COPD: Journal of Chronic Obstructive Pulmonary Disease最新文献_第2页

Machine-Learning Model Identifies Patients With Alpha-1 Antitrypsin Deficiency Using Claims Records. 机器学习模型利用索赔记录识别 Alpha-1 抗胰蛋白酶缺乏症患者。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-09-23 DOI: 10.1080/15412555.2024.2393348

Rajani Sharma, D Kyle Hogarth, Richard Colbaugh, Kristin Glass, Adel Mezine, Vassia Liakoni, Christopher Rudolf, Iris Himmelhan, Jimmy Hinson, Marie Sanchirico

{"title":"Machine-Learning Model Identifies Patients With Alpha-1 Antitrypsin Deficiency Using Claims Records.","authors":"Rajani Sharma, D Kyle Hogarth, Richard Colbaugh, Kristin Glass, Adel Mezine, Vassia Liakoni, Christopher Rudolf, Iris Himmelhan, Jimmy Hinson, Marie Sanchirico","doi":"10.1080/15412555.2024.2393348","DOIUrl":"https://doi.org/10.1080/15412555.2024.2393348","url":null,"abstract":"Identifying patients with rare diseases like alpha-1 antitrypsin deficiency (AATD) is challenging. Machine-learning models may be trained to identify patients with rare diseases using large-scale, real-world databases, whereas electronic medical records have low numbers of confirmed cases and have limited use in training such models. We applied a machine-learning model to a large US claims database to identify undiagnosed symptomatic patients with AATD. Using deidentified data from the Komodo US claims database (April 26, 2016-January 31, 2023), a model was trained to identify symptomatic patients with high probability of AATD. Eighty claims records for high-probability candidates identified by the model were independently reviewed and validated by 2 clinical experts. The experts independently indicated that of the 80 high-probability candidate patients, 65 (81%) and 62 (78%) patients, respectively, should be tested for AATD. Feedback from this validation step informed model optimization. The optimized model was applied to claims data to identify symptomatic patients with probable AATD. Eleven and 14 \"features\" of the claims data were informative in distinguishing patients with AATD from patients with COPD without AATD and from unspecified chronic liver diseases. Moreover, patients with diagnosed AATD and COPD without AATD had unique cadences of similar medical events in their diagnostic journeys. Our work shows that a machine-learning model trained on a large US claims database can accurately identify symptomatic patients with AATD and provides useful insights into the diagnostic journey of patients with AATD.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the Gaps in the Reporting of COPD Exacerbations by Patients: A Review. 了解患者在报告慢性阻塞性肺疾病恶化方面的差距：综述。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-02-29 DOI: 10.1080/15412555.2024.2316594

Paul Jones, Ashraf Alzaabi, Alejandro Casas Herrera, Mehmet Polatli, Marcelo Fouad Rabahi, Arturo Cortes Telles, Bhumika Aggarwal, Sudeep Acharya, Abdelkader El Hasnaoui, Chris Compton

引用次数: 0

Real-World Effectiveness of Single-Inhaler Triple Therapy for COPD: Impact of Diabetes Comorbidity. 单吸入器三联疗法治疗慢性阻塞性肺病的实际效果：糖尿病并发症的影响。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-03-20 DOI: 10.1080/15412555.2024.2327345

