Clinical radiology最新文献

{"title":"Ultra-fast single-sequence magnetic resonance imaging (MRI) for lower back pain: diagnostic performance of a deep learning T2-Dixon pprotocol","authors":"T.D. Diallo ,&nbsp;S. Wiedemann ,&nbsp;Z. Berkarda ,&nbsp;R. Strecker ,&nbsp;D. Nickel ,&nbsp;F. Bamberg ,&nbsp;A. Rau ,&nbsp;T. Mayrhofer ,&nbsp;M.F. Russe ,&nbsp;J. Weiss","doi":"10.1016/j.crad.2025.106987","DOIUrl":"10.1016/j.crad.2025.106987","url":null,"abstract":"<div><h3>Background</h3><div>Conventional magnetic resonance imaging (MRI) protocols for lower back pain require multiple sequences and long acquisition times, challenging healthcare systems amid rising demand for lumbar spine imaging.</div></div><div><h3>AIM</h3><div>To assess the diagnostic performance of an abbreviated, deep learning-accelerated sagittal T2w Dixon single sequence protocol (Protocol_abb-DL) versus the standard lumbar spine MRI protocol (Protocol_std).</div></div><div><h3>MATERIALS AND METHODS</h3><div>In this prospective, single-centre study, 30 patients (mean age: 48 ± 18.5 years; 67% female) with lower back pain (LBP) underwent a single MRI examination using both Protocol_std (sagittal T1w and T2w turbo spin-echo sequences) and Protocol_abb-DL. A senior radiologist (15 years experience) established the diagnostic reference standard using Protocol_std. Two independent readers (10 and 5 years’ experience) evaluated the images at a segmental level for degenerative pathologies, including Modic changes, disc pathology, facet arthropathy, neuroforaminal stenosis, and Schmorl nodes. Diagnostic performance, confidence, interprotocol, and interobserver agreements were analysed.</div></div><div><h3>RESULTS</h3><div>Protocol_abb-DL reduced acquisition time by 80% at 1.5 Tesla (1:33 vs 7:43 minutes) and 84% at 3 Tesla (1:26 vs 8:43 minutes). Diagnostic performance was high, with sensitivities up to 100% [95% CI, 90.7–100.0] for Modic changes and 94.7% [95% CI, 87.1–98.5] for disc pathology, and specificities up to 100% [95% CI, 97.8–100.0] for Schmorl nodes. Diagnostic confidence was comparable between protocols (<em>P</em> &gt; 0.05). Interprotocol agreement was excellent (κ: 0.84–1.00), and interobserver agreement for Protocol_abb-DL was substantial to excellent (κ: 0.67–0.93).</div></div><div><h3>CONCLUSION</h3><div>Protocol_abb-DL provides diagnostic performance comparable to Protocol_std for degenerative lumbar spine pathologies while reducing acquisition time by up to 84%.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106987"},"PeriodicalIF":2.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between bone marrow fat fraction and risk of anaemia in patients with Crohn's disease: a cross-sectional study based on chemical shift-encoded magnetic resonance imaging (CSE-MRI)","authors":"S. Wang ,&nbsp;S. Liu ,&nbsp;Y. Tu ,&nbsp;R. Ji ,&nbsp;R. Tang ,&nbsp;T. Hua ,&nbsp;Y. Han ,&nbsp;J. Zhu","doi":"10.1016/j.crad.2025.106988","DOIUrl":"10.1016/j.crad.2025.106988","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the relationship between anaemia and bone marrow fat fraction (BMFF) based on chemical shift-encoded magnetic resonance imaging (CSE-MRI) in Crohn's disease (CD) patients.</div></div><div><h3>Materials and Methods</h3><div>A total of 103 patients with CD and 67 healthy volunteers were enrolled in this study. Differences in BMFF, red blood cell (RBC), and haemoglobin (Hb) counts were compared between the two groups. The correlation between indicators of anaemia and BMFF, the relationship between changes in BMFF and the odds ratio of anaemia, and its linear dose-response association were evaluated. Finally, the areas under the receiver operating characteristic curves (AUCs) for BMFF in predicting anaemia were calculated.</div></div><div><h3>Results</h3><div>BMFF, RBC, and Hb levels were significantly lower in the CD group than in the control group (all <em>P</em> ≤ 0.05). After adjusting for age, sex, and body mass index (BMI), there was a moderate positive correlation between BMFF and Hb in patients with CD (<em>r</em> = 0.445, <em>P</em> &lt; 0.001). No significant correlation was present between BMFF and RBC (<em>r</em> = 0.183, <em>P</em> = 0.069). The change in BMFF was negatively associated with the odds ratio of anaemia even after adjustment for demographic and CD characteristics (all <em>P</em> ≤ 0.001). Restricted cubic spline (RCS) regression showed a linear dose-response association between BMFF and the odds ratio of anaemia (<em>P</em> overall = 0.004, <em>P</em> for nonlinearity = 0.652). The AUC to differentiate between anaemia and nonanaemia was 0.703 for BMFF.