in regional ventilation dynamics induced by DH. This approach was evaluated in a randomized, investigator-blinded, placebo-controlled, single-dose (SD) crossover trial with a two-week extension of once daily dual bronchodilator medication, in which patients with stable COPD underwent PREFUL MRI during resting tidal breathing (RTB) and during MPT. During RTB, no significant improvements in MRI-derived parameters were observed after SD treatment compared with placebo. During MPT, however, regional ventilation, flow-volume loop correlation, its defect percentage, and end-expiratory lung area improved significantly after SD treatment compared to the placebo scan (all <i>p</i> < 0.02). After multi-dose treatment, five out of six measured parameters improved during MPT, when compared to the baseline scan without bronchodilator treatment (all <i>p</i> < 0.03). In contrast to RTB, PREFUL MRI during MPT was able to detect changes in COPD patients already after SD treatment. The combination of MPT and PREFUL MRI represents a promising method to evaluate the effects of dual bronchodilators on regional ventilation dynamics and hyperinflation.</p>","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2706659"},"PeriodicalIF":2.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations in the Development of the AECOPD \"Infection Score\".","authors":"Rhushvi Thakkar, Deepika Raina, Chandana Maji, Vaseem Anjum","doi":"10.1080/15412555.2026.2661342","DOIUrl":"https://doi.org/10.1080/15412555.2026.2661342","url":null,"abstract":"","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":"23 1","pages":"2661342"},"PeriodicalIF":2.8,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}