K. Gambuś , B. Kużdżał , K. Moszczyński , S. Popovchenko , A. Szlubowski , L. Rudnicka , K. Żanowska , Ł. Trybalski , A. Galas , P. Kocoń
{"title":"Diagnostic validity of combined transbronchial and transoesophageal ultrasound in positron emission tomography node–negative lung cancer","authors":"K. Gambuś , B. Kużdżał , K. Moszczyński , S. Popovchenko , A. Szlubowski , L. Rudnicka , K. Żanowska , Ł. Trybalski , A. Galas , P. Kocoń","doi":"10.1016/j.crad.2025.106843","DOIUrl":"10.1016/j.crad.2025.106843","url":null,"abstract":"<div><h3>Aim</h3><div>The role of invasive mediastinal diagnostic methods in lung cancer with negative positron emission tomography (PET) remains unclear. This study aimed to determine the sensitivity and negative predictive value (NPV) of combined endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS), referred to as combined ultrasound (CUS), for diagnosing N2 disease in this group of patients.</div></div><div><h3>MATERIALS AND METHODS</h3><div>single-centre study analysing medical records of clinical stage I to IVA lung cancer patients was conducted. All patients underwent positron emission tomography computed tomography (PET-CT), followed by CUS imaging and lung resection with systematic lymph node dissection. Pathological examination of lymph nodes was the reference standard.</div></div><div><h3>RESULTS</h3><div>Data from 596 patients were analysed. The prevalence of N2 disease was 8%. The sensitivity, specificity, and the NPV of CUS in detecting N2 disease were 14%, 98%, and 93%, respectively. Sensitivity and NPV were not significantly associated with age, sex, body mass index (BMI), tumour grade, lobar location, or histological type (<em>P</em> > 0.05). Minimal N2 disease was found in 37 of 43 patients with negative CUS results; only 6 of 596 patients had more than minimal (N2b) disease missed by CUS. The NPV for minimal N2 involvement was 98%.</div></div><div><h3>CONCLUSION</h3><div>In PET-negative mediastinal lymph nodes, N2 disease prevalence is low. CUS has an NPV of 93% for N2 disease and 98% for more than minimal N2 involvement. The diagnostic yield of CUS is unaffected by clinical characteristics, making it a reliable method for ruling out significant N2 disease in PET-negative patients and potentially reducing the need for more invasive procedures.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"83 ","pages":"Article 106843"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A nomogram for predicting heterogeneous etiology of atherosclerosis in the left anterior descending coronary artery using geometric morphological parameters","authors":"X. Yu , Q.X. Gao , L.G. Sun , L.J. Peng","doi":"10.1016/j.crad.2025.106842","DOIUrl":"10.1016/j.crad.2025.106842","url":null,"abstract":"<div><h3>AIM</h3><div>This study aims to analyse the correlation between the geometric morphology of the left anterior descending (LAD) artery and the severity of arterial stenosis in order to explore potential causes of atherosclerotic heterogeneity.</div></div><div><h3>MATERIALS AND METHODS</h3><div>Geometric morphological parameters, including curvature, torsion, and tortuosity index (TI), along with anatomical features of surrounding accessory structures, were derived from coronary computed tomography angiography (CCTA). By integrating clinical indicators and serological results, a logistic regression model was developed to predict moderate to severe stenosis of the LAD (MSS-LAD). A novel nomogram was constructed based on significant influencing factors identified in the model, and its predictive performance was validated.</div></div><div><h3>RESULTS</h3><div>In this single-centre retrospective study, out of 115 CCTA cases in the training set, 49 were identified with MSS-LAD. Significant differences were observed in the classification of ramus intermedius-diagonal branch (RI-D), fat volume (FV), average torsion (AT), and AT of the proximal and mid (AT-PM) between groups (p<0.05). Multivariate logistic regression analysis indicated that body mass index (BMI), RI-D classification, FV, and AT-PM were significant predictors of MSS-LAD (p<0.05). A nomogram for predicting MSS-LAD was constructed based on these four indicators, demonstrating good predictive performance in both the training set (area under the curve [AUC]: 0.839; 95% confidence interval [CI]: 0.762–0.961) and the validation set (AUC: 0.790; 95% CI: 0.665–0.915).</div></div><div><h3>CONCLUSION</h3><div>There is a complex interaction between the geometric configuration of coronary arteries and atherosclerotic plaque formation. The risk nomogram established by combining anatomical features of surrounding accessory structures and clinical indicators effectively predicts MSS-LAD. It may be considered for inclusion in future risk assessment and management protocols for populations at high risk of coronary heart disease.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"83 ","pages":"Article 106842"},"PeriodicalIF":2.1,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Quantitative CT histogram indices for abdominal muscles are associated with coronary artery disease severity","authors":"G. Geng , Z. Li , T. Yuan , G.