</div></div><div><h3>Conclusion</h3><div>Decreased BMFF is associated with a high risk of anaemia in patients with CD.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106988"},"PeriodicalIF":2.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A nomogram based on magnetic resonance imaging to predict perineural invasion in mass intrahepatic cholangiocarcinoma: a two-centre, retrospective study","authors":"D. Liu ,&nbsp;H.-L. Chen ,&nbsp;F. Wang ,&nbsp;Y. He ,&nbsp;Y. Yang ,&nbsp;L. Wen ,&nbsp;Y.-F. Lv ,&nbsp;D. Zhang","doi":"10.1016/j.crad.2025.106985","DOIUrl":"10.1016/j.crad.2025.106985","url":null,"abstract":"<div><h3>AIM</h3><div>To evaluate the value of preoperative magnetic resonance imaging (MRI) in predicting perineural invasion (PNI) of mass intrahepatic cholangiocarcinoma (MICC) and construct a nomogram.</div></div><div><h3>MATERIALS AND METHODS</h3><div>This retrospective study included 228 patients with pathologically confirmed MICC who underwent preoperative MRI between January 2015 and November 2022 at two institutions. Patients were randomly divided into a training cohort (n = 160) and validation cohort (n = 68) in a 7:3 ratio based on PNI presence. Two radiologists independently analysed imaging features. Significant predictors were identified using univariate and multivariate logistic regression analyses. Predictive performance was validated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA). A nomogram was constructed based on the optimal model.</div></div><div><h3>RESULTS</h3><div>Age, presence of bile duct stones, T₂-weighted imaging (T₂WI) signal intensity, diffusion-weighted imaging (DWI) signal intensity, intratumoural exponential apparent diffusion coefficient (eADC) values, and the tumour-to-spleen eADC ratio were significant independent predictors of PNI (all <em>P</em> &lt; 0.05). The nomogram performed well in the training cohort (AUC: 0.839; 95% CI: 0.776–0.901) and validation cohort (AUC: 0.771; 95% CI: 0.658–0.883).</div></div><div><h3>CONCLUSION</h3><div>The T₂WI signal intensity, DWI signal intensity, intratumoural eADC values, and the tumour-to-spleen eADC ratio may serve as novel noninvasive biomarkers for predicting PNI in MICC patients. The proposed nomograms can be selectively applied to enhance the accuracy of preoperative PNI predictions in patient with ICC, thereby aiding in the development of surgical strategies.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106985"},"PeriodicalIF":2.1,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance (MR) and computed tomography (CT) imaging of temporal lobe encephalocele–associated epilepsy: a pictorial review","authors":"G.N. Cepeda De Jesus ,&nbsp;D. Nitz ,&nbsp;E. Damisah ,&nbsp;A. Mahajan ,&nbsp;A. Herlopian ,&nbsp;K.C. Vadivelu ,&nbsp;R.A. Bronen","doi":"10.1016/j.crad.2025.106980","DOIUrl":"10.1016/j.crad.2025.106980","url":null,"abstract":"<div><div>Temporal lobe encephaloceles (TLENs) are herniations of brain tissue through defects in the dura, often associated with conditions including elevated intracranial pressure, trauma, cerebrospinal fluid leak, and epilepsy. TLENs are frequently underdiagnosed, particularly in epilepsy patients, due to their subtle appearance on imaging and their location in the middle cranial fossa, delaying the diagnosis of this surgically treatable condition. This pictorial review will focus on the typical imaging appearance of TLENs in epilepsy patients, classic and unusual locations of TLENs associated with epilepsy, and related imaging features, such as those of idiopathic intracranial hypertension. We will also discuss some challenges and pitfalls that may lead to misdiagnosis and consider the tools and techniques which may help confirm the diagnosis.