Sophia Eilat-Tsanani, Pierre Ernst, Samy Suissa

{"title":"Real-World Effectiveness of Single-Inhaler Triple Therapy for COPD: Impact of Diabetes Comorbidity.","authors":"Sophia Eilat-Tsanani, Pierre Ernst, Samy Suissa","doi":"10.1080/15412555.2024.2327345","DOIUrl":"10.1080/15412555.2024.2327345","url":null,"abstract":"Type 2 diabetes is a frequent comorbidity in chronic obstructive pulmonary disease (COPD) patients, with the GOLD treatment recommendations asserting that the presence of diabetes be disregarded in the choice of treatment.In a cohort of COPD patients with frequent exacerbations, initiators of single-inhaler triple therapy or dual bronchodilators were compared on the incidence of COPD exacerbation and pneumonia over one year, adjusted by propensity score weighting and stratified by type 2 diabetes.The COPD cohort included 1,114 initiators of triple inhalers and 4,233 of dual bronchodilators (28% with type 2 diabetes). The adjusted hazard ratio (HR) of exacerbation with triple therapy was 1.04 (95% CI: 0.86-1.25) among COPD patients with type 2 diabetes and 0.74 (0.65-0.85) in those without. The incidence of severe pneumonia was elevated with triple therapy among patients with type 2 diabetes (HR 1.77; 1.14-2.75).Triple therapy in COPD is effective among those without, but not those with, type 2 diabetes. Future therapeutic trials in COPD should consider diabetes comorbidity.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In a Strained Healthcare System, Patients with Advanced COPD Struggle to Access the Needed Support from the Healthcare Professionals - A Qualitative Study. 在紧张的医疗保健系统中，晚期慢性阻塞性肺病患者很难从医疗保健专业人员那里获得所需的支持--一项定性研究。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-06-11 DOI: 10.1080/15412555.2024.2361669

M Lavesen, M Paine, D G Bove

{"title":"In a Strained Healthcare System, Patients with Advanced COPD Struggle to Access the Needed Support from the Healthcare Professionals - A Qualitative Study.","authors":"M Lavesen, M Paine, D G Bove","doi":"10.1080/15412555.2024.2361669","DOIUrl":"https://doi.org/10.1080/15412555.2024.2361669","url":null,"abstract":"This study aimed to explore the self-management strategies of Danish patients living with advanced Chronic Obstructive Pulmonary Disease (COPD), with a particular focus on their daily life and their interactions with the respiratory outpatient clinic. Data were collected through semi-structured interviews with 11 patients with COPD affiliated with a Danish respiratory outpatient clinic. The data were thematically analyzed as suggested by Braun & Clarke. The analysis revealed one overarching theme, three main themes, and six subthemes. The overarching theme 'In a strained healthcare system patients with COPD struggle to access needed support to be able to self-manage their disease' revolved around the challenges that patients face in an overburdened healthcare system as they seek support to effectively self-manage their condition. The three main themes were: (1) Only physical symptoms provide legal access to the respiratory outpatient clinic, (2) For patients, the measurements serve as indicators of their health status and overall well-being, (3) Healthcare professionals' skills and not the mode of contact matters to the patients. Healthcare professionals should be aware that the rhetoric surrounding a busy healthcare system with a stressed-out staff also affects patients. Patients with COPD may be particularly sensitive to this message and try to avoid burdening the healthcare system further by setting aside their own needs. However, this approach can lead to neglecting symptoms of deterioration and mental symptoms, which increase the risk of disease progression and subsequent risk of hospital admission.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID. 慢性阻塞性肺病或长期慢性阻塞性肺气肿女性患者的胸部 CT 气道和血管测量。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-09-02 DOI: 10.1080/15412555.2024.2394129

Harkiran K Kooner, Paulina V Wyszkiewicz, Alexander M Matheson, Marrissa J McIntosh, Mohamed Abdelrazek, Inderdeep Dhaliwal, J Michael Nicholson, Miranda Kirby, Sarah Svenningsen, Grace Parraga

