Clinical radiology最新文献

{"title":"Differential practice of peer review and peer feedback between National Health Service (NHS) imaging departments and teleradiology companies; how big is the gap?","authors":"R. Balasubramaniam,&nbsp;K. Drinkwater,&nbsp;M. Beavon,&nbsp;R. Greenhalgh","doi":"10.1016/j.crad.2025.106919","DOIUrl":"10.1016/j.crad.2025.106919","url":null,"abstract":"<div><h3>AIM</h3><div>Assessing the performance of peer review (PR) and peer feedback (PF) within National Health Service (NHS) imaging departments (NIDs) and teleradiology companies (TRCs) within the United Kingdom.</div></div><div><h3>MATERIAL AND METHODS</h3><div>All NHS providers with a clinical radiology audit lead registered with the Royal College of Radiologists and the major TRCs that provided services within the UK were invited to participate via a questionnaire.</div></div><div><h3>RESULTS</h3><div>All 6 TRCs (6/6) and 73% (146/200) of NIDs responded. All 6 TRCs performed formal PR and apportioned time for the role. Only 14/146 (10%) NIDs undertook formal PR, of which 4/14 (29%) received no remuneration for the work. In comparison, most NIDs 120/146 (82%) performed informal PR, using methods like multidisciplinary team meetings (MDTM) which occurred in 113/146 (77%). Peer feedback was practised by 104/146 (71%) NIDs and 5/6 (83%) TRCs, but only 30% to 49% of NIDs and 33% of TRCs used the content for reflective notes or incorporated it within appraisal. Electronic PF was possible in 36/146 (25%) NIDs and 3/6 (50%) TRCs. A peer moderator was present in 35% of NIDs and 50% of TRCs.</div></div><div><h3>CONCLUSION</h3><div>Formal PR was performed by all TRCs but underutilised within NIDs, where it was poorly remunerated. NHS imaging departments relied more on informal methods of PR, such as MDTM. The majority of NIDs and TRCs performed PF; however, the educational benefits of integrating PF within reflection and appraisal were often not implemented. Information technology systems to provide contemporaneous PF and a peer moderator could improve engagement but weren't present in most departments.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106919"},"PeriodicalIF":2.1,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning for liver lesion segmentation and classification on staging CT scans of colorectal cancer patients: a multi-site technical validation study","authors":"U. Bashir ,&nbsp;C. Wang ,&nbsp;R. Smillie ,&nbsp;A.K. Rayabat Khan ,&nbsp;H. Tamer Ahmed ,&nbsp;K. Ordidge ,&nbsp;N. Power ,&nbsp;M. Gerlinger ,&nbsp;G. Slabaugh ,&nbsp;Q. Zhang","doi":"10.1016/j.crad.2025.106914","DOIUrl":"10.1016/j.crad.2025.106914","url":null,"abstract":"<div><h3>AIM</h3><div>To validate a liver lesion detection and classification model using staging computed tomography (CT) scans of colorectal cancer (CRC) patients.</div></div><div><h3>MATERIALS AND METHODS</h3><div>A UNet-based deep learning model was trained on 272 public liver tumour CT scans and tested on 220 CRC staging CTs acquired from a single institution (2014–2019). Performance metrics included lesion detection rates by size (&lt;10 mm, 10–20 mm, &gt;20 mm), segmentation accuracy (dice similarity coefficient, DSC), volume measurement agreement (Bland–Altman limits of agreement, LOAs; intraclass correlation coefficient, ICC), and classification accuracy (malignant vs benign) at patient and lesion levels (detected lesions only).</div></div><div><h3>RESULTS</h3><div>The model detected 743 out of 884 lesions (84%), with detection rates of 75%, 91.3%, and 96% for lesions &lt;10 mm, 10–20 mm, and &gt;20 mm, respectively. The median DSC was 0.76 (95% CI: 0.72–0.80) for lesions &lt;10 mm, 0.83 (95% CI: 0.79–0.86) for 10–20 mm, and 0.85 (95% CI: 0.82–0.88) for &gt;20 mm. Bland–Altman analysis showed a mean volume bias of -0.12 cm³ (LOAs: -1.68 to +1.43 cm³), and ICC was 0.81. Lesion-level classification showed 99.5% sensitivity, 65.7% specificity, 53.8% positive predictive value (PPV), 99.7% negative predictive value (NPV), and 75.4% accuracy. Patient-level classification had 100% sensitivity, 27.1% specificity, 59.2% PPV, 100% NPV, and 64.5% accuracy.</div></div><div><h3>CONCLUSION</h3><div>The model demonstrates strong lesion detection and segmentation performance, particularly for sub-centimetre lesions. Although classification accuracy was moderate, the 100% NPV suggests strong potential as a CRC staging screening tool. Future studies will assess its impact on radiologist performance and efficiency.