{"title":"Computed tomography (CT)-based classification and management pathways for hybrid lesions in children: a comparative analysis of congenital pulmonary airway malformation (CPAM) and bronchopulmonary sequestration (BPS)","authors":"C. Zhou , D. He , J. Li , Q. He , J. Tian , H. Wu","doi":"10.1016/j.crad.2025.106996","DOIUrl":"10.1016/j.crad.2025.106996","url":null,"abstract":"<div><h3>AIM</h3><div>To establish a CT-based classification system for hybrid lesions in children, elucidate misdiagnosis mechanisms, and propose optimized clinical management pathways through comparative analysis with isolated CPAM and BPS.</div></div><div><h3>MATERIALS AND Methods</h3><div>This retrospective study analyzed 393 children with surgically confirmed congenital lesions (87 hybrids, 218 CPAMs, 88 BPS) from two centers (2010-2022). Hybrid lesions were classified preoperatively: Type A: cystic lesion + systemic arterial supply; Type B: solid lesion + systemic arterial supply; Type C: solid lesion - systemic arterial supply. Comparative analysis of clinical and imaging features was performed.</div></div><div><h3>Results</h3><div>Type A(51 cases, 58.6%): Predominantly Type 2 CPAMs (cyst diameter <2.85 cm, AUC = 0.963) with intralobar BPS (88.2%). Prenatal detection rate: 70.6% (36/51); symptomatic rate: 37.3% (19/51). Type B (33 cases, 37.9%): Solid lesions with extralobar BPS (78.8%). Prenatal detection rate: 84.8% (28/33); symptomatic rate: 24.2% (8/33). Type C (3 cases, 3.4%): 100% misdiagnosis due to absent systemic arterial supply. Hybrid lesions demonstrated significantly higher prenatal detection rates than isolated CPAMs and BPS (75.9% vs. 51.4% vs. 56.8%, P<0.001) but lower symptomatic rates (31.0% vs. 62.4% vs. 48.9%, P<0.001). Radiologically, hybrid lesions predominantly involved the left lower lobe (66.7% vs. 28.0% in CPAMs, P<0.001).</div></div><div><h3>Conclusions</h3><div>CT demonstrated 54.1% diagnostic accuracy for hybrid lesions. The proposed A/B/C classification clarifies misdiagnosis mechanisms, with left lower lobe predominance (66.7%) and systemic arterial supply (95.4%) as hallmark features. Microcystic Type 2 CPAMs (<2.85 cm) and extralobar BPS anatomical isolation synergistically reduce complication risks, providing an imaging-guided framework for risk-stratified management.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106996"},"PeriodicalIF":2.1,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Local trainee assessment: insights from a UK national survey of radiology training programme directors","authors":"A. Sawer , T.J. Sadler , P. Set , P. Riede","doi":"10.1016/j.crad.2025.106995","DOIUrl":"10.1016/j.crad.2025.106995","url":null,"abstract":"<div><h3>Aim</h3><div>Clinical radiology training in the UK follows the competency-based model of medical education, which holds trainee assessment as a core component in providing evidence of progress and the capability to work independently upon completion. The training curriculum published by the Royal College of Radiologists defines a set of competencies and a framework of assessment for these purposes. Nonetheless, it is postulated that many training schemes also employ additional locally-administered assessments of their trainees, which are not described in the training curriculum. This study aims to explore the extent, purpose, and validation of such assessments within UK radiology training programmes.</div></div><div><h3>Materials & methods</h3><div>An electronic survey was distributed to clinical radiology training programme directors and heads of schools, using multiple choice and free-text questions. Responses were analysed qualitatively.</div></div><div><h3>Results</h3><div>29 responses were received, representing 17 out of 20 Local Training and Education Boards. 88% reported employing local assessments, with 53 individual assessments described overall. These primarily involved trainees in the initial years of training (ST1-2), aimed at authorising independent reporting (68%). The majority were found to be summative in nature, with performance affecting progression, on-call eligibility and often requiring resitting. Formal evaluation or audit processes for these assessments were absent in 40% of training schemes.</div></div><div><h3>Conclusion</h3><div>Despite their prevalence and perceived value amongst trainers, the absence of robust evaluation and published evidence raises questions as to their validity and fairness. The study highlights the need for further investigation and guidance for their implementation locally in radiology training schemes.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106995"},"PeriodicalIF":2.1,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Empowering Radiology: Why Failing to Teach AI Could Cost the Specialty Its Leadership","authors":"James Baker","doi":"10.1016/j.crad.2025.106992","DOIUrl":"10.1016/j.crad.2025.106992","url":null,"abstract":"","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106992"},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S.J. Lee , D. Lee , C.H. Suh , S.Y. Jeong , H.M. Shin , W. Jung , J. Kim , J.-S. Lim , H.S. Kim , S.J. Kim , J.-H. Lee