-M. Quan","doi":"10.1016/j.crad.2025.106840","DOIUrl":"10.1016/j.crad.2025.106840","url":null,"abstract":"<div><h3>Aim</h3><div>To explore the relationship between quantitative CT histogram indices of abdominal muscles and coronary artery disease (CAD) severity.</div></div><div><h3>Materials and methods</h3><div>CAD patients and controls who received chest CT covering the L1-L2 intervertebral disc were enrolled. Abdominal muscles at the L1-L2 level, including the abdominal wall muscles, the psoas major muscles and the paraspinal muscles, were segmented. Six histogram indices, covering area, average and median attenuation, skewness, kurtosis and standard deviation (SD) of attenuation, were measured and compared with controls. Associations between histogram indices and coronary artery calcium score (CACS) and total coronary plaque burden were then assessed using multivariate regression analysis.</div></div><div><h3>Results</h3><div>Two hundred ninety male and 165 female CAD patients were enrolled. Compared with controls, both sexes of CAD patients had a broader, platykurtic and right-skewed distribution in the psoas major muscles and female CAD patients had a leptokurtic and left-skewed distribution in the abdominal wall muscles additionally. After adjusting for cardiovascular risk factors, BMI, liver fat fraction, visceral adipose tissue and subcutaneous adipose tissue, the SD in the psoas major muscles was positively associated with CACS in male CAD patients (β=0.13; 95% CI: 0.02 to 0.23; <em>P</em>=0.02), and kurtosis in the abdominal wall muscles was positively associated with total plaque burden in female CAD patients (β=0.15; 95% CI, 0.01 to 0.29; <em>P</em>=0.03).</div></div><div><h3>Conclusion</h3><div>The histogram indices for abdominal wall muscles were independently associated with CAD severity in CAD patients, and the relationships were different between the two sexes.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"83 ","pages":"Article 106840"},"PeriodicalIF":2.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A.M. Davies, A. Patel, C. Azzopardi, Sl James, R. Botchu
{"title":"Birmingham atypical cartilaginous tumour imaging protocol (BACTIP) revisited","authors":"A.M. Davies, A. Patel, C. Azzopardi, Sl James, R. Botchu","doi":"10.1016/j.crad.2025.106837","DOIUrl":"10.1016/j.crad.2025.106837","url":null,"abstract":"<div><h3>Aim</h3><div>To revalidate an MRI protocol for the management of solitary central cartilage tumours (CCTs) of the proximal humerus and around the knee, excluding the proximal fibula.</div></div><div><h3>Materials and methods</h3><div>Data on 387 patients with a solitary CCT assessed in a specialist orthopaedic oncology unit between 2007 and 2016 was updated and combined with a further 393 patients referred from 2017 to 2023. The initial MRI images and any follow-up scans were evaluated for craniocaudal length of the CCT, presence/absence of endosteal scalloping or aggressive/malignant features. The cases were categorised according to the BACTIP. Patient outcome was assessed to ascertain if the application of the protocol led to any delay in the diagnosis of high-grade chondrosarcoma (HGCS).</div></div><div><h3>Results</h3><div>HGCS is rare (7%) in this large series of 780 patients with a solitary CCT. Ascending BACTIP type correlates with malignancy. All Type IA, IB, and IIA lesions were either benign enchondroma or atypical cartilaginous tumour (ACT), whereas 69% of Type III were diagnosed as HGCS. Only 4 cases on follow-up MRI showed a delay in diagnosis with progression to a BACTIP Type III (Type IC x1 and Type IIB x3). All were identified within seven months of presentation and were shown to be HGCS. Therefore, malignant transformation is remarkably rare (0.4%) and tends to occur relatively early (<1year).</div></div><div><h3>Conclusion</h3><div>This combined retrospective and prospective study confirms that BACTIP remains a useful tool for the general radiologist in determining which cases of CCT of the proximal humerus and around the knee would benefit from onward referral to a specialist orthopaedic oncology service. It may also have a further role in the future as management preferences for borderline CCTs move away from surgical intervention to a watch-and-scan policy.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"83 ","pages":"Article 106837"},"PeriodicalIF":2.1,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y.T. Wong , S. Yang , P.W. Leong , D.L.Y. Chow , K.Y. Kwok , K.Y.K. Lau , O.C.A. Li