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106914"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local anaesthetics in interventional radiology: a primer for radiologists on applications and management of complications","authors":"J. Steinman ,&nbsp;K.T. Tan","doi":"10.1016/j.crad.2025.106917","DOIUrl":"10.1016/j.crad.2025.106917","url":null,"abstract":"<div><div>Local anaesthetics (LAs) allow a range of procedures to be performed in interventional radiology (IR) through improving patient comfort and reducing pain. This review serves as a primer for interventional radiologists, providing an overview of commonly used LAs and practical tips for their implementation. With its quick onset time and moderate duration of action, the amide lidocaine is the most used and applicable to a variety of procedures such as biopsies and embolization. In contrast, bupivacaine and ropivacaine (both amides) have longer durations of action, and are therefore suitable for lengthy procedures and pain control post-procedurally. Procaine, an ester, may be used in cases of amide anaesthetic allergies. This review examines the clinical applications of LAs in radiology and management of their adverse effects including local anaesthetic systemic toxicity (LAST) and allergic reactions. It concludes with a discussion of LAST, emphasising techniques for early intervention and management. The role of lipid emulsion therapy and modifications to the advanced cardiac life support (ACLS) protocol are highlighted, including a discussion of other aspects such as airway management. By presenting the latest strategies to manage LAST and adverse effects, this research aims to help standardise anaesthetic management in radiology. It provides actionable steps for selecting and injecting anaesthetics, and management of complications that will be beneficial for interventional radiologists performing a diverse array of procedures.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106917"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonrigid temporal registration of multiphase CT pulmonary angiography using low-kV and low contrast: a feasibility study with dual-source CT","authors":"Q.-H. Zhang ,&nbsp;S.-S. Lin ,&nbsp;X. Zhao ,&nbsp;Z. Qin ,&nbsp;H. Ge ,&nbsp;J.-X. Qian ,&nbsp;Y.-C. Wang","doi":"10.1016/j.crad.2025.106916","DOIUrl":"10.1016/j.crad.2025.106916","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to compare the nonrigid temporal registration of multiphase computed tomography pulmonary angiography (CTPA) with single-phase CTPA in terms of radiation dose, contrast agent usage, objective and subjective image quality.</div></div><div><h3>Materials and Methods</h3><div>Consecutive patients suspected of acute pulmonary embolism were prospectively included in this study, and randomly received multiphase or single-phase CTPA. Regarding the contrast media, 15 mL was applied in the multiphase CTPA in comparison with 40 mL applied in the single-phase CTPA. Temporal registration was performed for multiphase CTPA during post-processing. Two experienced radiologists independently evaluated the image quality (IQ) based on objective measurements, subjective impression and diagnostic confidence. Patient demographics, scan parameters and image quality were compared between the two groups.</div></div><div><h3>Results</h3><div>A total of 72 patients were analysed (37 multiphase CTPA and 35 single-phase CTPA). Positive pulmonary embolism was confirmed in five and seven patients, respectively. The two patient groups had similar demographics besides older age in those who underwent single-phase CTPA. Radiation dose and the contrast-to-noise ratio (CNR) were also similar between groups except for the CNR in the right main pulmonary artery. Both readers rated the multiphase CTPA with a statistically superior subjective IQ over the single-phase CTPA. The diagnostics confidence of the two CTPA protocols was similarly rated by one reader and slightly different according to the second reader.</div></div><div><h3>Conclusion</h3><div>The nonrigid temporal registration of multiphase CT pulmonary angiography could offer similar or even better image quality than the single-phase protocol and significantly reduce the amount of contrast usage.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106916"},"PeriodicalIF":2.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased cerebral hemodynamics during the interictal period of migraine and the association with migraine features","authors":"Y. Liu ,&nbsp;A. Sun ,&nbsp;Y. Zhang ,&nbsp;B. Wang ,&nbsp;X. Kuang ,&nbsp;F. Dai ,&nbsp;H. Wang ,&nbsp;J. Ding ,&nbsp;X. Wang","doi":"10.1016/j.crad.2025.106918","DOIUrl":"10.1016/j.crad.2025.106918","url":null,"abstract":"<div><h3>Aim</h3><div>To detect cerebral hemodynamic changes in migraine’s interictal period using 4D flow magnetic resonance imaging (MRI) and explore the relationships between altered hemodynamics and migraine features.