{"title":"Development and validation of a deep learning–based automatic classification algorithm for the medial temporal lobe atrophy score using a multimodality cascade transformer","authors":"S.J. Lee , D. Lee , C.H. Suh , S.Y. Jeong , H.M. Shin , W. Jung , J. Kim , J.-S. Lim , H.S. Kim , S.J. Kim , J.-H. Lee","doi":"10.1016/j.crad.2025.106993","DOIUrl":"10.1016/j.crad.2025.106993","url":null,"abstract":"<div><h3>AIM</h3><div>The aim of this study was to develop and validate a deep learning–based automatic classification algorithm for the medial temporal lobe atrophy (MTA) score in patients with cognitive impairment.</div></div><div><h3>MATERIALS AND METHODS</h3><div>This retrospective, observational study included consecutive patients with cognitive impairment from a tertiary hospital between March 2017 and June 2021. We developed a deep learning–based model and a machine learning–based model to automate MTA classification. We reorganised the MTA scores into 3 classes (0/1), (2), and (3/4) then classified the right and left MTA scores separately. The internal testing and external testing datasets were applied and compared to validate the performance of the MTA prediction model.</div></div><div><h3>RESULTS</h3><div>A total of 1694 patients were evaluated for the training dataset, and 297 patients evaluated for the internal testing dataset. 400 patients were evaluated for the external testing dataset. In the internal testing dataset, the accuracy was 0.82 and 0.87 for the left and right MTA classifications, respectively. In the external testing dataset, the accuracy was 0.82 and 0.85 for the left and right MTA classifications, respectively. When comparing the performance between a deep learning–based model and a machine learning–based model, the results were similar.</div></div><div><h3>CONCLUSION</h3><div>The deep learning– and machine learning–based automatic classification algorithms for the MTA score accurately classified the MTA score in patients with cognitive impairment.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106993"},"PeriodicalIF":2.1,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Calandrelli , F. Pilato , L. Tuzza , C. Arpaia , A. De Gioia , G. Vento , D.M. Romeo
{"title":"Visual-semiquantitative and quantitative magnetic resonance imaging (MRI) data may predict outcome in congenital cytomegalovirus infection","authors":"R. Calandrelli , F. Pilato , L. Tuzza , C. Arpaia , A. De Gioia , G. Vento , D.M. Romeo","doi":"10.1016/j.crad.2025.106991","DOIUrl":"10.1016/j.crad.2025.106991","url":null,"abstract":"<div><h3>AIM</h3><div>Develop a combined magnetic resonance imaging (MRI) scoring system to categorise brain abnormalities in symptomatic newborns with congenital cytomegalovirus (cCMV) infection and evaluate its usefulness in predicting long-term neurological outcomes.</div></div><div><h3>MATERIALS AND METHODS</h3><div>cCMV infection onset during pregnancy and clinical severity at birth were assessed; the overall 3-year clinical outcome for language, motor, and cognitive impairments was determined based on domain scores.</div><div>We developed an MRI score combining visual-semiquantitative findings with volumetric data from brain regions to assess overall brain damage, including cortex abnormalities, white matter changes, calcifications, hippocampal dysplasia, brain volume reductions, and increased ventricular volume. The final cumulative score was the sum of all regional subscores, with higher scores indicating more severe damage.</div></div><div><h3>RESULTS</h3><div>Twenty-eight symptomatic cCMV newborns from cytomegalovirus (CMV)–infected pregnant women were studied, with 21 infected in the first two trimesters (early infection) and 7 in the third trimester (late infection). At diagnosis, 21.4% had mild, 7.1% had moderate, and 71.4% had severe symptoms.</div><div>Long-term neurological outcomes were observed in 82.1% of the children. An association between clinical severity of cCMV and infection timing (early/late) was found (<em>P</em><0.001). The MRI score correlated with clinical outcomes (<em>P</em>=0.047; r=0.378) and identified infants at a high risk for severe impairment (<em>P</em>=0.033, odds ratio: 1.488) with a cut-off score of 4 distinguishing between higher and lower impairment levels (Area Under the Curve (AUC): 0.753, <em>P</em>=0.006).</div></div><div><h3>CONCLUSION</h3><div>The combined MRI score provides a reproducible tool to predict early neurodevelopmental impairments in cCMV patients, aiding clinicians in management and counselling.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106991"},"PeriodicalIF":2.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z.-H. Wang , Z.-Q. Song , R. Guo , Q. Song , Y. Wu , Y. Liu , J. Lei , J. Ma
