Clinical radiology最新文献

{"title":"Determinants of clinical success and complications in fluoroscopy-guided self-expandable metal stent for treatment of malignant rectal obstruction","authors":"Y. Wan ,&nbsp;M.-S. Zou ,&nbsp;D. Li ,&nbsp;H.-H. Wu ,&nbsp;B. Zhang","doi":"10.1016/j.crad.2025.106869","DOIUrl":"10.1016/j.crad.2025.106869","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate the safety and efficacy of self-expanding metal stents (SEMS) in the management of patients with malignant rectal obstruction (MRO), as well as to identify the factors contributing to clinical failure and associated complications.</div></div><div><h3>MATERIALS AND METHODS</h3><div>Cases of MRO from September 2014 to July 2024 were retrospectively collected and reviewed. Patient data were analyzed to identify determinants influencing clinical success rates and short-term complications. Subsequently, the log-rank test and Cox proportional hazards model were employed to investigate factors affecting stent patency in palliative treatment.</div></div><div><h3>RESULTS</h3><div>A cohort of 66 MRO patients was included in the analysis. The technical and clinical success rates were observed to be 98.5% and 95.5%, respectively. Multivariate analysis identified the time of obstruction as a significant predictor for clinical success rate (OR = 1.081; 95% CI = 1.081 to 1.148; p=0.010) and the incidence of short-term complications (OR = 1.061; 95% CI = 1.008 to 1.116; p=0.022). In a cohort of 38 patients undergoing palliative treatment, Cox regression analysis identified postoperative chemotherapy as the significant determinant influencing stent patency duration (OR = 0.25; 95% CI = 0.082 to 0.762; p=0.015).</div></div><div><h3>CONCLUSION</h3><div>For MRO patients, SEMS constitutes an efficacious and successful therapeutic approach. Prompt alleviation of the obstruction is associated with a high rate of clinical success and a reduced incidence of short-term complications. Furthermore, in patients undergoing palliative treatment, the administration of postoperative chemotherapy has been shown to extend the duration of stent patency.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"84 ","pages":"Article 106869"},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of TVUS and MRI in the preoperative evaluation of myometrial infiltration in patients with endometrial cancer: A meta-analysis","authors":"Y. Jin,&nbsp;C. Zhou","doi":"10.1016/j.crad.2025.106868","DOIUrl":"10.1016/j.crad.2025.106868","url":null,"abstract":"<div><h3>AIM</h3><div>The incidence of endometrial cancer is on the rise worldwide. Accurate preoperative evaluation of myometrial infiltration is crucial for developing treatment strategies. This study compares the diagnostic accuracy of transvaginal ultrasound (TVUS) and magnetic resonance imaging (MRI) for myometrial infiltration (MI) in endometrial cancer (EC).</div></div><div><h3>MATERIALS AND METHODS</h3><div>We performed a systematic review and meta-analysis of observational studies, identified by screening Web of Science, SCOPUS, MEDLINE, PubMed, Google Scholar, and EMBASE databases. Studies published between January 1964 and June 2024 comparing the diagnostic accuracy of TVUS and MRI for MI were included. The data analysis focused on sensitivity, specificity, and overall diagnostic accuracy.</div></div><div><h3>RESULTS</h3><div>Twenty-two studies in EC patients were included. The diagnostic odds ratio (OR) for TVUS and for MRI was 18 (95% CI: 22-26) and 20 (95% CI: 14-28), respectively. TVUS was associated with a sensitivity and specificity of 76% (95% CI: 72-82%) and 84% (95% CI: 79-88%), respectively, while MRI had a sensitivity and specificity of 79% (95% CI: 73-84%) and 84% (95% CI: 80-88%), respectively. The area under the receiver operating characteristic curve (AUCROC) was 0.88 for TVUS and 0.89 for MRI. No significant publication bias was detected.</div></div><div><h3>CONCLUSIONS</h3><div>Both TVUS and MRI demonstrated comparable diagnostic accuracy for the preoperative evaluation of MI in EC.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106868"},"PeriodicalIF":2.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics analysis of 18F-FDG PET/CT for visceral pleural invasion in non-small cell lung cancer with pleural attachment","authors":"Yi Li ,&nbsp;J.-J. Qi ,&nbsp;M.-J. Shen ,&nbsp;Q.-P. Zhao ,&nbsp;L.-Y. Hao ,&nbsp;X.-D. Wu ,&nbsp;W.