</div></div><div><h3>Materials and Methods</h3><div>Twenty-five patients (29 ± 4 years, 22 female) with migraine in the interictal period and twenty-five healthy controls (28 ± 4 years, 20 female) were consecutively enrolled. Migraine features including frequency, duration of migraine history, pain side and degree were collected in migraineurs. 4D flow MRI scan was performed for all subjects. Cross-sectional area, peak systolic through-plane velocity (PSV), average through-plane velocity (V_avg), average blood flow rate (Flow_avg), and average wall shear stress (WSS_avg) in the bilateral middle cerebral artery (MCA) and the posterior cerebral artery (PCA) were measured. Pulsatility index (PI) was calculated from the maximum, minimum and average blood flow velocity. The hemodynamic differences of MCA and PCA in migraineurs and controls were investigated. The relationships between hemodynamic changes and migraine features were further explored.</div></div><div><h3>Results</h3><div>Increased PSV, V_avg and Flow_avg in the MCA, as well as elevated V_avg, Flow_avg and WSS_avg in the PCA, were found among migraine patients. Flow_avg of PCA was significantly correlated with the duration of migraine history (r = 0.46, <em>P</em> = 0.02).</div></div><div><h3>Conclusion</h3><div>Cerebral hemodynamics is significantly elevated in migraineurs during the interictal period of migraine. Notably, the Flow_avg in the PCA is associated with the duration of migraine history.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106918"},"PeriodicalIF":2.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in paediatric splenic trauma management in adult and combined major trauma centres in England","authors":"H. Sanchez-Lewis ,&nbsp;P. Jenkins ,&nbsp;L. Sorrell ,&nbsp;L. Watkins ,&nbsp;J. Zhong ,&nbsp;J.E. Smith ,&nbsp;V. Allgar ,&nbsp;C. Roobottom ,&nbsp;I. Mccafferty","doi":"10.1016/j.crad.2025.106904","DOIUrl":"10.1016/j.crad.2025.106904","url":null,"abstract":"<div><h3>Aim</h3><div>Treatment options for paediatric splenic injuries include conservative management, splenic embolisation, and splenectomy. Within the UK, in addition to standalone paediatric trauma centres, adult and combined (adult and paediatric) major trauma centres (MTCs) receive traumatically injured children. We describe the treatment of paediatric splenic injuries between 2017 and 2021 in the United Kingdom adult and combined MTCs.</div></div><div><h3>Materials and Methods</h3><div>Data were extracted from the Trauma Audit and Research Network (TARN) for all patients &lt;18 years old with splenic injuries admitted between 01/01/17 and 31/12/21 at adult and combined MTCs. The relationship between injury and centre type, treatment, and outcomes was assessed using chi-squared and Fisher's exact tests.</div></div><div><h3>Results</h3><div>A total of 690 children were included. The median age was 13.9 years (interquartile range: 10.9-16.1), and 78.7% (543/690) of the patients were male. A total of 92.9% (641/690) of patients suffered blunt injuries; 7.1% (49/690) suffered penetrating. Of those known, 69.5% (182/262) were treated in a combined MTC and 30.5% (80/262) at an adult MTC.</div><div>Treatment included: A total of 90.4% (624/690) received conservative management, 5.5% (38/690) underwent splenic embolisation, and 4.1% (28/690) had a splenectomy. Embolisation and splenectomy rates at adult-only MTCs were 8.8% (7/80) and 10% (8/80), respectively, compared to 4.4% (8/182) and 1.6% (3/182) in combined MTCs (<em>P</em> = 0.002). No embolised patients required a subsequent splenectomy. The mortality rates were 8.8% (7/80) in adult and 3.3% (6/182) in combined centres (<em>P</em> = 0.118).</div></div><div><h3>Conclusion</h3><div>Embolisation is performed more (5.5%) than splenectomy (4.1%). Combined MTCs demonstrate superior outcomes and lower intervention rates than adult-only MTCs. These findings should inform strategies to standardise paediatric trauma care within the UK.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106904"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of MRI findings by pTERT mutation status and the prognostic significance in GBM patients with recurrent lesions","authors":"G. Quan ,&nbsp;C. Wang ,&nbsp;Y. Liu ,&nbsp;T. Yuan","doi":"10.1016/j.crad.2025.106913","DOIUrl":"10.1016/j.crad.2025.106913","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate the MRI characteristics of recurrent glioblastoma (GBM) in relation to telomerase reverse transcriptase-promoter (pTERT) mutation status and their prognostic significance.</div></div><div><h3>Materials and Methods</h3><div>A retrospective analysis was conducted on 80 patients with primary IDH wild-type GBM. MRI features, including conventional and functional imaging, were compared between pTERT mutant and wild-type groups. Cox regression and receiver operating characteristic (ROC) analyses were performed to evaluate survival outcomes and predictive models.