{"title":"Prediction of Ki-67 expression in hepatocellular carcinoma with a computed tomography (CT) extracellular volume-derived nomogram","authors":"Z.-H. Wang , Z.-Q. Song , R. Guo , Q. Song , Y. Wu , Y. Liu , J. Lei , J. Ma","doi":"10.1016/j.crad.2025.106989","DOIUrl":"10.1016/j.crad.2025.106989","url":null,"abstract":"<div><h3>AIM</h3><div>To investigate and verify the ability of the extracellular volume fraction (fECV) during the delayed computed tomography (CT) phase to noninvasively predict the preoperative Ki-67 expression level in hepatocellular carcinoma (HCC).</div></div><div><h3>MATERIALS AND METHODS</h3><div>The clinical and imaging data of 94 patients with HCC, pathologically diagnosed according to preoperative enhanced CT at our hospital, were retrospectively analysed The patients were randomly divided into a training group (66 patients) and a validation group (28 patients) at a 7:3 ratio. Univariable and multivariable logistic regression analyses were used to identify clinical risk factors, which were integrated with the fECV model to generate a joint nomogram model, whose performance was assessed using the Akaike information criterion (AIC), area under the curve (AUC), accuracy, sensitivity, and specificity. The clinical utility of the models was assessed via decision curve analysis (DCA).</div></div><div><h3>RESULTS</h3><div>In multivariate analysis, tumour capsule (OR = 0.178, <em>P</em> = 0.013) and fECV (OR = 1.282, P < 0.001) were independent predictors of high Ki-67 levels. The AUCs of the joint nomogram model constructed from these predictors and the fECV model were greater than those of the fECV model alone in the training and test sets, but the differences were not significant (<em>P</em> > 0.05, DeLong test). Moreover, the nomogram model had the lowest AIC value (21.09), indicating that it was the best model, and showed good clinical utility in both the training and validation sets.</div></div><div><h3>CONCLUSION</h3><div>The combined nomogram model based on the delayed-phase fECV has potential value in predicting individualised preoperative Ki-67 expression levels in HCC patients.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106989"},"PeriodicalIF":2.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144570746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Chen , J. Lin , R. Cui , S. Qin , Y. Chen , Y. Wang , J. Zhou , Y. Liu , G. Liu
{"title":"Clinical outcomes of initially unablatable synchronous colorectal liver metastasis after conversion chemotherapy followed by percutaneous microwave ablation","authors":"L. Chen , J. Lin , R. Cui , S. Qin , Y. Chen , Y. Wang , J. Zhou , Y. Liu , G. Liu","doi":"10.1016/j.crad.2025.106990","DOIUrl":"10.1016/j.crad.2025.106990","url":null,"abstract":"<div><h3>AIM</h3><div>To evaluate the clinical outcomes of patients with initially unablatable synchronous colorectal liver metastases (sCRLM) who underwent percutaneous microwave ablation (MWA) following conversion chemotherapy.</div></div><div><h3>MATERIALS AND METHODS</h3><div>Patients with initially unablatable sCRLM who underwent chemotherapy followed by MWA between 2013 and 2021 were enrolled. According to ablatability criteria (tumour number ≤5, tumour size ≤3 cm), patients meeting these criteria after chemotherapy received curative-intent MWA (c-MWA group), while those exceeding them received palliative-intent MWA (p-MWA group). Overall survival (OS), intrahepatic progression-free survival (ihPFS), complications, and local tumour progression (LTP) were analysed and compared to initially ablatable cases undergoing radical MWA (r-MWA group).</div></div><div><h3>RESULTS</h3><div>The ihPFS of the p-MWA group was significantly shorter than c-MWA group and r-MWA group (5.1 vs 15.0 and 24.8 months, <em>P</em> < 0.001). The OS did not significantly differ among the three groups (53.0, 66.3, and 78.5 months, <em>P</em> = 0.95). After demographics matching, the c-MWA and r-MWA groups demonstrated similar ihPFS (15.0 vs 18.9 months, <em>P</em> = 0.96) and OS (66.3 vs 64.7 months, <em>P</em> = 0.69), with no statistical difference in LTP per lesion (6.4% vs 7.6%, <em>P</em> = 0.587). The p-MWA group had the highest complication rate (48.5% vs 32.9% and 15.2%, <em>P</em> < 0.001) and LTP per-patient rate (44.8% vs 20.5% and 9.9%, respectively, <em>P</em> < 0.001) compared to c-MWA and r-MWA groups.</div></div><div><h3>CONCLUSION</h3><div>Initially unablatable patients who successfully converted to ablatable status and underwent c-MWA achieve comparable ihPFS and OS to initially ablatable cases, while those who remained unablatable and underwent p-MWA experience shorter ihPFS. However, conversion chemotherapy before MWA might increase the rates of LTP per patient and complications.</div></div>","PeriodicalId":10695,"journal":{"name":"Clinical radiology","volume":"88 ","pages":"Article 106990"},"PeriodicalIF":2.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144588096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}