-H. Li ,&nbsp;L. Zhao ,&nbsp;Y. Wang","doi":"10.1016/j.crad.2025.106867","DOIUrl":"10.1016/j.crad.2025.106867","url":null,"abstract":"<div><h3>AIM</h3><div>This study aimed to establish and validate a preoperative model that integrates clinical factors and radiomic features from 2-[¹⁸F]-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) positron emission tomography (PET)/computed tomography (CT) for predicting visceral pleural invasion (VPI) in non-small cell lung cancer (NSCLC) with radiological pleural attachment.</div></div><div><h3>MATERIALS AND METHODS</h3><div>A total of 974 NSCLC patients (408 with VPI-present and 566 with VPI-absent) were retrospectively included from two medical centres. Clinical data and PET/CT radiomic features were collected. The optimal predictors from these radiomic features were selected to create the radiomics score (Rad-score) for the PET/CT radiomics model. Significant clinical factors and Rad-scores were incorporated into a combined PET/CT radiomics-clinical model. The predictive performance of the models was assessed using receiver operating characteristic (ROC) analysis.</div></div><div><h3>RESULTS</h3><div>The combined PET/CT radiomics-clinical model predicted VPI status with areas under the ROC curve (AUCs) of 0.869, 0.858, and 0.863 in the training set (n=569), internal validation set (n=245), and external validation set (n=160), respectively. These were significantly higher than the AUCs of the PET/CT radiomics model, which were 0.828, 0.782, and 0.704 (all <em>P</em>&lt;0.001). In patients with a maximum tumour diameter (Dmax) ≤ 3 cm (n=537) and in patients with adenocarcinoma (n=659), the AUCs of the combined model were 0.876 and 0.877, respectively. A nomogram based on the combined model was developed, with well-fitted calibration curves.</div></div><div><h3>CONCLUSION</h3><div>The combined PET/CT radiomics-clinical model provides an advantage in predicting VPI status in NSCLC with pleural attachment.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106867"},"PeriodicalIF":2.1,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One class classification-empowered radiomics for noninvasively accurate prediction of glioma isocitrate dehydrogenase mutation using multiparametric magnetic resonance imaging","authors":"J. Jian ,&nbsp;L. Xu ,&nbsp;C. Gong ,&nbsp;S. Ding ,&nbsp;X. Gong ,&nbsp;X. Yuan ,&nbsp;W. Zheng ,&nbsp;X. Wang ,&nbsp;Y. Zhang","doi":"10.1016/j.crad.2025.106866","DOIUrl":"10.1016/j.crad.2025.106866","url":null,"abstract":"<div><h3>Background</h3><div>Noninvasive detection of isocitrate dehydrogenase (<em>IDH</em>) mutations is crucial for preoperative decision-making in patients with glioma. While radiomics has been applied, data imbalance—specifically between <em>IDH</em> wild-type and mutated genes—remains underexplored. We developed a one-class classification-empowered radiomics (OCCR) model, trained exclusively on <em>IDH</em> wild-type patients, to distinguish them from <em>IDH</em> mutation cases.</div></div><div><h3>Materials and Methods</h3><div>This study included 495 patients from the UCSF Preoperative Diffuse Glioma MRI dataset. T1, T1ce, and FLAIR sequences were registered to T2 and resampled to a 1-mm isotropic resolution. The coregistered data were skull-stripped, and the tumor region was segmented using an ensemble model, followed by manual refinement. We extracted 386 radiomics features from the four MRI sequences and input them into an auto-encoder with 7 hidden layers for reconstruction. The OCCR model was trained on wild-type <em>IDH</em> patients, using the mean square error between the original and reconstructed features as guidance. During validation, reconstruction error was used to differentiate <em>IDH</em> mutations from the wild type.</div></div><div><h3>Results</h3><div>The hold-out validation demonstrated that OCCR performance improved as the number of training samples increased, achieving a peak area under the receiver operating characteristic curve of 0.8018. Visualization of reconstruction errors highlighted first-order and gray-level co-occurrence matrix features in the T1ce sequence.</div></div><div><h3>Conclusions</h3><div>This study demonstrates the feasibility of integrating one-class classification into radiomics for the determination of preoperative <em>IDH</em> mutation status in patients with glioma using multiparametric MRI. This versatile model holds potential for other diseases with substantial data imbalance.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"84 ","pages":"Article 106866"},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year outcome of retrograde vascular access in peripheral arterial disease of Asian origin","authors":"G.-R. Liou ,&nbsp;C.-P. Hsu ,&nbsp;C.