{"title":"Chest CT Airway and Vascular Measurements in Females with COPD or Long-COVID.","authors":"Harkiran K Kooner, Paulina V Wyszkiewicz, Alexander M Matheson, Marrissa J McIntosh, Mohamed Abdelrazek, Inderdeep Dhaliwal, J Michael Nicholson, Miranda Kirby, Sarah Svenningsen, Grace Parraga","doi":"10.1080/15412555.2024.2394129","DOIUrl":"10.1080/15412555.2024.2394129","url":null,"abstract":"Chest CT provides a way to quantify pulmonary airway and vascular tree measurements. In patients with COPD, CT airway measurement differences in females are concomitant with worse quality-of-life and other outcomes. CT total airway count (TAC), airway lumen area (LA), and wall thickness (WT) also differ in females with long-COVID. Our objective was to evaluate CT airway and pulmonary vascular and quality-of-life measurements in females with COPD as compared to ex-smokers and patients with long-COVID. Chest CT was acquired 3-months post-COVID-19 infection in females with long-COVID for comparison with the same inspiratory CT in female ex-smokers and COPD patients. TAC, LA, WT, and pulmonary vascular measurements were quantified. Linear regression models were adjusted for confounders including age, height, body-mass-index, lung volume, pack-years and asthma diagnosis. Twenty-one females (53 ± 14 years) with long-COVID, 17 female ex-smokers (69 ± 9 years) and 13 female COPD (67 ± 6 years) patients were evaluated. In the absence of differences in quality-of-life scores, females with long-COVID reported significantly different LA (p = 0.006) compared to ex-smokers but not COPD (p = 0.7); WT% was also different compared to COPD (p = 0.009) but not ex-smokers (p = 0.5). In addition, there was significantly greater pulmonary small vessel volume (BV5) in long-COVID as compared to female ex-smokers (p = 0.045) and COPD (p = 0.003) patients and different large (BV10) vessel volume as compared to COPD (p = 0.03). In females with long-COVID and highly abnormal quality-of-life scores, there was CT evidence of airway remodelling, similar to ex-smokers and patients with COPD, but there was no evidence of pulmonary vascular remodelling.Clinical Trial Registration: www.clinicaltrials.gov NCT05014516 and NCT02279329.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Significance of Long Non-Coding RNA SNHG5 in the Diagnosis and Prognosis of Chronic Obstructive Pulmonary Disease. 长非编码 RNA SNHG5 在慢性阻塞性肺病诊断和预后中的临床意义

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-07-08 DOI: 10.1080/15412555.2024.2363630

Xue-Ting Yao, Wen-Ping Feng, Zhi-Peng Gong, Xin-Peng Li

{"title":"Clinical Significance of Long Non-Coding RNA SNHG5 in the Diagnosis and Prognosis of Chronic Obstructive Pulmonary Disease.","authors":"Xue-Ting Yao, Wen-Ping Feng, Zhi-Peng Gong, Xin-Peng Li","doi":"10.1080/15412555.2024.2363630","DOIUrl":"https://doi.org/10.1080/15412555.2024.2363630","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is preventable and requires early screening. The study aimed to examine the clinical values of long non-coding RNA (lncRNA) SNHG5 in COPD diagnosis and prognosis. Out of 160 COPD patients, 80 were in the stable stage and 80 were in the acute exacerbation of COPD stage (AECOPD). SNHG5 expression was detected via qRT-PCR. The survival analysis was conducted using Cox regression analysis and K-M curve. SNHG5 levels significantly reduced in both stable COPD and AECOPD groups compared with the control group, with AECOPD group recording the lowest values. SNHG5 levels were negatively correlated with GOLD stage. Serum SNHG5 can differentiate stable COPD patients from healthy individuals (AUC = 0.805), and can screen AECOPD from stable ones (AUC = 0.910). SNHG5 negatively influenced the release of inflammatory cytokines. For AECOPD patients, those with severe cough and wheezing dyspnea symptoms exhibited the lowest values of SNUG5. Among the 80 AECOPD patients, 16 cases died in the one-year follow-up, all of whom had low levels of SNHG5. SNHG5 levels independently influenced survival outcomes, patients with low SNHG5 levels had a poor prognosis. Thus, lncRNA SNHG5, which is downregulated in patients with COPD (especially AECOPD), can potentially protect against AECOPD and serve as a novel prognostic biomarker for AECOPD.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD. Granzyme B 可作为一种效应分子控制慢性阻塞性肺病的炎症过程。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-02-05 DOI: 10.1080/15412555.2023.2299104