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106980"},"PeriodicalIF":2.1,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous electromagnetic navigation system for computed tomography (CT)-guided liver ablation: how far can we insert the antenna in the first scan?","authors":"P. Papadopoulos ,&nbsp;D. Chalmoukis ,&nbsp;P. Grigoropoulos ,&nbsp;A. Giannakis ,&nbsp;A. Chatziioannou ,&nbsp;N. Kelekis ,&nbsp;G. Lymperopoulou ,&nbsp;M. Krokidis ,&nbsp;D. Filippiadis","doi":"10.1016/j.crad.2025.106967","DOIUrl":"10.1016/j.crad.2025.106967","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate technical/clinical success/efficacy of a commercially available electromagnetic navigation system in computed tomography (CT)-guided microwave ablation (MWA) of primary or metastatic liver tumours.</div></div><div><h3>Materials and Methods</h3><div>This prospective observational study evaluated tumours treated with percutaneous CT-guided MWA using a commercially available electromagnetic navigation system under intravenous analgesia. Technical parameters evaluated included procedural duration and ratio of inserted probe length in first/final control scan. Inserted needle lengths were measured from the skin surface to the antenna tip at firstand final control scan. Clinical success was defined as lack of tumour remnant in 1st-month imaging follow-up. The Cardiovascular and Interventional Radiological Society of Europe (CIRSE) classification system was used for complications' reporting.</div></div><div><h3>Results</h3><div>A total of 64 patients (66.25 ± 8.87 years) and 80 tumours (2.69 ± 1.10 cm) were included in the study. Technical success was 98.75%. The mean duration of the procedure was 47.63 ± 19.88 min. The mean ratio of inserted antenna length between first and final scan was 70.92% (±15.86). Primary clinical success was 96.25% (tumour remnant at one-month followup in 3/80 tumours; all three cases retreated with ablation). Secondary clinical success was 100% (no tumour remnant in imaging follow-up). Recorded complications were Grade 1 (4 self-limited perihepatic haematomas requiring nothing but observation) and Grade 3 (1 hepatic abscess treated with percutaneous drainage).</div></div><div><h3>Conclusion</h3><div>The use of an electromagnetic navigation system for CT-guided MWA of malignant liver lesions can permit insertion of &gt;70% of the required microwave antenna length to target lesion in the first pass, with satisfactory technical and clinical success and low complication rate.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106967"},"PeriodicalIF":2.1,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of machine learning based on magnetic resonance imaging (MRI) and biopsy whole-slide image to predict pathological complete response to breast cancer after neoadjuvant chemotherapy: a two-centre study","authors":"J. Liu ,&nbsp;X. Wang ,&nbsp;N. Mao ,&nbsp;H. Hua ,&nbsp;X. Zhong ,&nbsp;J. Han ,&nbsp;J. Chen","doi":"10.1016/j.crad.2025.106976","DOIUrl":"10.1016/j.crad.2025.106976","url":null,"abstract":"<div><h3>AIM</h3><div>To develop and validate a combined model based on magnetic resonance imaging (MRI), and whole-slide imaging (WSI) to predict pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast cancer.</div></div><div><h3>MATERIALS AND METHODS</h3><div>We retrospectively enrolled 331 patients from two institutions, who pathologically confirmed to have invasive breast cancer and underwent NAC. Radiological features from original lesions on MRI and clinicopathological data were analysed using univariate and multivariate logistic analyses, which established the clinical model. Radiomics features were extracted based on the region of interest by manually delineating the primary focus on the sequences of the first phase of enhanced MRI, diffusion weighted imaging (DWI), and apparent diffusion coefficient (ADC) mapping. The radiomics prediction model was established using the Pearson product-moment correlation coefficient, least absolute shrinkage and selection operator (LASSO) regression analysis. A deep learning pathological model (DLPM) was established from WSIs of patients used AlexNet. The combined model was developed based on clinicopathological features, radiomics features, and pathomics deep learning features, and presented as a nomogram.