-Y. Huang","doi":"10.1016/j.crad.2025.106865","DOIUrl":"10.1016/j.crad.2025.106865","url":null,"abstract":"<div><h3>Background</h3><div>Retrograde puncture is a safe alternative after the antegrade approach has failed, and complications at the puncture site are rare. However, the differences in the retrograde puncture side, outcomes, and complications between intermittent claudication (IC) and chronic limb ischaemia (CLI) remain unclear, particularly for Asian populations, and studies on this population are scarce.</div></div><div><h3>Material and methods</h3><div>A retrospective analysis was conducted on 255 consecutive patients with symptomatic peripheral arterial disease undergoing tibio-pedal or distal femoral artery retrograde puncture for endovascular intervention at our institute between January 2018 and December 2022. Preoperative, periprocedural, and postoperative complications and long-term outcomes were evaluated.</div></div><div><h3>Results</h3><div>The success rates for puncture and cannulation were 100% and 86.4%, respectively, in the intermittent claudication group (IC) and 95.8% and 81.5%, respectively, in the chronic limb ischaemia group (CLI). Failure was primarily due to vessel calcification and small vessel calibre hindering penetration and to occluded lesions. Puncture-related complications included fistula formation, haematoma, distal embolism, vessel spasm, and foreign body trapping in the lumen and occurred in 6.8% of patients in the IC group and 8.5% of those in the CLI group. The IC group had a significantly shorter admission duration (10.0 ± 14.4 vs. 16.4 ± 16.6 days, p=0.001∗).</div></div><div><h3>Conclusions</h3><div>In Asian patients with peripheral arterial disease, retrograde puncture is a safe and effective alternative in IC and CLI cases in which the antegrade method fails.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"84 ","pages":"Article 106865"},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the diagnostic efficacy of dual-energy computed tomography (DECT)-derived intervertebral muscle fat content and computed tomography (CT) attenuation for lumbar intervertebral disc degeneration","authors":"Z. Meng ,&nbsp;M. Liu ,&nbsp;A. Xiong,&nbsp;Y. Guo,&nbsp;S. Deng,&nbsp;J. Cao,&nbsp;X. Tian,&nbsp;X. Meng,&nbsp;J. Qin,&nbsp;X. Wang","doi":"10.1016/j.crad.2025.106864","DOIUrl":"10.1016/j.crad.2025.106864","url":null,"abstract":"<div><h3>AIM</h3><div>To evaluate the diagnostic performance of dual-energy computed tomography (DECT)-derived multifidus (MF) and erector spinae (ES) muscle fat content for lumbar intervertebral disc degeneration.</div></div><div><h3>MATERIAL AND METHODS</h3><div>A retrospective study analysed 36 patients who underwent DECT and magnetic resonance imaging within a week, assessing Pfirrmann grade across age (young, middle, elderly) and gender groups (female, male). ROIs were delineated to measure fat fraction (FF) and CT attenuation (HU). Correlation of MF-HU, MF-FF, ES-HU, and ES-FF with Pfirrmann grade was examined in total samples, age, and gender groups. Statistical differences in HU and FF among age and gender groups and Pfirrmann grade groups were compared. Receiver operating characteristic curve (AUC) analysis was performed to evaluate the performance and cutoff values of MF-FF, ES-FF, and combined models with body mass index (BMI) + age + MF-FF/ES-FF.</div></div><div><h3>RESULTS</h3><div>MF-FF、ES-FF showed moderate correlation with Pfirrmann grade (r = 0.587, 0.587). Values were higher in the young-age group (r = 0.579, 0.605) than in the middle-aged and high-year groups, with values in females (r = 0.614, 0.602) associated with higher Pfirrmann grade than in males. Female MF-FF and ES-FF were significantly higher than their male counterparts in each age group (P &lt; 0.05). AUC values for MF-FF and ES-FF were higher than other indicators in grades ≥2 and ≥ 3. Combined models of BMI + age + MF-FF/ES-FF improved AUC values in grades ≥4 and ≥ 5, especially for grades ≥5.</div></div><div><h3>CONCLUSION</h3><div>MF-FF and ES-FF exhibit stronger correlations in the young-age group, surpassing males in all age groups. Their diagnostic value is higher in early lumbar intervertebral disc degeneration compared to later stages. The combined model of BMI + age + MF-FF/ES-FF compensates for the diagnostic limitations in advanced intervertebral disc degeneration.