{"title":"Artefacts and diagnostic pitfalls in contrast-enhanced mammography: a pictorial review","authors":"Y.T. Wong , S. Yang , P.W. Leong , D.L.Y. Chow , K.Y. Kwok , K.Y.K. Lau , O.C.A. Li","doi":"10.1016/j.crad.2024.106763","DOIUrl":"10.1016/j.crad.2024.106763","url":null,"abstract":"<div><div>Contrast-enhanced mammography (CEM) is an advanced emerging imaging technique that uses iodine contrast medium to improve breast cancer detection. Understanding CEM artefacts and pitfalls is important to prevent diagnostic misinterpretation. This article aims to provide a comprehensive review of the artefacts and potential diagnostic pitfalls encountered in CEM, focusing on their characteristic imaging features and strategies to mitigate these issues.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"81 ","pages":"Article 106763"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Predicting high-intensity focused ultrasound efficacy in adenomyosis treatment based on magnetic resonance (MR) radiomics and clinical-imaging features","authors":"Z. Liu , Z. Liu , X. Wan, Y. Wang, X. Huang","doi":"10.1016/j.crad.2024.106778","DOIUrl":"10.1016/j.crad.2024.106778","url":null,"abstract":"<div><h3>AIMS</h3><div>To develop a model predicting high-intensity focused ultrasound (HIFU) efficacy in adenomyosis treatment using enhanced T1WI and T2WI-FS radiomics combined with clinical imaging features.</div></div><div><h3>MATERIALS AND METHODS</h3><div>The study included 137 adenomyosis patients treated with HIFU from September 2021 to December 2023. Based on nonperfused volume ratio (NPVR), participants were divided into two groups: NPVR < 50% (n=77) and NPVR ≥ 50% (n=60). Patients were randomly split into training and test sets (7:3 ratio). Radiomics features were extracted from enhanced T1WI and T2WI-FS sequences, while clinical imaging features were selected using univariate analysis and binary logistic regression. Logistic regression models were built for radiomics, clinical imaging, and combined data. Model performance was assessed using ROC curves, Delong's test, and calibration curves.</div></div><div><h3>RESULTS</h3><div>AUCs for the radiomics, clinical-imaging, and combined models in the training set were 0.831, 0.664, and 0.845, respectively, and 0.829, 0.597, and 0.831 in the test set. The combined model outperformed the clinical-imaging model (training p=0.001, test p=0.01) and the radiomics model (training p=0.012, test p=0.032). However, no significant difference was found between the combined and radiomics models (p>0.05). Calibration curves and decision curve analysis confirmed the combined model's accuracy and clinical applicability.</div></div><div><h3>CONCLUSION</h3><div>A model incorporating clinical-imaging features with T1WI and T2WI-FS radiomics effectively predicts HIFU success in adenomyosis treatment, offering valuable guidance for clinical decision-making.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"81 ","pages":"Article 106778"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Chen , Y. Qi , R. Pu , H. Lin , W. Wang , B. Sun
{"title":"Corrigendum to “CT histogram analysis to distinguish between acute intracerebral hemorrhage and cavernous hemangioma” [Clin Radiol 79 (11) (2024) e872–e879]","authors":"Y. Chen , Y. Qi , R. Pu , H. Lin , W. Wang , B. Sun","doi":"10.1016/j.crad.2024.106782","DOIUrl":"10.1016/j.crad.2024.106782","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"81 ","pages":"Article 106782"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H.-C. Breit , M. Obmann , F. Schlicht , J. Vosshenrich , M. Segeroth , M. Bach , M. Clauss , D. Harder , R. Donners
{"title":"New-generation 0.55T MRI in patients with total hip arthroplasty: a comparison with 1.5T MRI","authors":"H.-C. Breit , M. Obmann , F. Schlicht , J. Vosshenrich , M. Segeroth , M. Bach , M. Clauss , D. Harder , R. Donners","doi":"10.1016/j.crad.2024.106758","DOIUrl":"10.1016/j.crad.2024.106758","url":null,"abstract":"<div><h3>Purpose</h3><div>To quantitatively and qualitatively compare the magnitude of metal total hip arthroplasty-induced imaging artifacts in vivo between 1.5T and 0.55T MRI.</div></div><div><h3>Materials and Methods</h3><div>15 patients (69 ± 14 years) with THA, prospectively underwent 0.55T and 1.5T MRI of the hip. Two fellowship-trained musculoskeletal radiologists qualitatively rated artifact magnitude on T1-weighted and fluid-sensitive sequences using a 5-point Likert scale (0 = severe - 5 = no artifact). Quantitative artifact magnitude was assessed by a third fellowship-trained musculoskeletal radiologist, by measuring the maximum diameter of the THA-induced signal void (mm) anteroposteriorly d(ap) and mediolaterally d(ml) at the level of the acetabulum, proximal, mid and distal stem, including the prosthesis. Additionally, the area of signal void was noted (mm<sup>2</sup>). Statistical differences between Likert scores were evaluated using the t-test or the Wilcoxon signed-rank test (P-values <.05 = significant).</div></div><div><h3>Results</h3><div>Qualitative artifact magnitude was on average rated as moderate to small on 0.55T and as large to moderate on 1.5T by both readers. Artifacts were rated less severe on 0.55T compared with 1.5T on T1-weighted (3.7 ± 0.7 vs. 2.4 ± 1.1, p=0.004) and fluid-sensitive sequences (3.1 ± 0.5 vs. 2.2 ± 1.1, p=0.18). Overall image quality did not show any statistically significant differences between 0.55T and 1.5T MRI (each p≥0.18). Metal artifacts' areas and diameters were smaller on 0.55T when compared with 1.5T MRI for all sequences (each p>0.016).</div></div><div><h3>Conclusions</h3><div>Total hip arthroplasty-induced metal artifacts are perceived as less severe at new-generation 0.55T when compared with conventional 1.5T MRI with no difference in overall image quality.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"81 ","pages":"Article 106758"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}