Won-Dong Kim, Don D Sin

{"title":"Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD.","authors":"Won-Dong Kim, Don D Sin","doi":"10.1080/15412555.2023.2299104","DOIUrl":"10.1080/15412555.2023.2299104","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is caused by smoking, but only a small proportion of smokers have disease severe enough to develop COPD. COPD is not always progressive. The question then arises as to what explains the different trajectories of COPD. The role of autoimmunity and regulatory T (Treg) cells in the pathogenesis of COPD is increasingly being recognized. Nine published studies on Treg cells in the lung tissue or bronchoalveolar lavage fluid have shown that smokers with COPD have fewer Treg cells than smokers without COPD or nonsmokers. Three studies showed a positive correlation between Treg cell count and FEV1%, suggesting an important role for Treg cells in COPD progression. Treg cells can regulate immunological responses via the granzyme B (GzmB) pathway. Immunohistochemical staining for GzmB in surgically resected lungs with centrilobular emphysema showed that the relationship between the amount of GzmB+ cells and FEV1% was comparable to that between Treg cell count and FEV1% in the COPD lung, suggesting that GzmB could be a functional marker for Treg cells. The volume fraction of GzmB+ cells in the small airways, the number of alveolar GzmB+ cells, and GzmB expression measured by enzyme-linked immunosorbent assay in the lung tissue of smokers were significantly correlated with FEV1%. These results suggest that the GzmB content in lung tissue may determine the progression of COPD by acting as an effector molecule to control inflammatory process. Interventions to augment GzmB-producing immunosuppressive cells in the early stages of COPD could help prevent or delay COPD progression.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Bioactive Small Molecules in COPD Pathogenesis. 生物活性小分子在慢性阻塞性肺病发病机制中的作用

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-02-08 DOI: 10.1080/15412555.2024.2307618

Sha Liao, Yahong Chen

引用次数: 0

The Application of Self-Made Disseminating and Descending Breathing Exercises in Home Rehabilitation of Stable COPD. 自制发散式和下降式呼吸练习在稳定型慢性阻塞性肺疾病家庭康复中的应用。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-08-01 DOI: 10.1080/15412555.2024.2369541

Ling-Xiu Chen, Shu-Lei Peng, Liang-Ping Mao, Xin-Wei Luo, Qian He, Jian-Hua Xiang, Fu-Juan Long, Yan Jiao

{"title":"The Application of Self-Made Disseminating and Descending Breathing Exercises in Home Rehabilitation of Stable COPD.","authors":"Ling-Xiu Chen, Shu-Lei Peng, Liang-Ping Mao, Xin-Wei Luo, Qian He, Jian-Hua Xiang, Fu-Juan Long, Yan Jiao","doi":"10.1080/15412555.2024.2369541","DOIUrl":"https://doi.org/10.1080/15412555.2024.2369541","url":null,"abstract":"To investigate the clinical effects and application value of self-made disseminating and descending breathing exercises on home rehabilitation of patients with stable chronic obstructive pulmonary disease (COPD). Seeking to generate concepts for creating novel, convenient, and efficient COPD prognosis rehabilitation exercises aimed at enhancing the well-being and rehabilitation confidence of both COPD patients and their families. A total of 70 COPD patients admitted to our outpatient department from July 2019 to September 2021 were randomly divided into the exercise group (n = 35) and the control group (n = 35). The control group received routine breathing training, while the exercise group was treated with self-made disseminating and descending breathing exercises. The respiratory function, including pulmonary function (FVC, FEV1, FEV1/FVC) and respiratory muscle strength (MIP, MEP), exercise tolerance (6-min walking distance, 6MWT), Modified Medical Research Council Dyspnea Scale (mMRC, Borg), COPD quality of life score (CAT, SGRQ), anxiety and depression scores (HAMA, HAMD) were compared between the two groups after 12-week exercise. After 12-week training, the FEV1, MIP, and MEP in the exercise group were significantly higher than those in the control group (p < 0.001), and the 6MWT was significantly increased in the exercise group compared to the control group (p < 0.001); while the mMRC, Borg score, the scores of CAT, SGRQ, HAMA, and HAMD were found significantly lower than those in the control group (p < 0.001). The self-made disseminating and descending breathing exercises can improve respiratory function and reduce symptoms of dyspnea in COPD patients, while enhancing exercise tolerance and relieving anxiety and depression, and are worthy of clinical application.","PeriodicalId":10704,"journal":{"name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proposal for a 4-Level Classification System of Severe COPD Exacerbation According to Healthcare Resource Utilization. 根据医疗资源使用情况建立严重慢性阻塞性肺疾病恶化四级分类系统的建议。

IF 2.2 4区医学

COPD: Journal of Chronic Obstructive Pulmonary Disease Pub Date : 2024-12-01 Epub Date: 2024-05-28 DOI: 10.1080/15412555.2024.2358097

Georgios Hillas, Stelios Loukides, Athena Gogali, Konstantinos Kostikas

引用次数: 0