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"86 ","pages":"Article 106864"},"PeriodicalIF":2.1,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the therapeutic potential of ultrasound-guided nerve hydrodissection: a comprehensive retrospective analysis","authors":"M. Sabbineni ,&nbsp;P. Ajmera ,&nbsp;B. Wang ,&nbsp;V. Varma ,&nbsp;L. Mbuagbaw ,&nbsp;H.N. Choudur","doi":"10.1016/j.crad.2025.106863","DOIUrl":"10.1016/j.crad.2025.106863","url":null,"abstract":"<div><h3>Aim</h3><div>To determine the efficacy of ultrasound-guided nerve hydrodissection for the clinical improvement of commonly entrapped peripheral nerves.</div></div><div><h3>Materials and methods</h3><div>A retrospective review of patient information was conducted for the period of Jan 2015-Dec 2020. Potential patients were identified using a keyword search for ‘hydrodissection’ and/or ‘perineural injection’ from radiology reports. Data included patient age, sex, intervention date, target peripheral nerve, pre-intervention clinical presentation, electromyography (EMG) data and patient outcomes at 3 weeks, 3 months and 6 months post-procedure. Outcomes included pain (as rated on the visual analog scale, 1–10), numbness, tingling, paraesthesias, mobility and others. The data were used to assess intervention efficacy based on each peripheral nerve as well as total peripheral nerves.</div></div><div><h3>Results</h3><div>Data were collected for 204 patients for various peripheral nerves. At the 3-week follow-up, 48% demonstrated minimal improvement, 18% demonstrated moderate improvement and 34% demonstrated significant improvement. At the 3-month follow-up, 52% demonstrated minimal improvement, 20% demonstrated moderate improvement and 28% demonstrated significant improvement. Finally, at the 6-month follow-up, 56% demonstrated minimal improvement, 14% demonstrated moderate improvement and 30% demonstrated significant improvement.</div></div><div><h3>Conclusion</h3><div>Moderate to significant clinical improvement was noted in half of the patients and minimal improvement in the remaining half of the patients who had undergone ultrasound-guided nerve hydrodissection. To date, there are few studies assessing the effectiveness of ultrasound-guided hydrodissection. These results therefore have implications for the use of this dynamic, percutaneous, ultrasound-guided intervention using steroid and local anaesthetic for multiple peripheral nerves.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"85 ","pages":"Article 106863"},"PeriodicalIF":2.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143790959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative prediction of muscle invasion in bladder cancer in the Indian population using the Vesical Imaging-Reporting and Data System (VI-RADS) score and individual multiparametric magnetic resonance imaging (MRI) characteristics","authors":"A. Selvaraju ,&nbsp;N.K. Patbamniya ,&nbsp;M. Kumar ,&nbsp;A. Seth ,&nbsp;S. Kaushal ,&nbsp;C.J. Das","doi":"10.1016/j.crad.2025.106862","DOIUrl":"10.1016/j.crad.2025.106862","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to prospectively validate the Vesical Imaging-Reporting and Data System (VI-RADS) score in the preoperative prediction of muscle invasion in bladder cancer in the Indian population.</div></div><div><h3>Materials and Methods</h3><div>The study prospectively reviewed patients with bladder masses who underwent 1.5T multiparametric magnetic resonance imaging between December 2018 and April 2023. Clinical and pathological data were collected, and bladder tumors were evaluated using a 5-point VI-RADS scoring system. Independent measurements of quantitative parameters (maximum tumor diameter [DMax] and tumor contact length [TCL]) were performed. These parameters and VI-RADS scores were compared to postoperative pathology to assess muscle invasion. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated using a cutoff score of 4. Receiver Operating Characteristic (ROC) analysis evaluated the diagnostic performance of quantitative values.</div></div><div><h3>Results</h3><div>A total of 55 patients were included in the analysis, of whom 36 were non–muscle invasive and 19 were muscle invasive on the final histopathological report. A VI-RADS score of ≥4 as the cutoff for muscle invasion yielded a sensitivity and specificity of 94.7% (95% CI 72.7%–99.9%) and 97.2% (95% CI 85%–99.9%), with PPV and NPV value of 94.7% and 97.2%, respectively. The receiver operating curve showed an area under the curve (AUC) of 0.958 (95% CI 0.89-1.0). The AUC of TCL and TCL/DMax values for muscle invasion were 0.811 and 0.835, respectively.</div></div><div><h3>Conclusions</h3><div>The VI-RADS scoring system, qualitative parameters, as well as the TCL and TCL/Dmax exhibits a strong correlation with pathological staging, indicating to be an effective method for the preoperative determination of muscle invasion in bladder cancer.