</div></div><div><h3>Results</h3><div>Compared to patients with wild-type pTERT (n = 24), those with mutant pTERT (n = 56) were older (p = 0.008) and had shorter overall survival (OS) (p = 0.003). They also exhibited a higher incidence of massive-like enhancement (p = 0.036) and new subependymal enhancement (p = 0.034), lower relative apparent diffusion coefficient (rADC) (p = 0.006), and higher relative cerebral blood volume (rCBV) (p = 0.048) and choline/N-acetyl aspartate ratio (p = 0.033). Multivariate analysis identified new subependymal enhancement (HR = 2.348, p = 0.018) and massive-like enhancement (HR = 2.348, p = 0.018) as independent risk factors for shorter OS. The areas under the ROC curve (AUCs) for predicting poor OS using pTERT mutation status, conventional MRI, and combination models were 0.700, 0.695, and 0.764, respectively. Among the 31 patients with available functional MRI data, the AUCs for prediction using functional MRI, conventional MRI + pTERT mutation status, and the combination model were 0.783, 0.710, and 0.888, respectively.</div></div><div><h3>Conclusions</h3><div>MRI features, particularly subependymal and massive-like enhancements, along with pTERT mutation status, serve as valuable prognostic markers for survival outcomes in recurrent GBM patients. The combination model incorporating MRI characteristics and genetic status enhances predictive accuracy.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106913"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative chest computed tomography: regional differences in dual-energy-derived virtual vs. true non-contrast scans","authors":"Q.D. Strotzer ,&nbsp;C. Schachner ,&nbsp;L. Scheuermeyer ,&nbsp;F. Raab ,&nbsp;S. Meiler ,&nbsp;M.V. Malfertheiner ,&nbsp;C. Stroszczynski ,&nbsp;O.W. Hamer","doi":"10.1016/j.crad.2025.106912","DOIUrl":"10.1016/j.crad.2025.106912","url":null,"abstract":"<div><h3>Aim</h3><div>Quantitative analysis of chest computed tomography (CT) usually requires non-contrast scans. Multi-energy CT-derived virtual non-contrast (VNC) images may obviate additional true non-contrast (TNC) scans. We aimed to quantitatively compare virtual and true non-contrast images, with a focus on regional differences in pulmonary tissue.</div></div><div><h3>Materials and Methods</h3><div>This bi-center retrospective, IRB-approved study included consecutive patients who received contrast-enhanced dual-energy and non-contrast chest CT scans within one year between April 2018 and December 2022. Scans were co-registered and semi-manually segmented into various volumes of interest: whole lung, center/periphery, ventral/dorsal half and upper/middle/lower third. The mean lung density, high and low attenuation volumes and the lower 15th percentile were computed from the VNC and TNC scans for each volume. Correlation and agreement were assessed using Pearson’s and intraclass correlation coefficients and Bland–Altman analysis. Subgroup analyses involved body mass index and markers of pulmonary emphysema.</div></div><div><h3>Results</h3><div>Forty-eight patients were included (26 females, median age: 63 years, interquartile range: 58–69). Pearson’s and intraclass correlation coefficients &gt; 0.9 demonstrated high correlation and agreement for the mean lung density, low attenuation volume and the lower 15th percentile across the whole lung. The agreement for high attenuation volume was slightly less pronounced (intraclass correlation coefficient, 0.84 [95% confidence interval: 0.73, 0.91]). Regional differences were observed, for example, concerning the mean lung density with mean differences (HU_VNC minus HU_TNC) of -5.71 HU [-11.07, -0.35], 1.62 HU [-2.98, 6.23] and 5.77 HU [-0.47, 12.01] for the upper, middle and lower third, respectively.</div></div><div><h3>Conclusion</h3><div>Although slight regional differences were observed, quantitative analysis can be reliably performed using VNC images.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106912"},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCR meetings","authors":"","doi":"10.1016/S0009-9260(25)00079-0","DOIUrl":"10.1016/S0009-9260(25)00079-0","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"83 ","pages":"Article 106874"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paid MBP advert: 250120_Thoracic Imaging-CR-210x280-v2","authors":"","doi":"10.1016/S0009-9260(25)00080-7","DOIUrl":"10.1016/S0009-9260(25)00080-7","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"83 ","pages":"Article 106875"},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}