</div></div><div><h3>RESULTS</h3><div>Five clinical and three deep learning features were screened and combined with the Rad-score to establish a combined model. The results showed that the nomogram had good predictive efficiency, with area under the curve (AUC) values of 0.95, 0.84, and 0.83 in the training, test, and external validation cohorts, respectively. The DeLong’s test showed that the difference in AUC values between the combined model and the other single models was statistically significant (p &lt; 0.05).</div></div><div><h3>CONCLUSION</h3><div>A combined nomogram based on MRI and biopsy WSI can predict pCR to NAC in patients with breast cancer.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106976"},"PeriodicalIF":2.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of shear wave elastography and B-mod ultrasonography of the achilles tendons in psoriasis patients without clinical diagnosis of psoriatic arthritis","authors":"E. Temel ,&nbsp;S. Ozhan Oktar ,&nbsp;B. Temel ,&nbsp;E. Adisen","doi":"10.1016/j.crad.2025.106978","DOIUrl":"10.1016/j.crad.2025.106978","url":null,"abstract":"<div><h3>AIM</h3><div>To investigate the utility of shear wave elastography (SWE) and conventional ultrasonography (B-mode and Power Doppler) (CUS) as imaging modalities to detect subclinical enthesopathy in early psoriatic arthritis (PsA).</div></div><div><h3>MATERIALS AND METHODS</h3><div>This study involved controls and patients with psoriasis who did not have a diagnosis of psoriatic arthritis. This study was conducted prospectively between January 2021 and June 2021 in a single centre. Age, gender, Psoriasis Area Severity Index (PASI) of the patients was recorded. CUS findings (thickness, contour change, hypoechoic heterogeneity, effusions, enthesophyte, bursitis, bone erosion, and increased tendon vascularity) of the Achilles tendons (ATs) were evaluated. Subsequently, SWE measurements in kilopascals (kPa) were conducted at the enthesis sites of the tendons.</div></div><div><h3>RESULTS</h3><div>The ATs of each of the 62 participants (31 patients and 31 controls) were evaluated. The mean age of the patients was 44.96 ± 17.44 years with a female dominance. The stiffness of the AT was significantly higher than the controls (p &lt; 0.05). There were no statistically significant differences in AT thicknesses between the groups (p &gt; 0.05). No significant correlation was found between the SWE of AT and PASI scores (p &gt; 0.05, r = 0.1).</div></div><div><h3>CONCLUSION</h3><div>This study found that although CUS did not show any significant findings, the tendons of patients with psoriasis without musculoskeletal symptoms were statistically significantly stiffer according to SWE values compared to controls. These results suggest that SWE may be more effective than CUS in detecting subclinical enthesopathy and predicting the development of PsA in patients with psoriasis.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106978"},"PeriodicalIF":2.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144501862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity focused ultrasound treatment of unresectable soft tissue sarcoma and desmoid tumours – a systematic review","authors":"M. Chetan ,&nbsp;M. Gillies ,&nbsp;S. Rehman ,&nbsp;C. McCarthy ,&nbsp;T. Cosker ,&nbsp;F. Wu ,&nbsp;P.C. Lyon","doi":"10.1016/j.crad.2025.106977","DOIUrl":"10.1016/j.crad.2025.106977","url":null,"abstract":"<div><h3>AIM</h3><div>We review the evidence for high-intensity focused ultrasound (HIFU) in the treatment of soft tissue sarcoma (STS) and desmoid tumour (DT).</div></div><div><h3>MATERIALS AND METHODS</h3><div>We searched Embase, Medline, PubMed, and Google Scholar for relevant studies between 2000-2024 using search terms ‘high intensity focused ultrasound’ and ‘sarcoma’ or ‘chordoma’ or ‘desmoid’. We extracted data on patient demographics and treatment outcomes.