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"84 ","pages":"Article 106862"},"PeriodicalIF":2.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143680939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal vein sampling: accuracy of earlier sampling post adrenocorticotropic hormone (ACTH) administration","authors":"Q.X. Tee ,&nbsp;J.C.G. Doery ,&nbsp;A. Desra ,&nbsp;P.J. Fuller ,&nbsp;J. Yang ,&nbsp;K.K. Lau","doi":"10.1016/j.crad.2025.106861","DOIUrl":"10.1016/j.crad.2025.106861","url":null,"abstract":"<div><h3>Aim</h3><div>Multiple studies recommend sampling at least 15-30-minutes post administration of ACTH. The aim of this retrospective study was to determine the impact on adrenal vein sampling (AVS) result interpretation when obtaining post-ACTH blood samples earlier, at 5- and 10-minutes, compared to the standard 15-30 minutes.</div></div><div><h3>Materials and methods</h3><div>All consecutive adult patients who underwent AVS using the simultaneous sampling method between August 2023 and March 2024 were included. The differences in adrenal vein aldosterone and cortisol levels at 5- and 10-minutes were compared to the referenced 15-minute samples.</div></div><div><h3>Results</h3><div>A total of 46 AVS studies were included. On average, there was an 11- and 9-fold increase in the SI between the pre- and post-ACTH samples on the right and left respectively, indicating appropriate adrenal vein cannulation. Most of the percentage differences between the levels of cortisol and aldosterone at 5- and 10-minutes compared to those at 15-minutes were within 1 standard deviation from the median. There was no significant difference in LI or overall lateralisation between the 5-minute (paired t-test <em>P</em> = 0.18) and the 10-minute sample (paired t-test <em>P</em> = 0.61) compared to the 15-minute sample. The LI at 5-minutes and 10 minutes demonstrated strong correlation with that at 15-minutes. There was one exception where the LI of the 5- and 10-minute samples were discordant with the 15-minute sample, but concordant with the pre-ACTH sample.</div></div><div><h3>Conclusion</h3><div>AVS can be a lengthy and technically challenging procedure. Being able to sample much earlier post-ACTH may help improve procedural efficiency, reduce procedural risks and minimize patient discomfort.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"84 ","pages":"Article 106861"},"PeriodicalIF":2.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143682069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of triglyceride-glucose index in aortic valve calcification progression: a prospective and Mendelian randomization analysis","authors":"Q.-Y. Hao ,&nbsp;J.-W. Gao ,&nbsp;Y.-H. Zeng ,&nbsp;S.-L. Zhang ,&nbsp;Z.-C. Xiong ,&nbsp;S.-C. Li ,&nbsp;Z.-W. Lin ,&nbsp;P.-Z. Yang ,&nbsp;P.-M. Liu ,&nbsp;Z.-H. Li","doi":"10.1016/j.crad.2025.106860","DOIUrl":"10.1016/j.crad.2025.106860","url":null,"abstract":"<div><h3>Aim</h3><div>The triglyceride-glucose (TyG) index, recognized as a surrogate marker for insulin resistance, is an established cardiovascular risk factor. We aimed to prospectively investigate the association between the TyG index and aortic valve calcific (AVC) progression, as well as its relationship with incident calcific aortic valve stenosis (CAVS).</div></div><div><h3>Materials and Methods</h3><div>A post hoc analysis was conducted on 5589 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) database. The TyG index was calculated using ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL]/2). Multivariate Cox regression assessed the association between baseline TyG index and AVC progression. Two-sample Mendelian randomization (MR) analysis was employed to evaluate the potential causality between the TyG index and CAVS.</div></div><div><h3>Results</h3><div>Over a median 2.4 years follow up, 567 cases of AVC progression were idenrified. After adjusting for traditional cardiovascular risk factors, each 1-SD increase in the TyG index was associated with a 20.8% increased risk of AVC progression. Robustness was confirmed in sensitivity analyses and nearly all subgroups. Two sample MR analysis supported a causal relationship between a higher TyG index and increased risk of CAVS.</div></div><div><h3>Conclusion</h3><div>A higher TyG index independently predicts AVC progression and causally influences CAVS incidence in the general population.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"84 ","pages":"Article 106860"},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}