</div></div><div><h3>RESULTS</h3><div>We identified 12 studies pertaining to STS (n=178) and 15 studies pertaining to DT (n=417). These were prospective phase I/II open-label trials and retrospective case series or reports. The commonest adverse effects were skin burns, transient pain, and fever. Less common adverse effects of nerve injury and bowel perforation were depended on anatomic relations of the tumour. The majority of patients treated had unresectable disease that was partially ablated with HIFU for the purpose of local control. There was a high degree of variability in the reporting of outcomes making quantitative analysis challenging.</div></div><div><h3>CONCLUSION</h3><div>The studied papers show that HIFU has a favourable safety profile with a potential role in patients with unresectable STS and DT. HIFU may confer advantages in cases of oligometastatic progression for disease control, complex anatomy including proximity to vital structures, recurrent cases in previously radiotherapy-exposed and/or operated locations with limited other locally-directed treatment options. However, there is limited reporting of the clinically important outcomes of recurrence and survival and further research is required, and this may represent an opportunity for later-phase trials in the UK and worldwide.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106977"},"PeriodicalIF":2.1,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144481793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The role of the right atrial appendage and right atrium in post-radiofrequency ablation recurrence in different types of atrial fibrillation [Clin Radiol 79 (11) (2024) e1312–e1320]”","authors":"T. Pan ,&nbsp;X. Tian ,&nbsp;Y. Liu ,&nbsp;H.-Q. Yang ,&nbsp;G.-J. Ma ,&nbsp;X.-N. Han ,&nbsp;C.-Y. Li","doi":"10.1016/j.crad.2025.106945","DOIUrl":"10.1016/j.crad.2025.106945","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"86 ","pages":"Article 106945"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"T1 mapping of the sagittal images of the cervical cord: a potential biomarker to predict the severity of cervical spondylotic myelopathy","authors":"X. Wang ,&nbsp;X. Tian ,&nbsp;Y. Peng ,&nbsp;D. Zhang ,&nbsp;Y. Wang ,&nbsp;L. Zhang","doi":"10.1016/j.crad.2025.106974","DOIUrl":"10.1016/j.crad.2025.106974","url":null,"abstract":"<div><h3>Aims</h3><div>To investigate the applied value of quantitative assessment of the cervical spondylotic myelopathy (CSM) severity using T1 mapping of cervical spinal cord.</div></div><div><h3>Materials and Methods</h3><div>A total of 133 patients with CSM (CSM group) and 30 healthy volunteers (control group) were prospectively recruited between September 2023 and March 2024. Patients with CSM were categorized into a mild group (mJOA ≥12) and a severe group (mJOA &lt;12) according to the modified Japanese Orthopedic Association scores (mJOA). Cervical axial and sagittal T2WI, as well as sagittal T1 mapping were performed on all subjects. In the control group, native T1 was measured at each disc level (C2–C7); in the CSM group, native T1 was measured at the stenotic location, the disc level above and below the stenotic location (T1_stenosis,T1_above and T1_below). Interobserver agreement, univariate analyses, pearson's correlations, and ROC curves were performed.</div></div><div><h3>Results</h3><div>Native T1 showed excellent interobserver agreement in the control group. The mean T1 value of the control group (772.94 ± 57.87 ms) was significantly lower than the T1_stenosis(908.89 ± 135.61ms),T1_above (844.66 ± 126.97ms) and T1 _below (855.99 ± 125.52ms).The distribution of mJOA, T2(+), T1 _stenosis, T1_above and T1_below between the mild and severe groups differed (P&lt;0.05). All native T1 of CSM group showed negative correlations with mJOA. AUCs of T1 _stenosis,T1_above and T1_below identified the severity of CSM patients as 0.857, 0.711, and 0.733, respectively.</div></div><div><h3>Conclusions</h3><div>T1 mapping can quantitatively assess the severity of CSM patients, and native T1 of spinal cord at the stenosis level is a valuable parameter to differentiate between patients with mild and severe CSM.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"87 ","pages":"Article 106974"},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144321767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}